Anaphylaxis during the first course of high-dose methotrexate: A case report and literature review

Journal of Clinical Pharmacy and Therapeutics

Volumn 37, Issue 2, 2012, Pages 245-248

  Pugi, A ^a,b   Benemei, S ^b   Vietri, M ^a,b   Tondo, A ^c   Calvani, A M ^c   Mugelli, A ^a,b   Vannacci, A ^a,b   Lapi, F ^a,b  

^a Tuscan Regional Centre of Pharmacovigilance   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Adverse reaction; Anaphylaxis; Methotrexate; Pharmacovigilance

Indexed keywords

CISPLATIN; DOXORUBICIN; METHOTREXATE;

AGITATION; ANAPHYLAXIS; ANGIONEUROTIC EDEMA; ANTINEOPLASTIC ACTIVITY; ARTICLE; CASE REPORT; CHILD; DRUG HYPERSENSITIVITY; DRUG MEGADOSE; DRUG WITHDRAWAL; HUMAN; IMMUNE RESPONSE; IMMUNOPATHOLOGY; MALE; NAUSEA; OSTEOBLAST; OSTEOSARCOMA; OXYGEN SATURATION; SCHOOL CHILD; SIDE EFFECT; TACHYCARDIA; URTICARIA; VOMITING;

ANAPHYLAXIS; ANTIMETABOLITES, ANTINEOPLASTIC; BONE NEOPLASMS; CHILD; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG HYPERSENSITIVITY; HUMANS; MALE; METHOTREXATE; OSTEOSARCOMA;

EID: 84857999369     PISSN: 02694727     EISSN: 13652710     Source Type: Journal    
DOI: 10.1111/j.1365-2710.2011.01275.x     Document Type: Article

References (15)

1. Blay JY Chemotherapy for osteosarcoma without high-dose methotrexate: another piece in the puzzle. Onkologie, 2007;30:226-227.
2. Lluch-Bernal M, Cuesta-Herranz J, De las Heras M et al. Anaphylactic reaction to methotrexate. Allergy, 1997;52:1150-1151. (Pubitemid 27496272)
3. Postovsky S, Elhasid R, Ben-Barak A, Levin K, Ben Arush MW Allergic reaction to high-dose methotrexate. Medical and Pediatric Oncology, 2000;35:131-132.
4. Davis KA, Williams P, Walker JC Successful desensitization to high-dose methotrexate after systemic anaphylaxis. Annals of Allergy, Asthma & Immunology, 2003;90:87-89. (Pubitemid 36553821)
5. Ozguven AA, Uysal K, Gunes D, Koroglu T, Gurcu O, Olgun N Delayed renal excretion of methotrexate after a severe anaphylactic reaction to methotrexate in a child with osteosarcoma. Journal of Pediatric Hematology/oncology, 2009;31:289-291.
6. Gluck-Kuyt I, Irwin LE Anaphylactic reaction to high-dose methotrexate. Cancer Treatment Reports, 1979;63:797-798. (Pubitemid 9248176)
7. Klimo P, Ibrahim E Anaphylactic reaction to methotrexate used in high doses as an adjuvant treatment of osteogenic sarcoma. Cancer Treatment Reports, 1981;65:725. (Pubitemid 11046801)
8. Cohn JR, Cohn JB, Fellin F, Cantor R Systemic anaphylaxis from low dose methotrexate. Annals of Allergy, 1993;70:384-385. (Pubitemid 23149756)
9. Vega A, Cabanas R, Contreras J et al. Anaphylaxis to methotrexate: a possible IgE-mediated mechanism. Journal of Allergy and Clinical Immunology, 1994;94:268-270.
10. al-Lamki Z, Thomas E, el-Banna N, Jaffe N Acute urticaria and hepatitis complicating high-dose methotrexate therapy. Medical and Pediatric Oncology, 1995;24:137-140.
11. Lobelle C, Lopez Rivas M, Barreiro J, Rodicio M, Couselo JM Anaphylactic reaction to high-dose methotrexate. Pediatric Hematology and Oncology, 1995;12:213-214.
12. Devecioglu O, Biner B, Karabocuoglu M, Unuvar A, Agaoglu L Systemic near-fatal anaphylactic reaction after intrathecal methotrexate administration. Medical and Pediatric Oncology, 2000;34:151-152. (Pubitemid 30090485)
13. Elkiran ET, Altundag K, Aksoy S, Onal IK, Tekuzman G Systemic anaphylactic reaction following intrathecal administration of methotrexate in adult patient with primary central nervous system lymphoma. American Journal of Hematology, 2004;75:265. (Pubitemid 38451115)
14. Houtman PM, Jansen TL, Blanken R Anaphylactic reaction in a patient with rheumatoid arthritis: a rare side effect of methotrexate with etanercept as a provoking factor? Journal of Clinical Rheumatology, 2006;12:321-322. (Pubitemid 44915337)
15. Bouchireb K, Dodille A, Ponvert C, Gouraud F, Dubrel M, Brugieres L Management and successful desensitization in methotrexate-induced anaphylaxis. Pediatric Blood & Cancer, 2009;52:295-297.