Herbal remedies affecting coagulation: A review

Pharmaceutical Biology

Volumn 50, Issue 4, 2012, Pages 443-452

  Cordier, Werner ^a   Steenkamp, Vanessa ^a  

^a UNIVERSITY OF PRETORIA   (South Africa)

Author keywords

Anticoagulant; Antiplatelet; Antithrombotic; Extract; Perioperative bleeding

Indexed keywords

CATECHIN; COUMARIN DERIVATIVE; FUCOIDIN; HERBACEOUS AGENT; POLYPHENOL; POLYSACCHARIDE; SAPONIN; SEVOFLURANE; TAXANE DERIVATIVE; WARFARIN;

ANTICOAGULANT THERAPY; ARTICLE; BLOOD CLOTTING; BRAIN HEMORRHAGE; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; DYSPNEA; ECCHYMOSIS; ERYTHROCYTE AGGREGATION; FATIGUE; GALLBLADDER HEMORRHAGE; GARLIC; GINKGO BILOBA; GINSENG; HEMORRHOID HEMORRHAGE; HERB DRUG INTERACTION; HERBAL MEDICINE; HUMAN; HYPHEMA; IN VITRO STUDY; IN VIVO STUDY; METRORRHAGIA; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PHYTOCHEMISTRY; POSTOPERATIVE HEMORRHAGE; PROTHROMBIN TIME; SUBARACHNOID HEMORRHAGE; SUBDURAL HEMATOMA; THORAX PAIN; THROMBIN TIME; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE FUNCTION; VAGINA BLEEDING;

ANIMALS; ANTICOAGULANTS; BLOOD COAGULATION; COAGULANTS; EVIDENCE-BASED MEDICINE; FIBRINOLYTIC AGENTS; HEMORRHAGE; HERB-DRUG INTERACTIONS; HUMANS; PLANT PREPARATIONS; PLANTS, MEDICINAL; PLATELET AGGREGATION INHIBITORS; RISK ASSESSMENT; RISK FACTORS;

SCOPUS;

EID: 84858004528     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2011.611145     Document Type: Article

References (85)

