Carbofuran induced cytogenetic effects in root meristem cells of Allium cepa and Allium sativum: A spectroscopic approach for chromosome damage

Pesticide Biochemistry and Physiology

Volumn 96, Issue 2, 2010, Pages 93-100

  Saxena, P N ^a   Gupta, S K ^a   Murthy, R C ^a  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

Author keywords

Allium sativum and Allium cepa; Carbofuran; Carbofuran DNA interactions; Chromosomal and mitotic aberrations; FTIR and UV spectra; Molecular orbital calculations

Indexed keywords

ALLIUM CEPA; ALLIUM SATIVUM;

EID: 75149152245     PISSN: 00483575     EISSN: 10959939     Source Type: Journal    
DOI: 10.1016/j.pestbp.2009.09.006     Document Type: Article

References (41)

1. Hassal K.A. The Chemistry of Pesticides - Their Metabolism, Mode of Action and Uses in Crop Protection (1982), Macmillan, London pp. 67-96
2. Dobsikova R. Acute toxicity of carbofuran to selected species of aquatic and terrestrial organisms. Plant Protect. Sci. 39 (2003) 103-108
3. Feaster S.R., Lee K., Baker N., Hui D.Y., and Quinn D.M. Molecular recognition by cholesterol esterase of active site ligands: structure-reactivity effects for inhibition by aryl carbamates and subsequent carbamylenzyme turnover. Biochemistry 35 (1996) 16723-16734
4. Sharaf A.A., Temtamy S.A., Dehondt H.A., Belah M.H., and Kassam E.A. Effect of aldicarb(Temik), a carbamate insecticide, on chromosomes of the laboratory rat. Egypt. J. Genet. Cytol. 11 (1982) 143-151
5. Onfelt A., and Klasterska I. Spindle disturbances in mammalian cells II. Induction of viable aneuploid/polyploid cells and multiple chromatid exchanges after treatment of V79 Chinese hamster cells with carbaryl: modifying effects of glutathione and S9. Mutat. Res. 119 (1983) 319-330
6. Gonzalez C.M., Loria D., and Matos E. Genotoxicity of the pesticide propoxur and its nitrosoderivative, NP, on human lymphocytes in vitro. Mutat. Res. 232 (1990) 45-48
7. Wei L.Y., Chao J.S., and Hong C.C. Assessment of the ability of propoxur, methomyl and aldicarb, three carbamate insecticides to induce micronuclei in vitro in cultured Chinese hamster ovary cells and in vivo in BALB/c mice. Environ. Mol. Mutagen. 29 (1997) 386-393
8. Amer S.M., and Farah O.R. Cytological effects of pesticides I: mitotic effects of N-methyl-1-napthyl carbamate "sevin". Cytologia 30 (1968) 175-181
9. Blevins R.D., Lijinsky W., and Regan J.D. Nitrosated methylcarbamate insecticides: effect on the DNA of human cells. Mutat. Res. 44 (1977) 1-7
10. Georgieva V., Vachkova R., Tzoneva M., and Kappas A. Genotoxic activity of benomyl in different test systems. Environ. Mol. Mutagen. 16 (1996) 32-36
11. Vasudev V., and Krishnamurthy N.B. In vivo cytogenetic analysis of the carbamate pesticides Dithane M-45 and Baygon in mice. Mutat. Res. 323 (1994) 133-135
12. Gentile J.M., Gentile G.J., Bultman J., Sechriest R., Wagner E.D., and Plewa M.J. An evaluation of the genotoxic properties of insecticides following plant and animal activation. Mutat. Res. 101 (1982) 19-29
13. Zhou P., Liu B., and Lu Y. DNA damaging effects of carbofuran and its main metabolites on mice by micronucleus test and single gel electrophoresis. Sci. China C Life. Sci. 48 (2005) 40-47
14. Grant W.F. Chromosome aberration assays in Allium - a report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutat. Res. 99 (1982) 273-291
15. World Health Organisation, Guide to short term tests for detecting mutagenic and carcinogenic chemicals, Environ. Health. Criteria, 51, Geneva, 1985, 208 pp.
16. Fiskesjo G. The Allium test as a standard in environmental monitoring. Hereditas 102 (1985) 99-102
17. Saxena P.N., Chauhan L.K.S., Chandra S., and Gupta S.K. Genotoxic effects of diuron contaminated soil on the root meristem cells of Allium sativum: a possible mechanism of chromosome damage. Toxicol. Mech. Meth. 14 (2004) 281-286
18. Saxena P.N., Chauhan L.K.S., and Gupta S.K. Cytogenetic effects of commercial formulation of cypermethrin in root meristem cells of Allium sativum: spectroscopic basis of chromosome damage. Toxicology 216 (2005) 244-252
