Using C. elegans to screen for targets of ethanol and behavior-altering drugs

Biological Procedures Online

Volumn 6, Issue 1, 2004, Pages 113-119

  Davies, Andrew G ^a   McIntire, Steven L ^a  

^a UNIVERSITY OF CALIFORNIA SAN FRANCISCO   (United States)

Author keywords

Alcohol; Behavior; Genetics; Invertebrate

Indexed keywords

ALCOHOL; DRUG;

ANIMAL TISSUE; ARTICLE; BEHAVIOR; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DRUG EFFECT; DRUG RESPONSE; DRUG TARGETING; GENE IDENTIFICATION; GENETIC SCREENING; LOCOMOTION; METHODOLOGY; MUTANT; NONHUMAN; VERTEBRATE;

CAENORHABDITIS ELEGANS; INVERTEBRATA; VERTEBRATA;

EID: 25444530878     PISSN: 14809222     EISSN: None     Source Type: Journal    
DOI: 10.1251/bpo79     Document Type: Article

References (13)

1. Rand JB, Johnson CD. In: Epstein HF, Shakes DC, Caenorhabditis elegans: Modern biological analysis of an organism. San Diego: Academic Press; 1995. p. 187-204.
2. Matthews DJ, Kopczynski J. Using model-system genetics for drug-based target discovery. Drug Discov Today 2001; 6:141-149.
3. Brownlee DJ, Fairweather I. Exploring the neurotransmitter labyrinth in nematodes. Trends Neurosci 1999; 22:16-24.
4. Bargmann CI. Neurobiology of the Caenorhabditis elegans genome. Science 1998; 282:2028-2033.
5. ffrench-Constant RH, Anthony N, Aronstein K, Rocheleau T, Stilwell G. Cyclodiene insecticide resistance: from molecular to population genetics. Annu Rev Entomol 2000; 45:449-466.
6. Dent JA, Davis MW, Avery L. avr-15 encodes a chloride channel subunit that mediates inhibitory glutamatergic neurotransmission and ivermectin sensitivity in Caenorhabditis elegans. EMBO J 1997; 16:5867-5879.
7. Davies AG, Pierce-Shimomura JT, Kim H, VanHoven MK, Thiele TR, Bonci A, Bargmann CI, McIntire SL. A central role of the BK potassium channel in behavioral responses to ethanol in C. elegans. Cell 2003; 115:655-666.
8. Wang ZW, Saifee O, Nonet ML, Salkoff L. SLO-1 potassium channels control quantal content of neurotransmitter release at the C. elegans neuromuscular junction. Neuron 2001; 32:867-881.
9. Sulston J, Hodgkin J. In: Wood WB, The Nematode Caenorhabditis elegans. Plainview, NY: Cold Spring Harbor Laboratory Press; 1988. p. 587-606.
10. Colbert HA, Bargmann CI. Odorant-specific adaptation pathways generate olfactory plasticity in C. elegans. Neuron 1995; 14:803-812.
11. Sawin ER, Ranganathan R, Horvitz HR. C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway. Neuron 2000; 26:619-631.
12. de Bono M, Bargmann CI. Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in C. elegans. Cell 1998; 94:679-689.
13. Fujiwara M, Sengupta P, McIntire SL. Regulation of body size and behavioral state of C. elegans by sensory perception and the EGL-4 cGMP-dependent protein kinase. Neuron 2002; 36:1091-1102.