Maternal smoking during pregnancy and child emotional problems: The relevance of maternal and child 5-HTTLPR genotype

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 159 B, Issue 3, 2012, Pages 289-297

  Cents, Rolieke A M ^a   Tiemeier, Henning ^a   Velders, Fleur P ^a   Jaddoe, Vincent W V ^a   Hofman, Albert ^a   Verhulst, Frank C ^a   Lambregtse Van Den Berg, Mijke P ^a   Hudziak, James J ^a,b,c  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF VERMONT   (United States)

^c VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Emotional problems; Gene by environment interaction; Prenatal smoking; Serotonin transporter gene

Indexed keywords

SEROTONIN TRANSPORTER;

ARTICLE; CHILD; CHILD PARENT RELATION; EMOTIONAL DISORDER; GENE FREQUENCY; GENE INTERACTION; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HEALTH BEHAVIOR; HEREDITY; HETEROZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MATERNAL SMOKING; PATERNAL SMOKING; PREGNANCY; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SMOKING HABIT;

ADULT; AFFECTIVE SYMPTOMS; CHILD; CHILD, PRESCHOOL; FATHERS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MOTHERS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SMOKING;

EID: 84857932072     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.32026     Document Type: Article

References (44)

1. Achenbach T, Rescorla L. 2000. Manual for the ASEBA Preschool Forms & Profiles. Burlington, VT: University of Vermont, Research Center for Children, Youths & Families.
2. Ansorge MS, Morelli E, Gingrich JA. 2008. Inhibition of serotonin but not norepinephrine transport during development produces delayed, persistent perturbations of emotional behaviors in mice. J Neurosci 28(1): 199- 207.
3. Brennan PA, Hammen C, Sylvers P, Bor W, Najman J, Lind P, Montgomery G, Smith AK. 2011. Interactions between the COMT Val108/158Met polymorphism and maternal prenatal smoking predict aggressive behavior outcomes. Biol Psychol 87(1): 99- 105.
4. Brion MJ, Victora C, Matijasevich A, Horta B, Anselmi L, Steer C, Menezes AM, Lawlor DA, Davey Smith G. 2010. Maternal smoking and child psychological problems: Disentangling causal and noncausal effects. Pediatrics 126(1): e57- e65.
5. Caspi A, Hariri AR, Holmes A, Uher R, Moffitt TE. 2010. Genetic sensitivity to the environment: The case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry 167(5): 509- 527.
6. Cote F, Fligny C, Bayard E, Launay JM, Gershon MD, Mallet J, Vodjdani G. 2007. Maternal serotonin is crucial for murine embryonic development. Proc Natl Acad Sci USA 104(1): 329- 334.
7. de Beurs E. 2004. Brief symptom inventory. Leiden, the Netherlands: PITS B.V.
8. de Beurs E. 2009. Brief symptom inventory, handleiding addendum [Dutch manual addendum]. Leiden, the Netherlands: PITS B.V.
9. Derogatis L. 1993. Brief Symptom Inventory (BSI): Administration, scoring and procedures manual. Minneapolis, MN: National Computer Systems Inc.
10. Ernst M, Moolchan ET, Robinson ML. 2001. Behavioral and neural consequences of prenatal exposure to nicotine. J Am Acad Child Adolesc Psychiatry 40(6): 630- 641.
11. Falk L, Nordberg A, Seiger A, Kjaeldgaard A, Hellstrom-Lindahl E. 2005. Smoking during early pregnancy affects the expression pattern of both nicotinic and muscarinic acetylcholine receptors in human first trimester brainstem and cerebellum. Neuroscience 132(2): 389- 397.
