메뉴 건너뛰기




Volumn 87, Issue 4, 2012, Pages 401-411

Systemic mastocytosis in adults: 2012 Update on diagnosis, risk stratification, and management

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ALPHA2B INTERFERON; CD2 ANTIGEN; CLADRIBINE; DASATINIB; HYDROXYUREA; IMATINIB; INTERLEUKIN 2 RECEPTOR ALPHA; MASITINIB; MIDOSTAURIN; PREDNISONE; TRYPTASE;

EID: 84858163506     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.23134     Document Type: Article
Times cited : (74)

References (119)
  • 2
    • 0020511371 scopus 로고
    • Systemic mastocytosis. Extracutaneous manifestations
    • Brunning RD, McKenna RW, Rosai J, et al. Systemic mastocytosis. Extracutaneous manifestations. Am J Surg Pathol 1983; 7: 425-438.
    • (1983) Am J Surg Pathol , vol.7 , pp. 425-438
    • Brunning, R.D.1    McKenna, R.W.2    Rosai, J.3
  • 3
    • 0021804366 scopus 로고
    • Bone marrow findings in systemic mastocytosis
    • Horny HP, Parwaresch MR, Lennert K. Bone marrow findings in systemic mastocytosis. Hum Pathol 1985; 16: 808-814.
    • (1985) Hum Pathol , vol.16 , pp. 808-814
    • Horny, H.P.1    Parwaresch, M.R.2    Lennert, K.3
  • 4
    • 0034766591 scopus 로고    scopus 로고
    • Bone marrow mast cell morphologic features and hematopoietic dyspoiesis in systemic mast cell disease
    • Stevens EC, Rosenthal NS. Bone marrow mast cell morphologic features and hematopoietic dyspoiesis in systemic mast cell disease. Am J Clin Pathol 2001; 116: 177-182.
    • (2001) Am J Clin Pathol , vol.116 , pp. 177-182
    • Stevens, E.C.1    Rosenthal, N.S.2
  • 5
    • 0000124580 scopus 로고
    • The natural course of urticaria pigmentosa. Analysis and follow-up of 112 cases
    • Caplan RM. The natural course of urticaria pigmentosa. Analysis and follow-up of 112 cases. Arch Dermatol 1963; 87: 146-157.
    • (1963) Arch Dermatol , vol.87 , pp. 146-157
    • Caplan, R.M.1
  • 6
    • 69849091836 scopus 로고    scopus 로고
    • Pediatric-onset mastocytosis: a long term Clinical follow-up and correlation with bone marrow histopathology
    • Uzzaman A, Maric I, Noel P, et al. Pediatric-onset mastocytosis: a long term Clinical follow-up and correlation with bone marrow histopathology. Pediatr Blood Cancer 2009; 53: 629-634.
    • (2009) Pediatr Blood Cancer , vol.53 , pp. 629-634
    • Uzzaman, A.1    Maric, I.2    Noel, P.3
  • 8
    • 0028087953 scopus 로고
    • Pediatric mastocytosis
    • quiz 202-207.
    • Kettelhut BV, Metcalfe DD. Pediatric mastocytosis. Ann Allergy 1994; 73: 197-202; quiz 202-207.
    • (1994) Ann Allergy , vol.73 , pp. 197-202
    • Kettelhut, B.V.1    Metcalfe, D.D.2
  • 9
    • 67651120132 scopus 로고    scopus 로고
    • Systemic mastocytosis in 342 consecutive adults: Survival studies and prognostic factors
    • Lim KH, Tefferi A, Lasho TL, et al. Systemic mastocytosis in 342 consecutive adults: Survival studies and prognostic factors. Blood 2009; 113: 5727-5736.
    • (2009) Blood , vol.113 , pp. 5727-5736
    • Lim, K.H.1    Tefferi, A.2    Lasho, T.L.3
  • 10
    • 70349558437 scopus 로고    scopus 로고
    • Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1
    • Swerdlow SH, Editors. Lyon: International Agency for Research and Cancer (IARC)
    • Bain BJ, Gilliland DG, Horny HP, Vardiman JW. Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1. In: Swerdlow SH, et al., Editors. WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. Lyon: International Agency for Research and Cancer (IARC); 2008. pp 68-73.
    • (2008) WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues , pp. 68-73
    • Bain, B.J.1    Gilliland, D.G.2    Horny, H.P.3    Vardiman, J.W.4
  • 11
    • 0344987881 scopus 로고    scopus 로고
    • A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome
    • Cools J, DeAngelo DJ, Gotlib J, et al. A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med 2003; 348: 1201-1214.
    • (2003) N Engl J Med , vol.348 , pp. 1201-1214
    • Cools, J.1    DeAngelo, D.J.2    Gotlib, J.3
  • 12
    • 0038792233 scopus 로고    scopus 로고
    • Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness
    • Klion AD, Noel P, Akin C, et al. Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness. Blood 2003; 101: 4660-4666.
    • (2003) Blood , vol.101 , pp. 4660-4666
    • Klion, A.D.1    Noel, P.2    Akin, C.3
  • 13
    • 0942276859 scopus 로고    scopus 로고
    • Molecular remission and reversal of myelofibrosis in response to imatinib mesylate treatment in patients with the myeloproliferative variant of hypereosinophilic syndrome
    • Klion AD, Robyn J, Akin C, et al. Molecular remission and reversal of myelofibrosis in response to imatinib mesylate treatment in patients with the myeloproliferative variant of hypereosinophilic syndrome. Blood 2004; 103: 473-478.
    • (2004) Blood , vol.103 , pp. 473-478
    • Klion, A.D.1    Robyn, J.2    Akin, C.3
  • 14
    • 8644263305 scopus 로고    scopus 로고
    • FIP1L1-PDGFRA fusion: Prevalence and clinicopathologic correlates in 89 consecutive patients with moderate to severe eosinophilia
    • Pardanani A, Brockman SR, Paternoster SF, et al. FIP1L1-PDGFRA fusion: Prevalence and clinicopathologic correlates in 89 consecutive patients with moderate to severe eosinophilia. Blood 2004; 104: 3038-3045.
    • (2004) Blood , vol.104 , pp. 3038-3045
    • Pardanani, A.1    Brockman, S.R.2    Paternoster, S.F.3
  • 15
    • 0041656424 scopus 로고    scopus 로고
    • Imatinib for systemic mast-cell disease
    • Pardanani A, Elliott M, Reeder T, et al. Imatinib for systemic mast-cell disease. Lancet 2003; 362: 535-536.
    • (2003) Lancet , vol.362 , pp. 535-536
    • Pardanani, A.1    Elliott, M.2    Reeder, T.3
  • 16
    • 10744228486 scopus 로고    scopus 로고
    • CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy
    • Pardanani A, Ketterling RP, Brockman SR, et al. CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy. Blood 2003; 102: 3093-3096.
    • (2003) Blood , vol.102 , pp. 3093-3096
    • Pardanani, A.1    Ketterling, R.P.2    Brockman, S.R.3
  • 17
    • 33845941854 scopus 로고    scopus 로고
    • Imatinib mesylate responsiveness in aggressive systemic mastocytosis: Novel association with a platelet derived growth factor receptor beta mutation
    • Dalal BI, Horsman DE, Bruyere H, Forrest DL. Imatinib mesylate responsiveness in aggressive systemic mastocytosis: Novel association with a platelet derived growth factor receptor beta mutation. Am J Hematol 2007; 82: 77-79.
