Severe and disabling constipation: An adverse effect of pregabalin

Epilepsia

Volumn 51, Issue 6, 2010, Pages 1094-1096

  Kamel, Jordan T ^a   D'Souza, Wendyl J ^a   Cook, Mark J ^a  

^a ST VINCENT S HOSPITAL   (Australia)

Author keywords

Alpha2 delta ligand; Antiepileptic drugs; Constipation; Pregabalin

Indexed keywords

PREGABALIN;

ABDOMINAL DISTENSION; ABDOMINAL PAIN; ABDOMINAL RADIOGRAPHY; ADULT; ARTICLE; CONSTIPATION; DISEASE SEVERITY; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG WITHDRAWAL; EPILEPSY; FEMALE; GASTROINTESTINAL SYMPTOM; HEMORRHOID; HUMAN; MAJOR CLINICAL STUDY; MALE; NAUSEA; PRIORITY JOURNAL; TREATMENT OUTCOME;

ADULT; AMBULATORY CARE; CONSTIPATION; EPILEPSY; FEMALE; FOLLOW-UP STUDIES; GAMMA-AMINOBUTYRIC ACID; HUMANS; MALE; MIDDLE AGED; PAIN MEASUREMENT; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 77954637742     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2009.02381.x     Document Type: Article

References (12)

1. Abernethy DR, Schwartz JB. (1999) Calcium-antagonist drugs. N Engl J Med 341:1447-1457.
2. Arezzo JC, Rosenstock J, LaMoreaux L, Pauer L (2008) Efficacy and safety of pregabalin 600 mg/d for treating painful diabetic peripheral neuropathy: a double-blind placebo-controlled trial. BMC Neurol 8: doi:10.1186/1471-2377-8-33.
3. Ben-Menachem E. (2004) Pregabalin pharmacology and its relevance to clinical practice. Epilepsia 45(suppl 6):13-18. (Pubitemid 39350325)
4. Freynhagen R, Strojek K, Griesing T, Whalen E, Balkenohl M. (2005) Efficacy of pregabalin in neuropathic pain evaluated in a 12-week, randomised, double-blind, multicentre, placebo-controlled trial of flexible-and fixed-dose regimens. Pain 115:254-263. (Pubitemid 40725282)
5. Houghton LA, Fell C, Whorwell PJ, Jones I, Sudworth DP, Gale JD. (2007) Effect of a second-generation a2d ligand (pregabalin) on visceral sensation in hypersensitive patients with irritable bowel syndrome. Gut 56:1218-1225.
6. Krevsk B, Maurer AH, Niewiarowski T, Cohen S. (1992) Effect of verapamil on human intestinal transit. Dig Dis Sci 37:919-924.
7. Lesser H, Sharma U, LaMoreaux L, Poole RM. (2004) Pregabalin relieves symptoms of painful diabetic neuropathy: a randomized controlled trial. Neurology 63:2104-2110. (Pubitemid 39636259)
8. Lozsadi D, Hemming K, Marson AG (2008) Pregabalin add-on for drug-resistant partial epilepsy. Cochrane Database of Systematic Reviews. 1. Art. No.: CD005612. DOI: 10.1002/14651858.CD005612.pub2.
9. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I. (1981) A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 30:239-245. (Pubitemid 12149145)
10. Richter RW, Portenoy R, Sharma U, Lamoreaux L, Bockbrader H, Knapp LE. (2005) Relief of painful diabetic peripheral neuropathy with pregabalin: a randomized, placebo-controlled trial. J Pain 6:253-260. (Pubitemid 40488803)
11. Shneker BF, McAuley JW. (2005) Pregabalin: a new neuromodulator with broad therapeutic indications. Ann Pharmacother 39:2029-2037. (Pubitemid 41745948)
12. 2δ) type 1 protein. Neuroscience 155:510-521.