메뉴 건너뛰기




Volumn 426, Issue 1-2, 2012, Pages 153-161

Molecular modelling and multisimplex optimization of tocotrienol-rich Self Emulsified Drug Delivery Systems

Author keywords

Multisimplex ; Nanoemulsions; Physical characterization; SEDDS; Surfactants; Tocotrienol

Indexed keywords

ALPHA TOCOTRIENOL; CREMOPHOR; POLYSORBATE 80;

EID: 84857793326     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.01.049     Document Type: Article
Times cited : (23)

References (37)
  • 1
    • 39549095134 scopus 로고    scopus 로고
    • Comparison between lipolysis and compendial dissolution as alternative techniques for the in vitro characterization of α-tocopherol self-emulsified drug delivery systems (SEDDS)
    • H. Ali, M. Nazzal, A.-A.A. Zaghloul, and S. Nazzal Comparison between lipolysis and compendial dissolution as alternative techniques for the in vitro characterization of α-tocopherol self-emulsified drug delivery systems (SEDDS) Int. J. Pharm. 352 2008 104 114
    • (2008) Int. J. Pharm. , vol.352 , pp. 104-114
    • Ali, H.1    Nazzal, M.2    Zaghloul, A.-A.A.3    Nazzal, S.4
  • 3
    • 39149099088 scopus 로고    scopus 로고
    • Tocopherols and tocotrienols in membranes: A critical review
    • J. Atkinson, R.F. Epand, and R.M. Epand Tocopherols and tocotrienols in membranes: a critical review Free Radic. Biol. Med. 44 2008 739 764
    • (2008) Free Radic. Biol. Med. , vol.44 , pp. 739-764
    • Atkinson, J.1    Epand, R.F.2    Epand, R.M.3
  • 4
    • 85047692219 scopus 로고
    • Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism
    • DOI 10.1002/jps.2600821002
    • B.J. Aungst Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism J. Pharm. Sci. 82 1993 979 987 (Pubitemid 23314099)
    • (1993) Journal of Pharmaceutical Sciences , vol.82 , Issue.10 , pp. 979-987
    • Aungst, B.J.1
  • 5
    • 77950448927 scopus 로고    scopus 로고
    • Enhanced antiproliferative and apoptotic response to combined treatment of gamma-tocotrienol with erlotinib or gefitinib in mammary tumor cells
    • S. Bachawal, V. Wali, and P. Sylvester Enhanced antiproliferative and apoptotic response to combined treatment of gamma-tocotrienol with erlotinib or gefitinib in mammary tumor cells BMC Cancer 10 2010 84
    • (2010) BMC Cancer , vol.10 , pp. 84
    • Bachawal, S.1    Wali, V.2    Sylvester, P.3
  • 6
    • 32544433312 scopus 로고    scopus 로고
    • Advances in the use of tocols as drug delivery vehicles
    • DOI 10.1007/s11095-005-9262-9
    • P. Constantinides, J. Han, and S. Davis Advances in the use of tocols as drug delivery vehicles Pharm. Res. 23 2006 243 255 (Pubitemid 43237855)
    • (2006) Pharmaceutical Research , vol.23 , Issue.2 , pp. 243-255
    • Constantinides, P.P.1    Han, J.2    Davis, S.S.3
  • 7
    • 0029562489 scopus 로고
    • Lipid microemulsions for improving drug dissolution and oral absorption: Physical and biopharmaceutical aspects
    • DOI 10.1023/A:1016268311867
    • P.P. Constantinides Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects Pharm. Res. 12 1995 1561 1572 (Pubitemid 26005509)
    • (1995) Pharmaceutical Research , vol.12 , Issue.11 , pp. 1561-1572
    • Constantinides, P.P.1
  • 9
    • 0028949717 scopus 로고
    • An investigation into the mechanisms of self-emulsification using particle size analysis and low frequency dielectric spectroscopy
    • DOI 10.1016/0378-5173(94)00222-Q
    • D.Q.M. Craig, S.A. Barker, D. Banning, and S.W. Booth An investigation into the mechanisms of self-emulsification using particle size analysis and low frequency dielectric spectroscopy Int. J. Pharm. 114 1995 103 110 (Pubitemid 24377034)
    • (1995) International Journal of Pharmaceutics , vol.114 , Issue.1 , pp. 103-110
    • Craig, D.Q.M.1    Barker, S.A.2    Banning, D.3    Booth, S.W.4
  • 10