    • (2007) Am J Hematol , vol.82 , pp. 77-79
    • Dalal, B.I.1    Horsman, D.E.2    Bruyere, H.3    Forrest, D.L.4
  • 18
    • 33947543336 scopus 로고    scopus 로고
    • Characterization of three new imatinib-responsive fusion genes in chronic myeloproliferative disorders generated by disruption of the platelet-derived growth factor receptor beta gene
    • Walz C, Metzgeroth G, Haferlach C, et al. Characterization of three new imatinib-responsive fusion genes in chronic myeloproliferative disorders generated by disruption of the platelet-derived growth factor receptor beta gene. Haematologica 2007; 92: 163-169.
    • (2007) Haematologica , vol.92 , pp. 163-169
    • Walz, C.1    Metzgeroth, G.2    Haferlach, C.3
  • 19
    • 2642581620 scopus 로고    scopus 로고
    • Systemic mastocytosis with associated clonal haematological non-mast cell lineage diseases: A histopathological challenge
    • Horny HP, Sotlar K, Sperr WR, Valent P. Systemic mastocytosis with associated clonal haematological non-mast cell lineage diseases: A histopathological challenge. J Clin Pathol 2004; 57: 604-608.
    • (2004) J Clin Pathol , vol.57 , pp. 604-608
    • Horny, H.P.1    Sotlar, K.2    Sperr, W.R.3    Valent, P.4
  • 20
    • 0036843231 scopus 로고    scopus 로고
    • Detection of c-kit point mutation Asp-816 -> Val in microdissected pooled single mast cells and leukemic cells in a patient with systemic mastocytosis and concomitant chronic myelomonocytic leukemia
    • Sotlar K, Fridrich C, Mall A, et al. Detection of c-kit point mutation Asp-816 -> Val in microdissected pooled single mast cells and leukemic cells in a patient with systemic mastocytosis and concomitant chronic myelomonocytic leukemia. Leuk Res 2002; 26: 979-984.
    • (2002) Leuk Res , vol.26 , pp. 979-984
    • Sotlar, K.1    Fridrich, C.2    Mall, A.3
  • 21
    • 0023695019 scopus 로고
    • Li CY, Yam LT, Significance of systemic mast cell disease with associated hematologic disorders
    • Travis WD. Li CY, Yam LT, et al. Significance of systemic mast cell disease with associated hematologic disorders. Cancer 1988; 62: 965-972.
    • (1988) Cancer , vol.62 , pp. 965-972
    • Travis, W.D.1
  • 22
    • 70449706224 scopus 로고    scopus 로고
    • Prognostically relevant breakdown of 123 patients with systemic mastocytosis associated with other myeloid malignancies
    • Pardanani A, Lim KH, Lasho TL, et al. Prognostically relevant breakdown of 123 patients with systemic mastocytosis associated with other myeloid malignancies. Blood 2009; 114: 3769-3772.
    • (2009) Blood , vol.114 , pp. 3769-3772
    • Pardanani, A.1    Lim, K.H.2    Lasho, T.L.3
  • 23
    • 0038341142 scopus 로고    scopus 로고
    • Eosinophils are derived from the neoplastic clone in patients with systemic mastocytosis and eosinophilia
    • Pardanani A, Reeder T, Li CY, Tefferi A. Eosinophils are derived from the neoplastic clone in patients with systemic mastocytosis and eosinophilia. Leuk Res 2003; 27: 883-885.
    • (2003) Leuk Res , vol.27 , pp. 883-885
    • Pardanani, A.1    Reeder, T.2    Li, C.Y.3    Tefferi, A.4
  • 24
    • 8744225522 scopus 로고    scopus 로고
    • Demonstration that mast cells, T cells, and B cells bearing the activating kit mutation D816V occur in clusters within the marrow of patients with mastocytosis
    • Taylor ML, Sehgal D, Raffeld M, et al. Demonstration that mast cells, T cells, and B cells bearing the activating kit mutation D816V occur in clusters within the marrow of patients with mastocytosis. J Mol Diagn 2004; 6: 335-342.
    • (2004) J Mol Diagn , vol.6 , pp. 335-342
    • Taylor, M.L.1    Sehgal, D.2    Raffeld, M.3
  • 25
    • 3242742988 scopus 로고    scopus 로고
    • FIP1L1-PDGFRA and c-kit D816V mutation-based clonality studies in systemic mast cell disease associated with eosinophilia
    • Tefferi A, Lasho TL, Brockman SR, et al. FIP1L1-PDGFRA and c-kit D816V mutation-based clonality studies in systemic mast cell disease associated with eosinophilia. Haematologica 2004; 89: 871-873.
    • (2004) Haematologica , vol.89 , pp. 871-873
    • Tefferi, A.1    Lasho, T.L.2    Brockman, S.R.3
  • 26
    • 13444261048 scopus 로고    scopus 로고
    • Evaluation of mast cells in myeloproliferative disorders and myelodysplastic syndromes
    • Dunphy CH. Evaluation of mast cells in myeloproliferative disorders and myelodysplastic syndromes. Arch Pathol Lab Med 2005; 129: 219-222.
    • (2005) Arch Pathol Lab Med , vol.129 , pp. 219-222
    • Dunphy, C.H.1
  • 27
    • 2742529418 scopus 로고
    • Human proto-oncogene c-kit: A new cell surface receptor tyrosine kinase for an unidentified ligand
    • Yarden Y, Kuang WJ, Yang-Feng T, et al. Human proto-oncogene c-kit: A new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J 1987; 6: 3341-3351.
    • (1987) EMBO J , vol.6 , pp. 3341-3351
    • Yarden, Y.1    Kuang, W.J.2    Yang-Feng, T.3
  • 28
    • 23944452835 scopus 로고    scopus 로고
    • KIT (CD117): A review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation
    • Miettinen M, Lasota J. KIT (CD117): A review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation. Appl Immunohistochem Mol Morphol 2005; 13: 205-220.
    • (2005) Appl Immunohistochem Mol Morphol , vol.13 , pp. 205-220
    • Miettinen, M.1    Lasota, J.2
  • 29
    • 0026801434 scopus 로고
    • Induction of differentiation of human mast cells from bone marrow and peripheral blood mononuclear cells by recombinant human stem cell factor/kit-ligand in long-term culture
    • Valent P, Spanblochl E, Sperr WR, et al. Induction of differentiation of human mast cells from bone marrow and peripheral blood mononuclear cells by recombinant human stem cell factor/kit-ligand in long-term culture. Blood 1992; 80: 2237-2245.
    • (1992) Blood , vol.80 , pp. 2237-2245
    • Valent, P.1    Spanblochl, E.2    Sperr, W.R.3
  • 30
    • 33749368009 scopus 로고    scopus 로고
    • KIT mutation in mast cells and other bone marrow hematopoietic cell lineages in systemic mast cell disorders: A prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients
    • Garcia-Montero AC, Jara-Acevedo M, Teodosio C, et al. KIT mutation in mast cells and other bone marrow hematopoietic cell lineages in systemic mast cell disorders: A prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients. Blood 2006; 108: 2366-2372.
    • (2006) Blood , vol.108 , pp. 2366-2372
    • Garcia-Montero, A.C.1    Jara-Acevedo, M.2    Teodosio, C.3
  • 31
    • 0032456567 scopus 로고    scopus 로고
    • Identification of activating c-kit mutations in adult-, but not in childhood-onset indolent mastocytosis: A possible explanation for divergent clinical behavior
    • Buttner C, Henz BM, Welker P, et al. Identification of activating c-kit mutations in adult-, but not in childhood-onset indolent mastocytosis: A possible explanation for divergent clinical behavior. J Invest Dermatol 1998; 111: 1227-1231.
