Prophylaxis for venous thromboembolism: A great global divide between expert guidelines and clinical practice?

Seminars in Thrombosis and Hemostasis

Volumn 38, Issue 2, 2012, Pages 144-155

  Bikdeli, Behnood ^a,b   Sharif Kashani, Babak ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

guidelines adherence; prevention; prophylaxis; venous thromboembolism

Indexed keywords

ANTICOAGULANT AGENT;

AWARENESS; CLINICAL PRACTICE; CLINICAL PROTOCOL; DATA ANALYSIS; EVIDENCE BASED PRACTICE; HEPARIN INDUCED THROMBOCYTOPENIA; HUMAN; INTENSIVE CARE; INTERDISCIPLINARY COMMUNICATION; MEDICAL ERROR; MEDICAL SOCIETY; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROFESSIONAL KNOWLEDGE; REGISTER; REVIEW; RISK ASSESSMENT; SURGICAL PATIENT; THROMBOSIS PREVENTION; TREATMENT REFUSAL; VENOUS THROMBOEMBOLISM; WORKLOAD;

AFRICA; BRAZIL; CANADA; COMORBIDITY; FRANCE; GERMANY; GUIDELINE ADHERENCE; HUMANS; HYPERTENSION, PULMONARY; INTENSIVE CARE UNITS; MEXICO; MIDDLE EAST; POSTTHROMBOTIC SYNDROME; PRACTICE GUIDELINES AS TOPIC; SPAIN; STOCKINGS, COMPRESSION; SURGERY DEPARTMENT, HOSPITAL; UNITED STATES; VENOUS THROMBOEMBOLISM;

EID: 84858144428     PISSN: 00946176     EISSN: 10989064     Source Type: Journal    
DOI: 10.1055/s-0032-1301412     Document Type: Review

References (106)

