-
1
-
-
0018939225
-
Mevinolin: A highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent
-
DOI 10.1073/pnas.77.7.3957
-
AW Alberts J Chen G Kuron, et al. 1980 Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent Proc Natl Acad Sci USA 77 3957 3961 6933445 10.1073/pnas.77.7.3957 1:CAS:528:DyaL3cXlvFOlurk%3D (Pubitemid 10015499)
-
(1980)
Proceedings of the National Academy of Sciences of the United States of America
, vol.77
, Issue.7
, pp. 3957-3961
-
-
Alberts, A.W.1
Chen, J.2
Kuron, G.3
-
2
-
-
0023754423
-
Discovery, biochemistry and biology of lovastatin
-
AW Alberts 1988 Discovery, biochemistry and biology of lovastatin Am J Cardiol 62 10J 15J 3055919 10.1016/0002-9149(88)90002-1 1:CAS:528: DyaL1MXjtlajug%3D%3D (Pubitemid 18263851)
-
(1988)
American Journal of Cardiology
, vol.62
, Issue.15
-
-
Alberts, A.W.1
-
3
-
-
0035843962
-
Structural mechanism for statin inhibition of HMG-CoA reductase
-
DOI 10.1126/science.1059344
-
ES Istvan J Deisenhofer 2001 Structural mechanism for statin inhibition of HMG-CoA reductase Science 292 1160 1164 11349148 10.1126/science.1059344 1:CAS:528:DC%2BD3MXjs1Cgtbo%3D (Pubitemid 32440937)
-
(2001)
Science
, vol.292
, Issue.5519
, pp. 1160-1164
-
-
Istvan, E.S.1
Deisenhofer, J.2
-
4
-
-
0037031061
-
MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: A randomised placebo-controlled trial
-
DOI 10.1016/S0140-6736(02)09327-3
-
Group Heart Protection Study Collaborative 2002 MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20536 high-risk individuals: a randomised placebo-controlled trial Lancet 360 7 22 10.1016/S0140-6736(02) 09327-3 (Pubitemid 34756487)
-
(2002)
Lancet
, vol.360
, Issue.9326
, pp. 7-22
-
-
Collins, R.1
Armitage, J.2
Parish, S.3
Sleight, P.4
Peto, R.5
-
5
-
-
33645384019
-
Effects of statins beyond lipid lowering: Potential for clinical benefits
-
16054715 10.1016/j.ijcard.2005.05.056
-
K Almuti R Rimawi D Spevack, et al. 2006 Effects of statins beyond lipid lowering: potential for clinical benefits Int J Cardiol 109 7 15 16054715 10.1016/j.ijcard.2005.05.056
-
(2006)
Int J Cardiol
, vol.109
, pp. 7-15
-
-
Almuti, K.1
Rimawi, R.2
Spevack, D.3
-
6
-
-
29444438428
-
Clinical implications for statin pleiotropy
-
JK Liao 2005 Clinical implications for statin pleiotropy Curr Opin Lipidol 16 624 629 16276239 10.1097/01.mol.0000191913.16321.60 1:CAS:528:DC%2BD2MXhtFymtb%2FL (Pubitemid 43012159)
-
(2005)
Current Opinion in Lipidology
, vol.16
, Issue.6
, pp. 624-629
-
-
Liao, J.K.1
-
7
-
-
77958541531
-
The pleiotropic effects of the hydroxy-methyl-glutaryl-CoA reductase inhibitors in cardiovascular disease: A comprehensive review
-
20926939 10.1097/CRD.0b013e3181f52a7f
-
CG Mihos MJ Salas O Santana 2010 The pleiotropic effects of the hydroxy-methyl-glutaryl-CoA reductase inhibitors in cardiovascular disease: a comprehensive review Cardiol Rev 18 298 304 20926939 10.1097/CRD. 0b013e3181f52a7f
-
(2010)
Cardiol Rev
, vol.18
, pp. 298-304
-
-
Mihos, C.G.1
Salas, M.J.2
Santana, O.3
-
8
-
-
77951709095
-
Pleiotropic effects of statins.-basic research and clinical perspectives
-
20424337 10.1253/circj.CJ-10-0110 1:CAS:528:DC%2BC3cXms1ajsbw%3D
-
Q Zhou JK Liao 2010 Pleiotropic effects of statins.-basic research and clinical perspectives Circ J. 74 818 826 20424337 10.1253/circj.CJ-10-0110 1:CAS:528:DC%2BC3cXms1ajsbw%3D
-
(2010)
Circ J.
