An observational cohort comparison of facilitators of retention in care and adherence to anti-eetroviral therapy at an HIV treatment center in Kenya

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Achieng, Loice ^a,b   Musangi, Helen ^b   Ong'uti, Sharon ^c,d   Ombegoh, Edwin ^a   Bryant, LeeAnn ^d   Mwiindi, Jonathan ^d   Smith, Nathaniel ^a,e   Keiser, Philip ^d  

^a AIC Kijabe Hospital   (Kenya)

^b UNIVERSITY OF NAIROBI   (Kenya)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^e ARKANSAS DEPARTMENT OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ANTIRETROVIRAL THERAPY; ANTIVIRAL THERAPY; ARTICLE; CD4 LYMPHOCYTE COUNT; CLINICAL EFFECTIVENESS; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; COUNSELING; EMPLOYMENT STATUS; FEMALE; FOLLOW UP; HEALTH PROGRAM; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; KENYA; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MEDICAL CARE; OBSERVATIONAL STUDY; PATIENT COMPLIANCE; PATIENT PARTICIPATION; PHARMACY; PROFESSIONAL PRACTICE; PROSPECTIVE STUDY; PUBLIC HEALTH; SEX DIFFERENCE; SUPPORT GROUP; TREATMENT FAILURE; UNANNOUNCED PILL COUNT; VIRUS LOAD; DIRECTIVE COUNSELING; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; MEDICATION THERAPY MANAGEMENT; OBSERVATION; SELF HELP; STATISTICS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; COHORT STUDIES; DIRECTIVE COUNSELING; HIV INFECTIONS; HOUSE CALLS; HUMANS; KENYA; MEDICATION ADHERENCE; MEDICATION THERAPY MANAGEMENT; OBSERVATION; SELF-HELP GROUPS;

EID: 84857935620     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032727     Document Type: Article

References (30)