1. Aburjai T, Hudaib M. (2006). Antiplatelet, antibacterial and antifungal activities of Achillea falcata extracts and evaluation of volatile oil composition. Pharmacognosy Magnazine, 2, 191-198.
2. Aburjai TA. (2000). Anti-platelet stilbenes from aerial parts of Rheum palaestinum. Phytochemistry, 55, 407-410.
3. Basila D, Yuan CS. (2005). Effects of dietary supplements on coagulation and platelet function. Tromb Res, 117, 49-53; discussion 65. (Pubitemid 41597029)
4. Beckert BW, Concannon MJ, Henry SL, Smith DS, Puckett CL. (2007). The effect of herbal medicines on platelet function: An in vivo experiment and review of the literature. Plast Reconstr Surg, 120, 2044-2050. (Pubitemid 350306707)
5. Bent S, Goldberg H, Padula A, Avins AL. (2005). Spontaneous bleeding associated with Ginkgo biloba: A case report and systematic review of the literature: A case report and systematic review of the literature. J Gen Intern Med, 20, 657-661. (Pubitemid 41026255)
6. Bruno O, Schenone S, Ranise A, Bondavalli F, Barocelli E, Ballabeni V, Chiavarini M, Bertoni S, Tognolini M, Impicciatore M. (2001). New polycyclic pyrimidine derivatives with antiplatelet in vitro activity: Synthesis and pharmacological screening. Bioorg Med Chem, 9, 629-636. (Pubitemid 32208582)
7. Buch MH, Prendergast BD, Storey RF. (2010). Antiplatelet therapy and vascular disease: An update. Ter Adv Cardiovasc Dis, 4, 249-275.
8. Campos-Toimil M, Orallo F, Santana L, Uriarte E. (2002). Synthesis and vasorelaxant activity of new coumarin and furocoumarin derivatives. Bioorg Med Chem Lett, 12, 783-786. (Pubitemid 34164618)
9. Chandía NP, Matsuhiro B. (2008). Characterization of a fucoidan from Lessonia vadosa (Phaeophyta) and its anticoagulant and elicitor properties. Int J Biol Macromol, 42, 235-240. (Pubitemid 351273407)
10. Chang CL, Zhang LJ, Chen RY, Wu CC, Huang HC, Roy MC, Huang JP, Wu YC, Kuo YH. (2010). Quiquelignan A-H, eight new lignoids from the rattan palm Calamus quiquesetinervius and their antiradical, anti-infammatory and antiplatelet aggregation activities. Bioorg Med Chem, 18, 518-525.
11. Chen JJ, Chang YL, Teng CM, Lin WY, Chen YC, Chen IS. (2001). A new tetrahydroprotoberberine N-oxide alkaloid and anti-platelet aggregation constituents of Corydalis tashiroi. Planta Med, 67, 423-427.
12. Chen KS, Wu CC, Chang FR, Chia YC, Chiang MY, Wang WY, Wu YC. (2003). Bioactive coumarins from the leaves of Murraya omphalocarpa. Planta Med, 69, 654-657.
13. Chen YL, Lan YH, Hsieh PW, Wu CC, Chen SL, Yen CT, Chang FR, Hung WC, Wu YC. (2008). Bioactive cembrane diterpenoids of Anisomeles indica. J Nat Prod, 71, 1207-1212.
14. Chia YC, Chang FR, Wang JC, Wu CC, Chiang MY, Lan YH, Chen KS, Wu YC. (2008). Antiplatelet aggregation coumarins from the leaves of Murraya omphalocarpa. Molecules, 13, 122-128.
15. Chistokhodova N, Nguyen C, Calvino T, Kachirskaia I, Cunningham G, Howard Miles D. (2002). Antithrombin activity of medicinal plants from central Florida. J Ethnopharmacol, 81, 277-280. (Pubitemid 34628514)
16. Chukwumah Y, Walker L, Vogler B, Verghese M. (2007). Changes in the phytochemical composition and profle of raw, boiled, and roasted peanuts. J Agric Food Chem, 55, 9266-9273. (Pubitemid 350105582)
17. Chung MI, Weng JR, Wang JP, Teng CM, Lin CN. (2002). Antiplatelet and anti-infammatory constituents and new oxygenated xanthones from Hypericum geminiforum. Planta Med, 68, 25-29.
18. Coppinger JA, Cagney G, Toomey S, Kislinger T, Belton O, McRedmond JP, Cahill DJ, Emili A, Fitzgerald DJ, Maguire PB. (2004). Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood, 103, 2096-2104. (Pubitemid 38326225)
19. Cordier W, Cromarty AD, Botha E, Steenkamp V. (2011). Effects of selected South African plant extracts on haemolysis and coagulation. Hum Exp Toxicol. DOI: 10.1177/0960327111398675.
20. de Medeiros JM, Macedo M, Contancia JP, Nguyen C, Cunningham G, Miles DH. (2000). Antithrombin activity of medicinal plants of the Azores. J Ethnopharmacol, 72, 157-165.