1. RLK V. Thrombose und embolie. GefUssen entzLlndung und septische infektion. In: Virchow RLK., ed. Gesammelte Abhandlungen zur Wissenschaftlichen Medizin. Frankfurt Barth: 1856; 219 732
2. Wells PS, Anderson DR, Bormanis J., et al. Value of assessment of pretest probability of deep-vein thrombosis in clinical management. Lancet: 1997; 350 9094 1795 1798 (Pubitemid 28036513)
3. Wells PS, Anderson DR, Rodger M., et al. Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with the SimpliRED D-dimer. Thromb Haemost: 2000; 83 3 416 420 (Pubitemid 30148355)
4. Di Nisio M, Squizzato A, Rutjes AWS, Büller HR, Zwinderman AH, Bossuyt PMM. Diagnostic accuracy of D-dimer test for exclusion of venous thromboembolism: a systematic review. J Thromb Haemost: 2007; 5 2 296 304 (Pubitemid 46139454)
5. Hamper UM, DeJong MR, Scoutt LM. Ultrasound evaluation of the lower extremity veins. Radiol Clin North Am: 2007; 45 3 525 547, ix (Pubitemid 46963346)
6. Hayashino Y, Goto M, Noguchi Y, Fukui T. Ventilation-perfusion scanning and helical CT in suspected pulmonary embolism: meta-analysis of diagnostic performance. Radiology: 2005; 234 3 740 748 (Pubitemid 40250817)
7. Goldhaber SZ, Visani L, De Rosa M. Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER). Lancet: 1999; 353 9162 1386 1389 (Pubitemid 29192409)
8. Geerts WH, Pineo GF, Heit JA., et al. Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest: 2004; 126 3, Suppl 338S 400S (Pubitemid 39302602)
9. Kahn SR. The post-thrombotic syndrome: the forgotten morbidity of deep venous thrombosis. J Thromb Thrombolysis: 2006; 21 1 41 48 (Pubitemid 43231126)
10. Pini M, Spyropoulos AC. Prevention of venous thromboembolism. Semin Thromb Hemost: 2006; 32 8 755 766 (Pubitemid 44956970)
11. Tufano A, Coppola A, Cerbone AM, Ruosi C, Franchini M. Preventing postsurgical venous thromboembolism: pharmacological approaches. Semin Thromb Hemost: 2011; 37 3 252 266
12. Lippi G, Favaloro EJ, Cervellin G. Prevention of venous thromboembolism: focus on mechanical prophylaxis. Semin Thromb Hemost: 2011; 37 3 237 251
13. Geerts WH, Bergqvist D, Pineo GF., et al. American College of Chest Physicians. Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest: 2008; 133 381S 453S (Pubitemid 351894916)
14. Kucher N, Koo S, Quiroz R., et al. Electronic alerts to prevent venous thromboembolism among hospitalized patients. N Engl J Med: 2005; 352 10 969 977
15. Piazza G, Seddighzadeh A, Goldhaber SZ. Double trouble for 2,609 hospitalized medical patients who developed deep vein thrombosis: prophylaxis omitted more often and pulmonary embolism more frequent. Chest: 2007; 132 2 554 561 (Pubitemid 47282388)
16. Nicolaides AN, Fareed J, Kakkar AK., et al. Cardiovascular Disease Educational and Research Trust; Cyprus Cardiovascular Disease Educational and Research Trust; European Venous Forum; International Surgical Thrombosis Forum; International Union of Angiology; Union Internationale de Phlbologie. Prevention and treatment of venous thromboembolism. International Consensus Statement (guidelines according to scientific evidence). Int Angiol: 2006; 25 2 101 161 (Pubitemid 44043713)
17. Institute for Clinical Systems Improvement (ICSI). Venous thromboembolism prophylaxis. Bloomington (MN): Institute for Clinical Systems Improvement (ICSI); 2010; Aug:45
18. Caprini JA. Thrombosis risk assessment as a guide to quality patient care. Dis Mon: 2005; 51 2-3 70 80
19. Scottish Intercollegiate Guidelines Network (SIGN). Prevention and management of venous thromboembolism. Edinburgh: SIGN; 2010;. (SIGN publication no. 122). [Cited 10 Dec 2010]. Available at: http://www.sign.ac.uk
20. Lyman GH, Khorana AA, Falanga A., et al. American Society of Clinical Oncology. American Society of Clinical Oncology guideline: recommendations for venous thromboembolism prophylaxis and treatment in patients with cancer. J Clin Oncol: 2007; 25 34 5490 5505 (Pubitemid 350232226)
21. Wagman LD, Baird MF, Bennett CL., et al. National Comprehensive Cancer Network. Venous thromboembolic disease. NCCN. Clinical practice guidelines in oncology. J Natl Compr Canc Netw: 2008; 6 8 716 753