, vol.74
, pp. 818-826
-
-
Zhou, Q.1
Liao, J.K.2
-
9
-
-
77951716673
-
Basic science review: Statin therapy-Part I: The pleiotropic effects of statins in cardiovascular disease
-
10.1177/1538574410362922
-
B Sadowitz KG Maier V Gahtan 2010 Basic science review: statin therapy-Part I: the pleiotropic effects of statins in cardiovascular disease Vasc Endovasc Surg. 44 241 251 10.1177/1538574410362922
-
(2010)
Vasc Endovasc Surg.
, vol.44
, pp. 241-251
-
-
Sadowitz, B.1
Maier, K.G.2
Gahtan, V.3
-
10
-
-
0025120211
-
Regulation of the mevalonate pathway
-
DOI 10.1038/343425a0
-
JL Goldstein MS Brown 1990 Regulation of the mevalonate pathway Nature 343 425 430 1967820 10.1038/343425a0 1:CAS:528:DyaK3cXhtlCmtbw%3D (Pubitemid 20065229)
-
(1990)
Nature
, vol.343
, Issue.6257
, pp. 425-430
-
-
Goldstein, J.L.1
Brown, M.S.2
-
11
-
-
0030968580
-
Rho GTPases and signaling networks
-
L Van Aelst C D'Souza-Schorey 1997 Rho GTPases and signaling networks Genes Dev 11 2295 2322 9308960 10.1101/gad.11.18.2295 (Pubitemid 27408529)
-
(1997)
Genes and Development
, vol.11
, Issue.18
, pp. 2295-2322
-
-
Van Aelst, L.1
D'Souza-Schorey, C.2
-
12
-
-
0032568874
-
G proteins and small GTpases: Distant relatives keep in touch
-
DOI 10.1126/science.280.5372.2074
-
A Hall 1998 G proteins and small GTPases: distant relatives keep in touch Science 280 2074 2075 9669963 10.1126/science.280.5372.2074 1:CAS:528:DyaK1cXkt1Ggsrw%3D (Pubitemid 28366192)
-
(1998)
Science
, vol.280
, Issue.5372
, pp. 2074-2075
-
-
Hall, A.1
-
13
-
-
0026640530
-
Post-translational modifications of p21rho proteins
-
1400319 1:CAS:528:DyaK38XlsVGlsbk%3D
-
P Adamson CJ Marshall A Hall PA Tilbrook 1992 Post-translational modifications of p21rho proteins J Biol Chem 267 20033 20038 1400319 1:CAS:528:DyaK38XlsVGlsbk%3D
-
(1992)
J Biol Chem
, vol.267
, pp. 20033-20038
-
-
Adamson, P.1
Marshall, C.J.2
Hall, A.3
Tilbrook, P.A.4
-
14
-
-
20444432732
-
Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl- CoA reductase inhibition: A role for RhoA in ABCA1-mediated cholesterol efflux
-
DOI 10.1074/jbc.M502761200
-
CA Argmann JY Edwards CG Sawyez, et al. 2005 Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition J Biol Chem 280 22212 22221 15817453 10.1074/jbc.M502761200 1:CAS:528: DC%2BD2MXksl2htro%3D (Pubitemid 40827878)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.23
, pp. 22212-22221
-
-
Argmann, C.A.1
Edwards, J.Y.2
Sawyez, C.G.3
O'Neil, C.H.4
Hegele, R.A.5
Pickering, J.G.6
Huff, M.W.7
-
15
-
-
0028935780
-
Protein lipidation in cell signaling
-
7716512 10.1126/science.7716512 1:CAS:528:DyaK2MXltVCitLs%3D
-
PJ Casey 1995 Protein lipidation in cell signaling Science 268 221 225 7716512 10.1126/science.7716512 1:CAS:528:DyaK2MXltVCitLs%3D
-
(1995)
Science
, vol.268
, pp. 221-225
-
-
Casey, P.J.1
-
16
-
-
0033826581
-
The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
-
10973320 10.1038/79510 1:CAS:528:DC%2BD3cXmslSjsL0%3D
-
Y Kureishi Z Luo I Shiojima, et al. 2000 The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals Nat Med 6 1004 1010 10973320 10.1038/79510 1:CAS:528:DC%2BD3cXmslSjsL0%3D
-
(2000)
Nat Med
, vol.6
, pp. 1004-1010
-
-
Kureishi, Y.1
Luo, Z.2
Shiojima, I.3
-
17
-
-
33845707278
-
Statins activate AMP-activated protein kinase in vitro and in vivo
-
DOI 10.1161/CIRCULATIONAHA.106.630194, PII 0000301720061212000015
-
W Sun T-S Lee MJ Zhu, et al. 2006 Statins activate AMP-activated kinase in vitro and in vivo Circulation 114 2655 2662 17116771 10.1161/CIRCULATIONAHA. 106.630194 1:CAS:528:DC%2BD28Xht1Ohu7zP (Pubitemid 44967349)
-
(2006)
Circulation
, vol.114
, Issue.24
, pp. 2655-2662
-
-
Sun, W.1
Lee, T.-S.2
Zhu, M.3
Gu, C.4
Wang, Y.5
Zhu, Y.6
Shyy, J.Y.-J.7
-
18
-
-
53449093439
-
AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells via eNOS-derived NO
-
10.1161/ATVBAHA.108.172452
-
X Li Y Han W Pang, et al. 2008 AMP-activated protein kinase promotes the differentiation of endothelial progenitor cells via eNOS-derived NO Arterio Thromb Vasc Biol. 28 1789 1795 10.1161/ATVBAHA.108.172452
-
(2008)
Arterio Thromb Vasc Biol.
