-
1
-
-
67650732715
-
Advances in autism
-
Geschwind D.H. Advances in autism. Annu. Rev. Med. 2009, 60:367-380.
-
(2009)
Annu. Rev. Med.
, vol.60
, pp. 367-380
-
-
Geschwind, D.H.1
-
2
-
-
0000984981
-
Autistic disturbances of affective contact
-
Kanner L. Autistic disturbances of affective contact. Nerv. Child 1943, 2:217-250.
-
(1943)
Nerv. Child
, vol.2
, pp. 217-250
-
-
Kanner, L.1
-
3
-
-
0017530988
-
Infantile autism: a genetic study of 21 twin pairs
-
Folstein S., Rutter M. Infantile autism: a genetic study of 21 twin pairs. J. Child Psychol. Psychiatry 1977, 18:297-321.
-
(1977)
J. Child Psychol. Psychiatry
, vol.18
, pp. 297-321
-
-
Folstein, S.1
Rutter, M.2
-
4
-
-
0021960916
-
Concordance for the syndrome of autism in 40 pairs of afflicted twins
-
Ritvo E.R., et al. Concordance for the syndrome of autism in 40 pairs of afflicted twins. Am. J. Psychiatry 1985, 142:74-77.
-
(1985)
Am. J. Psychiatry
, vol.142
, pp. 74-77
-
-
Ritvo, E.R.1
-
5
-
-
0023722983
-
Autism and genetics. A decade of research
-
Smalley S.L., et al. Autism and genetics. A decade of research. Arch. Gen. Psychiatry 1988, 45:953-961.
-
(1988)
Arch. Gen. Psychiatry
, vol.45
, pp. 953-961
-
-
Smalley, S.L.1
-
6
-
-
42349095075
-
Advances in autism genetics: on the threshold of a new neurobiology
-
Abrahams B.S., Geschwind D.H. Advances in autism genetics: on the threshold of a new neurobiology. Nat. Rev. Genet. 2008, 9:341-355.
-
(2008)
Nat. Rev. Genet.
, vol.9
, pp. 341-355
-
-
Abrahams, B.S.1
Geschwind, D.H.2
-
7
-
-
79958032110
-
Rare de novo and transmitted copy-number variation in autistic spectrum disorders
-
Levy D., et al. Rare de novo and transmitted copy-number variation in autistic spectrum disorders. Neuron 2011, 70:886-897.
-
(2011)
Neuron
, vol.70
, pp. 886-897
-
-
Levy, D.1
-
8
-
-
79958074870
-
Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism
-
Sanders S.J., et al. Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism. Neuron 2011, 70:863-885.
-
(2011)
Neuron
, vol.70
, pp. 863-885
-
-
Sanders, S.J.1
-
9
-
-
77954657070
-
Functional impact of global rare copy number variation in autism spectrum disorders
-
Pinto D., et al. Functional impact of global rare copy number variation in autism spectrum disorders. Nature 2009, 466:368-372.
-
(2009)
Nature
, vol.466
, pp. 368-372
-
-
Pinto, D.1
-
10
-
-
67651010456
-
Genetic advances in autism: heterogeneity and convergence on shared pathways
-
Bill B.R., Geschwind D.H. Genetic advances in autism: heterogeneity and convergence on shared pathways. Curr. Opin. Genet. Dev. 2009, 19:271-278.
-
(2009)
Curr. Opin. Genet. Dev.
, vol.19
, pp. 271-278
-
-
Bill, B.R.1
Geschwind, D.H.2
-
11
-
-
79959262465
-
Transcriptomic analysis of autistic brain reveals convergent molecular pathology
-
Voineagu I., et al. Transcriptomic analysis of autistic brain reveals convergent molecular pathology. Nature 2011, 474:380-384.
