NC4 domain of cartilage-specific collagen IX inhibits complement directly due to attenuation of membrane attack formation and indirectly through binding and enhancing activity of complement inhibitors C4B-binding protein and factor H

Journal of Biological Chemistry

Volumn 286, Issue 32, 2011, Pages 27915-27926

  Kalchishkova, Nikolina ^a   Fürst, Camilla Melin ^a   Heinega, Dick ^a   Blom, Anna M ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CARTILAGE; CHEMICAL ACTIVATION; DISEASES; MACHINERY;

CHRONIC INFLAMMATION; COFACTOR ACTIVITY; COMPLEMENT ACTIVATIONS; COMPLEMENT SYSTEMS; MATRIX COMPONENTS; MEMBRANE ATTACK COMPLEXES; RHEUMATOID ARTHRITIS; TISSUE STABILITIES;

COLLAGEN;

COLLAGEN; COLLAGEN FIBRIL; COLLAGEN TYPE 2; COLLAGEN TYPE 9; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C4; COMPLEMENT COMPONENT C4B; COMPLEMENT COMPONENT C4B BINDING PROTEIN; COMPLEMENT COMPONENT C9; COMPLEMENT FACTOR H; FIBROMODULIN; MATRILIN; MATRIX PROTEIN; N TERMINAL NONCOLLAGENOUS DOMAIN 4 PROTEIN; OSTEOADHERIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTHROPATHY; ARTICLE; CARTILAGE; CARTILAGE DEGENERATION; COMPLEMENT ACTIVATION; COMPLEMENT INHIBITION; COMPLEMENT SYSTEM; CONTROLLED STUDY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN POLYMERIZATION; PROTEIN PROTEIN INTERACTION; TISSUE SPECIFICITY;

EID: 80051513019     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.242834     Document Type: Article

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