Activation of sorbitol pathway in metabolic syndrome and increased susceptibility to cataract in Wistar-Obese rats

Molecular Vision

Volumn 18, Issue , 2012, Pages 495-503

  Reddy, Paduru Yadagiri ^a   Giridharan, Nappan Veettil ^a   Reddy, Geereddy Bhanuprakash ^a  

^a NATIONAL INSTITUTE OF NUTRITION   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONYL DERIVATIVE; GLUCOSE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; POLYOL; SORBITOL; SUPEROXIDE DISMUTASE;

AGE DISTRIBUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATARACT; CATARACTOGENESIS; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENZYME ACTIVITY; IMPAIRED GLUCOSE TOLERANCE; LEAN BODY WEIGHT; METABOLIC SYNDROME X; NONHUMAN; OBESITY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONTENT; PROTEIN CROSS LINKING; RAT; RAT STRAIN; RISK ASSESSMENT; SIGNAL TRANSDUCTION; TISSUE LEVEL;

AGE FACTORS; ANIMALS; ANTIOXIDANTS; CATARACT; DISEASE MODELS, ANIMAL; DISEASE SUSCEPTIBILITY; EYE PROTEINS; GLUCOSE INTOLERANCE; LENS, CRYSTALLINE; LIPID PEROXIDATION; METABOLIC SYNDROME X; OBESITY; PHENOTYPE; RATS; RATS, TRANSGENIC; RATS, WISTAR; RISK; SORBITOL; TISSUE EXTRACTS;