  • 11
    • 31144477238 scopus 로고    scopus 로고
    • Hydrophilic matrices: Application of Placket-Burman screening design to model the effect of POLYOX-carbopol blends on drug release
    • DOI 10.1016/j.ijpharm.2005.11.032, PII S0378517305008045
    • Y. El-Malah, and S. Nazzal Hydrophilic matrices: application of Placket-Burman screening design to model the effect of POLYOX-carbopol blends on drug release Int. J. Pharm. 309 2006 163 170 (Pubitemid 43129479)
    • (2006) International Journal of Pharmaceutics , vol.309 , Issue.1-2 , pp. 163-170
    • El-Malah, Y.1    Nazzal, S.2
  • 12
    • 33750884087 scopus 로고    scopus 로고
    • D-Optimal mixture design: Optimization of ternary matrix blends for controlled zero-order drug release from oral dosage forms
    • DOI 10.1080/03639040600685167, PII W826177V5T377Q12
    • Y. El-Malah, S. Nazzal, and N.M. Khanfar D-optimal mixture design: optimization of ternary matrix blends for controlled zero-order drug release from oral dosage forms Drug Dev. Ind. Pharm. 32 2006 1207 1218 (Pubitemid 44721735)
    • (2006) Drug Development and Industrial Pharmacy , vol.32 , Issue.10 , pp. 1207-1218
    • El-Malah, Y.1    Nazzal, S.2    Khanfar, N.M.3
  • 13
    • 33646139384 scopus 로고    scopus 로고
    • MultiSimplex and experimental design as chemometric tools to optimize a SPE-HPLC-UV method for the determination of eprosartan in human plasma samples
    • N. Ferreirós, G. Iriarte, R.M. Alonso, and R.M. Jiménez MultiSimplex and experimental design as chemometric tools to optimize a SPE-HPLC-UV method for the determination of eprosartan in human plasma samples Talanta 69 2006 747 756
    • (2006) Talanta , vol.69 , pp. 747-756
    • Ferreirós, N.1    Iriarte, G.2    Alonso, R.M.3    Jiménez, R.M.4
  • 14
    • 0034601204 scopus 로고    scopus 로고
    • Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs
    • DOI 10.1016/S0939-6411(00)00089-8, PII S0939641100000898
    • T. Gershanik, and S. Benita Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs Eur. J. Pharm. Biopharm. 50 2000 179 188 (Pubitemid 30326696)
    • (2000) European Journal of Pharmaceutics and Biopharmaceutics , vol.50 , Issue.1 , pp. 179-188
    • Gershanik, T.1    Benita, S.2
  • 15
    • 1842684453 scopus 로고    scopus 로고
    • Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs
    • DOI 10.1016/j.biopha.2004.02.001, PII S0753332204000319
    • R.N. Gursoy, and S. Benita Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs Biomed. Pharmacother. 58 2004 173 182 (Pubitemid 38479922)
    • (2004) Biomedicine and Pharmacotherapy , vol.58 , Issue.3 , pp. 173-182
    • Gursoy, R.N.1    Benita, S.2
  • 17
    • 33947716119 scopus 로고    scopus 로고
    • Software news and update a semiempirical free energy force field with charge-based desolvation
    • DOI 10.1002/jcc.20634
    • R. Huey, G.M. Morris, A.J. Olson, and D.S. Goodsell A semiempirical free energy force field with charge-based desolvation J. Comput. Chem. 28 2007 1145 1152 (Pubitemid 46506716)
    • (2007) Journal of Computational Chemistry , vol.28 , Issue.6 , pp. 1145-1152
    • Huey, R.1    Morris, G.M.2    Olson, A.J.3    Goodsell, D.S.4
  • 18
    • 0342617694 scopus 로고    scopus 로고
    • Lipid-based vehicles for the oral delivery of poorly water soluble drugs
    • A.J. Humberstone, and W.N. Charman Lipid-based vehicles for the oral delivery of poorly water soluble drugs Adv. Drug Deliv. Rev. 25 1997 103 128
    • (1997) Adv. Drug Deliv. Rev. , vol.25 , pp. 103-128
    • Humberstone, A.J.1    Charman, W.N.2
  • 20
    • 0032103706 scopus 로고    scopus 로고
    • Formulation design and bioavailability assessment of lipidic self- emulsifying formulations of halofantrine
    • DOI 10.1016/S0378-5173(98)00054-4, PII S0378517398000544
