Early activation of the host complement system is required to restrict central nervous system invasion and limit neuropathology during Venezuelan equine encephalitis virus infection

Journal of General Virology

Volumn 93, Issue 4, 2012, Pages 797-806

  Brooke, Christopher B ^a,b,c   Schäfer, Alexandra ^a,b,d   Matsushima, Glenn K ^a   White, Laura J ^a,b,e   Johnston, Robert E ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d University of North Carolina at Chapel Hill   (United States)

^e Global Vaccines Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; COMPLEMENT SYSTEM; DISEASE SEVERITY; FEMALE; MOUSE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; VENEZUELAN EQUINE ENCEPHALITIS; VIRAL CLEARANCE;

ADAPTIVE IMMUNITY; ANIMALS; ANTIBODIES, VIRAL; BRAIN; CENTRAL NERVOUS SYSTEM INFECTIONS; COMPLEMENT ACTIVATION; COMPLEMENT C3; COMPLEMENT C5; ENCEPHALITIS VIRUS, VENEZUELAN EQUINE; ENCEPHALOMYELITIS, VENEZUELAN EQUINE; IMMUNITY, INNATE; MICE; MICE, INBRED C57BL; VIRAL LOAD;

ALPHAVIRUS; EQUIDAE; MUS; RNA VIRUSES; TOGAVIRIDAE; VENEZUELAN EQUINE ENCEPHALITIS VIRUS;

EID: 84858191792     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.038281-0     Document Type: Article

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