Pregabalin - A drug with abuse potential?;Pregabalin - Ein arzneistoff mit missbrauchspotential?

Archiv fur Kriminologie

Volumn 229, Issue 1-2, 2012, Pages 44-54

  Skopp, Gisela ^a   Zimmer, Gisela ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Misuse; Paradoxical agitation; Pregabalin

Indexed keywords

4 AMINOBUTYRIC ACID; ANALGESIC AGENT; ANTICONVULSIVE AGENT; DRUG DERIVATIVE; PREGABALIN;

ADDICTION; ADULT; ARTICLE; BLOOD; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DELUSION; DIFFERENTIAL DIAGNOSIS; DRUG CONTROL; HUMAN; LEGAL ASPECT; MALE; RESTLESSNESS; SUBSTANCE ABUSE;

ADULT; ANALGESICS; ANTICONVULSANTS; DELUSIONS; DIAGNOSIS, DIFFERENTIAL; DRUG AND NARCOTIC CONTROL; GAMMA-AMINOBUTYRIC ACID; HUMANS; MALE; PSYCHOMOTOR AGITATION; SUBSTANCE ABUSE DETECTION; SUBSTANCE-RELATED DISORDERS;

EID: 84857822888     PISSN: 00039225     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Addolorato, G., Leggio, L.: Pregabalin similar to lorazepam for alcohol withdrawal symptoms. Commentary on: Martinotti G, di Nicola M, Frustaci A, Romanelli R, Tedeschi D, Guglielmo R, Guerriero L, Bruschi A, De Filippis R, Pozzi G, Di Giannantonio M, Bria P, Janiri L (2010) Pregabalin, tiapride and lorazepam in alcohol withdrawal syndrome: a multi-centre, randomized, single-blind comparison trial. Addiction 105 (2010) 288-299.
2. Am. J. Psychiatr. 15 (2010) 73
3. Berry, D., Millington, C.: Analysis of pregabalin at therapeutic concentrations in human plasma/serum by reversed phase HPLC. Ther. Drug Monit. 27 (2005) 451-456 (Pubitemid 41098819)
4. Bockbrader, H. N., Radulovic, L. L., Posvar, E. L., Strand, J. C., Alvey, C. W., Busch, J. A., Randinitis, E. J., Corrigan. B. W., Haig, G. M., Boyd, R. A., Wesche, D. L.: Clinical pharmacokinetics of pregabalin in healthy volunteers. J. Clin. Pharmacol. 50 (2010) 941-950
5. ®) help patients reduce their use of benzodiazepines? A comparison with gabapentin using the Norwegian prescription database. Basic Clin. Pharmacol. Toxicol. 107 (2010) 883-886
6. Buvanendran. A., Kroin, J. S., Kari, M., Tuman, K. J.: Can a single dose of 300 mg pregabalin reach acute antihyperalgesic levels in the central nervous system? Reg. Anesth. Pain Med. 35 (2010) 535-538
7. Dannhardt, G., Kiefer, W.: Antiepileptika - Wirkprinzipien und strukturelle Parameter. Pharm, unserer Zeit 36 (2007) 270-281
8. Di Nicola, M., Martinotti, G., Tedeschi, D., Frustaci, A., Mazza, M., Sarchiapone, M., Pozzi, G., Bria, P., Janiri, L.: Pregabalin in outpatient detoxification of subjects with mild-to-moderate alcohol withdrawal syndrome. Hum. Psychopharmacol. Clin. Exp. 25 (2010) 268-275
9. Dzygiel, P., Fraier, D. Simultaneous determination of pregabalin, sildenafil and its active metabolite in rat plasma utilizing SPE followed by LC-MS-MS. Chromatographia 73 (2011) 1177-1182
10. Filipetto, F. A., Zipp, C. P., Coren, J. S.: Potential for pregabalin abuse or diversion after past drug-seeking behavior. J. Am. Osteopath. Assoc. 110 (2010) 605-607
11. Glaeske, G., Schicktanz, C.: Barmer GEK Arzneimittelreport 2011. Asgard-Verlag, St. Augustin (2011) S. 35-37
12. Grosshans, M., Mutschier, J., Hermann, D., Dressing, H., Kiefer, F., Mann, K.: Pregabalin abuse, dependence, and withdrawal: A case report. Am. J. Psychiatr. 167 (2010) 869
13. Herman, A. I., Waters, A. J., McKee, S. A., Sofuoglu, M.: Effects of pregabalin on smoking behavior, withdrawal symptoms, and cognitive performance in smokers. Psychopharmacology (2011) DOI 10.1007/s00213-011-2507-x
14. Hurley, R. W., Lesley, M. R., Adams, M. C. B., Brummett, C. M., Wu, C. L.: Pregabalin as a treatment for painful diabetes peripheral neuropathy: A meta-analysis. Reg. Anesth. Pain Med. 33 (2008) 389-394
15. Kamel, J. T., D'Souza, W. J., Cook, M. J.: Severe and disabling constipation: An adverse effect of pregabalin. Epilepsia 51 (2010) 1094-1096
16. Kumar, N., Laferriere, A., Yu, J. S. C., Leavitt, A., Coderre, T. J.: Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. J. Neurochem. 113 (2010) 552-561
17. Marks, D. M., Patkar, A. A., Masand, P. S., Pae, C. U.: Does pregabalin have neuropsychotropic effects? A short perspective. Psychiatry. Invest. 6 (2009) 55-58