-
(2011)
Nature
, vol.474
, pp. 380-384
-
-
Voineagu, I.1
-
12
-
-
36749100015
-
Genome-wide analyses of human perisylvian cerebral cortical patterning
-
Abrahams B.S., et al. Genome-wide analyses of human perisylvian cerebral cortical patterning. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:17849-17854.
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 17849-17854
-
-
Abrahams, B.S.1
-
13
-
-
38749140677
-
Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene
-
Alarcón M., et al. Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene. Am. J. Hum. Genet. 2008, 82:150-159.
-
(2008)
Am. J. Hum. Genet.
, vol.82
, pp. 150-159
-
-
Alarcón, M.1
-
14
-
-
33645415686
-
Recessive symptomatic focal epilepsy and mutant contactin-associated protein-like 2
-
Strauss K.A., et al. Recessive symptomatic focal epilepsy and mutant contactin-associated protein-like 2. N. Engl. J. Med. 2006, 354:1370-1377.
-
(2006)
N. Engl. J. Med.
, vol.354
, pp. 1370-1377
-
-
Strauss, K.A.1
-
15
-
-
38749096303
-
A common genetic variant in the neurexin superfamily member CNTNAP2 increases familial risk of autism
-
Arking D.E., et al. A common genetic variant in the neurexin superfamily member CNTNAP2 increases familial risk of autism. Am. J. Hum. Genet. 2008, 82:160-164.
-
(2008)
Am. J. Hum. Genet.
, vol.82
, pp. 160-164
-
-
Arking, D.E.1
-
16
-
-
77958582442
-
Traits contributing to the autistic spectrum
-
Steer C.D., et al. Traits contributing to the autistic spectrum. PLoS ONE 2010, 5:e12633.
-
(2010)
PLoS ONE
, vol.5
-
-
Steer, C.D.1
-
17
-
-
38749099110
-
Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders
-
Bakkaloglu B., et al. Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders. Am. J. Hum. Genet. 2008, 82:165-173.
-
(2008)
Am. J. Hum. Genet.
, vol.82
, pp. 165-173
-
-
Bakkaloglu, B.1
-
18
-
-
79956294419
-
Reduced transcript expression of genes affected by inherited and de novo CNVs in autism
-
Nord A.S., et al. Reduced transcript expression of genes affected by inherited and de novo CNVs in autism. Eur. J. Hum. Genet. 2011, 19:727-731.
-
(2011)
Eur. J. Hum. Genet.
, vol.19
, pp. 727-731
-
-
Nord, A.S.1
-
19
-
-
79957589237
-
Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations
-
O'Roak B.J., et al. Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations. Nat. Genet. 2011, 46:585-589.
-
(2011)
Nat. Genet.
, vol.46
, pp. 585-589
-
-
O'Roak, B.J.1
-
20
-
-
79952706051
-
Replication of CNTNAP2 association with nonword repetition and support for FOXP2 association with timed reading and motor activities in a dyslexia family sample
-
Peter B., et al. Replication of CNTNAP2 association with nonword repetition and support for FOXP2 association with timed reading and motor activities in a dyslexia family sample. J. Neurodev. Disord. 2011, 3:39-49.
-
(2011)
J. Neurodev. Disord.
, vol.3
, pp. 39-49
-
-
Peter, B.1
-
21
-
-
79954605497
-
A common genetic variant in the neurexin superfamily member CNTNAP2 is associated with increased risk for selective mutism and social anxiety-related traits
-
Stein M.B., et al. A common genetic variant in the neurexin superfamily member CNTNAP2 is associated with increased risk for selective mutism and social anxiety-related traits. Biol. Psychiatry 2011, 69:825-831.
-
(2011)
Biol. Psychiatry
, vol.69
, pp. 825-831
-
-
Stein, M.B.1
-
22
-
-
57149090343
-
A functional genetic link between distinct developmental language disorders
-
Vernes S.C., et al. A functional genetic link between distinct developmental language disorders. N. Engl. J. Med. 2008, 359:2337-2345.
