Association of C3435T multi drug resistance gene-1 polymorphism with aspirin resistance in ischemic stroke and its subtypes

Journal of the Neurological Sciences

Volumn 315, Issue 1-2, 2012, Pages 72-76

  Sharma, Vandana ^a,b   Kaul, Subhash ^c   Al Hazzani, Amal ^d   Prabha, T Surya ^c   Rao, Polugari Prem Kumar Manohar ^a   Dadheech, Sneha ^a   Jyothy, A ^a   Munshi, Anjana ^a,d  

^a OSMANIA UNIVERSITY   (India)

^b Dr NTR University of Health Sciences   (India)

^c NIZAM'S INSTITUTE OF MEDICAL SCIENCES   (India)

^d KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Aspirin; Ischemic stroke; Multiple drug resistance 1 (MDR 1) gene; Non responders; Responders

Indexed keywords

ACETYLSALICYLIC ACID; MULTIDRUG RESISTANCE PROTEIN 1;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; BLOOD SAMPLING; BRAIN ATHEROSCLEROSIS; BRAIN ISCHEMIA; CONTROLLED STUDY; DNA POLYMORPHISM; DRUG RESPONSE; FEMALE; FOLLOW UP; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RESISTANCE; GENOTYPE; HUMAN; INTRACRANIAL LARGE ARTERY ATHEROSCLEROSIS; MAJOR CLINICAL STUDY; MALE; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; RISK FACTOR; SEX RATIO; TELECONSULTATION; TREATMENT OUTCOME;

ADULT; AGED; ASPIRIN; BRAIN ISCHEMIA; DRUG RESISTANCE; FEMALE; FOLLOW-UP STUDIES; GENETIC ASSOCIATION STUDIES; HUMANS; MALE; MIDDLE AGED; P-GLYCOPROTEIN; POLYMORPHISM, GENETIC; STROKE;

EID: 84858002270     PISSN: 0022510X     EISSN: 18785883     Source Type: Journal    
DOI: 10.1016/j.jns.2011.11.027     Document Type: Article

References (26)

