A tripartite complex composed of ETV6-NTRK3, IRS1 and IGF1R is required for ETV6-NTRK3-mediated membrane localization and transformation

Oncogene

Volumn 31, Issue 10, 2012, Pages 1334-1340

  Tognon, C E ^a   Martin, M J ^a   Moradian, A ^a   Trigo, G ^a   Rotblat, B ^a   Cheng, S W G ^a   Pollard, M ^a   Uy, E ^a   Chow, C ^a   Carboni, J M ^b   Gottardis, M M ^b   Pollak, M ^c   Morin, G B ^a,d   Sorensen, P H B ^a  

^a BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

^b BRISTOL MYERS SQUIBB   (United States)

^c MCGILL UNIVERSITY   (Canada)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

BMS 536924; chimeric tyrosine kinase; ETV6 NTRK3; insulin receptor substrate 1 (IRS1); insulin like growth factor 1 receptor (IGF1R)

Indexed keywords

CHIMERIC PROTEIN; ETV6 NTRK3 PROTEIN; INSULIN RECEPTOR SUBSTRATE 1; SOMATOMEDIN C; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE; CELL STRAIN HEK293; CELL SURVIVAL; ENZYME ACTIVITY; GENETIC TRANSFORMATION; HUMAN; HUMAN CELL; MOLECULAR DOCKING; MOLECULAR WEIGHT; ONCOGENE; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION;

ANIMALS; CELL MEMBRANE; CELL TRANSFORMATION, NEOPLASTIC; INSULIN RECEPTOR SUBSTRATE PROTEINS; INTERLEUKIN-3; MICE; ONCOGENE PROTEINS, FUSION; PHOSPHORYLATION; RECEPTOR, IGF TYPE 1;

EID: 84858008391     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.323     Document Type: Article

References (23)

1. Argani P, Fritsch M, Kadkol SS, Schuster A, Beckwith JB, Perlman EJ. (2000). Detection of the ETV6-NTRK3 chimeric RNA of infantile fibrosarcoma/cellular congenital mesoblastic nephroma in paraffin-embedded tissue: application to challenging pediatric renal stromal tumors. Mod Pathol 13: 29-36. (Pubitemid 30077901)
2. Baserga R. (2005). The insulin-like growth factor-I receptor as a target for cancer therapy. Expert Opin Ther Targets 9: 753-768.
3. Craparo A, O'Neill TJ, Gustafson TA. (1995). Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor. J Biol Chem 270: 15639-15643.
4. Eguchi M, Eguchi-Ishimae M, Tojo A, Morishita K, Suzuki K, Sato Y et al. (1999). Fusion of ETV6 to neurotrophin-3 receptor TRKC in acute myeloid leukemia with t(12;15)(p13;q25). Blood 93: 1355-1363. (Pubitemid 29076151)
5. Forghieri F, Morselli M, Potenza L, Maccaferri M, Pedrazzi L, Paolini A et al. (2011). Chronic eosinophilic leukaemia with Etv6-Ntrk3 fusion transcript in an elderly patient affected with pancreatic carcinoma. Eur J Haematol 86: 352-355.
6. Huang EJ, Reichardt LF. (2003). Trk receptors: roles in neuronal signal transduction. Annu Rev Biochem 72: 609-642. (Pubitemid 36930455)
7. Kazakov DV, Hantschke M, Vanecek T, Kacerovska D, Michal M. (2010). Mammary-type secretory carcinoma of the skin. Am J Surg Pathol 34: 1226-1227; author reply 8.
8. Kerppola TK. (2009). Visualization of molecular interactions using bimolecular fluorescence complementation analysis: characteristics of protein fragment complementation. Chem Soc Rev 38: 2876-2886.
9. Knezevich SR, Garnett MJ, Pysher TJ, Beckwith JB, Grundy PE, Sorensen PH. (1998). ETV6-NTRK3 gene fusions and trisomy 11 establish a histogenetic link between mesoblastic nephroma and congenital fibrosarcoma. Cancer Res 58: 5046-5048. (Pubitemid 28521157)
10. Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH. (1998). A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma. Nat Genet 18: 184-187. (Pubitemid 28082471)
11. Lannon CL, Martin MJ, Tognon CE, Jin W, Kim SJ, Sorensen PH. (2004). A highly conserved NTRK3 C-terminal sequence in the ETV6-NTRK3 oncoprotein binds the phosphotyrosine binding domain of insulin receptor substrate-1: an essential interaction for transformation. J Biol Chem 279: 6225-6234. (Pubitemid 38248755)
12. Lannon CL, Sorensen PH. (2005). ETV6-NTRK3: a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages. Semin Cancer Biol 15: 215-223.
13. Martin MJ, Melnyk N, Pollard M, Bowden M, Leong H, Podor TJ et al. (2006). The insulin-like growth factor I receptor is required for Akt activation and suppression of anoikis in cells transformed by the ETV6-NTRK3 chimeric tyrosine kinase. Mol Cell Biol 26: 1754-1769.
14. Morrison KB, Tognon C, Garnett MJ, Deal C, Sorensen PHB. (2002). ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation. Oncogene 21: 5684-5695. (Pubitemid 35333001)
15. Myers Jr MG, Sun XJ, Cheatham B, Jachna BR, Glasheen EM, Backer JM et al. (1993). IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 30-kinase. Endocrinology 132: 1421-1430. (Pubitemid 23110508)
16. Skalova A, Vanecek T, Sima R, Laco J, Weinreb I, Perez-Ordonez B et al. (2010). Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. Am J Surg Pathol 34: 599-608.
17. Sun H, Baserga R. (2004). Deletion of the pleckstrin and phosphotyrosine binding domains of insulin receptor substrate-2 does not impair its ability to regulate cell proliferation in myeloid cells. Endocrinology 145: 5332-5343. (Pubitemid 39551155)
18. Tognon C, Garnett M, Kenward E, Kay R, Morrison K, Sorensen PH. (2001). The chimeric protein tyrosine kinase ETV6-NTRK3 requires both Ras-Erk1/2 and PI3-kinase-Akt signaling for fibroblast transformation. Cancer Res 61: 8909-8916. (Pubitemid 34013908)
19. Tognon C, Knezevich SR, Huntsman D, Roskelley CD, Melnyk N, Mathers JA et al. (2002). Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma. Cancer Cell 2: 367-376. (Pubitemid 41039103)
20. Tognon CE, Mackereth C, Somasiri AM, McIntosh LP, Sorensen PHB. (2004). Mutations in the SAM domain of the ETV6-NTRK3 chimeric tyrosine kinase block polymerization and transformation activity. Moll Cell Biol 24: 4636-4650. (Pubitemid 38668032)
21. Tognon CE, Somasiri AM, Evdokimova VE, Trigo G, Uy EE, Melnyk N et al. (2011). ETV6-NTRK3-mediated breast epithelial cell transformation is blocked by targeting the IGF1R signaling pathway. Cancer Res 71: 1060-1070.
22. Wai DH, Knezevich SR, Lucas T, Jansen B, Kay RJ, Sorensen PHB. (2000). The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells. Oncogene 19: 906-915. (Pubitemid 30153748)
23. Wittman M, Carboni J, Attar R, Balasubramanian B, Balimane P, Brassil P et al. (2005). Discovery of a (1H-benzoimidazol-2-yl)-1Hpyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity. J Med Chem 48: 5639-5643. (Pubitemid 41298335)