19. Saxena P.N., and Gupta V.D. Role of molecular geometry, valence charge distribution and vibrational modes in the bioactivity of cyclodiene insecticides. J. Appl. Toxicol. 25 (2005) 39-46
20. Tokiwa H., Sera N., Fukuhara K., Utsumi H., Sasaki S., and Miyata N. Structure-activity relationship between Salmonella-mutagenicity and nitro-orientation of nitroazaphenanthrenes. Chemico-Biol. Interact. 146 (2003) 19-25
21. M. Zhang, H.Y.N. Holman, M. Ferrari, J.C. Hunter-Cevera, Synchrotron infrared microspectroscopy for assessment of mutagenicity of metal implants, in: Biomedical Materials-Drug Delivery, Implants and Tissue Engineering, MRS Sym. Series, 1999, pp. 163-169.
22. Xu W., Tong B., and Huang Q. Chemical assessment of mutagenicity of halocarbons: FTIR, UV spectrum characteristics of guanine-halohydrocarbon adducts. Huang. Jing. Ke. Xue. 22 (2001) 67-70
23. Rank J., and Nielson M.H. Allium cepa anaphase-telophase root tip chromosome aberration assay on N-methyl-N-nitrosourea, maleic hydrazide, sodium azide, ethyl methyl sulfonate. Mutat. Res. 390 (1997) 121-127
24. Xu L.Z., Yu G.P., and Yang S.H. 2,3-Dihydro-2,2-dimethylbenzofuran-7-yl N-methylcarbamate. Acta. Cryst. E61 (2005) o1924-o1926
25. Srivastava R.C., Froehlich J., and Eichhorn G.L. The effect of platinum binding on the structure of DNA and its function in RNA synthesis. Biochimie 60 (1978) 879-891
26. Lockard J.M., Schuette B.P., and Sabharwal P.S. Inhibition by carbaryl of DNA, RNA and protein synthesis in cultured rat lung cells. Experientia 38 (1982) 686-687
27. Chauhan L.K.S., Pant N., Gupta S.K., and Srivastava S.P. Inductions of chromosome aberrations, micronucleus formation and sperm abnormalities in mouse following carbofuran exposure. Mutat. Res. 465 (2000) 123-129
28. Kuriyama R., and Sakai H. Role of tubulin-SH group in polymerization to microtubules. J. Biochem. 76 (1974) 651-654
29. Luo L.Z., Werner K.M., Gollin S.M., and Saunders W.S. Cigarette smoke induces anaphase bridges and genomic imbalances in normal cells. Mutat. Res. 554 (2004) 375-385
30. Chauhan L.K.S., Saxena P.N., and Gupta S.K. Evaluation of cytogenetic effects of isoproturon on the root meristem cells of Allium sativum. Biomed. Environ. Sci. 14 (2001) 214-219
31. McGill M., Sen P., and Hsu T.C. Effect of ethidium bromide on mitosis and chromosomes, a possible material basis for chromosome stickiness. Chromosoma 47 (1974) 157-167
32. Naravaneni R., and Jamil K. Cytogenetic biomarkers of carbofuran toxicity utilizing human lymphocytes cultures in vitro. Drug. Chem. Toxicol. 28 (2005) 359-372
33. Grover I.S., Ladhar S.S., and Randhawa S.K. Carbaryl - a selective genotoxicant. Environ. Pollut. 58 (1989) 313-323
34. Zeljezic D., Vrdoljak A.L., Radic B., Fuchs N., Berend S., Orescanin V., and Kopzar N. Comparative evaluation of acetylcholinesterase status and genome damage in blood cells of industrial workers exposed to carbofuran. Food Chem. Toxicol. 45 (2007) 2488-2498
35. Ashworth R.J., and Sheets T.J. Metabolism of carbofuran in tobacco. J. Agric. Food Chem. 20 (1972) 407-412
36. Bolognesi C., Peluso M., Degan P., Rabboni R., Munnia A., and Abbondandolo A. Genotoxic effects of the carbamate insecticide, methyomyl. II. In vivo studies with pure compound and the technical formulation, "Lannate 25". Environ. Mol. Mutagen. 24 (1994) 235-242
37. Seiler J.P. Herbicidal phenylalkylureas as possible mutagens. II. Chemical basis of mutagenic activity. Pestic. Biochem. Physiol. 12 (1979) 183-190
38. Onozato M., and Oshima S. Analysis of mutagenicity of nitrobenzanthrones by molecular orbital calculations. Polycycl. Aromat. Compd. 26 (2006) 93-101
39. Liu X.M., Sonar S., Lee C.P., Coleman M., Rajbhandary U.L., and Rothschild K.J. Site directed isotope labelling and FTIR spectroscopy: assignment of tyrosine bands in the bR-M difference spectroscopy of bacteriorhodopsin. Biophys. Chem. 56 (1995) 63-70
40. Bellamy L.J. The Infrared Spectra of Complex Molecules (1975), Chapman and Hall, London
41. Lewis D.F.V., Loannides C., and Parke D.V. Further evaluation of COMPACT, the molecular orbital approach for the prospective safety evaluation of chemicals. Mutat. Res. 412 (1998) 41-54