PRELP protein inhibits the formation of the complement membrane attack complex

Journal of Biological Chemistry

Volumn 287, Issue 11, 2012, Pages 8092-8100

  Happonen, Kaisa E ^a   Fürst, Camilla Melin ^a   Saxne, Tore ^b   Heinegård, Dick ^b   Blom, Anna M ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BASEMENT MEMBRANE; BINDING PROTEINS; CARTILAGE TISSUES; COMPLEMENT SYSTEMS; EXTRACELLULAR MATRICES; INFLAMMATORY DISEASE; MEMBRANE ATTACK COMPLEXES; PROTEOGLYCANS; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID;

BUILDINGS; CARTILAGE; TISSUE;

PROTEINS;

CLASSICAL COMPLEMENT PATHWAY C3 C5 CONVERTASE; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C5B; COMPLEMENT COMPONENT C8; COMPLEMENT COMPONENT C9; COMPLEMENT MEMBRANE ATTACK COMPLEX; PRELP PROTEIN; PROTEOGLYCAN; UNCLASSIFIED DRUG;

ARTICLE; BASEMENT MEMBRANE; CARTILAGE; CLINICAL ARTICLE; COMPLEMENT ACTIVATION; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT INHIBITION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; EMBRYO; FEMALE; HUMAN; HUMAN CELL; MALE; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION;

ARTHRITIS, RHEUMATOID; BASEMENT MEMBRANE; COMPLEMENT ACTIVATION; COMPLEMENT C3-C5 CONVERTASES; COMPLEMENT C4B-BINDING PROTEIN; COMPLEMENT C9; COMPLEMENT MEMBRANE ATTACK COMPLEX; COMPLEMENT SYSTEM PROTEINS; DOWN-REGULATION; EXTRACELLULAR MATRIX PROTEINS; FEMALE; GLYCOPROTEINS; HEK293 CELLS; HUMANS; MALE;

EID: 84858009778     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.291476     Document Type: Article

References (25)

