Rosmarinic acid as a protective agent against genotoxicity of ethanol in mice

Food and Chemical Toxicology

Volumn 50, Issue 5, 2012, Pages 1208-1214

  De Oliveira, Nânci C D ^a   Sarmento, Merielen S ^a   Nunes, Emilene A ^a   Porto, Carem M ^a   Rosa, Darlan P ^b   Bona, Silvia R ^b   Rodrigues, Graziella ^b   Marroni, Norma P ^a,b   Pereira, Patrícia ^a   Picada, Jaqueline N ^a   Ferraz, Alexandre B F ^a   Thiesen, Flavia V ^c   Da Silva, Juliana ^a  

^a UNIVERSIDADE LUTERANA DO BRASIL   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^c PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Antigenotoxicity; Comet assay; Ethanol; Micronucleus assay; Rosmarinic acid

Indexed keywords

ALCOHOL; CATALASE; DNA; ROSMARINIC ACID; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BONE MARROW; BRAIN CELL; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; FEMALE; GENOTOXICITY; LIVER; MALE; MICRONUCLEUS TEST; MOUSE; NONHUMAN; PROTECTION; SINGLE DRUG DOSE;

ANIMALS; ANTIMUTAGENIC AGENTS; CINNAMATES; COMET ASSAY; DEPSIDES; ETHANOL; FEMALE; MALE; MICE; MUTAGENS; REACTIVE OXYGEN SPECIES; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

MUS;

EID: 84858177807     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.01.028     Document Type: Article

References (44)

