Evaluation of acyclovir cream and gel formulations for transdermal iontophoretic delivery

Therapeutic Delivery

Volumn 3, Issue 3, 2012, Pages 327-338

  Siddoju, Srujana ^a   Sachdeva, Vishal ^a   Friden, Phillip M ^b   Banga, Ajay K ^a  

^a MERCER UNIVERSITY   (United States)

^b Transport Pharmaceuticals Inc ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; GLYCEROL; PROPYLENE GLYCOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL COMPOSITION; CONTROLLED STUDY; CREAM; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG EFFECT; DRUG FORMULATION; DRUG PENETRATION; DRUG SOLUBILITY; EMULSION; EVALUATION RESEARCH; GEL; HAIRLESS RAT; HYDROPHILICITY; IN VITRO STUDY; IN VIVO STUDY; IONTOPHORESIS; MALE; MICRODIALYSIS; MOLECULAR WEIGHT; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; RAT; SKIN PERMEABILITY; TREATMENT DURATION;

EID: 84858134243     PISSN: 20415990     EISSN: 20416008     Source Type: Journal    
DOI: 10.4155/tde.11.152     Document Type: Article

References (25)

1. Dixit N, Bali V, Baboota S, Ahuja A, Ali J. Iontophoresis-an approach for controlled drug delivery: a review. Curr. Drug Deliv. 4(1), 1-10 (2007). (Pubitemid 46066409)
2. Nirschl RP, Rodin DM, Ochiai DH, Maartmann-Moe C. Iontophoretic administration of dexamethasone sodium phosphate for acute epicondylitis. A randomized, double-blinded, placebo-controlled study. Am. J. Sports Med. 31(2), 189-195 (2003). (Pubitemid 36343322)
3. Banga AK. Transdermal and Intradermal Delivery of Therapeutic Agents: Application of Physical Technologies. CRC Press, Taylor and Francis, Boca Raton, FL, USA 1-285 (2011).
4. Sachdeva V, Banga AK. Iontophoresis: promises and challenges. Transdermal 2(1), 17-21 (2010).
5. Guy RH, Kalia YN, Delgado-Charro MB, Merino V, Lopez A, Marro D. Iontophoresis: electrorepulsion and electroosmosis. J. Control. Release 64(1-3), 129-132 (2000). (Pubitemid 30035313)
6. Kalia YN, Alberti I, Naik A, Guy RH. Assessment of topical bioavailability in vivo: the importance of stratum corneum thickness. Skin Pharmacol. Appl. Skin Physiol. 14(Suppl. 1), 82-86 (2001). (Pubitemid 34299168)
7. Pikal MJ. The role of electroosmotic flow in transdermal iontophoresis. Adv. Drug Deliv. Rev. 46(1-3), 281-305 (2001).
8. Vemulapalli V, Yang Y, Friden PM, Banga AK. Synergistic effect of iontophoresis and soluble microneedles for transdermal delivery of methotrexate. J. Pharm. Pharmacol. 60(1), 27-33 (2008).
9. Siddoju S, Sachdeva V, Friden PM, Yu YY, Banga AK. Acyclovir skin depot characterization following in vivo iontophoretic delivery. Skin Res. Technol. 17(2), 234-244 (2011).
10. Stagni G, Ali, ME, Weng D. Pharmacokinetics of acyclovir in rabbit skin after i.v.-bolus, ointment, and iontophoretic administrations. Int. J. Pharm. 274(1-2), 201-211 (2004). (Pubitemid 38457019)
11. Siddoju S, Sachdeva V, Friden PM, Banga AK. Iontophoretic delivery of acyclovir: intradermal drug monitoring using microdialysis and quantification by skin extraction. PDA J. Pharm. Sci. Tech. 65(5), 432-444 (2011).
12. Lashmar UT, Manger J. Investigation of the potential for iontophoresis facilitated transdermal delivery of acyclovir. Int. J. Pharm. 111, 73-82 (1994). (Pubitemid 24277380)
13. Volpato NM, Santi P, Laureri C, Colombo P. Assay of acyclovir in human skin layers by high-performance liquid chromatography. J. Pharm. Biomed. Anal. 16(3), 515-520 (1997). (Pubitemid 27514395)
14. Volpato NM, Nicoli S, Laureri C, Colombo P, Santi P. In vitro acyclovir distribution in human skin layers after transdermal iontophoresis. J. Control. Release 50(1-3), 291-296 (1998). (Pubitemid 28044124)
15. Kikwai L, Babu RJ, Prado R et al. In vitro and in vivo evaluation of topical formulations of spantide II. AAPS Pharm. Sci. Tech. 6(4), E565-E572 (2005).
16. Sachdeva V, Kim HD, Friden PM, Banga AK. Iontophoresis mediated in vivo intradermal delivery of terbinafine hydrochloride. Int. J. Pharm. 393(1-2), 112-118 (2010).
17. Sachdeva V, Siddoju S, Yu YY, Kim HD, Friden PM, Banga AK. Transdermal iontophoretic delivery of terbinafine hydrochloride: quantitation of drug levels in stratum corneum and underlying skin. Int. J. Pharm. 388(1-2), 24-31 (2010).
18. Yanagimoto G, Hayashi T, Hasegawa T et al. Skin disposition of drugs after topical application in hairless rats. Chem. Pharm. Bull. 47(6), 749-754 (1999). (Pubitemid 29315359)
19. Yeganeh MH, Mclachlan AJ. Determination of terbinafine in tissues. Biomed. Chromatogr. 14(4), 261-268 (2000). (Pubitemid 30348997)
20. Shukla C, Friden P, Juluru R, Stagni G. In vivo quantification of acyclovir exposure in the dermis following iontophoresis of semisolid formulations. J. Pharm. Sci. 98(3), 917-925 (2009).
21. Handbook of Pharmaceutical Excipients (5th Edition) Rowe RC, Sheskey PJ, Owen SC (Eds). Pharmaceutical Press, London, UK (2006).
22. Gloor M, Bettinger J, Gehring W. Modification of stratum corneum quality by glycerin-containing external ointments. Hautarzt 49(1), 6-9 (1998). (Pubitemid 28083584)
23. Rawlings A, Harding C, Watkinson A, Banks J, Ackerman C, Sabin R. The effect of glycerol and humidity on desmosome degradation in stratum corneum. Arch. Dermatol. Res. 287(5), 457-464 (1995).
24. Subedi RK, Oh SY, Chun MK, Choi HK. Recent advances in transdermal drug delivery. Arch. Pharm. Res. 33(3), 339-351 (2010).
25. Yamashita F, Bando H, Koyama Y, Kitagawa S, Takakura Y, Hashida M. In vivo and in vitro analysis of skin penetration enhancement based on a two-layer diffusion model with polar and nonpolar routes in the stratum corneum. Pharm. Res. 11(2), 185-191 (1994). (Pubitemid 24076210)