    • (1998) J Invest Dermatol , vol.111 , pp. 1227-1231
    • Buttner, C.1    Henz, B.M.2    Welker, P.3
  • 32
    • 0027359443 scopus 로고
    • Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product
    • Furitsu T, Tsujimura T, Tono T, et al. Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product. J Clin Invest 1993; 92: 1736-1744.
    • (1993) J Clin Invest , vol.92 , pp. 1736-1744
    • Furitsu, T.1    Tsujimura, T.2    Tono, T.3
  • 33
    • 0344643427 scopus 로고    scopus 로고
    • One-step detection of c-kit point mutations using peptide nucleic acid-mediated polymerase chain reaction clamping and hybridization probes
    • Sotlar K, Escribano L, Landt O, et al. One-step detection of c-kit point mutations using peptide nucleic acid-mediated polymerase chain reaction clamping and hybridization probes. Am J Pathol 2003; 162: 737-746.
    • (2003) Am J Pathol , vol.162 , pp. 737-746
    • Sotlar, K.1    Escribano, L.2    Landt, O.3
  • 34
    • 0032104728 scopus 로고    scopus 로고
    • In vivo differentiation of mast cells from acute myeloid leukemia blasts carrying a novel activating ligand-independent C-kit mutation
    • Beghini A, Cairoli R, Morra E, Larizza L. In vivo differentiation of mast cells from acute myeloid leukemia blasts carrying a novel activating ligand-independent C-kit mutation. Blood Cells Mol Dis 1998; 24: 262-270.
    • (1998) Blood Cells Mol Dis , vol.24 , pp. 262-270
    • Beghini, A.1    Cairoli, R.2    Morra, E.3    Larizza, L.4
  • 35
    • 13044305857 scopus 로고    scopus 로고
    • Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis
    • Longley BJ Jr, Metcalfe DD, Tharp M, et al. Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis. Proc Natl Acad Sci USA 1999; 96: 1609-1614.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 1609-1614
    • Longley Jr., B.J.1    Metcalfe, D.D.2    Tharp, M.3
  • 36
    • 0033749308 scopus 로고    scopus 로고
    • Mast cell disease associated with acute myeloid leukemia: Detection of a new c-kit mutation Asp816His
    • Pullarkat VA, Pullarkat ST, Calverley DC, Brynes RK. Mast cell disease associated with acute myeloid leukemia: Detection of a new c-kit mutation Asp816His. Am J Hematol 2000; 65: 307-309.
    • (2000) Am J Hematol , vol.65 , pp. 307-309
    • Pullarkat, V.A.1    Pullarkat, S.T.2    Calverley, D.C.3    Brynes, R.K.4
  • 37
    • 0031039992 scopus 로고    scopus 로고
    • A new c-kit mutation in a case of aggressive mast cell disease
    • Pignon JM, Giraudier S, Duquesnoy P, et al. A new c-kit mutation in a case of aggressive mast cell disease. Br J Haematol 1997; 96: 374-376.
    • (1997) Br J Haematol , vol.96 , pp. 374-376
    • Pignon, J.M.1    Giraudier, S.2    Duquesnoy, P.3
  • 38
    • 76649094569 scopus 로고    scopus 로고
    • Pediatric mastocytosis is a clonal disease associated with D816V and other activating c-KIT mutations
    • Bodemer C, Hermine O, Palmerini F, et al. Pediatric mastocytosis is a clonal disease associated with D816V and other activating c-KIT mutations. J Invest Dermatol 2010; 130: 804-815.
    • (2010) J Invest Dermatol , vol.130 , pp. 804-815
    • Bodemer, C.1    Hermine, O.2    Palmerini, F.3
  • 39
    • 18744382426 scopus 로고    scopus 로고
    • c-kit Mutations in patients with childhood-onset mastocytosis and genotype-phenotype correlation
    • Yanagihori H, Oyama N, Nakamura K, Kaneko F. c-kit Mutations in patients with childhood-onset mastocytosis and genotype-phenotype correlation. J Mol Diagn 2005; 7: 252-257.
    • (2005) J Mol Diagn , vol.7 , pp. 252-257
    • Yanagihori, H.1    Oyama, N.2    Nakamura, K.3    Kaneko, F.4
  • 40
    • 33845961736 scopus 로고    scopus 로고
    • C-kit Asp-816-Val mutation analysis in patients with mastocytosis
    • Verzijl A, Heide R, Oranje AP, van Schaik RH. C-kit Asp-816-Val mutation analysis in patients with mastocytosis. Dermatology 2007; 214: 15-20.
    • (2007) Dermatology , vol.214 , pp. 15-20
    • Verzijl, A.1    Heide, R.2    Oranje, A.P.3    van Schaik, R.H.4
  • 41
    • 0032989226 scopus 로고    scopus 로고
    • c-kit proto-oncogene exon 8 in-frame deletion plus insertion mutations in acute myeloid leukaemia
    • Gari M, Goodeve A, Wilson G, et al. c-kit proto-oncogene exon 8 in-frame deletion plus insertion mutations in acute myeloid leukaemia. Br J Haematol 1999; 105: 894-900.
    • (1999) Br J Haematol , vol.105 , pp. 894-900
    • Gari, M.1    Goodeve, A.2    Wilson, G.3
  • 42
    • 0033883060 scopus 로고    scopus 로고
    • KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors
    • Lux ML, Rubin BP, Biase TL, et al. KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors. Am J Pathol 2000; 156: 791-795.
    • (2000) Am J Pathol , vol.156 , pp. 791-795
    • Lux, M.L.1    Rubin, B.P.2    Biase, T.L.3
  • 43
    • 26944447953 scopus 로고    scopus 로고
    • Mutations in KIT and RAS are frequent events in pediatric core-binding factor acute myeloid leukemia
    • Goemans BF, Zwaan CM, Miller M, et al. Mutations in KIT and RAS are frequent events in pediatric core-binding factor acute myeloid leukemia. Leukemia 2005; 19: 1536-1542.
    • (2005) Leukemia , vol.19 , pp. 1536-1542
    • Goemans, B.F.1    Zwaan, C.M.2    Miller, M.3
  • 44
    • 24144503371 scopus 로고    scopus 로고
    • Novel germline mutation of KIT associated with familial gastrointestinal stromal tumors and mastocytosis
    • Hartmann K, Wardelmann E, Ma Y, et al. Novel germline mutation of KIT associated with familial gastrointestinal stromal tumors and mastocytosis. Gastroenterology 2005; 129: 1042-1046.
    • (2005) Gastroenterology , vol.129 , pp. 1042-1046
    • Hartmann, K.1    Wardelmann, E.2    Ma, Y.3
  • 45
    • 32844455834 scopus 로고    scopus 로고
    • A novel K509I mutation of KIT identified in familial mastocytosis-in vitro and in vivo responsiveness to imatinib therapy
    • Zhang LY, Smith ML, Schultheis B, et al. A novel K509I mutation of KIT identified in familial mastocytosis-in vitro and in vivo responsiveness to imatinib therapy. Leuk Res 2006; 30: 373-378.
    • (2006) Leuk Res , vol.30 , pp. 373-378
    • Zhang, L.Y.1    Smith, M.L.2    Schultheis, B.3
  • 46
    • 1842579440 scopus 로고    scopus 로고
    • A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib
    • Akin C, Fumo G, Yavuz AS, et al. A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib. Blood 2004; 103: 3222-3225.
