메뉴 건너뛰기




Volumn 26, Issue 1, 2012, Pages 5-7

The pleiotropic effects of statins in the prevention of atherosclerosis: Editorial to: "simvastatin suppresses apoptosis in vulnerable atherosclerotic plaques through regulating the expression of p53, Bcl-2 en Bcl-xL" by Weiwei Qin et al.

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; ADVANCED GLYCATION END PRODUCT RECEPTOR; C REACTIVE PROTEIN; CERIVASTATIN; CHOLESTEROL; CYTOKINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GELATINASE A; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; MATRIX METALLOPROTEINASE; MEVALONIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PRAVASTATIN; ROSUVASTATIN; SIMVASTATIN; THROMBOPLASTIN; VASCULAR CELL ADHESION MOLECULE 1;

EID: 84857790486     PISSN: 09203206     EISSN: 15737241     Source Type: Journal    
DOI: 10.1007/s10557-011-6353-1     Document Type: Editorial
Times cited : (7)

References (30)
  • 1
    • 0018939225 scopus 로고
    • Mevinolin: A highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent
    • DOI 10.1073/pnas.77.7.3957
    • AW Alberts J Chen G Kuron, et al. 1980 Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent Proc Natl Acad Sci USA 77 3957 3961 6933445 10.1073/pnas.77.7.3957 1:CAS:528:DyaL3cXlvFOlurk%3D (Pubitemid 10015499)
    • (1980) Proceedings of the National Academy of Sciences of the United States of America , vol.77 , Issue.7 , pp. 3957-3961
    • Alberts, A.W.1    Chen, J.2    Kuron, G.3
  • 2
    • 0023754423 scopus 로고
    • Discovery, biochemistry and biology of lovastatin
    • AW Alberts 1988 Discovery, biochemistry and biology of lovastatin Am J Cardiol 62 10J 15J 3055919 10.1016/0002-9149(88)90002-1 1:CAS:528: DyaL1MXjtlajug%3D%3D (Pubitemid 18263851)
    • (1988) American Journal of Cardiology , vol.62 , Issue.15
    • Alberts, A.W.1
  • 3
    • 0035843962 scopus 로고    scopus 로고
    • Structural mechanism for statin inhibition of HMG-CoA reductase
    • DOI 10.1126/science.1059344
    • ES Istvan J Deisenhofer 2001 Structural mechanism for statin inhibition of HMG-CoA reductase Science 292 1160 1164 11349148 10.1126/science.1059344 1:CAS:528:DC%2BD3MXjs1Cgtbo%3D (Pubitemid 32440937)
    • (2001) Science , vol.292 , Issue.5519 , pp. 1160-1164
    • Istvan, E.S.1    Deisenhofer, J.2
  • 4
    • 0037031061 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: A randomised placebo-controlled trial
    • DOI 10.1016/S0140-6736(02)09327-3
    • Group Heart Protection Study Collaborative 2002 MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20536 high-risk individuals: a randomised placebo-controlled trial Lancet 360 7 22 10.1016/S0140-6736(02) 09327-3 (Pubitemid 34756487)
    • (2002) Lancet , vol.360 , Issue.9326 , pp. 7-22
    • Collins, R.1    Armitage, J.2    Parish, S.3    Sleight, P.4    Peto, R.5
  • 5
    • 33645384019 scopus 로고    scopus 로고
    • Effects of statins beyond lipid lowering: Potential for clinical benefits
    • 16054715 10.1016/j.ijcard.2005.05.056
    • K Almuti R Rimawi D Spevack, et al. 2006 Effects of statins beyond lipid lowering: potential for clinical benefits Int J Cardiol 109 7 15 16054715 10.1016/j.ijcard.2005.05.056
