Dephosphorylation of circulating human osteopontin correlates with severe valvular calcification in patients with calcific aortic valve disease

Biomarkers

Volumn 17, Issue 2, 2012, Pages 111-118

  Sainger, Rachana ^a   Grau, Juan B ^a,b   Poggio, Paolo ^a,c   Branchetti, Emanuela ^a   Bavaria, Joseph E ^a   Gorman III, Joseph H ^a   Gorman, Robert C ^a   Ferrari, Giovanni ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Columbia University Collage of Physician and Surgeons ^*  (United States)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

CAVD; Osteopontin; Plasma purification

Indexed keywords

BIOLOGICAL MARKER; OSTEOPONTIN; PHOSPHOSERINE; PHOSPHOTHREONINE; PHOSPHOTYROSINE;

AGED; AORTA VALVE; AORTA VALVE DISEASE; AORTIC VALVE CALCIUM SCORE; ARTICLE; BIOMINERALIZATION; CALCIFIC AORTIC VALVE DISEASE; CALCIFICATION; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PROTEIN BLOOD LEVEL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SCORING SYSTEM;

AGED; AGED, 80 AND OVER; AORTIC VALVE; AORTIC VALVE STENOSIS; BIOLOGICAL MARKERS; CALCINOSIS; CALCIUM; CASE-CONTROL STUDIES; FEMALE; HUMANS; MALE; OSTEOPONTIN; PHOSPHORYLATION; PHOSPHOTHREONINE; PROTEIN PROCESSING, POST-TRANSLATIONAL; SEVERITY OF ILLNESS INDEX;

EID: 84857839990     PISSN: 1354750X     EISSN: 13665804     Source Type: Journal    
DOI: 10.3109/1354750X.2011.642407     Document Type: Article

References (31)