18. Martinotti, G., di Nicola, M., Frustaci, A., Romanelli, R., Tedeschi, D., Guglielmo, R., Guerriero, L., Bruschi, A., De Filippis, R., Pozzi, G., Di Giannantonio, M., Bria, P., Janiri, L.: Pregabalin, tiapride and lorazepam in alcohol withdrawal syndrome: a multi-centre, randomized, single-blind comparison trial. Addiction 105 (2010) 288-299
19. Oertel, R., Arnz, N., Pietsch, J., Kirch, W.: Simultaneous determination of three anticonvulsants using hydrophilic interaction LC-MS. J. Sep. Sci. 32 (2009) 238-243
20. Oulis, P., Konstantakopoulos, G.: Pregabalin in the treatment of alcohol and benzodiazepine dependence. CNS Neurosci. Ther. 16 (2010) 45-50
21. Quinones, L., Sasso, J., Tamayo, E., Catalan, J., Gonzalez, J. P., Escala, M., Varela, N., Leon, J., Caceres, D. D., Saavedra, I.: A comparative bioavailability study of two formulations of pregabalin in healthy Chilean volunteers. Ther. Adv. Chronic Dis. 11 (2010) 141-148
22. Randinitis, E. J., Posvar, E. L., Alvey, C. W., Sedman, A. J., Cook, J. A., Bockbrader, H. N.: Pharmacokinetics of pregabalin in subjects with various degrees of renal function. J. Clin. Pharmacol. 43 (2003) 277-283 (Pubitemid 36232656)
23. Rubio, G., Bobes, J., Cervera, G., Teran, A., Perez, M., Lopez-Gomez, V., Rejas, J.: Effects of pregabalin on subjective sleep disturbance symptoms during withdrawal from long-term benzodiazepine use. Eur. Addict. Res. 17 (2011) 262-270
24. Schifano, F.: Is there a recreational misuse potential for pregabalin? Analysis of anecdotal online reports in comparison with related gabapentin and clonazepam data. Psychother. Psychosom. 80 (2011) 118-122
25. Schmitz, B.: Effects of antiepileptic drugs on mood and behavior. Epilepsia 47, Suppl. 2 (2006) 28-33 (Pubitemid 44684616)
26. Schwan, S., Sundström, A., Stjernberg. E., Hallberg, E., Hallberg, P.: A signal for an abuse liability for pregabalin - results from the Swedish spontaneous adverse drug reaction reporting system. Eur. J. Clin. Pharmacol. 66 (2010) 947-953
27. Shneker, B. F., McAuley, J. W.: Pregabalin: A new neuromodulator with broad therapeutic indications. Ann. Pharmacother. 39 (2005) 2029-2037 (Pubitemid 41745948)
28. Shoij, S., Suzuki, M., Tomono, Y., Bockbrader, H. N., Matsui, S.: Population pharmacokinetics of pregabalin in healthy subjects and patients with post-herpetic neuralgia or diabetic peripheral neuropathy. Br. J. Clin. Pharmacol. 72 (2011) 63-76
29. Silverman, R. B.: From basic science to blockbuster drug: The discovery of Lyrica. Angew. Chem. Int. Ed. 47 (2008) 3500-3504
30. Stopponi, S., Somaini, L., Cippitelli, A., de Guglielmo, G., Kallupi, M., Cannella, N., Gerra, G., Massi, M., Ciccocioppo, R.: Pregabalin reduces alcohol drinking and relapse to alcohol seeking in the rat. Psychopharmacology (2011) DOI 10.1007/S00213-011-2457-3
31. Tzellos, T., Papazisis, G., Amaniti, E., Kouvelas, D.: Efficacy of pregabalin and gabapentin for neuropathic pain in spinal-cord injury: An evidence-based evaluation of the literature. Eur. J. Clin. Pharmacol. 64 (2008) 851-858
32. Uthmann, B. M., Bazil, C. W., Beydoun, A., Schulze-Bonhage, A., Benabou, R., Whalen, E., Emir, B., Griesing, T., Leon, T.: Long-term add-on pregabalin treatment in patients with partial-onset epilepsy: Pooled analysis of open-label clinical trials. Epilepsia 51 (2010) 968-978
33. Vaidya, V. V., Yetal, S. M., Roy, S. M. N., Gomes, N. A., Joshi, S. S.: LC-MS-MS determination of pregabalin in human plasma. Chromatographia 66 (2007) 925-928 (Pubitemid 350211969)
34. Vermeij, T. A., Edelbroek, P. M.: Simultaneous high performance liquid chromatographic analysis of pregabalin, gabapentin and vigabatrin in human serum by precolumn derivatization with o-phthaldialdehyde and fluorescence detection. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 810 (2004) 297-303 (Pubitemid 39243318)
35. Vranken, J. H., Dijkgraaf, M. G. W., Kruis, M. R., van der Vegt, M. H., Hollmann, M. W., Heesen, M.: Pregabalin in patients with central neuropathic pain: A randomized, double-blind, placebo-controlled trial of a flexible-dose regimen. Pain 136 (2008) 150-157 (Pubitemid 351491377)
36. Yargic, I., Ozdemiroglu, F. A.: Pregabalin abuse: A case report. Bull. Clin. Psychopharmacol. 21 (2011) 64-66
37. Zaccara, G., Gangemi, P. F., Cincotta, M.: Central nervous system adverse effects of new antiepileptic drugs. A meta-analysis of placebo-controlled studies. Seizure 17 (2008) 405-421
38. Zum Missbrauchspotential von Pregabalin (Lyrica). Arzneimitteltelegramm 37 (2006) 52