Indomethacin uptake into poly(2-hydroxyethyl methacrylate-co-3,9-divinyl-2, 4,8,10-tetraoxaspiro [5.5]-undecane) network: In vitro and in vivo controlled release study

International Journal of Pharmaceutics

Volumn 426, Issue 1-2, 2012, Pages 90-99

  Nita, Loredana E ^a   Chiriac, Aurica P ^a   Nistor, Manuela T ^a   Tartau, Liliana ^b  

^a PETRU PONI INSTITUTE OF MACROMOLECULAR CHEMISTRY   (Romania)

^b GRIGORE T POPA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

2 Hydroxyethyl methacrylate; Controlled release; Copolymer network; In vitro and In vivo; Indomethacin; Spiroacetal moiety

Indexed keywords

COPOLYMER; INDOMETACIN; POLY (2 HYDROXYETHYL METHACRYLATE CO 3,9 DIVINYL 2,4,8,10 TETRAOXASPIRO [5 5] UNDECANE); UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BIOCOMPATIBILITY; CHEMICAL STRUCTURE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; MALE; MOUSE; NOCICEPTION; NONHUMAN; PH; POLYMERIZATION; PRIORITY JOURNAL; ROOM TEMPERATURE; SCANNING ELECTRON MICROSCOPY; TAIL FLICK TEST; THERMOGRAVIMETRY; THERMOSTABILITY; WRITHING TEST;

ACETIC ACID; ADMINISTRATION, ORAL; ANALGESICS; ANIMALS; BEHAVIOR, ANIMAL; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DISEASE MODELS, ANIMAL; DRUG CARRIERS; DRUG COMPOUNDING; HYDROGEN-ION CONCENTRATION; INDOMETHACIN; KINETICS; MALE; MICE; MICROSCOPY, ELECTRON, SCANNING; PAIN; PAIN THRESHOLD; PARTICLE SIZE; POLYMERS; POLYMETHACRYLIC ACIDS; REACTION TIME; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SPIRO COMPOUNDS; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; THERMOGRAVIMETRY;

EID: 84857790470     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.01.028     Document Type: Article

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