1. Ashkar S, Weber GF, Panoutsakopoulou V, Sanchirico ME, Jansson M, Zawaideh S, Rittling SR, Denhardt DT, Glimcher MJ, Cantor H. (2000). Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity. Science 287:860-864. (Pubitemid 30084330)
2. Bach DS, Radeva JI, Birnbaum HG, Fournier AA, Tuttle EG. (2007). Prevalence, referral patterns, testing, and surgery in aortic valve disease: leaving women and elderly patients behind? J Heart Valve Dis 16:362-369.
3. Balmer C, Beghetti M, Fasnacht M, Friedli B, Arbenz U. (2004). balloon aortic valvoplasty in paediatric patients: progressive aortic regurgitation is common. Heart 90:77-81. (Pubitemid 38064551)
4. Beckmann E, Grau JB, Sainger R, Poggio P, Ferrari G. (2010). Insights into the use of biomarkers in calcifc aortic valve disease. J Heart Valve Dis 19:441-452.
5. Bergler-Klein J, Klaar U, Heger M, Rosenhek R, Mundigler G, Gabriel H, binder T, Pacher R, Maurer G, baumgartner H. (2004). Natriuretic peptides predict symptom-free survival and postoperative outcome in severe aortic stenosis. Circulation 109:2302-2308. (Pubitemid 38678520)
6. Cho HJ, Cho HJ, Kim HS. (2009). Osteopontin: a multifunctional protein at the crossroads of infammation, atherosclerosis, and vascular calcifcation. Curr Atheroscler Rep 11:206-213.
7. Cowell SJ, Newby DE, Boon NA, Elder AT. (2004). Calcifc aortic stenosis: same old story? Age Ageing 33:538-544. (Pubitemid 39504283)
8. Davies SW, Gershlick AH, Balcon R. (1991). Progression of valvar aortic stenosis: a long-term retrospective study. Eur Heart J 12:10-14.
9. Freeman RV, Otto CM. (2005). Spectrum of calcifc aortic valve disease: pathogenesis, disease progression, and treatment strategies. Circulation 111:3316-3326. (Pubitemid 40875006)
10. Goldbarg SH, Elmariah S, Miller MA, Fuster V. (2007). Insights into degenerative aortic valve disease. J Am Coll Cardiol 50:1205-1213. (Pubitemid 47405136)
11. Jono S, Peinado C, Giachelli CM. (2000). Phosphorylation of osteopontin is required for inhibition of vascular smooth muscle cell calcifcation. J Biol Chem 275:20197-20203. (Pubitemid 30441631)
12. Koos R, Kühl HP, Mühlenbruch G, Wildberger JE, Günther RW, Mahnken AH. (2006). Prevalence and clinical importance of aortic valve calcifcation detected incidentally on CT scans: comparison with echocardiography. Radiology 241:76-82. (Pubitemid 44433337)
13. Leon Mb, Smith CR, Mack M, Miller DC, Moses JW, Svensson LG, Tuzcu EM, Webb JG, Fontana GP, Makkar RR, brown DL, block PC, Guyton RA, Pichard AD, bavaria JE, Herrmann HC, Douglas PS, Petersen JL, Akin JJ, Anderson WN, Wang D, Pocock S; PARTNER Trial Investigators. (2010). Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery. N Engl J Med 363:1597-1607.
14. Minoretti P, Falcone C, Calcagnino M, Emanuele E, buzzi MP, Coen E, Geroldi D. (2006). Prognostic signifcance of plasma osteopontin levels in patients with chronic stable angina. Eur Heart J 27:802-807.
15. Mohler ER 3rd, Adam LP, McClelland P, Graham L, Hathaway DR. (1997). Detection of osteopontin in calcifed human aortic valves. Arterioscler Tromb Vasc Biol 17:547-552. (Pubitemid 27133146)
16. Ngo DT, Heresztyn T, Mishra K, Marwick TH, Horowitz JD. (2007). Aortic stenosis is associated with elevated plasma levels of asymmetric dimethylarginine (ADMA). Nitric Oxide 16:197-201. (Pubitemid 46149393)
17. O'brien KD, Kuusisto J, Reichenbach DD, Ferguson M, Giachelli C, Alpers CE, Otto CM. (1995). Osteopontin is expressed in human aortic valvular lesions. Circulation 92:2163-2168.
18. O'brien KD. (2006). Pathogenesis of calcifc aortic valve disease: a disease process comes of age (and a good deal more). Arterioscler Tromb Vasc Biol 26:1721-1728. (Pubitemid 44305324)
19. Perin MA, brito FS Jr, Almeida bO, Pereira MA, Abizaid A, Tarasoutchi F, Grube E. (2009). Percutaneous aortic valve replacement for the treatment of aortic stenosis: early experience in brazil. Arq Bras Cardiol 93:299-306.
20. Rajamannan NM, Subramaniam M, Rickard D, Stock SR, Donovan J, Springett M, Orszulak T, Fullerton DA, Tajik AJ, bonow RO, Spelsberg T. (2003). Human aortic valve calcifcation is associated with an osteoblast phenotype. Circulation 107:2181-2184. (Pubitemid 36547209)
21. Reynolds MR, Magnuson EA, Lei Y, Leon Mb, Smith CR, Svensson LG, Webb JG, babaliaros VC, Bowers BS, Fearon WF, Herrmann HC, Kapadia S, Kodali SK, Makkar RR, Pichard AD, Cohen DJ; for the Placement of Aortic Transcatheter Valves (PARTNER) Investigators. (2011). Health-Related Quality of Life After Transcatheter Aortic Valve Replacement in Inoperable Patients With Severe Aortic Stenosis. Circulation 124:1964-1972.
22. Rosenhek R, Binder T, Porenta G, Lang I, Christ G, Schemper M, Maurer G, baumgartner H. (2000). Predictors of outcome in severe, asymptomatic aortic stenosis. N Engl J Med 343:611-617. (Pubitemid 30659472)
23. Shen M, Marie P, Farge D, Carpentier S, De Pollak C, Hott M, Chen L, Martinet b, Carpentier A. (1997). Osteopontin is associated with bioprosthetic heart valve calcifcation in humans. C R Acad Sci III, Sci Vie 320:49-57.
24. Shetty R, Pepin A, Charest A, Perron J, Doyle D, Voisine P, Dagenais F, Pibarot P, Mathieu P. (2006). Expression of bone-regulatory proteins in human valve allografts. Heart 92:1303-1308. (Pubitemid 44298888)
25. Siddiqui RF, Abraham JR, butany J. (2009). bioprosthetic heart valves: modes of failure. Histopathology 55:135-144.
26. Soejima H, Irie A, Fukunaga T, Oe Y, Kojima S, Kaikita K, Kawano H, Sugiyama S, Yoshimura M, Kishikawa H, Nishimura Y, Ogawa H. (2007). Osteopontin expression of circulating T cells and plasma osteopontin levels are increased in relation to severity of heart failure. Circ J 71:1879-1884. (Pubitemid 350261410)
27. Soejima H, Irie A, Fukunaga T, Sugamura K, Kojima S, Sakamoto T, Yoshimura M, Kishikawa H, Nishimura Y, Ogawa H. (2006). Elevated plasma osteopontin levels were associated with osteopontin expression of CD4+ T cells in patients with unstable angina. Circ J 70:851-856. (Pubitemid 43979121)
28. Speer MY, Giachelli CM. (2004). Regulation of cardiovascular calcifcation. Cardiovasc Pathol 13:63-70.
29. Wang A, Harrison JK, bashore TM. (1997). balloon aortic valvuloplasty. Prog Cardiovasc Dis 40:27-36. (Pubitemid 27319119)
30. Weber M, Arnold R, Rau M, Elsaesser A, brandt R, Mitrovic V, Hamm C. (2005). Relation of N-terminal pro b-type natriuretic peptide to progression of aortic valve disease. Eur Heart J 26: 1023-1030. (Pubitemid 40695033)
31. Yu PJ, Skolnick A, Ferrari G, Heretis K, Mignatti P, Pintucci G, Rosenzweig b, Diaz-Cartelle J, Kronzon I, Perk G, Pass HI, Galloway AC, Grossi EA, Grau JB. (2009). Correlation between plasma osteopontin levels and aortic valve calcifcation: potential insights into the pathogenesis of aortic valve calcifcation and stenosis. J Torac Cardiovasc Surg 138:196-199.