    • (2004) Blood , vol.103 , pp. 3222-3225
    • Akin, C.1    Fumo, G.2    Yavuz, A.S.3
  • 47
    • 19444371824 scopus 로고    scopus 로고
    • A germline mutation in KIT in familial diffuse cutaneous mastocytosis
    • Tang X, Boxer M, Drummond A, et al. A germline mutation in KIT in familial diffuse cutaneous mastocytosis. J Med Genet 2004; 41: e88.
    • (2004) J Med Genet , vol.41
    • Tang, X.1    Boxer, M.2    Drummond, A.3
  • 48
    • 29144489542 scopus 로고    scopus 로고
    • Mastocytosis in mice expressing human Kit receptor with the activating Asp816Val mutation
    • Zappulla JP, Dubreuil P, Desbois S, et al. Mastocytosis in mice expressing human Kit receptor with the activating Asp816Val mutation. J Exp Med 2005; 202: 1635-1641.
    • (2005) J Exp Med , vol.202 , pp. 1635-1641
    • Zappulla, J.P.1    Dubreuil, P.2    Desbois, S.3
  • 49
    • 79951495806 scopus 로고    scopus 로고
    • Mast cell hyperplasia, B cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit
    • Gerbaulet A, Wickenhauser C, Scholten J, et al. Mast cell hyperplasia, B cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit. Blood 2011; 117: 2012-2021.
    • (2011) Blood , vol.117 , pp. 2012-2021
    • Gerbaulet, A.1    Wickenhauser, C.2    Scholten, J.3
  • 50
    • 67349145955 scopus 로고    scopus 로고
    • Frequent TET2 mutations in systemic mastocytosis: Clinical, KITD816V and FIP1L1-PDGFRA correlates
    • Tefferi A, Levine RL, Lim KH, et al. Frequent TET2 mutations in systemic mastocytosis: Clinical, KITD816V and FIP1L1-PDGFRA correlates. Leukemia 2009; 23: 900-904.
    • (2009) Leukemia , vol.23 , pp. 900-904
    • Tefferi, A.1    Levine, R.L.2    Lim, K.H.3
  • 51
    • 79952336888 scopus 로고    scopus 로고
    • Clonal analysis of NRAS activating mutations in KIT-D816V systemic mastocytosis
    • Wilson TM, Maric I, Simakova O, et al. Clonal analysis of NRAS activating mutations in KIT-D816V systemic mastocytosis. Haematologica 2011; 96: 459-463.
    • (2011) Haematologica , vol.96 , pp. 459-463
    • Wilson, T.M.1    Maric, I.2    Simakova, O.3
  • 52
    • 16444369795 scopus 로고    scopus 로고
    • Expression of a constitutively active mutant of M-Ras in normal bone marrow is sufficient for induction of a malignant mastocytosis/mast cell leukemia, distinct from the histiocytosis/monocytic leukemia induced by expression of activated H-Ras
    • Guo X, Schrader KA, Xu Y, Schrader JW. Expression of a constitutively active mutant of M-Ras in normal bone marrow is sufficient for induction of a malignant mastocytosis/mast cell leukemia, distinct from the histiocytosis/monocytic leukemia induced by expression of activated H-Ras. Oncogene 2005; 24: 2330-2342.
    • (2005) Oncogene , vol.24 , pp. 2330-2342
    • Guo, X.1    Schrader, K.A.2    Xu, Y.3    Schrader, J.W.4
  • 53
    • 0031682307 scopus 로고    scopus 로고
    • Diagnostic value of immunostaining for tryptase in patients with mastocytosis
    • Horny HP, Sillaber C, Menke D, et al. Diagnostic value of immunostaining for tryptase in patients with mastocytosis. Am J Surg Pathol 1998; 22: 1132-1140.
    • (1998) Am J Surg Pathol , vol.22 , pp. 1132-1140
    • Horny, H.P.1    Sillaber, C.2    Menke, D.3
  • 54
    • 0036207693 scopus 로고    scopus 로고
    • Histopathological and immunohistochemical aspects of mastocytosis
    • Horny HP, Valent P. Histopathological and immunohistochemical aspects of mastocytosis. Int Arch Allergy Immunol 2002; 127: 115-117.
    • (2002) Int Arch Allergy Immunol , vol.127 , pp. 115-117
    • Horny, H.P.1    Valent, P.2
  • 55
    • 5044230101 scopus 로고    scopus 로고
    • CD25 indicates the neoplastic phenotype of mast cells: A novel immunohistochemical marker for the diagnosis of systemic mastocytosis (SM) in routinely processed bone marrow biopsy specimens
    • Sotlar K, Horny HP, Simonitsch I, et al. CD25 indicates the neoplastic phenotype of mast cells: A novel immunohistochemical marker for the diagnosis of systemic mastocytosis (SM) in routinely processed bone marrow biopsy specimens. Am J Surg Pathol 2004; 28: 1319-1325.
    • (2004) Am J Surg Pathol , vol.28 , pp. 1319-1325
    • Sotlar, K.1    Horny, H.P.2    Simonitsch, I.3
  • 56
    • 0034987361 scopus 로고    scopus 로고
    • Immunohistochemical properties of bone marrow mast cells in systemic mastocytosis: Evidence for expression of CD2, CD117/Kit, and bcl-x(L)
    • Jordan JH, Walchshofer S, Jurecka W, et al. Immunohistochemical properties of bone marrow mast cells in systemic mastocytosis: Evidence for expression of CD2, CD117/Kit, and bcl-x(L). Hum Pathol 2001; 32: 545-552.
    • (2001) Hum Pathol , vol.32 , pp. 545-552
    • Jordan, J.H.1    Walchshofer, S.2    Jurecka, W.3
  • 57
    • 79953331926 scopus 로고    scopus 로고
    • Aberrant expression of CD30 in neoplastic mast cells in high-grade mastocytosis
    • Sotlar K, Cerny-Reiterer S, Petat-Dutter K, Hessel et al. Aberrant expression of CD30 in neoplastic mast cells in high-grade mastocytosis. Mod Pathol 2011; 24: 585-595.
    • (2011) Mod Pathol , vol.24 , pp. 585-595
    • Sotlar, K.1    Cerny-Reiterer, S.2    Petat-Dutter, K.3    Hessel4
  • 58
    • 33747332572 scopus 로고    scopus 로고
    • Flow cytometric analysis of normal and neoplastic mast cells: Role in diagnosis and follow-up of mast cell disease
    • Escribano L, Garcia Montero AC, Nunez R, Orfao A. Flow cytometric analysis of normal and neoplastic mast cells: Role in diagnosis and follow-up of mast cell disease. Immunol Allergy Clin North Am 2006; 26: 535-547.
    • (2006) Immunol Allergy Clin North Am , vol.26 , pp. 535-547
    • Escribano, L.1    Garcia Montero, A.C.2    Nunez, R.3    Orfao, A.4
  • 59
    • 2942596256 scopus 로고    scopus 로고
    • Bone marrow mast cell immunophenotyping in adults with mast cell disease: A prospective study of 33 patients
    • Pardanani A, Kimlinger T, Reeder T, et al. Bone marrow mast cell immunophenotyping in adults with mast cell disease: A prospective study of 33 patients. Leuk Res 2004; 28: 777-783.