22. American Academy of Orthopaedic Surgeons Clinical Guideline on Prevention of Symptomatic Pulmonary Embolism in Patients Undergoing Total Hip or Knee Arthroplasty Adopted by the American Academy of Orthopedic Surgeons Board of Directors May. 2007;. Available at: www.aaos.org/research/guidelines/VTE/VTE- full-guideline.pdf. Accessed Jan 2011
23. Stahl TJ, Gregorcyk SG, Hyman NH, Buie WD.; Standards Practice Task Force of The American Society of Colon and Rectal Surgeons. Practice parameters for the prevention of venous thrombosis. Dis Colon Rectum: 2006; 49 10 1477 1483 (Pubitemid 44796114)
24. ACOG Practice Bulletin No. 84: Prevention of deep vein thrombosis and pulmonary embolism. Obstet Gynecol: 2007; 110 2 Pt 1 429 440
25. Bergqvist D. Group prophylaxis is the best strategy. Dis Mon: 2010; 56 10 560 562
26. Caprini JA. Individual risk assessment is the best strategy for thromboembolic prophylaxis. Dis Mon: 2010; 56 10 552 559
27. Spyropoulos AC, Mahan C. Venous thromboembolism prophylaxis in the medical patient: controversies and perspectives. Am J Med: 2009; 122 12 1077 1084
28. Kakkar AK, Davidson BL, Haas SK.; Investigators Against Thromboembolism (INATE) Core Group. Compliance with recommended prophylaxis for venous thromboembolism: improving the use and rate of uptake of clinical practice guidelines. J Thromb Haemost: 2004; 2 2 221 227 (Pubitemid 40186034)
29. Lachiewicz PF. Comparison of ACCP and AAOS guidelines for VTE prophylaxis after total hip and total knee arthroplasty. Orthopedics: 2009; 32 12, Suppl 74 78
30. Eikelboom JW, Karthikeyan G, Fagel N, Hirsh J. American Association of Orthopedic Surgeons and American College of Chest Physicians guidelines for venous thromboembolism prevention in hip and knee arthroplasty differ: what are the implications for clinicians and patients? Chest: 2009; 135 2 513 520
31. Sharif-Kashani B, Bikdeli B, Moradi A., et al. Coexisting venous thromboembolism in patients with tuberculosis. Thromb Res: 2010; 125 5 478 480
32. Spyropoulos AC, Mahan C. Venous thromboembolism prophylaxis in the medical patient: controversies and perspectives. Am J Med: 2009; 122 12 1077 1084
33. Cohen AT, Tapson VF, Bergmann JF., et al. ENDORSE Investigators. Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE study): a multinational cross-sectional study. Lancet: 2008; 371 9610 387 394 (Pubitemid 351173321)
34. Dentali F, Riva N, Gianni M., et al. Prevalence of renal failure and use of antithrombotic prophylaxis among medical inpatients at increased risk of venous thromboembolic events. Thromb Res: 2008; 123 1 67 71
35. Anderson FA Jr, Goldhaber SZ, Tapson VF., et al. ENDORSE Investigators. Improving Practices in US Hospitals to Prevent Venous Thromboembolism: lessons from ENDORSE. Am J Med: 2010; 123 12 1099 1106, e8
36. Sharif-Kashani B, Raeissi S, Bikdeli B., et al. Sticker reminders improve thromboprophylaxis appropriateness in hospitalized patients. Thromb Res: 2010; 126 3 211 216
37. Bikdeli B, Sharif-Kashani B, Raeissi S, Ehteshami-Afshar S, Behzadnia N, Masjedi MR. Chest physicians' knowledge of appropriate thromboprophylaxis: insights from the PROMOTE study. Blood Coagul Fibrinolysis: 2011; 22 667 672
38. Sharif-Kashani B, Bikdeli B, Shahabi P., et al. AssessMent of ProphylAxis for VenouS ThromboembolIsm in Hospitalized Patients. The MASIH Study. Clin Appl Thromb Haemost, in press, DOI: 10.1177/1076029611431955
39. Tapson VF, Decousus H, Pini M., et al. IMPROVE Investigators. Venous thromboembolism prophylaxis in acutely ill hospitalized medical patients: findings from the International Medical Prevention Registry on Venous Thromboembolism. Chest: 2007; 132 3 936 945
40. Friedman RJ, Gallus A, Gil-Garay E, FitzGerald G, Cushner F. Practice patterns in the use of venous thromboembolism prophylaxis after total joint arthroplastyinsights from the Multinational Global Orthopaedic Registry (GLORY). Am J Orthop: 2010; 39 9, Suppl 14 21
41. Kakkar AK, Levine M, Pinedo HM, Wolff R, Wong J. Venous thrombosis in cancer patients: insights from the FRONTLINE survey. Oncologist: 2003; 8 4 381 388 (Pubitemid 36929723)
42. Yu HT, Dylan ML, Lin J, Dubois RW. Hospitals' compliance with prophylaxis guidelines for venous thromboembolism. Am J Health Syst Pharm: 2007; 64 1 69 76 (Pubitemid 46395711)
43. Kahn SR, Panju A, Geerts W., et al. CURVE study investigators. Multicenter evaluation of the use of venous thromboembolism prophylaxis in acutely ill medical patients in Canada. Thromb Res: 2007; 119 2 145 155 (Pubitemid 44810862)