    • (2006) Int J Cardiol , vol.109 , pp. 7-15
    • Almuti, K.1    Rimawi, R.2    Spevack, D.3
  • 6
    • 29444438428 scopus 로고    scopus 로고
    • Clinical implications for statin pleiotropy
    • JK Liao 2005 Clinical implications for statin pleiotropy Curr Opin Lipidol 16 624 629 16276239 10.1097/01.mol.0000191913.16321.60 1:CAS:528:DC%2BD2MXhtFymtb%2FL (Pubitemid 43012159)
    • (2005) Current Opinion in Lipidology , vol.16 , Issue.6 , pp. 624-629
    • Liao, J.K.1
  • 7
    • 77958541531 scopus 로고    scopus 로고
    • The pleiotropic effects of the hydroxy-methyl-glutaryl-CoA reductase inhibitors in cardiovascular disease: A comprehensive review
    • 20926939 10.1097/CRD.0b013e3181f52a7f
    • CG Mihos MJ Salas O Santana 2010 The pleiotropic effects of the hydroxy-methyl-glutaryl-CoA reductase inhibitors in cardiovascular disease: a comprehensive review Cardiol Rev 18 298 304 20926939 10.1097/CRD. 0b013e3181f52a7f
    • (2010) Cardiol Rev , vol.18 , pp. 298-304
    • Mihos, C.G.1    Salas, M.J.2    Santana, O.3
  • 8
    • 77951709095 scopus 로고    scopus 로고
    • Pleiotropic effects of statins.-basic research and clinical perspectives
    • 20424337 10.1253/circj.CJ-10-0110 1:CAS:528:DC%2BC3cXms1ajsbw%3D
    • Q Zhou JK Liao 2010 Pleiotropic effects of statins.-basic research and clinical perspectives Circ J. 74 818 826 20424337 10.1253/circj.CJ-10-0110 1:CAS:528:DC%2BC3cXms1ajsbw%3D
    • (2010) Circ J. , vol.74 , pp. 818-826
    • Zhou, Q.1    Liao, J.K.2
  • 9
    • 77951716673 scopus 로고    scopus 로고
    • Basic science review: Statin therapy-Part I: The pleiotropic effects of statins in cardiovascular disease
    • 10.1177/1538574410362922
    • B Sadowitz KG Maier V Gahtan 2010 Basic science review: statin therapy-Part I: the pleiotropic effects of statins in cardiovascular disease Vasc Endovasc Surg. 44 241 251 10.1177/1538574410362922
    • (2010) Vasc Endovasc Surg. , vol.44 , pp. 241-251
    • Sadowitz, B.1    Maier, K.G.2    Gahtan, V.3
  • 10
    • 0025120211 scopus 로고
    • Regulation of the mevalonate pathway
    • DOI 10.1038/343425a0
    • JL Goldstein MS Brown 1990 Regulation of the mevalonate pathway Nature 343 425 430 1967820 10.1038/343425a0 1:CAS:528:DyaK3cXhtlCmtbw%3D (Pubitemid 20065229)
    • (1990) Nature , vol.343 , Issue.6257 , pp. 425-430
    • Goldstein, J.L.1    Brown, M.S.2
  • 11
    • 0030968580 scopus 로고    scopus 로고
    • Rho GTPases and signaling networks
    • L Van Aelst C D'Souza-Schorey 1997 Rho GTPases and signaling networks Genes Dev 11 2295 2322 9308960 10.1101/gad.11.18.2295 (Pubitemid 27408529)
    • (1997) Genes and Development , vol.11 , Issue.18 , pp. 2295-2322
    • Van Aelst, L.1    D'Souza-Schorey, C.2
  • 12
    • 0032568874 scopus 로고    scopus 로고
    • G proteins and small GTpases: Distant relatives keep in touch
    • DOI 10.1126/science.280.5372.2074
    • A Hall 1998 G proteins and small GTPases: distant relatives keep in touch Science 280 2074 2075 9669963 10.1126/science.280.5372.2074 1:CAS:528:DyaK1cXkt1Ggsrw%3D (Pubitemid 28366192)
    • (1998) Science , vol.280 , Issue.5372 , pp. 2074-2075
    • Hall, A.1
  • 13
