Popeye proteins: Muscle for the aging sinus node

Journal of Clinical Investigation

Volumn 122, Issue 3, 2012, Pages 810-813

  Boukens, Bastiaan J ^a   Christoffels, Vincent M ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; PROTEIN POPEYE DOMAIN CONTAINING 1; PROTEIN POPEYE DOMAIN CONTAINING 2; UNCLASSIFIED DRUG;

AGING; DISEASE ASSOCIATION; HEART RATE; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN DOMAIN; PROTEIN FUNCTION; SINUS NODE; SINUS NODE DYSFUNCTION;

ANIMALS; CELL ADHESION MOLECULES; MUSCLE PROTEINS; POTASSIUM CHANNELS, TANDEM PORE DOMAIN;

EID: 84857860678     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI62588     Document Type: Note

References (19)

1. Keith A, Flack M. The form and nature of the muscular connections between the primary divisions of the vertebrate heart. J Anat Physiol. 1907;41(pt 3):172-189.
2. Christoffels VM, Smits GJ, Kispert A, Moorman AF. Development of the pacemaker tissues of the heart. Circ Res. 2010;106(2):240-254.
3. Boyett MR, Honjo H, Kodama I. The sinoatrial node, a heterogeneous pacemaker structure. Cardiovasc Res. 2000;47(4):658-687.
4. Joyner RW, van Capelle FJL. Propagation through electrically coupled cells. How a small SA node drives a large atrium. Biophys J. 1986;50(6):1157-1164. (Pubitemid 17206001)
5. Mond HG, Proclemer A. The 11th world survey of cardiac pacing and implantable cardioverterdefibrillators: calendar year 2009 - a World Society of Arrhythmia's project. Pacing Clin Electrophysiol. 2011;34(8):1013-1027.
6. Mangrum JM, DiMarco JP. The evaluation and management of bradycardia. N Engl J Med. 2000;342(10):703-709.
7. Dobrzynski H, Boyett MR, Anderson RH. New insights into pacemaker activity: promoting understanding of sick sinus syndrome. Circulation. 2007;115(14):1921-1932. (Pubitemid 46598906)
8. Froese A, et al. Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice. J Clin Invest. 2012;122(3):1119-1130.
9. Brand T. The Popeye domain-containing gene family. Cell Biochem Biophys. 2005;43(1):95-103. (Pubitemid 41095277)
10. Hammermeister KE, Yunis AA, Krebs EG. Studies on phosphorylase activation in the heart. J Biol Chem. 1965;240:986-991.
11. Toda N, Shimamoto K. The influence of sympathetic stimulation on transmembrane potentials in the S-A node. J Pharmacol Exp Ther. 1968;159(2):298-305.
12. Patel AJ, et al. A mammalian two pore domain mechano-gated S-like K+ channel. EMBO J. 1998;17(15):4283-4290. (Pubitemid 28362619)
13. Opthof T, de Jonge B, Jongsma HJ, Bouman LN. Functional morphology of the pig sinoatrial node. J Mol Cell Cardiol. 1987;19(12):1221-1236.
14. Glukhov AV, Fedorov VV, Anderson ME, Mohler PJ, Efimov IR. Functional anatomy of the murine sinus node: high-resolution optical mapping of ankyrin-B heterozygous mice. Am J Physiol Heart Circ Physiol. 2010;299(2):H482-H491.
15. Benson DW, et al. Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A). J Clin Invest. 2003;112(7):1019-1028. (Pubitemid 38056317)
16. Le SS, et al. Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease. Proc Natl Acad Sci U S A. 2008;105(40):15617-15622.
17. Nathan RD. Two electrophysiologically distinct types of cultured pacemaker cells from rabbit sinoatrial node. Am J Physiol. 1986;250(2 pt 2):H325-H329.
18. Lei M, et al. Sinus node dysfunction following targeted disruption of the murine cardiac sodium channel gene Scn5a. J Physiol. 2005;567(pt 2):387-400. (Pubitemid 41301040)
19. Hao X, et al. TGF-beta1-mediated fibrosis and ion channel remodeling are key mechanisms in producing the sinus node dysfunction associated with SCN5A deficiency and aging. Circ Arrhythm Electrophysiol. 2011;4(3):397-406.