Adhesion molecule CADM1 contributes to gap junctional communication among pancreatic islet α-cells and prevents their excessive secretion of glucagon

Islets

Volumn 4, Issue 1, 2012, Pages

  Ito, Akihiko ^a,b   Ichiyanagi, Naoki ^a   Ikeda, Yuki ^a   Hagiyama, Man ^a,b   Inoue, Takao ^b   Kimura, Keiko B ^a   Sakurai, Minami A ^b,c   Hamaguchi, Kazuyuki ^d   Murakami, Yoshinori ^a  

^a University of Tokyo   (Japan)

^b KINKI UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d OITA UNIVERSITY   (Japan)

Author keywords

Cell cell interaction; Connexin; Diabetes mellitus; Hyperglucagonemia; Necl 2; SynCAM

Indexed keywords

CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 1; CONNEXIN 36; SMALL INTERFERING RNA;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; GAP JUNCTION; GLUCAGON RELEASE; IMMUNOCYTOCHEMISTRY; MOUSE; NONHUMAN; PANCREAS CELL; PANCREATIC ISLET ALPHA CELL; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

EID: 84858229611     PISSN: 19382014     EISSN: 19382022     Source Type: Journal    
DOI: 10.4161/isl.4.1.18675     Document Type: Article

References (30)