1. Groeneveld, T. W., Oroszlán, M., Owens, R. T., Faber-Krol, M. C., Bakker, A. C., Arlaud, G. J., McQuillan, D. J., Kishore, U., Daha, M. R., and Roos, A. (2005) Interactions of the extracellular matrix proteoglycans decorin and biglycan with C1q and collectins. J. Immunol. 175, 4715-4723 (Pubitemid 41362013)
2. Sjöberg, A. P., Manderson, G. A., Mörgelin, M., Day, A. J., Heinegård, D., and Blom, A. M. (2009) Mol. Immunol. 46, 830-839
3. Sjöberg, A., Onnerfjord, P., Mörgelin, M., Heinegård, D., and Blom, A. M. (2005) The extracellular matrix and inflammation: fibromodulin activates the classical pathway of complement by directly binding C1q. J. Biol. Chem. 280, 32301-32308 (Pubitemid 41361839)
4. Happonen, K. E., Sjöberg, A. P., Mörgelin, M., Heinegård, D., and Blom, A. M. (2009) Complement inhibitor C4b-binding protein interacts directly with small glycoproteins of the extracellular matrix. J. Immunol. 182, 1518-1525
5. Volanakis, J. E., and Kaplan, M. H. (1974) Interaction of C-reactive protein complexes with the complement system. II. Consumption of guinea pig complement by CRP complexes: requirement for human C1q. J. Immunol. 113, 9-17
6. Sarma, J. V., and Ward, P. A. (2011) The complement system. Cell Tissue Res. 343, 227-235
7. Davies, A., Simmons, D. L., Hale, G., Harrison, R. A., Tighe, H., Lachmann, P. J., and Waldmann, H. (1989) CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells. J. Exp. Med. 170, 637-654 (Pubitemid 19226653)
8. Podack, E. R., Kolb, W. P., and Müller-Eberhard, H. J. (1978) The C5b-6 complex: formation, isolation, and inhibition of its activity by lipoprotein and the S-protein of human serum. J. Immunol. 120, 1841-1848 (Pubitemid 8356923)
9. Murphy, B. F., Saunders, J. R., O'Bryan, M. K., Kirszbaum, L., Walker, I. D., and d'Apice, A. J. (1989) SP-40,40 is an inhibitor of C5b-6-initiated haemolysis. Int. Immunol. 1, 551-554 (Pubitemid 19258090)
10. Heinegård, D., Larsson, T., Sommarin, Y., Franzén, A., Paulsson, M., and Hedbom, E. (1986) Two novel matrix proteins isolated from articular cartilage show wide distributions among connective tissues. J. Biol. Chem. 261, 13866-13872
11. Grover, J., Chen, X. N., Korenberg, J. R., Recklies, A. D., and Roughley, P. J. (1996) The gene organization, chromosome location, and expression of a 55-kDa matrix protein (PRELP) of human articular cartilage. Genomics 38, 109-117 (Pubitemid 26424588)
12. Bengtsson, E., Neame, P. J., Heinegård, D., and Sommarin, Y. (1995) The primary structure of a basic leucine-rich repeat protein, PRELP, found in connective tissues. J. Biol. Chem. 270, 25639-25644
13. Bengtsson, E., Aspberg, A., Heinegard, D., Sommarin, Y., and Spillmann, D. (2000) The amino-terminal part of PRELP binds to heparin and heparan sulfate. J. Biol. Chem. 275, 40695-40702 (Pubitemid 32054886)
14. Rucci, N., Rufo, A., Alamanou, M., Capulli, M., Del Fattore, A., Ahrman, E., Capece, D., Iansante, V., Zazzeroni, F., Alesse, E., Heinegård, D., and Teti, A. (2009) The glycosaminoglycan-binding domain of PRELP acts as a cell type-specific NF-κB inhibitor that impairs osteoclastogenesis. J. Cell Biol. 187, 669-683
15. Kalchishkova, N., Fürst, C. M., Heinegård, D., and Blom, A. M. (2011) NC4 Domain of cartilage-specific collagen IX inhibits complement directly due to attenuation of membrane attack formation and indirectly through binding and enhancing activity of complement inhibitors C4B-binding protein and factor H. J. Biol. Chem. 286, 27915-27926
16. Jeppsson, J. O., and Laurell, C. B. (1974) Isolation and Fragmentation of alfa-1-antitrypsin., Springer-Verlag, New York
17. Laurell, C. B., Dahlqvist, I., and Persson, U. (1983) The use of thiol-disulphide exchange chromatography for the automated isolation of α1-antitrypsin and other plasma proteins with reactive thiol groups. J. Chromatogr 278, 53-61 (Pubitemid 14219486)
18. Blom, A. M., Kask, L., and Dahlbäck, B. (2001) Structural requirements for the complement regulatory activities of C4BP. J. Biol. Chem. 276, 27136-27144
19. Ferreira, V. P., Cortes, C., and Pangburn, M. K. (2010) Native polymeric forms of properdin selectively bind to targets and promote activation of the alternative pathway of complement. Immunobiology 215, 932-940
20. Blom, A. M., Nandakumar, K. S., and Holmdahl, R. (2009) C4b-binding protein (C4BP) inhibits development of experimental arthritis in mice. Ann. Rheum. Dis. 68, 136-142
21. Wang, Y., Rollins, S. A., Madri, J. A., and Matis, L. A. (1995) Anti-C5 monoclonal antibody therapy prevents collagen-induced arthritis and ameliorates established disease. Proc. Natl. Acad. Sci. U.S.A. 92, 8955-8959
22. Nandakumar, K. S., Jansson, A., Xu, B., Rydell, N., Ahooghalandari, P., Hellman, L., Blom, A. M., and Holmdahl, R. (2010)Arecombinant vaccine effectively induces c5a-specific neutralizing antibodies and prevents arthritis. PLoS One 5, e13511
23. Williams, A. S., Mizuno, M., Richards, P. J., Holt, D. S., and Morgan, B. P. (2004) Deletion of the gene encoding CD59a in mice increases disease severity in a murine model of rheumatoid arthritis. Arthritis Rheum. 50, 3035-3044 (Pubitemid 39209543)
24. Fraser, D. A., Harris, C. L., Williams, A. S., Mizuno, M., Gallagher, S., Smith, R. A., and Morgan, B. P. (2003) Generation of a recombinant, membrane-targeted form of the complement regulator CD59: activity in vitro and in vivo. J. Biol. Chem. 278, 48921-48927
25. Malmsten, M., Davoudi, M., and Schmidtchen, A. (2006) Bacterial killing by heparin-binding peptides from PRELP and thrombospondin. Matrix. Biol. 25, 294-300 (Pubitemid 43949123)