44. Amin A, Stemkowski S, Lin J, Yang G. Thromboprophylaxis rates in US medical centers: success or failure? J Thromb Haemost: 2007; 5 8 1610 1616 (Pubitemid 47091400)
45. Deheinzelin D, Braga AL, Martins LC., et al. Trombo Risc Investigators. Incorrect use of thromboprophylaxis for venous thromboembolism in medical and surgical patients: results of a multicentric, observational and cross-sectional study in Brazil. J Thromb Haemost: 2006; 4 6 1266 1270
46. Caiafa JS, de Bastos M, Moura LK, Raymundo S.; Brazilian Registry of venous thromboembolism prophylaxis. Managing venous thromboembolism in Latin American patients: emerging results from the Brazilian Registry. Semin Thromb Hemost: 2002; 28 Suppl 3 47 50 (Pubitemid 34971915)
47. Martnez-Zubieta R. [Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE II study): results of a Mexican national cross-sectional study]. Cir Cir: 2010; 78 4 333 341
48. Akinmoladun VI, Arotiba JT, Fasola OA, Alonge TO, Oginni FO, Obuekwe ON. The use of thromboembolic prophylaxis by surgeons: a multicentre Nigerian study. Niger Postgrad Med J: 2007; 14 4 330 335
49. Zotz RB, Kauschat-Brüning D, Bramlage P.; ENDORSE Studienleiter. [Thromboembolic risk and prophylaxis in hospitalized surgical and internal medicine patients. German results of the international ENDORSE study]. Dtsch Med Wochenschr: 2009; 134 43 2163 2169
50. Rashid ST, Thursz MR, Razvi NA., et al. Venous thromboprophylaxis in UK medical inpatients. J R Soc Med: 2005; 98 11 507 512 (Pubitemid 41617763)
51. Gussoni G, Campanini M, Silingardi M., et al. GEMINI Study Group. In-hospital symptomatic venous thromboembolism and antithrombotic prophylaxis in Internal Medicine. Findings from a multicenter, prospective study. Thromb Haemost: 2009; 101 5 893 901
52. Mokhtari M, Salameh P, Kouchek M, Kashani BS, Taher A, Waked M.; Avail Me Extension Study Group. The AVAIL ME Extension: a multinational Middle Eastern survey of venous thromboembolism risk and prophylaxis. J Thromb Haemost: 2011; 9 7 1340 1349
53. Safavi E, Zahedpour Anaraki MR, Firooz Bakhsh S, Nikparvar Fard M. The study of diagnosed venous thromboembolism. Tanaffos: 2003; 5 15 22
54. Heidar Nezhad H, Zendeh Del N, Kolahi S, Pirzeh A, Eslam Panah S. Practice of deep vein thrombosis prophylaxis in teaching hospitals of Tabriz. Tanaffos: 2003; 6 31 37
55. Zeitoun AA, Dimassi HI, El Kary DY, Akel MG. An evaluation of practice pattern for venous thromboembolism prevention in Lebanese hospitals. J Thromb Thrombolysis: 2009; 28 2 192 199
56. Sen RK, Tripathy SK, Singh AK. Is routine thromboprophylaxis justified among Indian patients sustaining major orthopedic trauma? A systematic review. Indian J Orthop: 2011; 45 3 197 207
57. Zheng H, Liu L, Sun H., et al. Prophylaxis of deep venous thrombosis and adherence to guideline recommendations among inpatients with acute stroke: results from a multicenter observational longitudinal study in China. Neurol Res: 2008; 30 4 370 376 (Pubitemid 351881289)
58. Gibbs H, Fletcher J, Blombery P, Collins R, Wheatley D. Venous thromboembolism prophylaxis guideline implementation is improved by nurse directed feedback and audit. Thromb J: 2011; 9 1 7
59. National Institute of Clinical Studies. The prevalence of chemoprophylaxis in surgical and medical cases at high risk of venous thromboembolism. Prepared by The School of Population Health, University of Western Australia. NICS, Melbourne: 2005
60. Goldhaber SZ, Dunn K, MacDougall RC. New onset of venous thromboembolism among hospitalized patients at Brigham and Women's Hospital is caused more often by prophylaxis failure than by withholding treatment. Chest: 2000; 118 6 1680 1684 (Pubitemid 32001795)
61. Rajaganeshan R, Dussa CU, Sahni V. National survey in the United Kingdom of prophylaxis of deep vein thrombosis for patients with fracture of the neck of the femur. Injury: 2006; 37 8 721 726 (Pubitemid 44066976)
62. Seddighzadeh A, Zurawska U, Shetty R, Goldhaber SZ. Venous thromboembolism in patients undergoing surgery: low rates of prophylaxis and high rates of filter insertion. Thromb Haemost: 2007; 98 6 1220 1225 (Pubitemid 350239092)