21. Drozd NN, Kuznetsova SA, Lapikova ES, Davydova AI, Makarov VA, Kuznetsov BN, Butylkina AI, Vasil'eva NIu, Skvortsova GP. (2008). Anticoagulant activity of arabinogalactane sulfate and cedar bark extract studied in vitro. Eksp Klin Farmakol, 71, 30-34.
22. Eisenreich A, Rauch U. (2011). PI3K inhibitors in cardiovascular disease. Cardiovasc Ter, 29, 29-36.
23. Elliott Middleton JR, Chithan K, Teoharis CT. (2000). The effects of plant favonoids on mammalian cells: Implications for infammation, heart disease, and cancer. Pharmacol Rev, 52, 673-751.
24. Francischetti IM, Monteiro RQ, Guimarães JA, Francischetti B. (1997). Identifcation of glycyrrhizin as a thrombin inhibitor. Biochem Biophys Res Commun, 235, 259-263.
25. Gadi D, Bnouham M, Aziz M, Ziyyat A, Legssyer A, Legrand C, Lafeve FF, Mekhf H. (2009). Parsley extract inhibits in vitro and ex vivo platelet aggregation and prolongs bleeding time in rats. J Ethnopharmacol, 125, 170-174.
26. Gilani AH, Mehmood MH, Janbaz KH, Khan AU, Saeed SA. (2008). Ethnopharmacological studies on antispasmodic and antiplatelet activities of Ficus carica. J Ethnopharmacol, 119, 1-5.
27. Goker H, Haznedaroglu IC, Ercetin S, Kirazli S, Akman U, Ozturk Y, Firat HC. (2008). Haemostatic actions of the folkloric medicinal plant extract Ankaferd Blood Stopper. J Int Med Res, 36, 163-170. (Pubitemid 351255983)
28. Goun EA, Petrichenko VM, Solodnikov SU, Suhinina TV, Kline MA, Cunningham G, Nguyen C, Miles H. (2002). Anticancer and antithrombin activity of Russian plants. J Ethnopharmacol, 81, 337-342. (Pubitemid 34786318)
29. Henderson L, Yue QY, Bergquist C, Gerden B, Arlett P. (2002). St John's wort (Hypericum perforatum): Drug interactions and clinical outcomes. Br J Clin Pharmacol, 54, 349-356. (Pubitemid 35334946)
30. Hoult JR, Payá M. (1996). Pharmacological and biochemical actions of simple coumarins: Natural products with therapeutic potential. Gen Pharmacol, 27, 713-722. (Pubitemid 26233347)
31. Hutchings A, Scott AG, Lewis G, Cunningham A. (1996). Zulu Medicinal Plants-An Inventory. University of Natal Press, Pietermaritzburg.
32. Hyun KW, Jeong SC, Lee DH, Park JS, Lee JS. (2006). Isolation and characterization of a novel platelet aggregation inhibitory peptide from the medicinal mushroom Inonotus obliquus. Peptides, 27, 1173-1178. (Pubitemid 43766990)
33. Im JH, Jin YR, Lee JJ, Yu JY, Han XH, Im SH, Hong JT, Yoo HS, Pyo MY, Yun YP. (2009). Antiplatelet activity of beta-carboline alkaloids from Perganum harmala: A possible mechanism through inhibiting PLCgamma2 phosphorylation. Vascul Pharmacol, 50, 147-152.
34. Izzat MB, Yim AP, El-Zufari MH. (1998). A taste of Chinese medicine! Ann Torac Surg, 66, 941-942. (Pubitemid 28462137)
35. Jantan I, Raweh SM, Sirat HM, Jamil S, Yasin YHM, Jalil J, Jamal JA (2008). Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation. Phytomedicine 15, 306-309.
36. Jeon WK, Lee JH, Kim HK, Lee AY, Lee SO, Kim YS, Ryu SY, Kim SY, Lee YJ, Ko BS. (2006). Anti-platelet effects of bioactive compounds isolated from the bark of Rhus vernicifua Stokes. J Ethnopharmacol, 106, 62-69. (Pubitemid 43732486)
37. Jeon WK, Kim YE, Park SO, Kwon DY, Ahn SW, Lee JH, Ji MS, Ko BS. (2008). The modifed Je-Ho-Tang, Korean herbal medicine, inhibits whole-blood aggregation and platelet adhesion to collagen under fow. Tromb Res, 122, 804-809.
38. Jurgens T, Whelan AM. (2009). Advising patients on the use of natural health products to treat premenstrual syndrome. Can Pharmacists J, 142, 228-233.
39. Kagamizono T, Nishino E, Matsumoto K, Kawashima A, Kishimoto M, Sakai N, He BM, Chen ZX, Adachi T, Morimoto S. (1995). Bassiatin, a new platelet aggregation inhibitor produced by Beauveria bassiana K-717. J Antibiot, 48, 1407-1412. (Pubitemid 26016898)
40. Kim MS, Lee KA. (2006). Antithrombotic activity of methanolic extract of Umbilicaria esculenta. J Ethnopharmacol, 105, 342-345.
41. Kim SY, Yun-Choi HS. (2010). A comparative optical aggregometry study of antiplatelet activity of taxanes from Taxus cuspidata. Tromb Res, 125, e281-e284.