    • 0026640530 scopus 로고
    • Post-translational modifications of p21rho proteins
    • 1400319 1:CAS:528:DyaK38XlsVGlsbk%3D
    • P Adamson CJ Marshall A Hall PA Tilbrook 1992 Post-translational modifications of p21rho proteins J Biol Chem 267 20033 20038 1400319 1:CAS:528:DyaK38XlsVGlsbk%3D
    • (1992) J Biol Chem , vol.267 , pp. 20033-20038
    • Adamson, P.1    Marshall, C.J.2    Hall, A.3    Tilbrook, P.A.4
  • 14
    • 20444432732 scopus 로고    scopus 로고
    • Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl- CoA reductase inhibition: A role for RhoA in ABCA1-mediated cholesterol efflux
    • DOI 10.1074/jbc.M502761200
    • CA Argmann JY Edwards CG Sawyez, et al. 2005 Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition J Biol Chem 280 22212 22221 15817453 10.1074/jbc.M502761200 1:CAS:528: DC%2BD2MXksl2htro%3D (Pubitemid 40827878)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.23 , pp. 22212-22221
    • Argmann, C.A.1    Edwards, J.Y.2    Sawyez, C.G.3    O'Neil, C.H.4    Hegele, R.A.5    Pickering, J.G.6    Huff, M.W.7
  • 15
    • 0028935780 scopus 로고
    • Protein lipidation in cell signaling
    • 7716512 10.1126/science.7716512 1:CAS:528:DyaK2MXltVCitLs%3D
    • PJ Casey 1995 Protein lipidation in cell signaling Science 268 221 225 7716512 10.1126/science.7716512 1:CAS:528:DyaK2MXltVCitLs%3D
    • (1995) Science , vol.268 , pp. 221-225
    • Casey, P.J.1
  • 16
    • 0033826581 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
    • 10973320 10.1038/79510 1:CAS:528:DC%2BD3cXmslSjsL0%3D
    • Y Kureishi Z Luo I Shiojima, et al. 2000 The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals Nat Med 6 1004 1010 10973320 10.1038/79510 1:CAS:528:DC%2BD3cXmslSjsL0%3D
    • (2000) Nat Med , vol.6 , pp. 1004-1010
    • Kureishi, Y.1    Luo, Z.2    Shiojima, I.3
  • 17
    • 33845707278 scopus 로고    scopus 로고
    • Statins activate AMP-activated protein kinase in vitro and in vivo
    • DOI 10.1161/CIRCULATIONAHA.106.630194, PII 0000301720061212000015
    • W Sun T-S Lee MJ Zhu, et al. 2006 Statins activate AMP-activated kinase in vitro and in vivo Circulation 114 2655 2662 17116771 10.1161/CIRCULATIONAHA. 106.630194 1:CAS:528:DC%2BD28Xht1Ohu7zP (Pubitemid 44967349)
    • (2006) Circulation , vol.114 , Issue.24 , pp. 2655-2662
    • Sun, W.1    Lee, T.-S.2    Zhu, M.3    Gu, C.4    Wang, Y.5    Zhu, Y.6    Shyy, J.Y.-J.7
  • 18
    • 53449093439 scopus 로고    scopus 로고
    • AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells via eNOS-derived NO
    • 10.1161/ATVBAHA.108.172452
    • X Li Y Han W Pang, et al. 2008 AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells via eNOS-derived NO Arterio Thromb Vasc Biol. 28 1789 1795 10.1161/ATVBAHA.108.172452
    • (2008) Arterio Thromb Vasc Biol. , vol.28 , pp. 1789-1795
    • Li, X.1    Han, Y.2    Pang, W.3
  • 19
    • 0032584177 scopus 로고    scopus 로고
    • Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors
    • U Laufs V La Fata J Plutzky, et al. 1998 Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors Circulation 97 1129 1135 9537338 1:CAS:528:DyaK1cXisVWmsrY%3D (Pubitemid 28152885)
