The endoperoxide ascaridol shows strong differential cytotoxicity in nucleotide excision repair-deficient cells

Toxicology and Applied Pharmacology

Volumn 259, Issue 3, 2012, Pages 302-310

  Abbasi, Rashda ^a   Efferth, Thomas ^b   Kuhmann, Christine ^a   Opatz, Till ^b   Hao, Xiaojiang ^c   Popanda, Odilia ^a   Schmezer, Peter ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c KUNMING INSTITUTE OF BOTANY   (China)

Author keywords

Cancer therapy; CSB; ERCC6; Synthetic lethal; Traditional chinese medicine; XPC

Indexed keywords

2' METHOXY KURARINONE; 3 (3 HYDROXYMETHYL 2 BUTENYL) 7 (3 METHYL 2 BUTENYL) 1H INDOLE; ARSENIC TRIOXIDE; ASCARIDOLE; CARBALEXINE A; CARBALEXINE B; CHINESE DRUG; DIHYDROSPIRAMINE C; ENDOPEROXIDE; GLYCOBORININE; ISONARDOSINON; NORKURARINOL; PLANT MEDICINAL PRODUCT; QUERCETIN; REACTIVE OXYGEN METABOLITE; SCOPOLETIN; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CELL VIABILITY; CHINESE MEDICINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DRUG CYTOTOXICITY; DRUG SCREENING; EXCISION REPAIR; G2 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; GENOTOXICITY; HUMAN; HUMAN CELL; IC 50; M PHASE CELL CYCLE CHECKPOINT;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; INHIBITORY CONCENTRATION 50; M PHASE CELL CYCLE CHECKPOINTS; MEDICINE, CHINESE TRADITIONAL; MONOTERPENES; PEROXIDES; REACTIVE OXYGEN SPECIES;

EID: 84858078951     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.01.006     Document Type: Article

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