EID: 84857817818     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. James PT. Obesity the worldwide epidemic. Clin Dermatol 2004; 22:276-80. [PMID: 15475226]
2. Hossain P, Kawar B, El Nahas M. Obesity and diabetes in the developing world-a growing challenge. N Engl J Med 2007; 356:213-5. [PMID: 17229948]
3. Prentice AM. The emerging epidemic of obesity in developing countries. Int J Epidemiol 2006; 35:93-9. [PMID: 16326822]
4. Bohlman H. Communicating the ocular and systemic complications of obesity to patients. Optometry 2005; 76:701-12. [PMID: 16361032]
5. Cheung N, Wong TY. Obesity and eye diseases. Surv Ophthalmol 2007; 52:180-95. [PMID: 17355856]
6. Congdon NG, Friedman DS, Lietman T. Important causes of visual impairment in the world today. JAMA 2003; 290:2057-60. [PMID: 14559961]
7. Tabin G, Chen M, Espandar L. Cataract surgery for the developing world. Curr Opin Ophthalmol 2008; 19:55-9. [PMID: 18090899]
8. Weintraub JM, Willett WC, Rosner B, Colditz GA, Seddon JM, Hankinson SE. A prospective study of the relationship between body mass index and cataract extraction among US women and men. Int J Obes Relat Metab Disord 2002; 26:1588-95. [PMID: 12461675]
9. Glynn RJ, Christen WG, Manson JE, Bernheimer J, Hennekens CH. Body mass index. An independent predictor of cataract. Arch Ophthalmol 1995; 113:1131-7. [PMID: 7661746]
10. Hankinson SE, Seddon JM, Colditz GA, Stampfer MJ, Rosner B, Speizer FE, Willett WC. A prospective study of aspirin use and cataract extraction in women. Arch Ophthalmol 1993; 111:503-8. [PMID: 8470984]
11. Hiller R, Podgor MJ, Sperduto RD, Nowroozi L, Wilson PW, D'Agostino RB, Colton T. A longitudinal study of body mass index and lens opacities. The Framingham Studies. Ophthalmology 1998; 105:1244-50. [PMID: 9663229]
12. Schaumberg DA, Glynn RJ, Christen WG, Hankinson SE, Hennekens CH. Relations of body fat distribution and height with cataract in men. Am J Clin Nutr 2000; 72:1495-502. [PMID: 11101477]
13. Caulfield LE, West SK, Barro'n Y, Cid-Ruzafa J. Anthropometric status and cataract: The Salisbury Eye Evaluation Project. Am J Clin Nutr 1999; 69:237-42. [PMID: 9989686]
14. Jacques PF, Moeller SM, Hankinson SE, Chylack LT Jr, Rogers G, Tung W, Wolfe JK, Willett WC, Taylor A. Weight status, abdominal adiposity, diabetes, and early age-related lens opacities. Am J Clin Nutr 2003; 78:400-5. [PMID: 12936921]
15. Leske MC, Wu SY, Hennis A. Diabetes, hypertension, and central obesity as cataract risk factors in a black population. The Barbados Eye Study. Ophthalmology 1999; 106:35-41. [PMID: 9917778]
16. Kuang TM, Tsai SY, Hsu WM, Cheng CY, Liu JH, Chou P. Body mass index and age-related cataract: The Shihpai Eye Study. Arch Ophthalmol 2005; 123:1109-14. [PMID: 16087846]
17. Age-Related Eye Disease Study Research Group. Risk factors associated with age-related nuclear and cortical cataract: a case-control study in the Age-Related Eye Disease Study, AREDS Report No. 5. Ophthalmology 2001; 108:1400-8. [PMID: 11470690]
18. Harding J. In Cataract: biochemistry, epidemiology, and pharmacology.1st ed. London: Chapman and Hall; 1991.
19. Serrano Rios M. Relationship between obesity and the increased risk of major complications in non-insulin-dependent diabetes mellitus. Eur J Clin Invest 1998; 28:14-7. [PMID: 9777322]
20. Bakker SJ, Ijzerman RG, Teerlink T, Westerhoff HV, Gans RO, Heine RJ. Cytosolic triglycerides and oxidative stress in central obesity: the missing link between excessive atherosclerosis, endothelial dysfunction, and beta-cell failure. Atherosclerosis 2000; 148:17-21. [PMID: 10580166]
21. Giridharan NV. Animal models of obesity and their usefulness in molecular approach to obesity. Indian J Med Res 1998; 108:225-42. [PMID: 9863278]
22. Girdharan NV, Harishankar N, Satyavani M. A new rat model for the study of obesity. Scand J Lab Anim Sci 1996; 23:131-7.
23. Harishankar N, Vajreswari A, Giridharan NV. WNIN/GR-Ob - an insulin-resistant obese rat model from inbred WNIN strain. Indian J Med Res 2011; 134:320-9. [PMID: 21985815]
24. Harishankar N, Kumar PU, Sesikeran B, Giridharan N. Obesity associated pathophysiological & histological changes in WNIN obese mutant rats. Indian J Med Res 2011; 134:330-40. [PMID: 21985816]
25. Reddy GB, Vasireddy V, Mandal MN, Tiruvalluru M, Wang XF, Jablonski MM, Nappanveettil G, Ayyagari R. A novel rat model with obesity-associated retinal degeneration. Invest Ophthalmol Vis Sci 2009; 50:3456-63. [PMID: 19369235]