1. Anon. "Sixth Annual Report to Congress on PEPFAR Program Results" (2010) Available: http://www.pepfar.gov/press/sixth_annual_report/ Accessed 2011 Apr 28.
2. Anon. "JOINT WHO-UNICEF-UNAIDS- PEPFAR CAPACITY-BUILDING WORKSHOP: STRENGTHENING REPORTING AND MONITORING IN THE HEALTH SECTOR FOR THE AFRICA REGION" (2010) Available: http://whqlibdoc.who.int/publications/2011/9789241501323_eng.pdf. Accessed 2011 Apr 28.
3. Ekouevi DK, Balestre E, Ba-Gomis FO, Eholie SP, Maiga M, et al. (2010) Low retention of HIV-infected patients on antiretroviral therapy in 11 clinical centres in West Africa. Tropical Medicine & International Health 15: 34-42.
4. Rosen S, Fox MP, Gill CJ, (2007) Patient Retention in Antiretroviral Therapy Programs in Sub-Saharan Africa: A Systematic Review. PLoS Med 4: e298.
5. Fox MP, Rosen S, (2010) Patient retention in antiretroviral therapy programs up to three years on treatment in sub-Saharan Africa, 2007-2009: systematic review. Tropical Medicine & International Health 15: 1-15.
6. Bendavid E, Bhattacharya J, (2009) The President's Emergency Plan for AIDS Relief in Africa: An Evaluation of Outcomes. Annals of Internal Medicine 150: 688-695.
7. Chalker J, Wagner A, Tomson G, Laing R, Johnson K, Wahlström R, et al. (2010) Urgent Need for Coordination in Adopting Standardized Antiretroviral Adherence Performance Indicators. JAIDS Journal of Acquired Immune Deficiency Syndromes 53: 159-161.
8. Bangsberg DR, Hecht FM, Charlebois ED, Zolopa AR, Holodniy M, et al. (2000) Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population. AIDS 14: 357-366.
9. Bangsberg DR, Perry S, Charlebois ED, Clark RA, Roberston M, Zolopa AR, et al. (2001) Non-adherence to highly active antiretroviral therapy predicts progression to AIDS. AIDS 15: 1181-1183.
10. Chung MH, Richardson BA, Tapia K, Benki-Nugent S, Kiarie JN, Simoni JM, et al. (2011) A Randomized Controlled Trial Comparing the Effects of Counseling and Alarm Device on HAART Adherence and Virologic Outcomes. PLoS Med 8: e1000422.
11. Jerome G, Ivers LC, (2010) Community health workers in health systems strengthening: a qualitative evaluation from rural Haiti. AIDS 24: S67-S72 [cited 2011 Mar 14.
12. Krebs DW, Chi BH, Mulenga Y, Morris M, Cantrell RA, et al. (2008) Community-based follow-up for late patients enrolled in a district-wide programme for antiretroviral therapy in Lusaka, Zambia. AIDS Care 20: 311-317.
13. Ford N, Nachega JB, Engel ME, Mills EJ, (2009) Directly observed antiretroviral therapy: a systematic review and meta-analysis of randomised clinical trials. Lancet 374: 2064-2071.
14. Chang LW, Kagaayi J, Nakigozi G, Ssempijja V, Packer AH, et al. (2010) Effect of Peer Health Workers on AIDS Care in Rakai, Uganda: A Cluster-Randomized Trial. PLoS ONE 5: e10923.
15. Mugusi F, Mugusi S, Bakari M, Hejdemann B, Josiah R, et al. (2009) Enhancing adherence to antiretroviral therapy at the HIV clinic in resource constrained countries; the Tanzanian experience. Trop Med Int Health 14: 1226-1232.
16. Muyingo SK, Walker AS, Reid A, Munderi P, Gibb DM, et al. (2008) Patterns of individual and population-level adherence to antiretroviral therapy and risk factors for poor adherence in the first year of the DART trial in Uganda and Zimbabwe. J Acquir Immune Defic Syndr 48: 468-475.
17. Fairley CK, Levy R, Rayner CR, Allardice K, Costello K, et al. (2003) Randomized trial of an adherence programme for clients with HIV. Int J STD AIDS 14: 805-809.
18. Nachega JB, Knowlton AR, Deluca A, Schoeman JH, Watkinson L, et al. (2006) Treatment supporter to improve adherence to antiretroviral therapy in HIV-infected South African adults. A qualitative study. J Acquir Immune Defic Syndr 43: S127-133.
19. Nellen JFJB, Nieuwkerk PT, Burger DM, Wibaut M, Gras LA, et al. (2009) Which method of adherence measurement is most suitable for daily use to predict virological failure among immigrant and non-immigrant HIV-1 infected patients? AIDS Care 2009 21: 842-850.
20. Pearson CR, Micek MA, Simoni JM, Hoff PD, Matediana E, et al. (2007) Randomized control trial of peer-delivered, modified directly observed therapy for HAART in Mozambique. J Acquir Immune Defic Syndr 46: 238-244.
21. Haberer JE, Kahane J, Kigozi I, Emenyonu N, Hunt P, et al. (2010) Real-time adherence monitoring for HIV antiretroviral therapy. AIDS Behav 14: 1340-1346.
22. Etienne M, Burrows L, Osotimehin B, Macharia T, Hossain B, et al. (2010) Situational analysis of varying models of adherence support and loss to follow up rates; findings from 27 treatment facilities in eight resource limited countries. Trop Med Int Health 1: 76-81.
23. Stevens G, Rekhviashvili N, Scott LE, Gonin R, Stevens W, (2005) Evaluation of Two Commercially Available, Inexpensive Alternative Assays Used for Assessing Viral Load in a Cohort of Human Immunodeficiency Virus Type 1 Subtype C-Infected Patients from South Africa. J Clin Microbiol 43: 857-861.
24. El-Khatib Z, Katzenstein D, Marrone G, Laher F, Mohapi L, et al. (2011) Adherence to Drug-Refill Is a Useful Early Warning Indicator of Virologic and Immunologic Failure among HIV Patients on First-Line ART in South Africa. PLoS ONE 6: e17518.
25. Dalal RP, Macphail C, Mqhayi M, Wing J, Feldman C, et al. (2008) Characteristics and outcomes of adult patients lost to follow-up at an antiretroviral treatment clinic in johannesburg, South Africa. J Acquir Immune Defic Syndr 47: 101-107.
26. Bassett IV, Wang B, Chetty S, Mazibuko M, Bearnot B, et al. (2009) Loss to care and death before antiretroviral therapy in Durban, South Africa. J Acquir Immune Defic Syndr 51: 135-139.
27. Klausner JD, Serenata C, O'Bra H, Mattson CL, Brown JW, et al. (2011) Scale-up and continuation of antiretroviral therapy in South African treatment programs, 2005-2009. J Acquir Immune Defic Syndr 56: 292-295.
28. Anglaret X, Toure S, Gourvellec G, Tchehy A, Zio L, et al. (2004) Impact of vital status investigation procedures on estimates of survival in cohorts of HIV-infected patients from Sub-Saharan Africa. J Acquir Immune Defic Syndr 35: 320-323.
29. Geng EH, Glidden DV, Emenyonu N, Musinguzi N, Bwana MB, et al. (2010) Tracking a sample of patients lost to follow-up has a major impact on understanding determinants of survival in HIV-infected patients on antiretroviral therapy in Africa. Trop Med Int Health 15: 63-69.
30. Geng EH, Bangsberg DR, Musinguzi N, Emenyonu N, Bwana MB, et al. (2010) Understanding reasons for and outcomes of patients lost to follow-up in antiretroviral therapy programs in Africa through a sampling-based approach. J Acquir Immune Defic Syndr 53: 405-411.