    • (1998) Circulation , vol.97 , Issue.12 , pp. 1129-1135
    • Laufs, U.1    La Fata, V.2    Plutzky, J.3    Liao, J.K.4
  • 20
    • 0031451344 scopus 로고    scopus 로고
    • Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase
    • DOI 10.1074/jbc.272.50.31725
    • U Laufs V La Fata JK Liao 1997 Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase J Biol Chem 272 31725 31729 9395516 10.1074/jbc.272.50. 31725 1:CAS:528:DyaK2sXotVSkurY%3D (Pubitemid 28013321)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.50 , pp. 31725-31729
    • Laufs, U.1    La Fata, V.2    Liao, J.K.3
  • 22
    • 46849111226 scopus 로고    scopus 로고
    • Benefit of adding Pioglitazone to successful statin therapy in nondiabetic patients with coronary artery disease
    • DOI 10.1253/circj.72.1193
    • K Sugamura S Sugiyama Y Matsuzawa, et al. 2008 Benefit of adding pioglitazone to successful statin therapy in nondiabetic patients with coronary artery disease Circ J 72 1193 1197 18577834 10.1253/circj.72.1193 1:CAS:528:DC%2BD1cXovFelt78%3D (Pubitemid 351957091)
    • (2008) Circulation Journal , vol.72 , Issue.7 , pp. 1193-1197
    • Sugamura, K.1    Sugiyama, S.2    Matsuzawa, Y.3    Nozaki, T.4    Horibata, Y.5    Ogawa, H.6
  • 23
    • 0036445650 scopus 로고    scopus 로고
    • Modulation of inflammatory mediators and PPARγ and NFκB expression by pravastatin in response to lipoproteins in human monocytes in vitro
    • DOI 10.1006/phrs.2001.0922
    • I Zelvyte R Dominaitiene M Crisby S Janciauskiene 2002 Modulation of inflammatory mediators and PPARgamma and NFkappaB expression by pravastatin in response to lipoproteins in human monocytes in vitro Pharmacol Res 45 147 154 11846628 10.1006/phrs.2001.0922 1:CAS:528:DC%2BD38XhtFCltLc%3D (Pubitemid 35425654)
    • (2002) Pharmacological Research , vol.45 , Issue.2 , pp. 147-154
    • Zelvyte, I.1    Dominaitiene, R.2    Crisby, M.3    Janciauskiene, S.4
  • 24
    • 0842309101 scopus 로고    scopus 로고
    • The Selective Peroxisomal Proliferator-Activated Receptor-Gamma Agonist Has an Additive Effect on Plaque Regression in Combination with Simvastatin in Experimental Atherosclerosis: In Vivo Study by High-Resolution Magnetic Resonance Imaging
    • DOI 10.1016/j.jacc.2003.08.048
    • R Corti JI Osende JT Fallon, et al. 2004 The selective peroxisomal proliferator-activated receptor-gamma agonist has an additive effect on plaque regression in combination with simvastatin in experimental atherosclerosis: in vivo study by high-resolution magnetic resonance imaging J Am Coll Cardiol 43 464 473 15013132 10.1016/j.jacc.2003.08.048 1:CAS:528:DC%2BD2cXitV2jtbY%3D (Pubitemid 38167710)
    • (2004) Journal of the American College of Cardiology , vol.43 , Issue.3 , pp. 464-473
    • Corti, R.1    Osende, J.I.2    Fallon, J.T.3    Fuster, V.4    Mizsei, G.5    Jneid, H.6    Wright, S.D.7    Chaplin, W.F.8    Badimon, J.J.9
  • 25
    • 84857782055 scopus 로고    scopus 로고
    • Simvastatin suppresses apoptosis in vulnerable atherosclerotic plaques through regulating the expression of p53, Bcl-2 and Bcl-xL
    • this issue