63. Cook D, Laporta D, Skrobik Y., et al. Canadian ICU Directors Group. Prevention of venous thromboembolism in critically ill surgery patients: a cross-sectional study. J Crit Care: 2001; 16 4 161 166 (Pubitemid 34106651)
64. Lacherade JC, Cook D, Heyland D, Chrusch C, Brochard L, Brun-Buisson C.; French and Canadian ICU Directors Groups. Prevention of venous thromboembolism in critically ill medical patients: a Franco-Canadian cross-sectional study. J Crit Care: 2003; 18 4 228 237 (Pubitemid 38036904)
65. Robertson MS, Nichol AD, Higgins AM., et al. VTE Point Prevalence Investigators for the Australian and New Zealand Intensive Care Research Centre; Australian and New Zealand Intensive Care Society Clinical Trials Group. Venous thromboembolism prophylaxis in the critically ill: a point prevalence survey of current practice in Australian and New Zealand intensive care units. Crit Care Resusc: 2010; 12 1 9 15
66. Goldhaber SZ. Venous thromboembolism in the intensive care unit: the last frontier for prophylaxis. Chest: 1998; 113 1 5 7 (Pubitemid 28044915)
67. Marsh H, Reynard J. Thromboprophylaxis for patients at high risk of VTE. Lancet: 2008; 371 9628 1912, author reply 1912-1913 (Pubitemid 351778183)
68. Tooher R, Middleton P, Pham C., et al. A systematic review of strategies to improve prophylaxis for venous thromboembolism in hospitals. Ann Surg: 2005; 241 3 397 415 (Pubitemid 40299716)
69. Cabana MD, Rand CS, Powe NR., et al. Why don't physicians follow clinical practice guidelines? A framework for improvement. JAMA: 1999; 282 15 1458 1465 (Pubitemid 29493800)
70. Bhanji F, Mancini ME, Sinz E., et al. Part 16: education, implementation, and teams: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation: 2010; 122 18, Suppl 3 S920 S933
71. Rahim SA, Panju A, Pai M, Ginsberg J. Venous thromboembolism prophylaxis in medical inpatients: a retrospective chart review. Thromb Res: 2003; 111 4-5 215 219 (Pubitemid 38021938)
72. McCarney R, Warner J, Iliffe S, van Haselen R, Griffin M, Fisher P. The Hawthorne Effect: a randomised, controlled trial. BMC Med Res Methodol: 2007; 7 30
73. Bikdeli B, Piazza G. Review of Piazza et al. Coexisting heart failure in DVT patients. Ethrombosis, June 2008. Available at: http://www.natfonline.org/ ethrombosis/review-of-piazza-et-al-coexisting-heart-failure-in-dvt-patients
74. Piazza G, Seddighzadeh A, Goldhaber SZ. Heart failure in patients with deep vein thrombosis. Am J Cardiol: 2008; 101 7 1056 1059
75. Adams KF, Lindenfeld J, Arnold JMO., et al. Heart Failure Society Of America. HFSA 2006 Comprehensive Heart Failure Practice Guideline. J Card Fail: 2006; 12 1 e1 e2
76. Dickstein K, Cohen-Solal A, Filippatos G., et al. ESC Committee for Practice Guidelines (CPG). ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur Heart J: 2008; 29 19 2388 2442
77. Jessup M, Abraham WT, Casey DE., et al, writing on behalf of the 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult Writing Committee. 2009 Focused update: ACCF/AHA guidelines for the diagnosis and management of heart failure in adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation: 2009; 119 14 1917 2016
78. Mosen D, Elliott CG, Egger MJ., et al. The effect of a computerized reminder system on the prevention of postoperative venous thromboembolism. Chest: 2004; 125 5 1635 1641 (Pubitemid 38648391)
79. Holley AB, Moores LK, Jackson JL. Provider preferences for DVT prophylaxis. Thromb Res: 2006; 117 5 563 568 (Pubitemid 43326143)
80. Golash A, Collins PW, Kynaston HG, Jenkins BJ. Venous thromboembolic prophylaxis for transurethral prostatectomy: practice among British urologists. J R Soc Med: 2002; 95 3 130 131 (Pubitemid 34242344)
81. Gnanalingham KK, Holland JP. Attitudes to the use of prophylaxis for thrombo-embolism in neurosurgical patients. J Clin Neurosci: 2003; 10 4 467 469 (Pubitemid 36876658)
82. Sharif KM, Rehman SF, Nunn T, Bagga TK. Implementation of the NICE guidelines for venous thromboprophylaxis; a national survey of hip surgeons. Hip Int: 2009; 19 1 58 63
83. Ahmad HA, Geissler A, MacLellan DG. Deep venous thrombosis prophylaxis: are guidelines being followed? ANZ J Surg: 2002; 72 5 331 334 (Pubitemid 34535384)
84. Burns PJ, Wilsom RG, Cunningham C. Venous thromboembolism prophylaxis used by consultant general surgeons in Scotland. J R Coll Surg Edinb: 2001; 46 6 329 333 (Pubitemid 33133355)