26. Reddy GB, Reddy PY, Vijayalakshmi A, Kumar MS, Suryanarayana P, Sesikeran B. Effect of long-term dietary manipulation on the aggregation of rat lens crystallins: Role of alpha-crystallin chaperon function. Mol Vis 2002; 8:298-305. [PMID: 12193883]
27. Suryanarayana P, Saraswat M, Mrudula T, Krishna TP, Krishnaswamy K, Reddy GB. Curcumin and turmeric delay streptozotocin-induced diabetic cataract in rats. Invest Ophthalmol Vis Sci 2005; 46:2092-9. [PMID: 15914628]
28. Suryanarayana P, Krishnaswamy K, Reddy GB. Effect of curcumin on galactose-induced cataractogenesis in rats. Mol Vis 2003; 9:223-30. [PMID: 12802258]
29. Suryanarayana P, Saraswat M, Petrash JM, Reddy GB. Emblica officinalis and its enriched tannoids delay streptozotocin-induced diabetic cataract in rats. Mol Vis 2007; 13:1291-7. [PMID: 17679931]
30. Reddy GB, Satyanarayana A, Balakrishna N, Ayyagari R, Padma M, Viswanath K, Petrash JM. Erythrocyte aldose reductase activity and sorbitol levels in diabetic retinopathy. Mol Vis 2008; 14:593-601. [PMID: 18385795]
31. Hegde KR, Varma SD. Combination of glycemic and oxidative stress in lens: implications in augmentation of cataract formation in diabetes. Free Radic Res 2005; 39:513-7. [PMID: 16036327]
32. Truscott RJ. Age-related nuclear cataract-oxidation is the key. Exp Eye Res 2005; 80:709-25. [PMID: 15862178]
33. Spector A. Oxidative stress and disease. J Ocul Pharmacol Ther 2000; 16:193-201. [PMID: 10803430]
34. Lee AY, Chung SS. Contributions of polyol pathway to oxidative stress in diabetic cataract. FASEB J 1999; 13:23-30. [PMID: 9872926]
35. Singh R, Barden A, Mori T, Beilin L. Advanced glycation end products: a review. Diabetologia 2001; 44:129-46. [PMID: 11270668]
36. van Boekel MA, Hoenders HJ. Glycation of crystallins in lenses from aging and diabetic individuals. FEBS Lett 1992; 314:1-4. [PMID: 1451795]
37. Kumar PA, Kumar MS, Reddy GB. Effect of glycation on alpha-crystallin structure and chaperone-like function. Biochem J 2007; 408:251-8. [PMID: 17696877]
38. Beswick HT, Harding JJ. Conformational changes induced in lens alpha- and gamma-crystallins by modification with glucose 6-phosphate. Implications for cataract. Biochem J 1987; 246:761-9. [PMID: 3689329]
39. Brownlee M. Advanced protein glycosylation in diabetes and aging. Annu Rev Med 1995; 46:223-34. [PMID: 7598459]
40. Kinoshita JH, Nishimura C. The involvement of aldose reductase in diabetic complications. Diabetes Metab Rev 1988; 4:323-37. [PMID: 3134179]
41. Varma SD, Schocket SS, Richards RD. Implications of aldose reductase in cataracts in human diabetes. Invest Ophthalmol Vis Sci 1979; 18:237-41. [PMID: 106020]
42. Saraswat M, Mrudula T, Kumar PU, Suneetha A, Rao TS, Srinivasulu M, Reddy GB. Overxpression of aldose reductase in human cancer tissues. Med Sci Monit 2006; 12:CR525-9. [PMID: 17136009]
43. Kumar PA, Reddy GB. Modulation of alpha-crystallin chaperone activity: a target to prevent or delay cataract? IUBMB Life 2009; 61:485-95. [PMID: 19391162]
44. Srivastava SK, Ramana KV, Bhatnagar A. Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options. Endocr Rev 2005; 26:380-92. [PMID: 15814847]
45. Drel VR, Mashtalir N, Ilnytska O, Shin J, Li F, Lyzogubov VV, Obrosova IG. The leptin-deficient (Ob/Ob) Mouse: A new animal model of peripheral neuropathy of type 2 diabetes and obesity. Diabetes 2006; 55:3335-43. [PMID: 17130477]
46. Obrosova IG, Ilnytska O, Lyzogubov VV, Pavlov IA, Mashtalir N, Nadler JL, Drel VR. High-fat diet-induced neuropthay of pre-diabetes and obesity: Effects of Healthy diet and aldose reductase inhibition. Diabetes 2007; 56:2598-608. [PMID: 17626889]
47. Rajala RVS, Ivanovic I, Dilly AK. Retinal insulin receptor signaling in hyperosmotic stress. In Vitamins and Hormones. 80: 583-612, Academic Press, Burlington, 2009.
48. Suryanarayana P, Patil MA, Reddy GB. Insulin resistance mediated biochemical alterations in the eye lens of neonatal streptozotocin-induced diabetic rat model. Indian J Exp Biol 2011; 49:749-55. [PMID: 22013741]
49. Hwang YC, Kaneko M, Bakr S, Liao H, Lu Y, Lewis ER, Yan S, Ii S, Itakura M, Rui L, Skopicki H, Homma S, Schmidt AM, Oates PJ, Szabolcs M, Ramasamy R. Central role for aldose reductase pathway in myocardial ischemic injury. FASEB J 2004; 18:1192-9. [PMID: 15284219]
50. Hallam K, Gomez T, Li Q, Ananthakrishnan R, Yan S, Schmidt AM, Ramasamy R. Polyol pathway inhibition improves age- related vascular dysfunction in rats. Exp Biol 2006; 18:C276.