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 2337-2345
-
-
Vernes, S.C.1
-
23
-
-
79952443636
-
Investigation of dyslexia and SLI risk variants in reading- and language-impaired subjects
-
Newbury D., et al. Investigation of dyslexia and SLI risk variants in reading- and language-impaired subjects. Behav. Genet. 2011, 41:90-104.
-
(2011)
Behav. Genet.
, vol.41
, pp. 90-104
-
-
Newbury, D.1
-
24
-
-
76549104658
-
Disruption of CNTNAP2 and additional structural genome changes in a boy with speech delay and autism spectrum disorder
-
Poot M., et al. Disruption of CNTNAP2 and additional structural genome changes in a boy with speech delay and autism spectrum disorder. Neurogenetics 2010, 11:81-89.
-
(2010)
Neurogenetics
, vol.11
, pp. 81-89
-
-
Poot, M.1
-
25
-
-
78649671271
-
Deletion of 7q34-q36.2 in two siblings with mental retardation, language delay, primary amenorrhea, dysmorphic features
-
Sehested L.T., et al. Deletion of 7q34-q36.2 in two siblings with mental retardation, language delay, primary amenorrhea, dysmorphic features. Am. J. Med. Genet. 2010, 152A:3115-3119.
-
(2010)
Am. J. Med. Genet.
, vol.152 A
, pp. 3115-3119
-
-
Sehested, L.T.1
-
26
-
-
78649665537
-
Identification of a microdeletion at the 7q33-q35 disrupting the CNTNAP2 gene in a Brazilian stuttering case
-
Petrin A.L., et al. Identification of a microdeletion at the 7q33-q35 disrupting the CNTNAP2 gene in a Brazilian stuttering case. Am. J. Med. Genet. 2010, 152A:3164-3172.
-
(2010)
Am. J. Med. Genet.
, vol.152 A
, pp. 3164-3172
-
-
Petrin, A.L.1
-
27
-
-
33744821617
-
Genetic heterogeneity between the three components of the autism spectrum: a twin study
-
Ronald A., et al. Genetic heterogeneity between the three components of the autism spectrum: a twin study. J. Am. Acad. Child Adolesc. Psychiatry 2006, 45:691-699.
-
(2006)
J. Am. Acad. Child Adolesc. Psychiatry
, vol.45
, pp. 691-699
-
-
Ronald, A.1
-
28
-
-
7444246191
-
Using self-report to identify the broad phenotype in parents of children with autistic spectrum disorders: a study using the autism-spectrum quotient
-
Bishop D.V., et al. Using self-report to identify the broad phenotype in parents of children with autistic spectrum disorders: a study using the autism-spectrum quotient. J. Child Psychol. Psychiatry 2004, 45:1431-1436.
-
(2004)
J. Child Psychol. Psychiatry
, vol.45
, pp. 1431-1436
-
-
Bishop, D.V.1
-
29
-
-
54549086639
-
Autism: many genes, common pathways?
-
Geschwind D.H. Autism: many genes, common pathways?. Cell 2008, 135:391-395.
-
(2008)
Cell
, vol.135
, pp. 391-395
-
-
Geschwind, D.H.1
-
30
-
-
79958067224
-
CNTNAP2 variants affect early language development in the general population
-
Whitehouse A.J., et al. CNTNAP2 variants affect early language development in the general population. Genes Brain Behav. 2011, 10:451-456.
-
(2011)
Genes Brain Behav.
, vol.10
, pp. 451-456
-
-
Whitehouse, A.J.1
-
31
-
-
0035807360
-
A forkhead-domain gene is mutated in a severe speech and language disorder
-
Lai C.S., et al. A forkhead-domain gene is mutated in a severe speech and language disorder. Nature 2001, 413:519-523.
-
(2001)
Nature
, vol.413
, pp. 519-523
-
-
Lai, C.S.1
-
32
-
-
21044445447
-
Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits
-
MacDermot K.D., et al. Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits. Am. J. Hum. Genet. 2005, 76:1074-1080.
