Increased expression of VDAC1 sensitizes carcinoma cells to apoptosis induced by DNA cross-linking agents

Biochemical Pharmacology

Volumn 83, Issue 9, 2012, Pages 1172-1182

  Sharaf El Dein, Ossama ^a   Gallerne, Cindy ^a,b   Brenner, Catherine ^a   Lemaire, Christophe ^a,b  

^a Universite Paris Sud   (France)

^b LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

Author keywords

Apoptosis; Cancer; Cisplatin; Melphalan; Permeability transition pore; VDAC1

Indexed keywords

ALPHA TUBULIN; ARSENIC TRIOXIDE; CASPASE; CISPLATIN; CREATINE KINASE; CROSS LINKING REAGENT; DNA FRAGMENT; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MELPHALAN; MERCHLORETHAMINE; PROCASPASE 9; PROTEIN ANT1; PROTEIN ANT3; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; REGULATOR PROTEIN; UNCLASSIFIED DRUG; VOLTAGE DEPENDENT ANION CHANNEL 1;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL NUCLEUS; CONTROLLED STUDY; DNA CROSS LINKING; ENZYME ACTIVATION; HELA CELL; HUMAN; HUMAN CELL; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SENSITIZATION; UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CELL LINE, TUMOR; CISPLATIN; COLONIC NEOPLASMS; CROSS-LINKING REAGENTS; DNA; FEMALE; HELA CELLS; HUMANS; MECHLORETHAMINE; MELPHALAN; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; UTERINE CERVICAL NEOPLASMS; VOLTAGE-DEPENDENT ANION CHANNEL 1;

EID: 84858081016     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.01.017     Document Type: Article

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