    • (2004) Leuk Res , vol.28 , pp. 777-783
    • Pardanani, A.1    Kimlinger, T.2    Reeder, T.3
  • 60
    • 13944277507 scopus 로고    scopus 로고
    • Mast cells as "tunable" effector and immunoregulatory cells: Recent advances
    • Galli SJ, Kalesnikoff J, Grimbaldeston MA, et al. Mast cells as "tunable" effector and immunoregulatory cells: Recent advances. Annu Rev Immunol 2005; 23: 749-786.
    • (2005) Annu Rev Immunol , vol.23 , pp. 749-786
    • Galli, S.J.1    Kalesnikoff, J.2    Grimbaldeston, M.A.3
  • 61
    • 70349256069 scopus 로고    scopus 로고
    • Elevated tryptase levels selectively cluster in myeloid neoplasms: A novel diagnostic approach and screen marker in clinical haematology
    • Sperr WR, El-Samahi A, Kundi M, et al. Elevated tryptase levels selectively cluster in myeloid neoplasms: A novel diagnostic approach and screen marker in clinical haematology. Eur J Clin Invest 2009; 39: 914-923.
    • (2009) Eur J Clin Invest , vol.39 , pp. 914-923
    • Sperr, W.R.1    El-Samahi, A.2    Kundi, M.3
  • 62
    • 74949103091 scopus 로고    scopus 로고
    • WHO subvariants of indolent mastocytosis: Clinical details and prognostic evaluation in 159 consecutive adults
    • Pardanani A, Lim KH, Lasho TL, et al. WHO subvariants of indolent mastocytosis: Clinical details and prognostic evaluation in 159 consecutive adults. Blood 2010; 115: 150-151.
    • (2010) Blood , vol.115 , pp. 150-151
    • Pardanani, A.1    Lim, K.H.2    Lasho, T.L.3
  • 63
    • 33748615147 scopus 로고    scopus 로고
    • Molecular diagnosis of mast cell disorders: A paper from the 2005 William Beaumont Hospital Symposium on Molecular Pathology
    • Akin C. Molecular diagnosis of mast cell disorders: A paper from the 2005 William Beaumont Hospital Symposium on Molecular Pathology. J Mol Diagn 2006; 8: 412-419.
    • (2006) J Mol Diagn , vol.8 , pp. 412-419
    • Akin, C.1
  • 64
    • 0037100321 scopus 로고    scopus 로고
    • Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit gene
    • Yavuz AS, Lipsky PE, Yavuz S, et al. Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit gene. Blood 2002; 100: 661-665.
    • (2002) Blood , vol.100 , pp. 661-665
    • Yavuz, A.S.1    Lipsky, P.E.2    Yavuz, S.3
  • 65
    • 77949865698 scopus 로고    scopus 로고
    • Variable presence of KITD816V in clonal haematological non-mast cell lineage diseases associated with systemic mastocytosis (SM-AHNMD)
    • Sotlar K, Colak S, Bache A, et al. Variable presence of KITD816V in clonal haematological non-mast cell lineage diseases associated with systemic mastocytosis (SM-AHNMD). J Pathol 2010; 220: 586-595.
    • (2010) J Pathol , vol.220 , pp. 586-595
    • Sotlar, K.1    Colak, S.2    Bache, A.3
  • 66
    • 0024271215 scopus 로고
    • Systemic mast cell disease. Analysis of 58 cases and literature review
    • Travis WD, Li CY, Bergstralh EJ, et al. Systemic mast cell disease. Analysis of 58 cases and literature review. Medicine (Baltimore) 1988; 67: 345-368.
    • (1988) Medicine (Baltimore) , vol.67 , pp. 345-368
    • Travis, W.D.1    Li, C.Y.2    Bergstralh, E.J.3
  • 67
    • 69349102308 scopus 로고    scopus 로고
    • Prognosis in adult indolent systemic mastocytosis: A long-term study of the Spanish Network on Mastocytosis in a series of 145 patients
    • Escribano L, Alvarez-Twose I, Sanchez-Munoz L, et al. Prognosis in adult indolent systemic mastocytosis: A long-term study of the Spanish Network on Mastocytosis in a series of 145 patients. J Allergy Clin Immunol 2009; 124: 514-521.
    • (2009) J Allergy Clin Immunol , vol.124 , pp. 514-521
    • Escribano, L.1    Alvarez-Twose, I.2    Sanchez-Munoz, L.3
  • 68
    • 81155151867 scopus 로고    scopus 로고
    • Blood CD34-c-Kit+ cell rate correlates with aggressive forms of systemic mastocytosis and behaves like a mast cell precursor
    • Georgin-Lavialle S, Lhermitte L, Baude C, et al. Blood CD34-c-Kit+ cell rate correlates with aggressive forms of systemic mastocytosis and behaves like a mast cell precursor. Blood 2011; 118: 5246-5249.
    • (2011) Blood , vol.118 , pp. 5246-5249
    • Georgin-Lavialle, S.1    Lhermitte, L.2    Baude, C.3
  • 69
    • 84860739874 scopus 로고    scopus 로고
    • An immature immunophenotype of bone marrow mast cells predicts for multilineage D816V KIT mutation in systemic mastocytosis
    • doi: 10.1038/leu.2011.293. [Epub ahead of print].
    • Teodosio C, Garcia-Montero AC, Jara-Acevedo M, et al. An immature immunophenotype of bone marrow mast cells predicts for multilineage D816V KIT mutation in systemic mastocytosis. Leukemia 2011. doi: 10.1038/leu.2011.293. [Epub ahead of print].
    • (2011) Leukemia
    • Teodosio, C.1    Garcia-Montero, A.C.2    Jara-Acevedo, M.3
  • 70
    • 77949268924 scopus 로고    scopus 로고
    • Mast cells from different molecular and prognostic subtypes of systemic mastocytosis display distinct immunophenotypes
    • 726 e1-726e4.
    • Teodosio C, Garcia-Montero AC, Jara-Acevedo M, et al. Mast cells from different molecular and prognostic subtypes of systemic mastocytosis display distinct immunophenotypes. J Allergy Clin Immunol 2010; 125: 719-726, 726 e1-726e4.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 719-726
    • Teodosio, C.1    Garcia-Montero, A.C.2    Jara-Acevedo, M.3
  • 71
    • 32844466631 scopus 로고    scopus 로고
    • A pilot study of nonmyeloablative allogeneic hematopoietic stem cell transplant for advanced systemic mastocytosis
    • Nakamura R, Chakrabarti S, Akin C, et al. A pilot study of nonmyeloablative allogeneic hematopoietic stem cell transplant for advanced systemic mastocytosis. Bone Marrow Transplant 2006; 37: 353-358.
    • (2006) Bone Marrow Transplant , vol.37 , pp. 353-358
    • Nakamura, R.1    Chakrabarti, S.2    Akin, C.3
  • 72
    • 34249333084 scopus 로고    scopus 로고
    • Standards and standardization in mastocytosis: Consensus statements on diagnostics, treatment recommendations and response criteria
    • Valent P, Akin C, Escribano L, et al. Standards and standardization in mastocytosis: Consensus statements on diagnostics, treatment recommendations and response criteria. Eur J Clin Invest 2007; 37: 435-453.
    • (2007) Eur J Clin Invest , vol.37 , pp. 435-453
    • Valent, P.1    Akin, C.2    Escribano, L.3
  • 73
    • 77950998333 scopus 로고    scopus 로고
    • Proposal for a revised classification of systemic mastocytosis
    • Pardanani A, Tefferi A. Proposal for a revised classification of systemic mastocytosis. Blood 2010; 115: 2720-2721.