-
(2005)
Am. J. Hum. Genet.
, vol.76
, pp. 1074-1080
-
-
MacDermot, K.D.1
-
33
-
-
3242709413
-
Birdsong and singing behavior
-
Williams H. Birdsong and singing behavior. Ann. N. Y. Acad. Sci. 2004, 1016:1-30.
-
(2004)
Ann. N. Y. Acad. Sci.
, vol.1016
, pp. 1-30
-
-
Williams, H.1
-
34
-
-
77952158569
-
Language-related Cntnap2 gene is differentially expressed in sexually dimorphic song nuclei essential for vocal learning in songbirds
-
Panaitof S.C., et al. Language-related Cntnap2 gene is differentially expressed in sexually dimorphic song nuclei essential for vocal learning in songbirds. J. Comp. Neurol. 2010, 518:1995-2018.
-
(2010)
J. Comp. Neurol.
, vol.518
, pp. 1995-2018
-
-
Panaitof, S.C.1
-
35
-
-
0017160887
-
Sexual dimorphism in vocal control areas of the songbird brain
-
Nottebohm F., Arnold A.P. Sexual dimorphism in vocal control areas of the songbird brain. Science 1976, 194:211-213.
-
(1976)
Science
, vol.194
, pp. 211-213
-
-
Nottebohm, F.1
Arnold, A.P.2
-
36
-
-
1842610982
-
Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction
-
Teramitsu I., et al. Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction. J. Neurosci. 2004, 24:3152-3163.
-
(2004)
J. Neurosci.
, vol.24
, pp. 3152-3163
-
-
Teramitsu, I.1
-
37
-
-
33746083657
-
FoxP2 regulation during undirected singing in adult songbirds
-
Teramitsu I., White S.A. FoxP2 regulation during undirected singing in adult songbirds. J. Neurosci. 2006, 26:7390-7394.
-
(2006)
J. Neurosci.
, vol.26
, pp. 7390-7394
-
-
Teramitsu, I.1
White, S.A.2
-
38
-
-
77649101847
-
Striatal FoxP2 is actively regulated during songbird sensorimotor learning
-
Teramitsu I., et al. Striatal FoxP2 is actively regulated during songbird sensorimotor learning. PLoS ONE 2010, 5:e8548.
-
(2010)
PLoS ONE
, vol.5
-
-
Teramitsu, I.1
-
39
-
-
38549176222
-
Incomplete and inaccurate vocal imitation after knockdown of FoxP2 in songbird basal ganglia nucleus Area X
-
Haesler S., et al. Incomplete and inaccurate vocal imitation after knockdown of FoxP2 in songbird basal ganglia nucleus Area X. PLoS Biol. 2007, 5:e321.
-
(2007)
PLoS Biol.
, vol.5
-
-
Haesler, S.1
-
40
-
-
77958506741
-
Twitter evolution: converging mechanisms in birdsong and human speech
-
Bolhuis J.J., et al. Twitter evolution: converging mechanisms in birdsong and human speech. Nat. Rev. Neurosci. 2010, 11:747-759.
-
(2010)
Nat. Rev. Neurosci.
, vol.11
, pp. 747-759
-
-
Bolhuis, J.J.1
-
41
-
-
80053540965
-
Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities and core autism-related deficits
-
Peñagarikano O., et al. Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities and core autism-related deficits. Cell 2011, 147:235-246.
-
(2011)
Cell
, vol.147
, pp. 235-246
-
-
Peñagarikano, O.1
-
42
-
-
77956225035
-
Normal variation in fronto-occipital circuitry and cerebellar structure with an autism-associated polymorphism of CNTNAP2
-
Tan G.C., et al. Normal variation in fronto-occipital circuitry and cerebellar structure with an autism-associated polymorphism of CNTNAP2. Neuroimage 2010, 53:1030-1042.