1. Alamed J., Chaiyasit W., Mcclements D.J., Decker E.A. Relationships between free radical scavenging and antioxidant activity in foods. J. Agric. Food Chem. 2009, 57:2969-2976.
2. Alkam T., Nitta A., Mizoguchi H., Itoh A., Nabeshima T. A natural scavenger of peroxynitrites, rosmarinic acid, protects against impairment of memory induced by Aβ25-35. Behav. Brain Res. 2007, 180:139-145.
3. Azevedo L., Gomes J.C., Stringleta P.C., Gontijo A.M.M.C., Padovani C.R., Ribeiro L.R., Salvadori D.M.F. Black bean (Phaseolus vulgaris L.) as a protective agent against DNA damage in mice. Food Chem. Toxicol. 2003, 41:1671-1676.
4. Benavente-García O., Castillo J., Marín F.R., Ortuño A., Del Rio J.A. Uses and properties of citrus flavonoids. J. Agric. Food Chem. 1997, 45:4505-4515.
5. Blasiak J., Trzeciak A., Malecka-Panas E., Drzewoski J., Wojewoâdzka M. In vitro genotoxicity of ethanol and acetaldehyde in human lymphocytes and the gastrointestinal tract mucosa cells. Toxicol. In Vitro 2000, 14:287-295.
6. Boveris A., Chance B. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem. J. 1973, 13(3):707-716.
7. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
8. Brooks P.J., Theruvathu J.A. DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis. Alcohol 2005, 35:187-193.
9. Buege J.A., Aust S.D. Microsomal lipid peroxidation. Methods Enzymol. 1978, 52:302-310.
10. Cederbaum A.I., Lu Y., Wu D. Role of oxidative stress in alcohol-induced liver injury. Archiv. Toxicol. 2009, 83:519-548.
11. Cemeli E., Baumgartner A., Anderson D. Antioxidants and the Comet assay. Mut. Res. 2009, 681:51-67.
12. Chen J.H., Ho C.T. Antioxidant activities of caffeic acid and its related hydroxycinnamic acid compounds. J. Agric. Food Chem. 1997, 45:2374-2378.
13. Chen Y.H., Chang S.P., Lu T.C. The in vivo deleterious effects of ethanol. Int. J. Sport Exer. Sci. 2009, 1:81-86.
14. D'Errico M., Parlanti E., Dogliotti E. Mechanism of oxidative DNA damage repair and relevance to human pathology. Mut. Res. 2008, 659:4-14.
15. Da Silva J., Freitas T.R.O., Heuser V., Marinho J.R., Bittencourt F., Cerski C.T.S., Kliemann L.M., Erdtmann B. Effects of chronic exposure to coal in wild rodents (Ctenomys torquatus) evaluated by multiple methods and tissues. Mutat. Res. 2000, 470:39-51.
16. Del Baño M.J., Castillo J., Benavente-García O., Lorente J., Martín-Gil R., Acevedo C., Alcaraz M. Radioprotective-antimutagenic effects of rosemary phenolics against chromosomal damage induced in human lymphocytes by γ-rays. J. Agric. Food Chem. 2006, 54:2064-2068.
17. Dinu D., Nechifor M.T., Movileanu L. Ethanol-induced alterations of the antioxidant defense system in rat kidney. J. Biochem. Mol. Toxicol. 2006, 19:386-395.
18. Furtado M., Almeida L.C.F., Furtado R.A., Cunha W.R., Tavares D.C. Antimutagenicity of rosmarinic acid in Swiss mice evaluated by the micronucleus assay. Mutat. Res. 2008, 657:150-154.
19. Groff A., Da Silva J., Nunes E., Ianistcki M., Guecheva T., Oliveira A., Oliveira C., Val A., Henriques J.A.P. UVA/UVB-induced genotoxicity and lesion repair in Colossoma macropomum and Arapaima gigas Amazonian fish. J. Photochem. Photobiol. B 2010, 99(2):93-99.
20. Guo L., Wang L.H., Sun B., Yang J.Y., Zhao Y.Q., Dong Y.X., Sprancer M.A., Wu C.F. Direct in vivo evidence of protective effects of grape seed procyanidin fractions and other antioxidants against ethanol-induced oxidative DNA damage in mouse brain cells. J. Agric. Food Chem. 2007, 55:5881-5891.
21. Guo L., Yang J.Y., Wu C.F. Oxidative DNA damage induced by ethanol in mouse peripheral leucocytes. Basic Clin. Pharmacol. Toxicol. 2008, 103:222-227.
22. IARC, International Agency for Research on Cancer, Alcohol drinking (Group 1), 1998. Monographs on the evaluation of carcinogenic risks to humans, 44, 35.
23. Ishikawa H., Ishikawa T., Yamamoto H., Fukao A., Yokoyama K. Genotoxic effects of alcohol in human peripheral lymphocytes modulated by ADH1B and ALDH2 gene polymorphisms. Mutat. Res. 2007, 615:134-142.
24. Jordão Júnior A.A., Chiarello P.G., Bernardes M.S.M., Vannucchi H. Peroxidação lipídica e etanol: papel da glutationa reduzida e da vitamina E. Medic. 1998, 31:434-449.
25. Kapiszewska M., Soltys E., Visioli F., Cierniak A., Zajac G. The protective ability of the Mediterranean plant extract against the oxidative DNA damage. The role of the radical oxygen species and the polyphenol content. J. Physiol. Pharm. 2005, 56:183-197.
26. Kayani M.A., Parry J.M. The in vitro genotoxicity of ethanol and acetaldehyde. Toxicol. In Vitro 2010, 24:56-60.
27. Kido R., Sato I., Tsuda S. Detection of in vivo DNA damage induced by ethanol in multiple organ of pregnant mice using alkaline single cell gell electrophoresis (comet) assay. J. Vet. Med. Sci. 2006, 68:41-47.
28. Lamarche F., Gonthier B., Signorini N., Eysserich H., Barret L. Acute exposure of cultured neurones to ethanol results in reversible DNA single-strand breaks; whereas chronic exposure causes loss of cell viability. Alcohol Alcohol 2003, 38:550-558.
29. Lee H.J., Cho H.S., Park E., Kim S., Lee S.Y., Kim C.S., Kim D.K., Kim S.J., Chun H.S. Rosmarinic acid protects human dopaminergic neuronal cells against hydrogen peroxide-induced apoptosis. Toxicology 2008, 250:109-115.
30. Mavournin K.H., Blakey D.H., Cimino M.C., Salamone M.F., Hedle J.A. The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the U.S. Environmental Protection Agency. Gene-Tox. Program. Mutat. Res. 1990, 239:29-80.
31. Misra, H.P., Fridovich, I., 1972. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J. Biol. Chem. 247, 3170-3175.
32. Moon J.K., Shibamoto T. Antioxidant assays for plant and food components. J. Agric. Food Chem. 2009, 57:1655-1666.
33. Nadin S.B., Vargas-Roig L.M., Ciocca D.R. A silver staining method for single-cell gel assay. J. Histochem. Cytochem. 2001, 49:1183-1186.
34. Pereira P., Tysca D., Oliveira P., Brum L.F.S., Picada J.N., Argendhi P. Neurobehavioral and genotoxic aspects of rosmarinic acid. Pharmacol. Res. 2005, 55:199-203.
35. Petersen M., Simmonds M.S.J. Rosmarinic acid. Phytochemistry 2003, 62:121-125.
36. Phillips B.J., Jenkinson P. Is a ethanol genotoxic? A review of the published data. Mutagenesis 2001, 16:91-101.
37. Renzulli C., Galvano F., Pierdomenico L., Speroni E., Guerra M.C. Effects of rosmarinic acid against Aflatoxin B1 and ochratoxin-A-induced cell damage in a human hepatoma cell line (Hep G2). J. Appl. Toxicol. 2004, 24:289-296.
38. Roesler R., Malta L.G., Carrasco L.C., Holanda R.B., Sousa C.A.S., Pastore G.M. Atividade antioxidante de frutas do cerrado. Ciênc. Tecnol. Alim. 2007, 27:53-60.
39. Sánchez-Campillo M., Gabaldon J.A., Castillo J., Benavente-García O., Del Baño M.J., Alcaraz M., Vicente V., Alvarez N., Lozano J.A. Rosmarinic acid, a photo-protective agent against UV and other ionizing radiations. Food Chem. Toxicol. 2009, 47:386-392.
40. Singh N.P., Lai H., Khan A. Ethanol-induced single-strand DNA breaks in rat brain cells. Mutat. Res. 1995, 345:191-196.
41. Singh N.P., Mccoy M.T., Tice R.R., Schneider E.L. A simple technique for quantification of low levels of DNA damage in individual cells. Exp. Cell Res. 1998, 175:184-191.
42. Soobratee M.A., Neerghenn V.S., Luximon-Ramma A., Aruoma O.I., Bahorun T. Phenolics as potential antioxidant therapeutic agents: mechanism and actions. Mutat. Res. 2005, 579:200-213.
43. Tice R.R. Applications of the single cell gel assay to environmental biomonitoring for genotoxic pollutants. Biomonitors and Biomarkers as Indicators of Environmental Change 1995, 69-79. Plenum Press, New York. B.E. Butterworth, L.D. Cokum, J. Guzmán-Rincón (Eds.).
44. Yan Y., Yang J., Chen G., Mou Y., Zhao Y., Pan L., Ma C., Liu X., Wu C. Protection of resveratrol and its analogues against ethanol-induced oxidative DNA damage in human peripheral lymphocytes. Mutat. Res. 2011, 721:171-177.