In-vitro carbofuran induced genotoxicity in human lymphocytes and its mitigation by vitamins C and e

Disease Markers

Volumn 32, Issue 3, 2012, Pages 153-163

  Sharma, Ratnesh Kumar ^a   Sharma, Bechan ^a  

^a UNIVERSITY OF ALLAHABAD   (India)

Author keywords

Carbofuran; comet assay; genotoxicity; human lymphocytes; vitamin C; vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; CARBOFURAN; HYDROGEN PEROXIDE; PESTICIDE;

ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; CELL VIABILITY; COMET ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; GENE EXPRESSION; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; NORMAL HUMAN; OXIDATIVE STRESS; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL;

ANIMALIA;

EID: 84858172073     PISSN: 02780240     EISSN: 18758630     Source Type: Journal    
DOI: 10.3233/DMA-2011-0870     Document Type: Article

References (45)

1. A. Agrawal and B. Sharma, Pesticide induced oxidative stress in mammalian systems, Int J Biol Med Res 1(3) (2010), 90-104.
2. A. Carr and B. Frei, Does vitamin C act as a pro-oxidant under physiological conditions? FASEBJ 13(1999), 1007-1024. (Pubitemid 29249726)
3. A. Uzum, O. Topark, M.K. Gumustak, S. Ciftci and S. Sen, Effect of vitamin E therapy on oxidative stress and erythro-cyte osmotic fragility in patients on peritoneal dialysis and hemodialysis, J Nephrol 19 (2006), 739-745. (Pubitemid 46415978)
4. A. Boyum, Isolation of lymphocytes, granulocytes, and macrophages, Scand J Immunol 5 (1976), 9-15.
5. A.C. Carr and B. Frei, Human neutrophils oxidize low-density lipoprotein by a hypochlorous acid-dependent mechanism: the role of vitamin C, Biol Chem 383 (2002), 627-636. (Pubitemid 34506300)
6. A. Kamboj, R. Kiran and R. Sandhir, N-acetylcysteine ameliorates carbofuran induced alterations in lipid composition and activity of membrane bound enzymes, Mol Cell Biochem 286 (2006), 107-114.
7. A.R. Collins, M. Dusinska, M. Franklin et al., Comet assay in human biomonitoring studies: reliability, validation and applications, Environ Mol Mutagen 30 (1997), 139-146. (Pubitemid 27440590)
8. B.W. Wilson, J.R. Sanborn, M.A. O'Malley, J.D. Henderson and J.R. Billitti, Monitoring the pesticide exposed worker, Occup Med State of the Art Rev 12 (1997), 347-363.
9. B. Tavazzi, D. Pierro and A.M. Amorini, Energy metabolism and lipid peroxidation of human erythrocytes as a function of increased oxidative stress, Eur J Biochem 267 (2000), 684-689. (Pubitemid 30082380)
10. C.M. Menzie, Metabolism of Pesticides, U.S. Department of the Interior,Bureau of Sport Fisheries and Wildlife, Publication 127 (1969), Washington, DC: U.S. Government Printing, p. 216.
11. C. Datta, J. Gupta, A. Sarkar and D. Sengupta, Effect of organophosphorus insecticide phosphomidon on antioxidant defence components of human erythrocyte and plasma, Indian J Exp Biol 30 (1992), 65-67.
12. D. Agarwal, P. Sultana and G.S.D. Gupta, Oxidative stress and glutathione redox system in erythrocytes from rats treated with hexa chloro hexane, Food Chem Toxicol 29 (1991), 459-462.
13. D. Anderson, T.W. Yu, B.J. Philips and P. Schmezer, The effect of various antioxidants and other modifying agents on oxygen radical generated DNA damage in human lymphocytes in the comet assay, Mutat Res 307 (1994), 261-271. (Pubitemid 24155057)
14. D.C. Tarng, T.Y. Liu, and T.P. Huang, Protective effect of vitamin C on 8-hydroxy-2'-deoxyguanosine level in peripheral blood lymphocytes of chronic hemodialysis patients, Kidney Intern 66 (2004), 820-831.
15. D.K. Rai, R.K. Sharma, P.K. Rai, G. Watal and B. Sharma, Role of aqueous extract of Cynodon dactylon in prevention of carbofuran induced Oxidative stress and acetyl cholinesterase inhibition in rat brain, Cell Mol Biol 57(1) (2011), 135-142.
16. D.K. Rai, P.K. Rai, S.I. Rizvi, G. Watal and B. Sharma, Carbofuran-induced toxicity in rats:Protective role of vitamin C, Experi and Toxicol Pathol 61 (2009), 531-535.
17. D.M. Aabdallah and N.I. Eid, Possible neuroprotective effects of lecithin and alpha tocopherol alone or in combination against ischemia/reperfusion insult in rat brain, J Biochem Mol Toxicol 18 (2004), 273-278. (Pubitemid 39463520)
18. D. Milatovic, R.C. Gupta and M. Aschner, Anticholinesterase toxicity and oxidative stress, Sci World J 28 (2006), 295-310.
19. D.W. Fairbairn, P.L. Olive and K.L. O'Neill, The COMET assay: a comprehensive review, Mutat Res 339 (1995),37-59.
20. D. Zeljezic, A.L. Vrdoljak, N. Kopjar, B. Radic and S.M. Kraus, Cholinesterase inhibiting and genotoxic effect of Acute Carbofuran intoxication in Man: A case report, Basic and Clin Pharmacol and Toxicol 103 (2008), 329-335.