    • Qin W, Lu Y, Zhan C, et al. Simvastatin suppresses apoptosis in vulnerable atherosclerotic plaques through regulating the expression of p53, Bcl-2 and Bcl-xL. Cardiovasc Drugs Ther 2012;26: this issue
    • (2012) Cardiovasc Drugs Ther , pp. 26
    • Qin, W.1    Lu, Y.2    Zhan, C.3
  • 26
    • 0035895319 scopus 로고    scopus 로고
    • An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro
    • M Aikawa E Rabkin S Sugiyama, et al. 2001 An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro Circulation 103 276 283 11208689 1:CAS:528:DC%2BD3MXhtFaitr4%3D (Pubitemid 32095415)
    • (2001) Circulation , vol.103 , Issue.2 , pp. 276-283
    • Aikawa, M.1    Rabkin, E.2    Sugiyama, S.3    Voglic, S.J.4    Fukumoto, Y.5    Furukawa, Y.6    Shiomi, M.7    Schoen, F.J.8    Libby, P.9
  • 27
    • 0035916233 scopus 로고    scopus 로고
    • Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques: Implications for plaque stabilization
    • M Crisby G Nordin-Fredriksson PK Shah, et al. 2001 Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques: implications for plaque stabilization Circulation 103 926 933 11181465 1:CAS:528: DC%2BD3MXit1Cru70%3D (Pubitemid 32183796)
    • (2001) Circulation , vol.103 , Issue.7 , pp. 926-933
    • Crisby, M.1    Nordin-Fredriksson, G.2    Shah, P.K.3    Yano, J.4    Zhu, J.5    Nilsson, J.6
  • 28
    • 0001539238 scopus 로고    scopus 로고
    • Effects of statins on vascular wall: Vasomotor function, inflammation, and plaque stability
    • 10974215 10.1016/S0008-6363(00)00146-2 1:CAS:528:DC%2BD3cXmt1WqtLk%3D
    • KK Koh 2000 Effects of statins on vascular wall: vasomotor function, inflammation, and plaque stability Cardiovasc Res 47 648 657 10974215 10.1016/S0008-6363(00)00146-2 1:CAS:528:DC%2BD3cXmt1WqtLk%3D
    • (2000) Cardiovasc Res , vol.47 , pp. 648-657
    • Koh, K.K.1
  • 29
    • 63649095045 scopus 로고    scopus 로고
    • Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: A prospective study of the JUPITER trial
    • 19329177 10.1016/S0140-6736(09)60447-5 1:CAS:528:DC%2BD1MXktV2gsL8%3D
    • PM Ridker E Danielson FA Fonseca, et al. 2009 Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial Lancet 373 1175 1182 19329177 10.1016/S0140-6736(09)60447-5 1:CAS:528:DC%2BD1MXktV2gsL8%3D
    • (2009) Lancet , vol.373 , pp. 1175-1182
    • Ridker, P.M.1    Danielson, E.2    Fonseca, F.A.3
  • 30
    • 73249141160 scopus 로고    scopus 로고
    • Effect of rosuvastatin on coronary atheroma in stable coronary artery disease: Multicenter coronary atherosclerosis study measuring effects of rosuvastatin using intravascular ultrasound in Japanese subjects (COSMOS)
    • 19801853 10.1253/circj.CJ-09-0358 1:CAS:528:DC%2BD1MXhsVKgsbzE
    • T Takayama T Hiro M Yamagishi, et al. 2009 Effect of rosuvastatin on coronary atheroma in stable coronary artery disease: Multicenter coronary atherosclerosis study measuring effects of rosuvastatin using intravascular ultrasound in Japanese subjects (COSMOS) Circ J 73 2110 2117 19801853 10.1253/circj.CJ-09-0358 1:CAS:528:DC%2BD1MXhsVKgsbzE
    • (2009) Circ J , vol.73 , pp. 2110-2117
    • Takayama, T.1    Hiro, T.2    Yamagishi, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.