-
(2010)
Neuroimage
, vol.53
, pp. 1030-1042
-
-
Tan, G.C.1
-
43
-
-
78149301263
-
Altered functional connectivity in frontal lobe circuits is associated with variation in the autism risk gene CNTNAP2
-
Scott-Van Zeeland A.A., et al. Altered functional connectivity in frontal lobe circuits is associated with variation in the autism risk gene CNTNAP2. Sci. Transl. Med. 2010, 2:56-80.
-
(2010)
Sci. Transl. Med.
, vol.2
, pp. 56-80
-
-
Scott-Van Zeeland, A.A.1
-
44
-
-
77956517416
-
Prediction of individual brain maturity using fMRI
-
Dosenbach N.U., et al. Prediction of individual brain maturity using fMRI. Science 2010, 329:1358-1361.
-
(2010)
Science
, vol.329
, pp. 1358-1361
-
-
Dosenbach, N.U.1
-
45
-
-
7044254733
-
Autism and abnormal development of brain connectivity
-
Belmonte M.K., et al. Autism and abnormal development of brain connectivity. J. Neurosci. 2004, 24:9228-9241.
-
(2004)
J. Neurosci.
, vol.24
, pp. 9228-9241
-
-
Belmonte, M.K.1
-
46
-
-
33846921789
-
Autism spectrum disorders: developmental disconnection syndromes
-
Geschwind D.H., Levitt P. Autism spectrum disorders: developmental disconnection syndromes. Curr. Opin. Neurobiol. 2007, 17:103-111.
-
(2007)
Curr. Opin. Neurobiol.
, vol.17
, pp. 103-111
-
-
Geschwind, D.H.1
Levitt, P.2
-
48
-
-
79952668314
-
Development of the cerebral cortex: implications for neurodevelopmental disorders
-
Rubenstein J.L. Development of the cerebral cortex: implications for neurodevelopmental disorders. J. Child Psychol. Psychiatry 2011, 52:339-355.
-
(2011)
J. Child Psychol. Psychiatry
, vol.52
, pp. 339-355
-
-
Rubenstein, J.L.1
-
49
-
-
0035307374
-
The human contactin-associated protein-like 2 gene (CNTNAP2) spans over 2 Mb of DNA at chromosome 7q35
-
Nakabayashi K., Scherer S.W. The human contactin-associated protein-like 2 gene (CNTNAP2) spans over 2 Mb of DNA at chromosome 7q35. Genomics 2001, 73:108-112.
-
(2001)
Genomics
, vol.73
, pp. 108-112
-
-
Nakabayashi, K.1
Scherer, S.W.2
-
50
-
-
0033396331
-
Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels
-
Poliak S., et al. Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels. Neuron 1999, 24:1037-1047.
-
(1999)
Neuron
, vol.24
, pp. 1037-1047
-
-
Poliak, S.1
-
51
-
-
0026769035
-
Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin
-
Ushkaryov Y.A., et al. Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin. Science 1992, 257:50-56.
-
(1992)
Science
, vol.257
, pp. 50-56
-
-
Ushkaryov, Y.A.1
-
52
-
-
0029036374
-
Neuroligin 1: a splice site-specific ligand for beta-neurexins
-
Ichtchenko K., et al. Neuroligin 1: a splice site-specific ligand for beta-neurexins. Cell 1995, 81:435-443.
-
(1995)
Cell
, vol.81
, pp. 435-443
-
-
Ichtchenko, K.1
-
53
-
-
84856218706
-
Modeling the functional genomics of autism using human neurons
-
Konopka G., et al. Modeling the functional genomics of autism using human neurons. Mol. Psychiatry 2012, 17:202-214.
-
(2012)
Mol. Psychiatry
, vol.17
, pp. 202-214
-
-
Konopka, G.1
-
54
-
-
0345690096
-
The local differentiation of myelinated axons at nodes of Ranvier
-
Poliak S., Peles E. The local differentiation of myelinated axons at nodes of Ranvier. Nat. Rev. Neurosci. 2003, 4:968-980.