    • S.-M. Khoo, A.J. Humberstone, C.J.H. Porter, G.A. Edwards, and W.N. Charman Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of halofantrine Int. J. Pharm. 167 1998 155 164 (Pubitemid 28341517)
    • (1998) International Journal of Pharmaceutics , vol.167 , Issue.1-2 , pp. 155-164
    • Khoo, S.-M.1    Humberstone, A.J.2    Porter, C.J.H.3    Edwards, G.A.4    Charman, W.N.5
  • 21
    • 0030728789 scopus 로고    scopus 로고
    • Pharmacokinetic cyclosporine A profiles under long-term neoral treatment in renal transplant recipients: Does fat intake still matter?
    • R.M. Klauser, H. Irschik, J. Kletzmayr, I. Sturm, W. Brunner, W. Woloszczuk, and J. Kovarik Pharmacokinetic cyclosporine A profiles under long-term neoral treatment in renal transplant recipients: does fat intake still matter? Transplant. Proc. 29 1997 3137 3140
    • (1997) Transplant. Proc. , vol.29 , pp. 3137-3140
    • Klauser, R.M.1    Irschik, H.2    Kletzmayr, J.3    Sturm, I.4    Brunner, W.5    Woloszczuk, W.6    Kovarik, J.7
  • 23
    • 0042594614 scopus 로고    scopus 로고
    • The molecular basis of vitamin E retention: Structure of human α-tocopherol transfer protein
    • DOI 10.1016/S0022-2836(03)00724-1
    • R. Meier, T. Tomizaki, C. Schulze-Briese, U. Baumann, and A. Stocker The molecular basis of vitamin E Retention: structure of human α-tocopherol transfer protein J. Mol. Biol. 331 2003 725 734 (Pubitemid 36937156)
    • (2003) Journal of Molecular Biology , vol.331 , Issue.3 , pp. 725-734
    • Meier, R.1    Tomizaki, T.2    Schulze-Briese, C.3    Baumann, U.4    Stocker, A.5
  • 24
    • 0036099985 scopus 로고    scopus 로고
    • Separation and first structure elucidation of Cremophor EL-components by hyphenated capillary electrophoresis and delayed extraction-matrix assisted laser desorption/ionization-time of flight-mass spectrometry
    • T. Meyer, D. Waidelich, and A.W. Frahm Separation and first structure elucidation of Cremophor EL-components by hyphenated capillary electrophoresis and delayed extraction-matrix assisted laser desorption/ionization-time of flight-mass spectrometry Electrophoresis 23 2002 1053 1062
    • (2002) Electrophoresis , vol.23 , pp. 1053-1062
    • Meyer, T.1    Waidelich, D.2    Frahm, A.W.3
  • 25
    • 0003889197 scopus 로고    scopus 로고
    • Emulsions and nanosuspensions for the formulation of poorly soluble drugs
    • R.H. Müller, S. Benita, and B.H.L. Böhm Emulsions and nanosuspensions for the formulation of poorly soluble drugs Medpharm 1998
    • (1998) Medpharm
    • Müller, R.H.1    Benita, S.2    Böhm, B.H.L.3
  • 26
    • 1842684453 scopus 로고    scopus 로고
    • Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs
    • DOI 10.1016/j.biopha.2004.02.001, PII S0753332204000319
    • R. Neslihan Gursoy, and S. Benita Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs Biomed. Pharmacother. 58 2004 173 182 (Pubitemid 38479922)
    • (2004) Biomedicine and Pharmacotherapy , vol.58 , Issue.3 , pp. 173-182
    • Gursoy, R.N.1    Benita, S.2
  • 27
    • 0343487750 scopus 로고    scopus 로고
    • Formulation of self-emulsifying drug delivery systems
    • DOI 10.1016/S0169-409X(96)00490-5, PII S0169409X96004905
    • C.W. Pouton Formulation of self-emulsifying drug delivery systems Adv. Drug Deliv. Rev. 25 1997 47 58 (Pubitemid 27107790)
    • (1997) Advanced Drug Delivery Reviews , vol.25 , Issue.1 , pp. 47-58
    • Pouton, C.W.1
  • 28
    • 0033513691 scopus 로고    scopus 로고
    • Simplex optimization of protein crystallization conditions
    • B.D. Prater, S.C. Tuller, and L.J. Wilson Simplex optimization of protein crystallization conditions J. Cryst. Growth 196 1999 674 684
    • (1999) J. Cryst. Growth , vol.196 , pp. 674-684
    • Prater, B.D.1    Tuller, S.C.2    Wilson, L.J.3
  • 29
    • 33751061128 scopus 로고    scopus 로고