, vol.28
, pp. 1789-1795
-
-
Li, X.1
Han, Y.2
Pang, W.3
-
19
-
-
0032584177
-
Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors
-
U Laufs V La Fata J Plutzky, et al. 1998 Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors Circulation 97 1129 1135 9537338 1:CAS:528:DyaK1cXisVWmsrY%3D (Pubitemid 28152885)
-
(1998)
Circulation
, vol.97
, Issue.12
, pp. 1129-1135
-
-
Laufs, U.1
La Fata, V.2
Plutzky, J.3
Liao, J.K.4
-
20
-
-
0031451344
-
Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase
-
DOI 10.1074/jbc.272.50.31725
-
U Laufs V La Fata JK Liao 1997 Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase J Biol Chem 272 31725 31729 9395516 10.1074/jbc.272.50. 31725 1:CAS:528:DyaK2sXotVSkurY%3D (Pubitemid 28013321)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.50
, pp. 31725-31729
-
-
Laufs, U.1
La Fata, V.2
Liao, J.K.3
-
21
-
-
34249723258
-
Statins activate peroxisome proliferator-activated receptor γ through extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent cyclooxygenase-2 expression in macrophages
-
DOI 10.1161/01.RES.0000268411.49545.9c
-
M Yano T Matsumura T Senokuchi, et al. 2007 Statins activate peroxisome proliferator-activated receptor gamma through extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent cyclooxygenase-2 expression in macrophages Circ Res 100 1442 1451 17463321 10.1161/01.RES. 0000268411.49545.9c 1:CAS:528:DC%2BD2sXltl2ntr4%3D (Pubitemid 46834756)
-
(2007)
Circulation Research
, vol.100
, Issue.10
, pp. 1442-1451
-
-
Yano, M.1
Matsumura, T.2
Senokuchi, T.3
Ishii, N.4
Murata, Y.5
Taketa, K.6
Motoshima, H.7
Taguchi, T.8
Sonoda, K.9
Kukidome, D.10
Takuwa, Y.11
Kawada, T.12
Brownlee, M.13
Nishikawa, T.14
Araki, E.15
-
22
-
-
46849111226
-
Benefit of adding Pioglitazone to successful statin therapy in nondiabetic patients with coronary artery disease
-
DOI 10.1253/circj.72.1193
-
K Sugamura S Sugiyama Y Matsuzawa, et al. 2008 Benefit of adding pioglitazone to successful statin therapy in nondiabetic patients with coronary artery disease Circ J 72 1193 1197 18577834 10.1253/circj.72.1193 1:CAS:528:DC%2BD1cXovFelt78%3D (Pubitemid 351957091)
-
(2008)
Circulation Journal
, vol.72
, Issue.7
, pp. 1193-1197
-
-
Sugamura, K.1
Sugiyama, S.2
Matsuzawa, Y.3
Nozaki, T.4
Horibata, Y.5
Ogawa, H.6
-
23
-
-
0036445650
-
Modulation of inflammatory mediators and PPARγ and NFκB expression by pravastatin in response to lipoproteins in human monocytes in vitro
-
DOI 10.1006/phrs.2001.0922
-
I Zelvyte R Dominaitiene M Crisby S Janciauskiene 2002 Modulation of inflammatory mediators and PPARgamma and NFkappaB expression by pravastatin in response to lipoproteins in human monocytes in vitro Pharmacol Res 45 147 154 11846628 10.1006/phrs.2001.0922 1:CAS:528:DC%2BD38XhtFCltLc%3D (Pubitemid 35425654)
-
(2002)
Pharmacological Research
, vol.45
, Issue.2
, pp. 147-154
-
-
Zelvyte, I.1
Dominaitiene, R.2
Crisby, M.3
Janciauskiene, S.4
-
24
-
-
0842309101
-
The Selective Peroxisomal Proliferator-Activated Receptor-Gamma Agonist Has an Additive Effect on Plaque Regression in Combination with Simvastatin in Experimental Atherosclerosis: In Vivo Study by High-Resolution Magnetic Resonance Imaging
-
DOI 10.1016/j.jacc.2003.08.048
-
R Corti JI Osende JT Fallon, et al. 2004 The selective peroxisomal proliferator-activated receptor-gamma agonist has an additive effect on plaque regression in combination with simvastatin in experimental atherosclerosis: in vivo study by high-resolution magnetic resonance imaging J Am Coll Cardiol 43 464 473 15013132 10.1016/j.jacc.2003.08.048 1:CAS:528:DC%2BD2cXitV2jtbY%3D (Pubitemid 38167710)