    • (2010) Blood , vol.115 , pp. 2720-2721
    • Pardanani, A.1    Tefferi, A.2
  • 74
    • 0026570013 scopus 로고
    • Response to interferon alfa-2b in a patient with systemic mastocytosis
    • Kluin-Nelemans HC, Jansen JH, Breukelman H, et al. Response to interferon alfa-2b in a patient with systemic mastocytosis. N Engl J Med 1992; 326: 619-623.
    • (1992) N Engl J Med , vol.326 , pp. 619-623
    • Kluin-Nelemans, H.C.1    Jansen, J.H.2    Breukelman, H.3
  • 75
    • 0031943841 scopus 로고    scopus 로고
    • Response of severe systemic mastocytosis to interferon alpha
    • Butterfield JH. Response of severe systemic mastocytosis to interferon alpha. Br J Dermatol 1998; 138: 489-495.
    • (1998) Br J Dermatol , vol.138 , pp. 489-495
    • Butterfield, J.H.1
  • 76
    • 10644277956 scopus 로고    scopus 로고
    • Successful treatment of systemic mastocytosis with high-dose interferon-alfa: long-term follow-up of a case
    • Butterfield JH, Tefferi A, Kozuh GF. Successful treatment of systemic mastocytosis with high-dose interferon-alfa: long-term follow-up of a case. Leuk Res 2005; 29: 131-134.
    • (2005) Leuk Res , vol.29 , pp. 131-134
    • Butterfield, J.H.1    Tefferi, A.2    Kozuh, G.F.3
  • 77
    • 0029013848 scopus 로고
    • Treatment of urticaria pigmentosa using interferon alpha
    • Kolde G, Sunderkotter C, Luger TA. Treatment of urticaria pigmentosa using interferon alpha. Br J Dermatol 1995; 133: 91-94.
    • (1995) Br J Dermatol , vol.133 , pp. 91-94
    • Kolde, G.1    Sunderkotter, C.2    Luger, T.A.3
  • 78
    • 0029796701 scopus 로고    scopus 로고
    • Severe osteoporosis due to systemic mast cell disease: Successful treatment with interferon alpha-2B
    • Lehmann T, Beyeler C, Lammle B, et al. Severe osteoporosis due to systemic mast cell disease: Successful treatment with interferon alpha-2B. Br J Rheumatol 1996; 35: 898-900.
    • (1996) Br J Rheumatol , vol.35 , pp. 898-900
    • Lehmann, T.1    Beyeler, C.2    Lammle, B.3
  • 79
    • 0032589561 scopus 로고    scopus 로고
    • IFNalpha treatment in systemic mastocytosis
    • Lehmann T, Lammle B. IFNalpha treatment in systemic mastocytosis. Ann Hematol 1999; 78: 483-484.
    • (1999) Ann Hematol , vol.78 , pp. 483-484
    • Lehmann, T.1    Lammle, B.2
  • 80
    • 0031870101 scopus 로고    scopus 로고
    • Systemic mastocytosis with extensive polypoid lesions in the intestines; successful treatment with interferon-alpha
    • Takasaki Y, Tsukasaki K, Jubashi T, et al. Systemic mastocytosis with extensive polypoid lesions in the intestines; successful treatment with interferon-alpha. Intern Med 1998; 37: 484-488.
    • (1998) Intern Med , vol.37 , pp. 484-488
    • Takasaki, Y.1    Tsukasaki, K.2    Jubashi, T.3
  • 81
    • 0030026895 scopus 로고    scopus 로고
    • Successful treatment of osteoporosis in systemic mastocytosis with interferon alpha-2b
    • Weide R, Ehlenz K, Lorenz W, et al. Successful treatment of osteoporosis in systemic mastocytosis with interferon alpha-2b. Ann Hematol 1996; 72: 41-43.
    • (1996) Ann Hematol , vol.72 , pp. 41-43
    • Weide, R.1    Ehlenz, K.2    Lorenz, W.3
  • 82
    • 0346154747 scopus 로고    scopus 로고
    • Response to therapy with interferon alpha-2b and prednisolone in aggressive systemic mastocytosis: Report of five cases and review of the literature
    • Hauswirth AW, Simonitsch-Klupp I, Uffmann M, et al. Response to therapy with interferon alpha-2b and prednisolone in aggressive systemic mastocytosis: Report of five cases and review of the literature. Leuk Res 2004; 28: 249-257.
    • (2004) Leuk Res , vol.28 , pp. 249-257
    • Hauswirth, A.W.1    Simonitsch-Klupp, I.2    Uffmann, M.3
  • 83
    • 0029999826 scopus 로고    scopus 로고
    • Long-term effect of interferon alpha treatment in mastocytosis
    • Lippert U, Henz BM. Long-term effect of interferon alpha treatment in mastocytosis. Br J Dermatol 1996; 134: 1164-1165.
    • (1996) Br J Dermatol , vol.134 , pp. 1164-1165
    • Lippert, U.1    Henz, B.M.2
  • 84
    • 0028912332 scopus 로고
    • Systemic mastocytosis associated with chronic myelomonocytic leukemia: Clinical features and response to interferon alfa therapy
    • Petit A, Pulik M, Gaulier A, et al. Systemic mastocytosis associated with chronic myelomonocytic leukemia: Clinical features and response to interferon alfa therapy. J Am Acad Dermatol 1995; 32: 850-853.
    • (1995) J Am Acad Dermatol , vol.32 , pp. 850-853
    • Petit, A.1    Pulik, M.2    Gaulier, A.3
  • 85
    • 0029826042 scopus 로고    scopus 로고
    • Treatment of three patients with systemic mastocytosis with interferon alpha-2b
    • Worobec AS, Kirshenbaum AS, Schwartz LB, Metcalfe DD. Treatment of three patients with systemic mastocytosis with interferon alpha-2b. Leuk Lymphoma 1996; 22: 501-508.
    • (1996) Leuk Lymphoma , vol.22 , pp. 501-508
    • Worobec, A.S.1    Kirshenbaum, A.S.2    Schwartz, L.B.3    Metcalfe, D.D.4
  • 86
    • 0032539359 scopus 로고    scopus 로고
    • [Interferon alpha and pamidronate: A useful combination in the treatment of osteoporosis and systemic mastocytosis]
    • Brunel V, Tadrist Z, Cailleres S, et al. [Interferon alpha and pamidronate: A useful combination in the treatment of osteoporosis and systemic mastocytosis]. Presse Med 1998; 27: 64.
    • (1998) Presse Med , vol.27 , pp. 64
    • Brunel, V.1    Tadrist, Z.2    Cailleres, S.3
  • 87
    • 0028226956 scopus 로고
    • Interferon treatment of patients with chronic urticaria and mastocytosis
    • Czarnetzki BM, Algermissen B, Jeep S, et al. Interferon treatment of patients with chronic urticaria and mastocytosis. J Am Acad Dermatol 1994; 30: 500-501.
    • (1994) J Am Acad Dermatol , vol.30 , pp. 500-501
    • Czarnetzki, B.M.1    Algermissen, B.2    Jeep, S.3
  • 88
    • 7244257364 scopus 로고    scopus 로고
    • Management of patients with systemic mastocytosis: Review of M. D. Anderson Cancer Center experience
    • Hennessy B, Giles F, Cortes J, et al. Management of patients with systemic mastocytosis: Review of M. D. Anderson Cancer Center experience. Am J Hematol 2004; 77: 209-214.