    • γ-Tocotrienol inhibits ErbB3-dependent PI3K/Akt mitogenic signalling in neoplastic mammary epithelial cells
    • DOI 10.1111/j.1365-2184.2006.00412.x
    • G.V. Samant, and P.W. Sylvester γ-Tocotrienol inhibits ErbB3-dependent PI3K/Akt mitogenic signalling in neoplastic mammary epithelial cells Cell Prolif. 39 2006 563 574 (Pubitemid 44760206)
    • (2006) Cell Proliferation , vol.39 , Issue.6 , pp. 563-574
    • Samant, G.V.1    Sylvester, P.W.2
  • 30
    • 0038518250 scopus 로고    scopus 로고
    • Routine analysis of mercury species using commercially available instrumentation: Chemometric optimisation of the instrumental variables
    • DOI 10.1016/S0003-2670(03)00514-2
    • J. Sanz, A. de Diego, J.C. Raposo, and J.M. Madariaga Routine analysis of mercury species using commercially available instrumentation: chemometric optimisation of the instrumental variables Anal. Chim. Acta 486 2003 255 267 (Pubitemid 36694938)
    • (2003) Analytica Chimica Acta , vol.486 , Issue.2 , pp. 255-267
    • Sanz, J.1    De Diego, A.2    Raposo, J.C.3    Madariaga, J.M.4
  • 31
    • 54349092622 scopus 로고    scopus 로고
    • MultiSimplex optimization of on-line sorbent proconcentration and determination of iron by FI-AAS and microcolumn of immobilized ferron
    • F. Shakerian, S. Dadfarnia, A.M.H. Shabani, and M. Rohani MultiSimplex optimization of on-line sorbent proconcentration and determination of iron by FI-AAS and microcolumn of immobilized ferron Talanta 77 2008 551 555
    • (2008) Talanta , vol.77 , pp. 551-555
    • Shakerian, F.1    Dadfarnia, S.2    Shabani, A.M.H.3    Rohani, M.4
  • 32
    • 77953285620 scopus 로고    scopus 로고
    • Synergistic anticancer effects of combined γ-tocotrienol and celecoxib treatment are associated with suppression in Akt and NFκB signaling
    • A.B. Shirode, and P.W. Sylvester Synergistic anticancer effects of combined γ-tocotrienol and celecoxib treatment are associated with suppression in Akt and NFκB signaling Biomedicine & Pharmacotherapy 64 2010 327 332
    • (2010) Biomedicine & Pharmacotherapy , vol.64 , pp. 327-332
    • Shirode, A.B.1    Sylvester, P.W.2
  • 33
    • 20144363212 scopus 로고    scopus 로고
    • Intracellular signaling mechanisms mediating the antiproliferative and apoptotic effects of γ-tocotrienol in neoplastic mammary epithelial cells
    • DOI 10.1016/j.jplph.2005.04.014, PII S0176161705001409
    • P.W. Sylvester, S.J. Shah, and G.V. Samant Intracellular signaling mechanisms mediating the antiproliferative and apoptotic effects of γ-tocotrienol in neoplastic mammary epithelial cells J. Plant Physiol. 162 2005 803 810 (Pubitemid 40772096)
    • (2005) Journal of Plant Physiology , vol.162 , Issue.7 , pp. 803-810
    • Sylvester, P.W.1    Shah, S.J.2    Samant, G.V.3
  • 34
    • 37349000972 scopus 로고    scopus 로고
    • Synergistic antiproliferative effects of γ-tocotrienol and statin treatment on mammary tumor cells
    • DOI 10.1007/s11745-007-3102-0
    • V. Wali, and P. Sylvester Synergistic antiproliferative effects of γ-tocotrienol and statin treatment on mammary tumor cells Lipids 42 2007 1113 1123 (Pubitemid 350303593)
    • (2007) Lipids , vol.42 , Issue.12 , pp. 1113-1123
    • Wali, V.B.1    Sylvester, P.W.2
  • 37
    • 0037249854 scopus 로고    scopus 로고
    • Influence of route of administration on the absorption and disposition of α-, γ- and δ-tocotrienols in rats
    • S.P. Yap, K.H. Yuen, and A.B. Lim Influence of route of administration on the absorption and disposition of α-, γ- and δ-tocotrienols in rats J. Pharm. Pharmacol. 55 2003 53 58 (Pubitemid 36142081)
    • (2003) Journal of Pharmacy and Pharmacology , vol.55 , Issue.1 , pp. 53-58
    • Yap, S.P.1    Yuen, K.H.2    Lim, A.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.