12. Fligny C, Hatia S, Amireault P, Mallet J, Cote F. 2009. Mammalian prenatal development: The influence of maternally derived molecules. Bioessays 31(9): 935- 943.
13. Gaspar P, Cases O, Maroteaux L. 2003. The developmental role of serotonin: News from mouse molecular genetics. Nat Rev Neurosci 4(12): 1002- 1012.
14. Gleason G, Liu B, Bruening S, Zupan B, Auerbach A, Mark W, Oh JE, Gal-Toth J, Lee F, Toth M. 2010. The serotonin1A receptor gene as a genetic and prenatal maternal environmental factor in anxiety. Proc Natl Acad Sci USA 107(16): 7592- 7597.
15. Gross C, Hen R. 2004. The developmental origins of anxiety. Nat Rev Neurosci 5(7): 545- 552.
16. Halmoy A, Johansson S, Winge I, McKinney JA, Knappskog PM, Haavik J. 2010. Attention-deficit/hyperactivity disorder symptoms in offspring of mothers with impaired serotonin production. Arch Gen Psychiatry 67(10): 1033- 1043.
17. Hellstrom-Lindahl E, Seiger A, Kjaeldgaard A, Nordberg A. 2001. Nicotine-induced alterations in the expression of nicotinic receptors in primary cultures from human prenatal brain. Neuroscience 105(3): 527- 534.
18. Hu XZ, Lipsky RH, Zhu G, Akhtar LA, Taubman J, Greenberg BD, Xu K, Arnold PD, Richter MA, Kennedy JL, Murphy DL, Goldman D. 2006. Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet 78(5): 815- 826.
19. Huppertz B, Peeters LL. 2005. Vascular biology in implantation and placentation. Angiogenesis 8(2): 157- 167.
20. Jaddoe VW, Verburg BO, de Ridder MA, Hofman A, Mackenbach JP, Moll HA, Steegers EA, Witteman JC. 2007. Maternal smoking and fetal growth characteristics in different periods of pregnancy: The generation R study. Am J Epidemiol 165(10): 1207- 1215.
21. Jaddoe VW, van Duijn CM, van der Heijden AJ, Mackenbach JP, Moll HA, Steegers EA, Tiemeier H, Uitterlinden AG, Verhulst FC, Hofman A. 2010. The Generation R Study: Design and cohort update 2010. Eur J Epidemiol 25(11): 823- 841.
22. Jauniaux E, Gulbis B, Acharya G, Thiry P, Rodeck C. 1999. Maternal tobacco exposure and cotinine levels in fetal fluids in the first half of pregnancy. Obstet Gynecol 93(1): 25- 29.
23. Kahn RS, Khoury J, Nichols WC, Lanphear BP. 2003. Role of dopamine transporter genotype and maternal prenatal smoking in childhood hyperactive-impulsive, inattentive, and oppositional behaviors. J Pediatr 143(1): 104- 110.
24. Karg K, Burmeister M, Shedden K, Sen S. 2011. The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: Evidence of genetic moderation. Arch Gen Psychiatry 68(5): 444- 454.
25. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL. 1996. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274(5292): 1527- 1531.
26. Muneoka K, Ogawa T, Kamei K, Muraoka S, Tomiyoshi R, Mimura Y, Kato H, Suzuki MR, Takigawa M. 1997. Prenatal nicotine exposure affects the development of the central serotonergic system as well as the dopaminergic system in rat offspring: Involvement of route of drug administrations. Brain Res Dev Brain Res 102(1): 117- 126.
27. Murphy DL, Lesch KP. 2008b. Targeting the murine serotonin transporter: Insights into human neurobiology. Nat Rev Neurosci 9(2): 85- 96.
28. Murphy DL, Fox MA, Timpano KR, Moya PR, Ren-Patterson R, Andrews AM, Holmes A, Lesch KP, Wendland JR. 2008a. How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems. Neuropharmacology 55(6): 932- 960.