1. Wakayama T, Ohashi K, Mizuno K, Iseki S. Cloning and characterization of a novel mouse immunoglobulin superfamily gene expressed in early spermatogenic cells. Mol Reprod Dev 2001; 60:158-64; PMID:11553913; http://dx.doi.org/10.1002/ mrd.1072
2. Shingai T, Ikeda W, Kakunaga S, Morimoto K, Takekuni K, Itoh S, et al. Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells. J Biol Chem 2003; 278:35421-7; PMID:12826663; http://dx.doi.org/10.1074/jbc. M305387200
3. Kuramochi M, Fukuhara H, Nobukuni T, Kanbe T, Maruyama T, Ghosh HP, et al. TSLC1 is a tumorsuppressor gene in human non-small-cell lung cancer. Nat Genet 2001; 27:427-30; PMID:11279526; http://dx.doi.org/10.1038/86934
4. Biederer T, Sara Y, Mozhayeva M, Atasoy D, Liu X, Kavalali ET, et al. SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science 2002; 297:1525-31; PMID:12202822; http://dx.doi.org/10.1126/science.1072356
5. Ito A, Okada M, Uchino K, Wakayama T, Koma Y, Iseki S, et al. Expression of the TSLC1 adhesion molecule in pulmonary epithelium and its downregulation in pulmonary adenocarcinoma other than bronchioloalveolar carcinoma. Lab Invest 2003; 83: 1175-83; PMID:12920246; http://dx.doi.org/10.1097/01.LAB.0000081391. 28136.80
6. Ito A, Nishikawa Y, Ohnuma K, Ohnuma I, Koma Y, Sato A, et al. SgIGSF is a novel biliary-epithelial cell adhesion molecule mediating duct/ductule development. Hepatology 2007; 45:684-94; PMID:17326163; http://dx.doi.org/10. 1002/hep.21501
7. Koma Y, Furuno T, Hagiyama M, Hamaguchi K, Nakanishi M, Masuda M, et al. Cell adhesion molecule 1 is a novel pancreatic-islet cell adhesion molecule that mediates nerve-islet cell interactions. Gastroenterology 2008; 134:1544-54; PMID:18471525; http://dx.doi.org/10.1053/j.gastro.2008.01.081
8. Usami Y, Ito A, Ohnuma K, Fuku T, Komori T, Yokozaki H. Tumor suppressor in lung cancer-1 as a novel ameloblast adhesion molecule and its downregulation in ameloblastoma. Pathol Int 2007; 57: 68-75; PMID:17300670; http://dx.doi.org/10.1111/j.1440-1827.2006.02064.x
9. Ito A, Jippo T, Wakayama T, Morii E, Koma Y, Onda H, et al. SgIGSF: a new mast-cell adhesion molecule used for attachment to fibroblasts and transcriptionally regulated by MITF. Blood 2003; 101:2601-8; PMID: 12456501; http://dx.doi.org/10.1182/blood-2002-07- 2265
10. Furuno T, Ito A, Koma Y, Watabe K, Yokozaki H, Bienenstock J, et al. The spermatogenic Ig superfamily/ synaptic cell adhesion molecule mast-cell adhesion molecule promotes interaction with nerves. J Immunol 2005; 174:6934-42; PMID:15905536
11. Wakayama T, Koami H, Ariga H, Kobayashi D, Sai Y, Tsuji A, et al. Expression and functional characterization of the adhesion molecule spermatogenic immunoglobulin superfamily in the mouse testis. Biol Reprod 2003; 68:1755-63; PMID:12606335; http://dx.doi.org/10.1095/biolreprod.102.012344
12. Watabe K, Ito A, Koma YI, Kitamura Y. IGSF4: a new intercellular adhesion molecule that is called by three names, TSLC1, SgIGSF and SynCAM, by virtue of its diverse function. Histol Histopathol 2003; 18:1321-9; PMID:12973698
13. Orci L, Malaisse-Lagae F, Ravazzola M, Rouiller D, Renold AE, Perrelet A, et al. A Morphological basis for intercellular communication between alfa- and betacells in the endocrine pancreas. J Clin Invest 1975; 56: 1066-70; PMID:1099118; http://dx.doi.org/10.1172/ JCI108154
14. Michaels RL, Sheridan JD. Islets of Langerhans: Dye coupling among immunocytochemically distinct cell types. Science 1981; 214:801-3; PMID:6117129; http://dx.doi.org/10.1126/science.6117129
15. Kanno T, Göpel SO, Rorsman P, Wakui M. Cellular function in multicellular system for hormone-secretion: slectrophysiological aspect of studies on α-, β-, and δ-cells of the pancreatic islet. Neurosci Res 2002; 42: 79-90; PMID:11849727; http://dx.doi.org/10.1016/S0168- 0102(01)00318-2
16. Goodenough DA, Paul DL. Beyond the gap: Functions of unpaired connexon channels. Nat Rev Mol Cell Biol 2003; 4:285-94; PMID:12671651; http://dx.doi.org/10.1038/nrm1072
17. Willecke K, Eiberger J, Degen J, Eckardt D, Romauldi A, Güldenagel M, et al. Structual and functional diversity of connexin genes in the mouse and human genome. Biol Chem 2002; 383:725-37; PMID:12108537; http://dx.doi.org/10. 1515/BC.2002.076
18. Li J, Patel VV, Kostetskii I, Xiong Y, Chu AF, Jacobson JT, et al. Cardiac-specific loss of N-Cadherin leads to alteration in connexins with conduction slowing and arrhythmogenesis. Circ Res 2005; 97:474-81; PMID:16100040; http://dx.doi.org/10.1161/01.RES. 0000181132.11393.18
19. Rogers GJ, Hodgkin MN, Squires PE. A role in architecture and function in the pancreatic islet. Cell Physiol Biochem 2007; 20:987-94; PMID:17982281; http://dx.doi.org/10.1159/000110459
20. Hamaguchi K, Leiter EH. Comparison of cytokine effects on mouse pancreatic α-cell and β-cell lines. Viability, secretory function, and MHC antigen expression. Diabetes 1990; 39:415-25; PMID:2108069; http://dx.doi.org/10.2337/diabetes.39.4.415
21. Ito A, Morita N, Miura D, Koma Y, Kataoka TR, Yamasaki H, et al. A derivative of oleamide potently inhibits the spontaneous metastasis of mouse melanoma BL6 cells. Carcinogenesis 2004; 25:2015-22; PMID: 15205356; http://dx.doi.org/10.1093/carcin/bgh208
22. Diao J, Asghar Z, Chan CB, Wheeler MB. Glucoseregulated glucagon secretion requires insulin receptor expression in pancreatic α-cells. J Biol Chem 2005; 280:33487-96; PMID:16027126; http://dx.doi.org/10.1074/jbc. M506276200
23. Quesada I, Tuduri E, Ripoll C, Nadal A. Physiology of the pancreatic α-cell and glucagon secretion: role in glucose homeostasis and siabetes. J Endocrinol 2008; 199:5-19; PMID:18669612; http://dx.doi.org/10.1677/JOE-08-0290
24. Kawamori D, Kurpad AJ, Hu J, Liew CW, Shih JL, Ford EL, et al. Insulin signaling in α cells modulates glucagon secretion in vivo. Cell Metab 2009; 9:350-61; PMID:19356716; http://dx.doi.org/10.1016/j.cmet.2009.02.007
25. Zhiling Y, Fujita E, Tanabe Y, Yamagata T, Momoi T, Momoi MY. Mutations in the gene encoding CADM1 are associated with autism spectrum disorder. Biochem Biophys Res Commun 2008; 377:926-9; PMID: 18957284; http://dx.doi.org/10.1016/ j.bbrc.2008.10.107
26. Ito A, Hagiyama M, Mimura T, Matsumoto M, Wakayama T, Iseki S, et al. Expression of cell adhesion molecule 1 in malignant pleural mesothelioma as a cause of efficient and growth on mesothelium. Lab Invest 2008; 88:504-14; PMID:18332875; http://dx.doi.org/10.1038/labinvest.2008.15
27. Yamada D, Yoshida M, Williams YN, Fukami T, Kikuchi S, Masuda M, et al. Disruption of spermatogenic cell adhesion and male infertility in mice lacking TSLC1/IGSF4, an immunoglobulin superfamily cell adhesion molecule. Mol Cell Biol 2006; 26:3610-24; PMID:16612000; http://dx.doi.org/10.1128/MCB.26.9.3610-3624. 2006
28. Wollheim CB, Meda P, Halban PA. Isolation of pancreatic islets and primary culture of the intact microorgans or of dispersed islet cells. Methods Enzymol 1990; 192:188-223; PMID:1963663; http://dx.doi.org/10.1016/0076-6879(90) 92071-K
29. Koma Y, Ito A, Wakayama T, Watabe K, Okada M, Tsubota N, et al. Cloning of a soluble isoform of the SgIGSF adhesion molecule that binds the extracellular domain of the membrane-bound isoform. Oncogene 2004; 23:5687-92; PMID:15184876; http://dx.doi.org/10.1038/sj.onc.1207761
30. Murakami Y, Koshimura K, Yamauchi K, Nishiki M, Tanaka J, Furuya H, et al. Pituitary adenylate cyclase activating polypeptide (PACAP) stimulates growth hormone release from GH3 cells through type II PACAP receptor. Regul Pept 1995; 56:35-40; PMID:7770631; http://dx.doi.org/10.1016/0167-0115(95)00003-T