    • (2004) Am J Hematol , vol.77 , pp. 209-214
    • Hennessy, B.1    Giles, F.2    Cortes, J.3
  • 89
    • 0028899220 scopus 로고
    • Interferon-alpha in combination with corticosteroids improves systemic mast cell disease
    • Delaporte E, Pierard E, Wolthers BG, et al. Interferon-alpha in combination with corticosteroids improves systemic mast cell disease. Br J Dermatol 1995; 132: 479-482.
    • (1995) Br J Dermatol , vol.132 , pp. 479-482
    • Delaporte, E.1    Pierard, E.2    Wolthers, B.G.3
  • 90
    • 0029999826 scopus 로고    scopus 로고
    • Long-term effect of interferon alpha treatment in mastocytosis [comment]
    • Lippert U, Henz BM. Long-term effect of interferon alpha treatment in mastocytosis [comment]. Br J Dermatol 1996; 134: 1164-1165.
    • (1996) Br J Dermatol , vol.134 , pp. 1164-1165
    • Lippert, U.1    Henz, B.M.2
  • 91
    • 73349111582 scopus 로고    scopus 로고
    • Cytoreductive therapy in 108 adults with systemic mastocytosis: Outcome analysis and response prediction during treatment with interferon-alpha, hydroxyurea, imatinib mesylate or 2-chlorodeoxyadenosine
    • Lim KH, Pardanani A, Butterfield JH, et al. Cytoreductive therapy in 108 adults with systemic mastocytosis: Outcome analysis and response prediction during treatment with interferon-alpha, hydroxyurea, imatinib mesylate or 2-chlorodeoxyadenosine. Am J Hematol 2009; 84: 790-794.
    • (2009) Am J Hematol , vol.84 , pp. 790-794
    • Lim, K.H.1    Pardanani, A.2    Butterfield, J.H.3
  • 92
    • 3042651671 scopus 로고    scopus 로고
    • Interest of interferon alpha in systemic mastocytosis. The French experience and review of the literature
    • Simon J, Lortholary O, Caillat-Vigneron N, et al. Interest of interferon alpha in systemic mastocytosis. The French experience and review of the literature. Pathol Biol (Paris) 2004; 52: 294-299.
    • (2004) Pathol Biol (Paris) , vol.52 , pp. 294-299
    • Simon, J.1    Lortholary, O.2    Caillat-Vigneron, N.3
  • 93
    • 77955485221 scopus 로고    scopus 로고
    • In vitro and in vivo growth-inhibitory effects of cladribine on neoplastic mast cells exhibiting the imatinib-resistant KIT mutation D816V
    • Bohm A, Sonneck K, Gleixner KV, et al. In vitro and in vivo growth-inhibitory effects of cladribine on neoplastic mast cells exhibiting the imatinib-resistant KIT mutation D816V. Exp Hematol 2010; 38: 744-755.
    • (2010) Exp Hematol , vol.38 , pp. 744-755
    • Bohm, A.1    Sonneck, K.2    Gleixner, K.V.3
  • 94
    • 30444446680 scopus 로고    scopus 로고
    • PKC412 inhibits in vitro growth of neoplastic human mast cells expressing the D816V-mutated variant of KIT: comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effects
    • Gleixner KV, Mayerhofer M, Aichberger KJ, et al. PKC412 inhibits in vitro growth of neoplastic human mast cells expressing the D816V-mutated variant of KIT: comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effects. Blood 2006; 107: 752-759.
    • (2006) Blood , vol.107 , pp. 752-759
    • Gleixner, K.V.1    Mayerhofer, M.2    Aichberger, K.J.3
  • 95
    • 27644454273 scopus 로고    scopus 로고
    • Cladribine therapy in a patient with an aleukemic subvariant of mast cell leukemia
    • Penack O, Sotlar K, Noack F, et al. Cladribine therapy in a patient with an aleukemic subvariant of mast cell leukemia. Ann Hematol 2005; 84: 692-693.
    • (2005) Ann Hematol , vol.84 , pp. 692-693
    • Penack, O.1    Sotlar, K.2    Noack, F.3
  • 98
    • 0344741334 scopus 로고    scopus 로고
    • Treatment of systemic mast cell disease with 2-chlorodeoxyadenosine
    • Pardanani A, Hoffbrand AV, Butterfield JH, Tefferi A. Treatment of systemic mast cell disease with 2-chlorodeoxyadenosine. Leuk Res 2004; 28: 127-131.
    • (2004) Leuk Res , vol.28 , pp. 127-131
    • Pardanani, A.1    Hoffbrand, A.V.2    Butterfield, J.H.3    Tefferi, A.4
  • 99
    • 84858268181 scopus 로고    scopus 로고
    • Long term efficacy and safety of cladribine in adult systemic mastocytosis: A French multicenter study of 44 patients. ASH Annual Meeting Abstracts
    • Hermine O, Hirsh I, Damaj G, et al. Long term efficacy and safety of cladribine in adult systemic mastocytosis: A French multicenter study of 44 patients. ASH Annual Meeting Abstracts. Blood 2010; 116: 1982.
    • (2010) Blood , vol.116 , pp. 1982
    • Hermine, O.1    Hirsh, I.2    Damaj, G.3
  • 100
    • 0344987886 scopus 로고    scopus 로고
    • Effect of tyrosine kinase inhibitor STI571 on the kinase activity of wild-type and various mutated c-kit receptors found in mast cell neoplasms
    • Zermati Y, De Sepulveda P, Feger F, et al. Effect of tyrosine kinase inhibitor STI571 on the kinase activity of wild-type and various mutated c-kit receptors found in mast cell neoplasms. Oncogene 2003; 22: 660-664.
    • (2003) Oncogene , vol.22 , pp. 660-664
    • Zermati, Y.1    De Sepulveda, P.2    Feger, F.3
  • 101
    • 0043169405 scopus 로고    scopus 로고
    • Effects of tyrosine kinase inhibitor STI571 on human mast cells bearing wild-type or mutated c-kit
    • Akin C, Brockow K, D'Ambrosio C, et al. Effects of tyrosine kinase inhibitor STI571 on human mast cells bearing wild-type or mutated c-kit. Exp Hematol 2003; 31: 686-692.
    • (2003) Exp Hematol , vol.31 , pp. 686-692
    • Akin, C.1    Brockow, K.2    D'Ambrosio, C.3
  • 102
    • 0036493872 scopus 로고    scopus 로고
    • The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations
    • Ma Y, Zeng S, Metcalfe DD, et al. The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations. Blood 2002; 99: 1741-1744.
    • (2002) Blood , vol.99 , pp. 1741-1744
    • Ma, Y.1    Zeng, S.2    Metcalfe, D.D.3
  • 103
    • 33947520803 scopus 로고    scopus 로고
    • Juxtamembrane-type c-kit gene mutation found in aggressive systemic mastocytosis induces imatinib-resistant constitutive KIT activation
    • Nakagomi N, Hirota S. Juxtamembrane-type c-kit gene mutation found in aggressive systemic mastocytosis induces imatinib-resistant constitutive KIT activation. Lab Invest 2007; 87: 365-371.
    • (2007) Lab Invest , vol.87 , pp. 365-371
    • Nakagomi, N.1    Hirota, S.2
  • 104
    • 33745863150 scopus 로고    scopus 로고
    • Imatinib mesylate in the treatment of systemic mastocytosis: A phase II trial
    • Droogendijk HJ, Kluin-Nelemans HJ, van Doormaal JJ, et al. Imatinib mesylate in the treatment of systemic mastocytosis: A phase II trial. Cancer 2006; 107: 345-351.