-
(2003)
Nat. Rev. Neurosci.
, vol.4
, pp. 968-980
-
-
Poliak, S.1
Peles, E.2
-
55
-
-
0141433266
-
Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1
-
Poliak S., et al. Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1. J. Cell Biol. 2003, 162:1149-1160.
-
(2003)
J. Cell Biol.
, vol.162
, pp. 1149-1160
-
-
Poliak, S.1
-
56
-
-
33644527244
-
Voltage-gated ion channels in the axon initial segment of human cortical pyramidal cells and their relationship with chandelier cells
-
Inda M.C., et al. Voltage-gated ion channels in the axon initial segment of human cortical pyramidal cells and their relationship with chandelier cells. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:2920-2925.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 2920-2925
-
-
Inda, M.C.1
-
57
-
-
45949094424
-
Postsynaptic density-93 clusters Kv1 channels at axon initial segments independently of Caspr2
-
Ogawa Y., et al. Postsynaptic density-93 clusters Kv1 channels at axon initial segments independently of Caspr2. J. Neurosci. 2008, 28:5731-5739.
-
(2008)
J. Neurosci.
, vol.28
, pp. 5731-5739
-
-
Ogawa, Y.1
-
58
-
-
40849132907
-
Behavioral phenotyping strategies for mutant mice
-
Crawley J.N. Behavioral phenotyping strategies for mutant mice. Neuron 2008, 57:809-818.
-
(2008)
Neuron
, vol.57
, pp. 809-818
-
-
Crawley, J.N.1
-
59
-
-
0009703087
-
Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies
-
Crawley J.N., et al. Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies. Psychopharmacology 1997, 132:107-124.
-
(1997)
Psychopharmacology
, vol.132
, pp. 107-124
-
-
Crawley, J.N.1
-
60
-
-
78650517693
-
Malformations of cortical development and aberrant cortical networks: epileptogenesis and functional organization
-
Guerrini R., Barba C. Malformations of cortical development and aberrant cortical networks: epileptogenesis and functional organization. J. Clin. Neurophysiol. 2010, 27:372-379.
-
(2010)
J. Clin. Neurophysiol.
, vol.27
, pp. 372-379
-
-
Guerrini, R.1
Barba, C.2
-
61
-
-
0242291090
-
Model of autism: increased ratio of excitation/inhibition in key neural systems
-
Rubenstein J.L., Merzenich M.M. Model of autism: increased ratio of excitation/inhibition in key neural systems. Genes Brain Behav. 2003, 2:255-267.
-
(2003)
Genes Brain Behav.
, vol.2
, pp. 255-267
-
-
Rubenstein, J.L.1
Merzenich, M.M.2
-
62
-
-
80052563319
-
Neocortical excitation/inhibition balance in information processing and social dysfunction
-
Yizhar O., et al. Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature 2011, 477:171-178.
-
(2011)
Nature
, vol.477
, pp. 171-178
-
-
Yizhar, O.1
-
63
-
-
33749081115
-
Neural synchrony in brain disorders: relevance for cognitive dysfunctions and pathophysiology
-
Uhlhaas P.J., Singer W. Neural synchrony in brain disorders: relevance for cognitive dysfunctions and pathophysiology. Neuron 2006, 52:155-168.
-
(2006)
Neuron
, vol.52
, pp. 155-168
-
-
Uhlhaas, P.J.1
Singer, W.2
-
64
-
-
66649110345
-
GABAergic hub neurons orchestrate synchrony in developing hippocampal networks
-
Sohal V.S., et al. GABAergic hub neurons orchestrate synchrony in developing hippocampal networks. Nature 2009, 459:698-702.
-
(2009)
Nature
, vol.459
, pp. 698-702
-
-
Sohal, V.S.1
|