85. Ploumis A, Ponnappan RK, Bessey JT, Patel R, Vaccaro AR. Thromboprophylaxis in spinal trauma surgery: consensus among spine trauma surgeons. Spine J: 2009; 9 7 530 536
86. Williams EV, Williams RS, Hughes JL, Williams KL, Foster ME, Lewis MH. Prevention of venous thromboembolism in Wales: results of a survey among general surgeons. Postgrad Med J: 2002; 78 916 88 91 (Pubitemid 34112342)
87. Bahl V, Hu HM, Henke PK, Wakefield TW, Campbell DA Jr, Caprini JA. A validation study of a retrospective venous thromboembolism risk scoring method. Ann Surg: 2010; 251 2 344 350
88. Barbar S, Noventa F, Rossetto V., et al. A risk assessment model for the identification of hospitalized medical patients at risk for venous thromboembolism: the Padua Prediction Score. J Thromb Haemost: 2010; 8 11 2450 2457
89. Harinath G, St John PH. Use of a thromboembolic risk score to improve thromboprophylaxis in surgical patients. Ann R Coll Surg Engl: 1998; 80 5 347 349 (Pubitemid 28423312)
90. Samama MM, Dahl OE, Mismetti P., et al. An electronic tool for venous thromboembolism prevention in medical and surgical patients. Haematologica: 2006; 91 1 64 70 (Pubitemid 43235387)
91. Maynard G, Stein J. Designing and implementing effective venous thromboembolism prevention protocols: lessons from collaborative efforts. J Thromb Thrombolysis: 2010; 29 2 159 166
92. Wolpin S, Lee JA, Glenny RW, Wittkowsky AK, Wolf FM, Zierler BK. Evaluation of online training on the prevention of venous thromboembolism. Vasc Endovascular Surg: 2011; 45 2 146 156
93. Fahimi F, Baniasadi S, Behzadnia N, Varahram F, Ghazi-Tabatabaie L. Enoxaparin utilization evaluation: an observational prospective study in medical inpatients. Iran J Pharmaceut Res: 2008; 7 77 82 (Pubitemid 351943812)
94. McMullin J, Cook D, Griffith L., et al. Minimizing errors of omission: behavioural reenforcement of heparin to avert venous emboli: the BEHAVE study. Crit Care Med: 2006; 34 3 694 699
95. North American Thrombosis Forum: Mission, Vision and Multidisciplinary Approach. Accessible at http://www.natfonline.org/about/mission-vision- multidisciplinary-approach. Last accessed, July 22,: 2011
96. Clark P, Wu O, Greer IA, Lowe GD. Venous thrombosis prevention - more than just guidelines. Br J Haematol: 2010; 149 1 50 54
97. Goldhaber SZ, Rosenbaum E. The Surgeon General's call to action exemplifies the role of advocacy in preventing venous thromboembolism. Am J Med: 2009; 122 9 791 792
98. Maynard G, Stein J. Preventing hospital-acquired venous thromboembolism: a guide for effective quality improvement. Prepared by the Society of Hospital Medicine. AHRQ Publication No. 08-0075. Rockville, MD: Agency for Healthcare Research and Quality. August 2008
99. Moll S, Mackman N. Venous thromboembolism: a need for more public awareness and research into mechanisms. Arterioscler Thromb Vasc Biol: 2008; 28 3 367 369
100. Galanis T, Thomson L, Palladino M, Merli GJ. New oral anticoagulants. J Thromb Thrombolysis: 2011; 31 3 310 320
101. Shachak A, Jadad AR. Electronic health records in the age of social networks and global telecommunications. JAMA: 2010; 303 5 452 453
102. Nair BG, Newman SF, Peterson GN, Wu WY, Schwid HA. Feedback mechanisms including real-time electronic alerts to achieve near 100% timely prophylactic antibiotic administration in surgical cases. Anesth Analg: 2010; 111 5 1293 1300
103. Cohen AT, Agnelli G, Anderson FA., et al. VTE Impact Assessment Group in Europe (VITAE). Venous thromboembolism (VTE) in Europe. The number of VTE events and associated morbidity and mortality. Thromb Haemost: 2007; 98 4 756 764 (Pubitemid 47555066)
104. Ageno W, Dentali F. Prevention of in-hospital VTE: why can't we do better? Lancet: 2008; 371 9610 361 362 (Pubitemid 351173303)
105. Spencer FA, Lessard D, Emery C, Reed G, Goldberg RJ. Venous thromboembolism in the outpatient setting. Arch Intern Med: 2007; 167 14 1471 1475 (Pubitemid 47124177)
106. Bosson JL, Pouchain D, Bergmann JF.; for the ETAPE Study Group. A prospective observational study of a cohort of outpatients with an acute medical event and reduced mobility: incidence of symptomatic thromboembolism and description of thromboprophylaxis practices. J Intern Med: 2006; 260 2 168 176 (Pubitemid 44051342)