Protective effect of cycloart-23-ene-3β, 25-diol (B2) isolated from Pongamia pinnata L. Pierre on vital organs in streptozotocin-nicotinamide induced diabetic mice

Asian Pacific Journal of Tropical Biomedicine

Volumn 1, Issue SUPPL. 2, 2011, Pages

  Badole, Sachin L ^a   Bodhankar, Subhash L ^b   Raut, Chandrashekhar G ^c  

^a Affiliated to Savitribai Phule Pune University   (India)

^b BHARATI VIDYAPEETH DEEMED UNIVERSITY   (India)

^c NATIONAL INSTITUTE OF VIROLOGY   (India)

Author keywords

25 diol; Cycloart 23 ene 3 ; Diabetes mellitus; Histopathology; Pongamia pinnata; Streptozotocin nicotinamide; Vital organs

Indexed keywords

ANTIDIABETIC AGENT; CYCLOART 23 ENE 3 BETA, 25 DIOL; EOSIN; GLIBENCLAMIDE; HEMATOXYLIN; NICOTINAMIDE; PLANT EXTRACT; PONGAMIA PINNATA EXTRACT; STREPTOZOCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; BRAIN TISSUE; CERVICAL SPINE DISLOCATION; CONTROLLED STUDY; DIABETES CONTROL; DRUG EFFECT; DRUG ISOLATION; DRUG STRUCTURE; EYE; HEART; KIDNEY; LIVER; MALE; MEDICINAL PLANT; MICROSCOPY; MOUSE; NONHUMAN; PONGAMIA PINNATA; PRIORITY JOURNAL; STREPTOZOCIN DIABETES;

MUS; PONGAMIA PINNATA;

EID: 84857991993     PISSN: 22211691     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2221-1691(11)60153-6     Document Type: Article

References (21)

1. Badole SL. Investigation of some medicinal plants for antidiabeticactivity in laboratory animals. Pune, India: Bharati Vidyapeeth Deemed University; 2010, p. 9-10.
2. Hoogwerf BJ. Complications of diabetes mellitus. Int J Diab Dev Ctries 2005; 25: 63-69.
3. Frode TS, Medeiros YS. Animal models to test drugs with potential antidiabetic activity. J Ethnopharmacol 2008; 115: 173-183.
4. Liu JP, Zhang M, Wang WY, Grimsgaard S. Chinese herbal medicines for type-2 diabetes mellitus. Cochrane Database Syst Rev 2004; 3: 3642-3645.
5. Joy PP, Thomos J, Mathew S, Skaria BP. Pongamia pinnata. In: Medicinal Plants. India: Kerala Agriculture University, Aromatic and Medicinal Plant Research Station; 1998, p. 73-74.
6. Badole SL, Bodhankar SL. Investigation of antihyperglycaemicactivity of alcoholic extract of stem bark of Pongamia pinnata on serum glucose in diabetic mice. Pharma Biol 2008; 46: 900-905.
7. Badole SL, Bodhankar SL. Investigation of antihyperglycaemicactivity of aqueous and petroleum ether extract of stem barkof Pongamia pinnata on serum glucose in diabetic mice. J Ethnopharmacol 2009; 123: 115-120.
8. Badole SL, Bodhankar SL. Concomitant administration of petroleum ether extract of stem bark of Pongamia pinnata (L.) Pierre with synthetic oral hypoglycaemic drugs in alloxaninduced diabetic mice. Eur J Integr Med 2009; 1: 73-79.
9. Badole SL, Bodhankar SL. Antihyperglycaemic activity of cycloart-23-ene-3β, 25-diol isolated from stem bark of Pongamia pinnata in alloxan induced diabetic mice. Res J Phytochem 2009; 3: 18-24.
10. Badole SL, Bodhankar SL. Antidiabetic activity of cycloart-23ene-3., 25-diol isolated from stem bark of Pongamia pinnatain sreptozotocin-nicotinamide induced diabetic mice. Eur J Pharmacol 2010; 632: 103-109.
11. Valentovic MA, Alejandro N, Betts CA, Brown PI, Ramos K. Streptozotocin (STZ) diabetes enhances benzo (alpha) pyrene induced renal injury in Sprague Dawley rats. Toxicol Lett 2006; 164: 214-220.
12. Tay YC, Wang Y, Kkairaitis I, Rangan GK, Zang C, Harris D. Can murine diabetic nephropathy be separated from superimposedacute renal failure? Kidney Int 2005; 290: 391-398.
13. Oberley LW. Free radicals and diabetes. Free Radic Biol Med 1988; 5: 113-124.
14. Shi Q, Yan H, Li MY, Harding JJ. Effect of a combination of carnosine and aspirin eye drops on streptozotocin-induceddiabetic cataract in rats. Mol Vis 2009; 15: 2129-2138.
15. Von SL, Grims P. Eye changes in streptozotocin diabetes in rats. Am J Ophthamol 1971; 71: 312-315.
16. Root-Bernstein R, Busik JV, Henry DN. Are diabetic neuropathy, retinopathy and nephropathy caused by hyperglycemic exclusionof dehydroascorbate uptake by glucose transporters? J Theor Biol 2002; 216: 345-359.
17. Sima AA, Zhang W, Grunberger G. Type 1 diabetic neuropathy and C-peptide. Exp Diab Res 2004; 5: 65-77.
18. Muranyi M, Fujioka M, Qing-Ping HE, Han A, Yong G, Csiszar K, et al. Diabetes activates cell death pathway after transient focalcerebral ischemia. Diabetes 2003; 52: 481-486.
19. Popov D, Simionescu M. Alterations of lung structurein experimental diabetes and diabetes associated withhyperlipidaemia in hamsters. Eur Respir J 1997; 10: 1850-1858.
20. Bell D, Collier A, Mathews DM, Cooksey EJ, McHardy GJ, Clarke BF. Are reduced lung volumes in IDDM due to defect in connective tissue? Diabetes 1988; 37: 829-831.
21. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001; 414: 813-820.