29. Neuman RJ, Lobos E, Reich W, Henderson CA, Sun LW, Todd RD. 2007. Prenatal smoking exposure and dopaminergic genotypes interact to cause a severe ADHD subtype. Biol Psychiatry 61(12): 1320- 1328.
30. Pluess M, Velders FP, Belsky J, van Ijzendoorn MH, Bakermans-Kranenburg MJ, Jaddoe VW, Hofman A, Arp PP, Verhulst FC, Tiemeier H. 2011. Serotonin transporter polymorphism moderates effects of prenatal maternal anxiety on infant negative emotionality. Biol Psychiatry 69(6): 520- 525.
31. Risch N, Herrell R, Lehner T, Liang KY, Eaves L, Hoh J, Griem A, Kovacs M, Ott J, Merikangas KR. 2009. Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: A meta-analysis. JAMA 301(23): 2462- 2471.
32. Roza SJ, Verburg BO, Jaddoe VW, Hofman A, Mackenbach JP, Steegers EA, Witteman JC, Verhulst FC, Tiemeier H. 2007. Effects of maternal smoking in pregnancy on prenatal brain development. The Generation R Study. Eur J Neurosci 25(3): 611- 617.
33. Rutter M, Moffitt TE, Caspi A. 2006. Gene-environment interplay and psychopathology: Multiple varieties but real effects. J Child Psychol Psychiatry 47(3-4): 226- 261.
34. Salichon N, Gaspar P, Upton AL, Picaud S, Hanoun N, Hamon M, De Maeyer E, Murphy DL, Mossner R, Lesch KP, Hen R, Seif I. 2001. Excessive activation of serotonin (5-HT) 1B receptors disrupts the formation of sensory maps in monoamine oxidase a and 5-ht transporter knock-out mice. J Neurosci 21(3): 884- 896.
35. Slotkin TA, Pinkerton KE, Tate CA, Seidler FJ. 2006a. Alterations of serotonin synaptic proteins in brain regions of neonatal Rhesus monkeys exposed to perinatal environmental tobacco smoke. Brain Res 1111(1): 30- 35.
36. Slotkin TA, Tate CA, Cousins MM, Seidler FJ. 2006b. Prenatal nicotine exposure alters the responses to subsequent nicotine administration and withdrawal in adolescence: Serotonin receptors and cell signaling. Neuropsychopharmacology 31(11): 2462- 2475.
37. Smith GD. 2008. Assessing intrauterine influences on offspring health outcomes: Can epidemiological studies yield robust findings? Basic Clin Pharmacol Toxicol 102(2): 245- 256.
38. Uher R, McGuffin P. 2008. The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: Review and methodological analysis. Mol Psychiatry 13(2): 131- 146.
39. Van den Bergh BR, Mulder EJ, Mennes M, Glover V. 2005. Antenatal maternal anxiety and stress and the neurobehavioural development of the fetus and child: Links and possible mechanisms. A review. Neurosci Biobehav Rev 29(2): 237- 258.
40. van der Put NM, Steegers-Theunissen RP, Frosst P, Trijbels FJ, Eskes TK, van den Heuvel LP, Mariman EC, den Heyer M, Rozen R, Blom HJ. 1995. Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet 346(8982): 1070- 1071.
41. van der Put NM, Eskes TK, Blom HJ. 1997. Is the common 677C->T mutation in the methylenetetrahydrofolate reductase gene a risk factor for neural tube defects? A meta-analysis. QJM 90(2): 111- 115.
42. Vardavas CI, Chatzi L, Patelarou E, Plana E, Sarri K, Kafatos A, Koutis AD, Kogevinas M. 2010. Smoking and smoking cessation during early pregnancy and its effect on adverse pregnancy outcomes and fetal growth. Eur J Pediatr 169(6): 741- 748.
43. Whitaker-Azmitia PM. 2001. Serotonin and brain development: Role in human developmental diseases. Brain Res Bull 56(5): 479- 485.
44. Xu Z, Seidler FJ, Ali SF, Slikker W Jr, Slotkin TA. 2001. Fetal and adolescent nicotine administration: Effects on CNS serotonergic systems. Brain Res 914(1-2): 166- 178.