1. Patron C, Baigent C, Hirsh J, Roth G. American College of Chest Physicians. Antiplatelet drugs: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition). Chest 2008;133(6):199S-233S. (Pubitemid 351894914)
2. Nutiu R, Bolcu C, Modra D, Albulescu M, Lagher R, Heiman C. Pratice in Organic Chemistry. 2nd Vol, in RomanianTimisoara: Eurostampa Publishing House; 2003.
3. Antithrombotic Trialists' Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 2002;324(7329):71-86.
4. Schrör K. Haemostasis and antithrombotic drugs: pharmacology and novel therapeutic approaches. Hämostaseologie 2006;26(2):104-5. (Pubitemid 44058658)
5. Cohen HW, Crandall JP, Hailpern SM, Billett HH. Aspirin resistance associated with HbA1c and obesity in diabetic patients. J Dia Compl 2008;22(3):224-8. (Pubitemid 351539062)
6. Goodman T, Sharma P, Ferro A. The genetics of aspirin resistance. Int J Clin Pract 2007;61:826-34. (Pubitemid 46587879)
7. Tourmousoglou CE, Rokkas CK. Clopidogrel and aspirin in cardiovascular medicine respondaers or not-current best available evidence. Cardiovasc Hematol Agents Med Chem 2008;6(4):312-22.
8. Simon T, Verstuyft C, Mary-Krause M, Quteineh L, Drouet E, Méneveau N, et al. Genetic determinants of response to clopidogral and cardiovascular events. N Engl J Med 2009;360:363-75.
9. Taubert D, von Beckerath N, Grimberg G, Lazar A, Jung N, Goeser T, et al. Impact of p-glycoprotein on clopidogral absorption. Clin Pharmacol Ther 2006;80:486-501.
10. Sparreboom A, Danesi R, Ando Y, Chan J, Figg WD. Pharmacogenomics of ABC transporters and its role in cancer chemotherapy. Drug Resist Updat 2003;6:71-84. (Pubitemid 36565766)
11. Sakaeda T, Nakamura T, Okumura K. MDR1 genotype-related pharmacokinetics and pharmacodynamics. Biol Pharm Bull 2002;25:1391-400. (Pubitemid 39663152)
12. Sakaeda T. MDR1 genotype-related pharmacokinetics: fact or fiction? Drug Metab Pharmacokinet 2005;20:391-414.
13. Cascorbi I, Gerloff T, Johne A, Meisel C, Hoffmeyer S, Schwab M, et al. Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects. Clin Pharmacol Ther 2001;69:169-74. (Pubitemid 32225417)
14. Adams HP, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST (Trial of Org 10172 in Acute Stroke Treatment). Stroke 1993;24:35-41. (Pubitemid 23014379)
15. Munshi A, Sultana S, Kaul S, Pulla Reddy B, Alladi S, Jyothy A. Angiotensin-converting enzyme insertion/deletion polymorphism and the risk of ischemic stroke in a South Indian population. J Neurol Sci 2008;272:132-5.
16. Gum PA, Kottke-Marchant K, Poggio ED, Gurm H, Welsh PA, Brooks L, et al. Profile and prevalence of aspirin resistance in patients with cardiovascular disease. AM J Cordial 2001;88:230-5. (Pubitemid 32721947)
17. Sadiq PA, Puri A, Dixit M, Ghatak A, Dwinder SK, Narain VS, et al. Profile and prevanlce of aspirin resistance in Indian patients with coronary artery disease. Indian Heart Jour 2005;57:658-61. (Pubitemid 43332284)
18. Mueller MR, Salat A, Stangl P, Murabito M, Pulaki S, Boehm D, et al. Variable platelet response to low dose ASA and the risk of limb deteoration in patients submitted to peripheral arterial angioplasty. Throm Haemosos 1997;78:1003-7. (Pubitemid 27417291)
19. Goodman T, Ferro A, Sharma P. Pharmacogenetics of aspirin resistance: a comprehensive systematic review. Br J Clin Pharmacol 2008;66(2):222-32.
20. Schulz UGR, Rothwell PM. Differences in vascular risk factors between etiological subtypes of ischemic stroke. Stroke 2003;34:2050-9. (Pubitemid 36944805)
21. Evans WE, Mc Leod HL. Pharmacogenomics - drug deposition, drug targets and side effects. N Eng J Med 2003;348:538-49. (Pubitemid 36159890)
22. Aarnoudse AJ, Dieleman JP, Visser LE, Arp PP, van der Heiden IP, van Schaik RH, et al. Common ATP - binding cassette B1 variants are associated with increased digoxin serum concentration. Pharmacogenet Genomics 2008;18:299-305. (Pubitemid 351367523)
23. Drescher S, Schaeffeler E, Hitzl M, Hofmann U, Schwab M, Brinkmann U, et al. MDR1 gene polymorphisms and disposition of the p-glycoprotein substrate fexofenadine. Br J Clin Pharmacol 2002;53:526-34. (Pubitemid 34527155)
24. Fellay J, Marzolini C, Meaden ER, Back DJ, Buclin T, Chave JP, et al. Swiss HIV Cohort Study. Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter1: a phamacogenetics study. Lancet 2002;359:30-6. (Pubitemid 34119193)
25. Kim RB, Leake BF, Choo EF, Dresser GK, Kubba SV, Schwarz UI, et al. Identification of functionally variant MDR1 alleles among European Americans and African Americans. Clin Pharmacol Ther 2001;70:189-99. (Pubitemid 32777772)
26. Hoffmeyer S, Burk O, von Richter O, Arnold HP, Brockmöller J, Johne A, et al. Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with p-glycoprotein expression and activity in vivo. Proc Natl Acad Sci USA 2000;97:3473-8. (Pubitemid 30183327)