42. Kim BH, Kim KP, Lim KS, Kim JR, Yoon SH, Cho JY, Lee YO, Lee KH, Jang IJ, Shin SG, Yu KS. (2010). Infuence of Ginkgo biloba extract on the pharmacodynamic effects and pharmacokinetic properties of ticlopidine: An open-label, randomized, two-period, two-treatment, two-sequence, single-dose crossover study in healthy Korean male volunteers. Clin Ter, 32, 380-390.
43. Krüth P, Brosi E, Fux R, Mörike K, Gleiter CH. (2004). Ginger-associated overanticoagulation by phenprocoumon. Ann Pharmacother, 38, 257-260. (Pubitemid 38112238)
44. Lambert FP, Cormier A. (2001). Potential interaction between warfarin and boldo-fenugreek. Pharmacother, 21, 509-512.
45. Lau AJ, Toh DF, Chua TK, Pang YK, Woo SO, Koh HL. (2009). Antiplatelet and anticoagulant effects of Panax notoginseng: Comparison of raw and steamed Panax notoginseng with Panax ginseng and Panax quinquefolium. J Ethnopharmacol, 125, 380-386.
46. Lee HS. (2006). Antiplatelet property of Curcuma longa L. rhizome-derived ar-turmerone. Bioresour Technol, 97, 1372-1376.
47. Lee J-O, Kim C, Lee S-W, Oak M-H. (2010). Antiplatelet and antithrombotic activities of Lindera obtusiloba extract in vitro and in vivo. Biomol Ter, 18, 205-210.
48. Lee MH, Son YK, Han YN. (2002). Tissue factor inhibitory favonoids from the fruits of Chaenomeles sinensis. Arch Pharm Res, 25, 842-850.
49. Lee MH, Son YK, Han YN. (2004). Tissue factor inhibitory sesquiterpene glycoside from Eriobotrya japonica. Arch Pharm Res, 27, 619-623. (Pubitemid 43073719)
50. Liao FL, Li B. (1997). Inhibition of shear-induced platelet aggregation by Chinese herbal medicines. Clin Hemorheol Microcirc, 17, 315-318. (Pubitemid 28078071)
51. Makino T, Wakushima H, Okamoto T, Okukubo Y, Saito K, Kano Y. (2002). Effects of Kangen-karyu on coagulation system and platelet aggregation in mice. Biol Pharm Bull, 25, 523-525. (Pubitemid 40036747)
52. Mao W, Li H, Li Y, Zhang H, Qi X, Sun H, Chen Y, Guo S. (2009). Chemical characteristic and anticoagulant activity of the sulfated polysaccharide isolated from Monostroma latissimum (Chlorophyta). Int J Biol Macromol, 44, 70-74.
53. Matthews MK Jr. (1998). Association of Ginkgo biloba with intracerebral hemorrhage. Neurology, 50, 1933-1934.
54. Mattiello T, Trifrò E, Jotti GS, Pulcinelli FM. (2009). Effects of pomegranate juice and extract polyphenols on platelet function. J Med Food, 12, 334-339.
55. Medeiros VP, Queiroz KC, Cardoso ML, Monteiro GR, Oliveira FW, Chavante SF, Guimaraes LA, Rocha HA, Leite EL. (2008). Sulfated galactofucan from Lobophora variegata: Anticoagulant and anti-infammatory properties. Biochemistry Mosc, 73, 1018-1024.
56. Mekhf H, El Haouari M, Legssyer A, Bnouham M, Aziz M, Atmani F, Remmal A, Ziyyat A. (2004). Platelet anti-aggregant property of some Moroccan medicinal plants. J Ethnopharmacol, 94, 317-322. (Pubitemid 39119934)
57. Mendes-Silva W, Assafm M, Ruta B, Monteiro RQ, Guimarães JA, Zingali RB. (2003). Antithrombotic effect of glycyrrhizin, a plant-derived thrombin inhibitor. Tromb Res, 112, 93-98.
58. Murphy KJ, Chronopoulos AK, Singh I, Francis MA, Moriarty H, Pike MJ, Turner AH, Mann NJ, Sinclair AJ. (2003). Dietary favanols and procyanidin oligomers from cocoa (Teobroma cacao) inhibit platelet function. Am J Clin Nutr, 77, 1466-1473. (Pubitemid 39655281)
59. Nurtjahja-Tjendraputra E, Ammit AJ, Roufogalis BD, Tran VH, Duke CC. (2003). Effective anti-platelet and COX-1 enzyme inhibitors from pungent constituents of ginger. Tromb Res, 111, 259-265. (Pubitemid 38021945)
60. Olas B, Wachowicz B, Stochmal A, Oleszek W. (2002). Anti-platelet effects of diferent phenolic compounds from Yucca schidigera Roezl. bark. Platelets, 13, 167-173. (Pubitemid 34638922)
61. Osoniyi O, Onajobi F. (2003). Coagulant and anticoagulant activities in Jatropha curcas latex. J Ethnopharmacol, 89, 101-105. (Pubitemid 37163806)
62. Page RL, Lawrence JD (1999). Potentiation of warfarin by Dong Quai. Pharmacother, 19, 870-876 (Pubitemid 29415843)
63. Pan SF, Sun Y, Li F, Li GH, Jin DD, Zhang ZM, Luo ZJ, Ye ZX, Hu JH, Qiu GX. (2006). Effects of Yunnan Baiyao on peri-operative bleeding of patients undergoing cervical open-door laminoplasty: A multi-center randomized double-blind placebo-control trial. Zhonghua Yi Xue Za Zhi, 86, 1888-1890.
