Multiple immunoassay systems are negatively interfered by circulating cardiac troponin I autoantibodies

Clinical and Experimental Medicine

Volumn 12, Issue 1, 2012, Pages 47-53

  Tang, Gusheng ^a   Wu, Yu ^b   Zhao, Weiguo ^a   Shen, Qian ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b The 94th Hospital of Chinese People's Liberation Army   (China)

Author keywords

AMI; cTnI autoantibody; Immunoassay systems; Negative interference

Indexed keywords

AUTOANTIBODY; TROPONIN I; TROPONIN I AUTOANTIBODY; UNCLASSIFIED DRUG;

ACUTE HEART INFARCTION; ADULT; AGED; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ERROR; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IMMUNOASSAY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; WESTERN BLOTTING;

ADULT; AGED; AGED, 80 AND OVER; AUTOANTIBODIES; BLOTTING, WESTERN; CASE-CONTROL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; RECOMBINANT FUSION PROTEINS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TROPONIN I;

EID: 84858153449     PISSN: 15918890     EISSN: 15919528     Source Type: Journal    
DOI: 10.1007/s10238-011-0141-x     Document Type: Article

References (22)

1. Alpert JS, Thygesen K, Antman E, Bassand JP (2000) Myocardial infarction redefined a consensus document of the joint European society of cardiology/American college of cardiology committee for the redefinition of myocardial infarction. J Am Coll Cardiol 36:959-969
2. Wu AH, Apple FS, Gibler WB, Jesse RL, Warshaw MM, Valdes RJ (1999) National academy of clinical biochemistry standards of laboratory practice: recommendations for the use of cardiac markers in coronary artery diseases. Clin Chem 45:1104-1121 (Pubitemid 29340557)
3. Bohner J, von Pape KW, Hannes W, Stegmann T (1996) False-negative immunoassay results for cardiac troponin I probably due to circulating troponin I autoantibodies. Clin Chem 42:2046
4. Eriksson S, Junikka M, Laitinen P, Majamaa-Voltti K, Alfthan H, Pettersson K (2003) Negative interference in cardiac troponin I immunoassays from a frequently occurring serum and plasma component. Clin Chem 49:1095-1104 (Pubitemid 36751096)
5. Eriksson S, Junikka M, Pettersson K (2004) An interfering component in cardiac troponin I immunoassays-its nature and inhibiting effect on the binding of antibodies against different epitopes. Clin Biochem 3:472-480 (Pubitemid 38746641)
6. Eriksson S, Halenius H, Pulkki K, Hellman J, Pettersson K (2005) Negative interference in cardiac troponin I immunoassays by circulating troponin autoantibodies. Clin Chem 51:839-847 (Pubitemid 40577920)
7. Tate JR (2008) Troponin revisited 2008: assay performance. Clin Chem Lab Med 46:1489-1500
8. Collinson PO, Boa FG, Gaze DC (2001) Measurement of cardiac troponins. Ann Clin Biochem 38:423-449 (Pubitemid 32846049)
9. Liu S, Zhang MY, Song Q, Ling M, Kadijevic L, Shi Q (2001) Recombinant single chain cardiac troponin I-C polypeptides: superior calibration and control materials for cardiac troponin I immunoassays. Clin Lab 47:19-27 (Pubitemid 32118095)
10. Adamczyk M, Brashear RJ, Mattingly PG (2009) Circulating cardiac troponin-I autoantibodies in human plasma and serum. Ann N Y Acad Sci 1173:67-74
11. Pettersson K, Eriksson S, Wittfooth S, Engström E, Nieminen M, Sinisalo J (2009) Antiantibodies to cardiac troponin associate with higher initial concentrations and longer release of troponin I in acute coronary syndrome patients. Clin Chem 55:938-945
12. Leuschner F, Li J, Göser S et al (2008) Absence of auto-antibodies against cardiac troponin I predicts improvement of left ventricular function after acute myocardial infarction. Eur Heart J 29:1949-1955
13. Düngen HD, Platzeck M, Vollert J, Searle J, Müller C, Reiche J, Mehrhof F, Müller R, Möckel M (2010) Autoantibodies against cardiac troponin I in patients with congestive heart failure. Eur J Heart Fail 12:668-675
14. Lindahl B, Venge P, Eggers KM, Gedeborg R, Ristiniemi N, Wittfooth S, Pettersson K (2010) Autoantibodies to cardiac troponin in acute coronary syndromes. Clin Chim Acta 21-22:1793-1798
15. Panteghini M, Gerhardt W, Apple FS, Dati F, Ravkilde J, Wu AH (2001) Quality specifications for cardiac troponin assays. Clin Chem Lab Med 39:175-179 (Pubitemid 32318485)
16. Eriksson S, Ilva T, Becker C, Lund J, Porela P, Pulkki K, Voipio- Pulkki LM, Pettersson K (2005) Comparison of cardiac troponin I immunoassays variably affected by circulating autoantibodies. Clin Chem 51:848-855 (Pubitemid 40577921)
17. Uettwiller-Geiger D, Wu AH, Apple FS, Jevans AW, Venge P, Olson MD, Darte C, Woodrum DL, Roberts S, Chan S (2002) Multicenter evaluation of an automated assay for troponin I. Clin Chem 48:869-876 (Pubitemid 34587586)
18. Giannitsis E, Becker M, Kurz K, Hess G, Zdunek D, Katus HA (2010) High-sensitivity cardiac troponin T for early prediction of evolving non-ST-segment elevation myocardial infarction in patients with suspected acute coronary syndrome and negative troponin results on admission. Clin Chem 56:642-650
19. Kavsak PA, MacRae AR, Yerna MJ, Jaffe AS (2009) Analytic and clinical utility of a next-generation, highly sensitive cardiac troponin I assay for early detection of myocardial injury. Clin Chem 55:573-577
20. Apple FS, Pearce LA, Smith SW, Kaczmarek JM, Murakami MM (2009) Role of monitoring changes in sensitive cardiac troponin I assay results for early diagnosis of myocardial infarction and prediction of risk of adverse events. Clin Chem 55:930-937
21. Keller T, Zeller T, Peetz D et al (2009) Sensitive troponin I assay in early diagnosis of acute myocardial infarction. NEW ENGL J MED 361:868-877
22. Göser S, Andrassy M, Buss SJ et al (2006) Cardiac troponin I but not cardiac troponin T induces severe autoimmune inflammation in the myocardium. Circulation 114:1693-1702 (Pubitemid 44607117)