Screening of chemicals for human bioaccumulative potential with a physiologically based toxicokinetic model

Archives of Toxicology

Volumn 86, Issue 3, 2012, Pages 393-403

  Tonnelier, Arnaud ^a,b   Coecke, Sandra ^a   Zaldívar, José Manuel ^a  

^a JOINT RESEARCH CENTRE   (Italy)

^b INRIA RHÔNE ALPES   (France)

Author keywords

Bioaccumulation assessment; In vitro in vivo extrapolation; PBTK modelling; Screening

Indexed keywords

2,4 DICHLOROPHENOXYACETIC ACID; 4,4' ISOPROPYLIDENEDIPHENOL; CHLORPHENOTANE; CHLORPYRIFOS; OXYTETRACYCLINE; PARATHION; PERFLUOROOCTANESULFONIC ACID; POLYCHLORINATED BIPHENYL; PROPRANOLOL; THIORIDAZINE; TRICLOSAN; WARFARIN;

ARTICLE; BIOACCUMULATION; CLEARANCE; HEALTH HAZARD; HYDROPHOBICITY; INTESTINE ABSORPTION; LIVER METABOLISM; LONG TERM EXPOSURE; PLASMA PROTEIN BINDING; PREDICTION; PRIORITY JOURNAL; RISK ASSESSMENT; SCREENING; TOXICOKINETICS; URINARY EXCRETION;

BLOOD PROTEINS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KIDNEY; LIVER; MODELS, BIOLOGICAL; PHARMACOKINETICS; PROTEIN BINDING; RISK ASSESSMENT;

EID: 84858077459     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-011-0768-0     Document Type: Article

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