64. Pawlaczyk I, Czerchawski L, Kanska J, Bijak J, Capek P, Pliszczak-Król A, Gancarz R. (2010). An acidic glycoconjugate from Lythrum salicaria L. with controversial effects on haemostasis. J Ethnopharmacol, 131, 63-69.
65. Plotnikova AM, Shulgau ZT, Plotnikova TM, Aliev OI, Kulesh NI, Mischenko NP, Fedoreyev SA. (2009). Antithrombogenic and antiplatelet activities of extract from Maackia amyrensis wood. Bull Exp Biol Med, 147, 204-207.
66. Preusch PC, Smalley DM. (1990). Vitamin K1 2,3-epoxide and quinone reduction: Mechanism and inhibition. Free Radic Res Commun, 8, 401-415. (Pubitemid 20262583)
67. Rafael L, Teresinha N, Moritz JC, Maria IG, Eduardo MD, Tânia SF. (2009). Evaluation of antimicrobial and antiplatelet aggregation effects of Solidago chilensis Meyen. Int J Green Pharmacy, 3, 35-39.
68. Rang HP, Dale MM, Ritter JM, Flower RJ. (2007). Haemostasis and thrombosis. In: Rang and Dale's Pharmacology 6th edition. Churchill Livingstone (Elsevier), pp 332-345.
69. Robert S, Baccelli C, Devel P, Dogné JM, Quetin-Leclercq J. (2010). Effects of leaf extracts from Croton zambesicus Müell. Arg. On hemostasis. J Ethnopharmacol, 128, 641-648.
70. Roby CA, Anderson GD, Kantor E, Dryer DA, Burstein AH. (2000). St John's Wort: Effect on CYP3A4 activity. Clin Pharmacol Ter, 67, 451-457. (Pubitemid 30327483)
71. Rose KD, Croissant PD, Parliament CF, Levin MB. (1990). Spontaneous spinal epidural hematoma with associated platelet dysfunction from excessive garlic ingestion: A case report. Neurosurgery, 26, 880-882. (Pubitemid 20152635)
72. Rosenblatt M, Mindel J. (1997). Spontaneous hyphema associated with ingestion of Ginkgo biloba extract. N Engl J Med, 336, 1108. (Pubitemid 27163872)
73. Ryu KH, Han HY, Lee SY, Jeon SD, Im GJ, Lee BY, Kim K, Lim KM, Chung JH. (2009). Ginkgo biloba extract enhances antiplatelet and antithrombotic effects of cilostazol without prolongation of bleeding time. Tromb Res, 124, 328-334.
74. Saw JT, Bahari MB, Ang HH, Lim YH. (2006). Potential drug-herb interaction with antiplatelet/anticoagulant drugs. Complement Ter Clin Pract, 12, 236-241. (Pubitemid 44490362)
75. Shahriyary L, Yazdanparast R. (2007). Inhibition of blood platelet adhesion, aggregation and secretion by Artemisia dracunculus leaves extracts. J Ethnopharmacol, 114, 194-198. (Pubitemid 47539820)
76. Srivastava KC. (1986). Evidence for the mechanism by which garlic inhibits platelet aggregation. Prostaglandins Leukot Med, 22, 313-321. (Pubitemid 16047580)
77. Steenkamp V, Stewart MJ. (2007). Medicinal applications and toxicological activities of Aloe products. Pharm Biol, 45, 411-420. (Pubitemid 46911973)
78. Su Y, Zhao Y, Zhang Z, Yue N. (1996). Effects of panaxatriol saponins isolated from sanchi (Panax pseudo-ginseng var. notoginseng) on animal platelet function and thrombosis. Chinese Traditional and Herbal Drugs, 27, 666-669.
79. Taylor JR, Wilt VM. (1999). Probable antagonism of warfarin by green tea. Ann Pharmacother, 33, 426-428. (Pubitemid 29215809)
80. Vane JR, Botting RM. (2003). The mechanism of action of aspirin. Tromb Res, 110, 255-258. (Pubitemid 37329821)
81. Wang J, Zhang Q, Zhang Z, Song H, Li P. (2010). Potential antioxidant and anticoagulant capacity of low molecular weight fucoidan fractions extracted from Laminaria japonica. Int J Biol Macromol, 46, 6-12.
82. World Health Organization. (2008). Fact Sheet no 134: Traditional medicine. Available at http://www.who.int/mediacentre/factsheets/fs134/en/. Accessed on 11 March 2011.
83. Yao Y, Wu WY, Liu AH, Deng SS, Bi KS, Liu X, Guo DA. (2008). Interaction of salvianolic acids and notoginsengnosides in inhibition of ADP-induced platelet aggregation. Am J Chin Med, 36, 313-328. (Pubitemid 351712438)
84. Zhang S, Yin T, Ling X, Liang H, Zhao Y. (2008). Interactions between thrombin and natural products of Millettia speciosa Champ. using capillary zone electrophoresis. Electrophoresis, 29, 3391-3397.
85. Zhou HY, Hong JL, Shu P, Ni YJ, Qin MJ. (2009). A new dicoumarin and anticoagulant activity from Viola yedoensis Makino. Fitoterapia, 80, 283-285.