-
(2004)
Journal of the American College of Cardiology
, vol.43
, Issue.3
, pp. 464-473
-
-
Corti, R.1
Osende, J.I.2
Fallon, J.T.3
Fuster, V.4
Mizsei, G.5
Jneid, H.6
Wright, S.D.7
Chaplin, W.F.8
Badimon, J.J.9
-
25
-
-
84857782055
-
Simvastatin suppresses apoptosis in vulnerable atherosclerotic plaques through regulating the expression of p53, Bcl-2 and Bcl-xL
-
this issue
-
Qin W, Lu Y, Zhan C, et al. Simvastatin suppresses apoptosis in vulnerable atherosclerotic plaques through regulating the expression of p53, Bcl-2 and Bcl-xL. Cardiovasc Drugs Ther 2012;26: this issue
-
(2012)
Cardiovasc Drugs Ther
, pp. 26
-
-
Qin, W.1
Lu, Y.2
Zhan, C.3
-
26
-
-
0035895319
-
An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro
-
M Aikawa E Rabkin S Sugiyama, et al. 2001 An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro Circulation 103 276 283 11208689 1:CAS:528:DC%2BD3MXhtFaitr4%3D (Pubitemid 32095415)
-
(2001)
Circulation
, vol.103
, Issue.2
, pp. 276-283
-
-
Aikawa, M.1
Rabkin, E.2
Sugiyama, S.3
Voglic, S.J.4
Fukumoto, Y.5
Furukawa, Y.6
Shiomi, M.7
Schoen, F.J.8
Libby, P.9
-
27
-
-
0035916233
-
Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques: Implications for plaque stabilization
-
M Crisby G Nordin-Fredriksson PK Shah, et al. 2001 Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques: implications for plaque stabilization Circulation 103 926 933 11181465 1:CAS:528: DC%2BD3MXit1Cru70%3D (Pubitemid 32183796)
-
(2001)
Circulation
, vol.103
, Issue.7
, pp. 926-933
-
-
Crisby, M.1
Nordin-Fredriksson, G.2
Shah, P.K.3
Yano, J.4
Zhu, J.5
Nilsson, J.6
-
28
-
-
0001539238
-
Effects of statins on vascular wall: Vasomotor function, inflammation, and plaque stability
-
10974215 10.1016/S0008-6363(00)00146-2 1:CAS:528:DC%2BD3cXmt1WqtLk%3D
-
KK Koh 2000 Effects of statins on vascular wall: vasomotor function, inflammation, and plaque stability Cardiovasc Res 47 648 657 10974215 10.1016/S0008-6363(00)00146-2 1:CAS:528:DC%2BD3cXmt1WqtLk%3D
-
(2000)
Cardiovasc Res
, vol.47
, pp. 648-657
-
-
Koh, K.K.1
-
29
-
-
63649095045
-
Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: A prospective study of the JUPITER trial
-
19329177 10.1016/S0140-6736(09)60447-5 1:CAS:528:DC%2BD1MXktV2gsL8%3D
-
PM Ridker E Danielson FA Fonseca, et al. 2009 Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial Lancet 373 1175 1182 19329177 10.1016/S0140-6736(09)60447-5 1:CAS:528:DC%2BD1MXktV2gsL8%3D
-
(2009)
Lancet
, vol.373
, pp. 1175-1182
-
-
Ridker, P.M.1
Danielson, E.2
Fonseca, F.A.3
-
30
-
-
73249141160
-
Effect of rosuvastatin on coronary atheroma in stable coronary artery disease: Multicenter coronary atherosclerosis study measuring effects of rosuvastatin using intravascular ultrasound in Japanese subjects (COSMOS)
-
19801853 10.1253/circj.CJ-09-0358 1:CAS:528:DC%2BD1MXhsVKgsbzE
-
T Takayama T Hiro M Yamagishi, et al. 2009 Effect of rosuvastatin on coronary atheroma in stable coronary artery disease: Multicenter coronary atherosclerosis study measuring effects of rosuvastatin using intravascular ultrasound in Japanese subjects (COSMOS) Circ J 73 2110 2117 19801853 10.1253/circj.CJ-09-0358 1:CAS:528:DC%2BD1MXhsVKgsbzE
-
(2009)
Circ J
, vol.73
, pp. 2110-2117
-
-
Takayama, T.1
Hiro, T.2
Yamagishi, M.3
|