    • (2006) Cancer , vol.107 , pp. 345-351
    • Droogendijk, H.J.1    Kluin-Nelemans, H.J.2    van Doormaal, J.J.3
  • 105
    • 68649118339 scopus 로고    scopus 로고
    • Phase II study of imatinib mesylate as therapy for patients with systemic mastocytosis
    • Vega-Ruiz A, Cortes JE, Sever M, et al. Phase II study of imatinib mesylate as therapy for patients with systemic mastocytosis. Leuk Res 2009; 33: 1481-1484.
    • (2009) Leuk Res , vol.33 , pp. 1481-1484
    • Vega-Ruiz, A.1    Cortes, J.E.2    Sever, M.3
  • 106
    • 64249092051 scopus 로고    scopus 로고
    • Advanced mast cell disease: An Italian Hematological Multicenter experience
    • Pagano L, Valentini CG, Caira M, et al. Advanced mast cell disease: An Italian Hematological Multicenter experience. Int J Hematol 2008; 88: 483-488.
    • (2008) Int J Hematol , vol.88 , pp. 483-488
    • Pagano, L.1    Valentini, C.G.2    Caira, M.3
  • 107
    • 31544459272 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies
    • Schittenhelm MM, Shiraga S, Schroeder A, et al. Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies. Cancer Res 2006; 66: 473-481.
    • (2006) Cancer Res , vol.66 , pp. 473-481
    • Schittenhelm, M.M.1    Shiraga, S.2    Schroeder, A.3
  • 108
    • 33645687784 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) inhibits KITD816V, an imatinib-resistant activating mutation that triggers neoplastic growth in most patients with systemic mastocytosis
    • Shah NP, Lee FY, Luo R, et al. Dasatinib (BMS-354825) inhibits KITD816V, an imatinib-resistant activating mutation that triggers neoplastic growth in most patients with systemic mastocytosis. Blood 2006; 108: 286-291.
    • (2006) Blood , vol.108 , pp. 286-291
    • Shah, N.P.1    Lee, F.Y.2    Luo, R.3
  • 109
    • 36349020293 scopus 로고    scopus 로고
    • Synergistic growth-inhibitory effects of two tyrosine kinase inhibitors, dasatinib and PKC412, on neoplastic mast cells expressing the D816V-mutated oncogenic variant of KIT
    • Gleixner KV, Mayerhofer M, Sonneck K, et al. Synergistic growth-inhibitory effects of two tyrosine kinase inhibitors, dasatinib and PKC412, on neoplastic mast cells expressing the D816V-mutated oncogenic variant of KIT. Haematologica 2007; 92: 1451-1459.
    • (2007) Haematologica , vol.92 , pp. 1451-1459
    • Gleixner, K.V.1    Mayerhofer, M.2    Sonneck, K.3
  • 110
    • 54349097778 scopus 로고    scopus 로고
    • Treatment responses to cladribine and dasatinib in rapidly progressing aggressive mastocytosis
    • Aichberger KJ, Sperr WR, Gleixner KV, et al. Treatment responses to cladribine and dasatinib in rapidly progressing aggressive mastocytosis. Eur J Clin Invest 2008; 38: 869-873.
    • (2008) Eur J Clin Invest , vol.38 , pp. 869-873
    • Aichberger, K.J.1    Sperr, W.R.2    Gleixner, K.V.3
  • 111
    • 61449256026 scopus 로고    scopus 로고
    • Chemotherapy and dasatinib induce long-term hematologic and molecular remission in systemic mastocytosis with acute myeloid leukemia with KIT D816V
    • Ustun C, Corless CL, Savage N, et al. Chemotherapy and dasatinib induce long-term hematologic and molecular remission in systemic mastocytosis with acute myeloid leukemia with KIT D816V. Leuk Res 2009; 33: 735-741.
    • (2009) Leuk Res , vol.33 , pp. 735-741
    • Ustun, C.1    Corless, C.L.2    Savage, N.3
  • 112
    • 52449085884 scopus 로고    scopus 로고
    • Phase II study of dasatinib in Philadelphia chromosome-negative acute and chronic myeloid diseases, including systemic mastocytosis
    • Verstovsek S, Tefferi A, Cortes J, et al. Phase II study of dasatinib in Philadelphia chromosome-negative acute and chronic myeloid diseases, including systemic mastocytosis. Clin Cancer Res 2008; 14: 3906-3915.
    • (2008) Clin Cancer Res , vol.14 , pp. 3906-3915
    • Verstovsek, S.1    Tefferi, A.2    Cortes, J.3
  • 113
    • 41849136506 scopus 로고    scopus 로고
    • Dasatinib therapy for systemic mastocytosis: four cases
    • Purtill D, Cooney J, Sinniah R, et al. Dasatinib therapy for systemic mastocytosis: four cases. Eur J Haematol 2008; 80: 456-458.
    • (2008) Eur J Haematol , vol.80 , pp. 456-458
    • Purtill, D.1    Cooney, J.2    Sinniah, R.3
  • 114
    • 22144455380 scopus 로고    scopus 로고
    • Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412
    • Growney JD, Clark JJ, Adelsperger J, et al. Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412. Blood 2005; 106: 721-724.
    • (2005) Blood , vol.106 , pp. 721-724
    • Growney, J.D.1    Clark, J.J.2    Adelsperger, J.3
  • 115
    • 27144506215 scopus 로고    scopus 로고
    • Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation
    • Gotlib J, Berube C, Growney JD, et al. Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation. Blood 2005; 106: 2865-2870.
    • (2005) Blood , vol.106 , pp. 2865-2870
    • Gotlib, J.1    Berube, C.2    Growney, J.D.3
  • 116
    • 79960404044 scopus 로고    scopus 로고
    • KIT Inhibitor midostaurin exhibits a high rate of Clinically meaningful and durable responses in advanced systemic mastocytosis: Report of a fully accrued phase II trial. ASH Annual Meeting Abstracts
    • Gotlib J, DeAngelo DJ, George TI, et al. KIT Inhibitor midostaurin exhibits a high rate of Clinically meaningful and durable responses in advanced systemic mastocytosis: Report of a fully accrued phase II trial. ASH Annual Meeting Abstracts. Blood 2010; 116: 316.
    • (2010) Blood , vol.116 , pp. 316
    • Gotlib, J.1    DeAngelo, D.J.2    George, T.I.3
  • 117
    • 70349658639 scopus 로고    scopus 로고
    • Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT
    • Dubreuil P, Letard S, Ciufolini M, et al. Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT. PLoS One 2009; 4: e7258.
    • (2009) PLoS One , vol.4
    • Dubreuil, P.1    Letard, S.2    Ciufolini, M.3
  • 118
    • 78649504351 scopus 로고    scopus 로고
    • Masitinib for the treatment of systemic and cutaneous mastocytosis with handicap: A phase 2a study
    • Paul C, Sans B, Suarez F, et al. Masitinib for the treatment of systemic and cutaneous mastocytosis with handicap: A phase 2a study. Am J Hematol 2010; 85: 921-925.
    • (2010) Am J Hematol , vol.85 , pp. 921-925
    • Paul, C.1    Sans, B.2    Suarez, F.3
  • 119
    • 80054848122 scopus 로고    scopus 로고
    • Depression in patients with mastocytosis: Prevalence, features and effects of masitinib therapy
    • Moura DS, Sultan S, Georgin-Lavialle S, et al. Depression in patients with mastocytosis: Prevalence, features and effects of masitinib therapy. PLoS One 2011; 6: e26375.
    • (2011) PLoS One , vol.6
    • Moura, D.S.1    Sultan, S.2    Georgin-Lavialle, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.