21. F. Gultekin, N. Delibas, S. Yasar and I. Kilinc, In vivo changes in antioxidant systems and protective role of melatonin and a combination of vitamin C and vitamin E on oxidative damage in erythrocytes induced by chlorpyrifosethyl in rats, Arch Toxicol 75 (2001), 88-96. (Pubitemid 32304541)
22. G. Speit and A. Hartmann, The comet assay (single-cell gel test). A sensitive genotoxicity for the detection of DNA damage and repair, Methods Mol Biol 113 (1999), 203-212.
23. I. Altuntas, N. Delibas and R. Sutcu, The effects of organophosphate insecticide methidathion on lipid peroxida-tion and antioxidant enzymes in rat erythrocytes: role of vitamins E and C, Hum Exp Toxicol 21 (2002), 681-685. (Pubitemid 36124501)
24. I.D. Podmore, H.R. Griffiths, K.E. Herbert et al., Vitamin C exhibits pro-oxidant properties, Nature 392 (1998), 559. (Pubitemid 28207702)
25. J. Blasiak, P. Jałoszynski, A. Trzeciak and K. Szyfter, In vitro studies on the genotoxicity of the organophosphorusinsecti-cide malathion and its two analogues, Mutation Research 445 (1999), 275-283. (Pubitemid 29518336)
26. J. Blasiak, E. Gloc, W. Katarzyna and C. Agnieszka, Genotox-icity of acrylamide in human lymphocytes, Chem Biol Inter 149 (2004), 137-149.
27. J. Eritsland, Safety considerations of polyunsaturated fatty acids, Am J Clin Nutr 71 (2000), 197-201.
28. L.K. Chauhan, N. Pant, S.K. Gupta and S.P. Srivastava, Induction of chromosome aberrations, micronucleus formation and sperm abnormalities in mouse following carbofuran exposure, Mutat Res 465 (2000), 123-129. (Pubitemid 30119926)
29. M. Mladinic, P. Perkovic and D. Zeljezic, Characterization of chromatin instabilities induced by glyphosate, terbuthylazine and carbofuran using FISH assay, Toxicol Lett 189 (2009), 130-137.
30. M.S. Cooke, M.D. Evans, I.D. Podmore et al., Novel repair action of vitamin C upon in vivo oxidative DNA damage, FEBS Lett 363 (1998), 363-367. (Pubitemid 28546676)
31. M. Schneider, K. Diemer, K. Engelhart et al., Protective effects of vitamins C and E on the number of micronuclei in lymphocytes in smokers and their role in ascorbate free radical formation in plasma, Free Radical Res 34 (2001), 209-219. (Pubitemid 32331651)
32. M. Singh, R. Kiran and A. Kamboj, Erythrocyte antioxi-dant enzymes in toxicological evaluation of commonly used organophosphate pesticides, Indian J Exp Biol 44 (2006), 580-603.
33. N. Gera, R. Kiran and A. Mehmood, Carbofuran adminstration induced genotoxic effects in epithelial cells across cryptvillus axis in rat intestine, Pest Biochem. and Physiol (2011), in press.
34. N.P. Singh, M.T. McCoy, R.R. Tice and E.L. Schneider, A simple technique for quantitation of low levels of DNA damage in individual cells, Exp Cell Res 175 (1988), 184-191.
35. N. Yamashita, M. Murata, S. Inoue, M.J. Burkitt, L. Milne and S. Kawanishi, Alpha tocopherol induces oxidative damage to DNA in the presence of copper(II) ions, Chem Res Toxicol 11 (1988), 855-862.
36. P. Zhou, B. Liu and Y. Lu, DNA damaging effects of carbofu-ran and its main metabolites on mice by micronucleus test and single cell gel electrophoresis, Sci China C Life Sci 48(SUPPL 1) (2005), 40-47. (Pubitemid 44898297)
37. P.N. Saxena, S.K. Gupta and R.C. Murthy, Carbofuran induced cytogenetic effects in root meristem cells of Allium cepa and Allium sativum: A spectroscopic approach for chromosome damage, Pest Biochem and Physiol 96 (2010), 93-100.
38. R.E. Gosselin, R.P. Smith and H.C. Hodge, Clinical Toxicology of Commercial Products, (5th ed.), Baltimore: Williams and Wilkins, p. II-305. (1984). Philadelphia, PA, USA.
39. R.J. Kuhr and H.W. Dorough, Carbamate Insecticides: Chemistry, Biochemistryand Toxicology, (1976). Cleveland, OH: CRC Press, Submitted to WHO by FMC Corp.
40. R.C. Gupta, Carbofuran toxicity, J Toxicol Environ Health 43 (1994), 383-418. (Pubitemid 24380175)
41. R.H. Bisby, S.A. Johnson and A.W. Parker, Quenching of reactive oxidative species by probucol and comparison with other antioxidants, Free Radical Biol Med 20 (1996), 411-420. (Pubitemid 26077864)
42. S.S.E. Petropoulou, A. Tsarbopoulos and P.A. Siskos, Determination of carbofuran, carbaryl and their main metabolites in plasma samples of agricultural populations using gas chro-matography tandem mass spectrometry, Anal Bioanal Chem 385 (2006), 1444-1456. (Pubitemid 44200020)
43. K1) cells, Mutation Research/Genetic Toxicology and Environmental Mutagenesis 656 (2008), 68-73.
44. W.H. Hickox, Public health goals for chemicals in drinking water, (2000), in: Carbofuran. California Environmental Protection Agency.
45. www.inchem.org/documents/jmpr/jmpmono/v96pr03.htm.