Chromosome-and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation

Nature Cell Biology

Volumn 14, Issue 3, 2012, Pages 311-317

  Kiyomitsu, Tomomi ^a   Cheeseman, Iain M ^a  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DYNACTIN; DYNEIN ADENOSINE TRIPHOSPHATASE; LGN PROTEIN; NUMA PROTEIN; POLO LIKE KINASE 1; RAN PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELLULAR DISTRIBUTION; CHROMOSOME; CONTROLLED STUDY; CYTOPLASM; HELA CELL; HUMAN; HUMAN CELL; MITOSIS SPINDLE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SPINDLE POLE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, NUCLEAR; BLOTTING, WESTERN; CELL CYCLE PROTEINS; CENTRIOLES; CHROMOSOME SEGREGATION; CYTOPLASMIC DYNEINS; DYNEINS; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICROSCOPY, FLUORESCENCE; MICROTUBULE-ASSOCIATED PROTEINS; MITOSIS; MITOTIC SPINDLE APPARATUS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; NIH 3T3 CELLS; NUCLEAR MATRIX-ASSOCIATED PROTEINS; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; RAN GTP-BINDING PROTEIN; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

EID: 84857788913     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb2440     Document Type: Article

References (28)

1. Grill, S. W. & Hyman, A. A. Spindle positioning by cortical pulling forces. Dev. Cell 8, 461-465 (2005). (Pubitemid 40450736)
2. Glotzer, M. The mechanism and control of cytokinesis. Curr. Opin. Cell Biol. 9, 815-823 (1997). (Pubitemid 27517270)
3. Gonczy, P. Mechanisms of asymmetric cell division:fiies and worms pave the way. Nat. Rev. Mol. Cell Biol. 9, 355-366 (2008). (Pubitemid 351574196)
4. Thery, M. et al. The extracellular matrix guides the orientation of the cell division axis. Nat. Cell Biol. 7, 947-953 (2005). (Pubitemid 41486267)
5. Toyoshima, F. & Nishida, E. Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1-and myosin X-dependent manner. EMBO J. 26, 1487-1498 (2007). (Pubitemid 46480928)
6. Siller, K. H. & Doe, C. Q. Spindle orientation during asymmetric cell division. Nat. Cell Biol. 11, 365-374 (2009).
7. Kardon, J. R. & Vale, R. D. Regulators of the cytoplasmic dynein motor. Nat. Rev. Mol. Cell Biol. 10, 854-865 (2009).
8. Woodard, G. E. et al. Ric-8A and Gi recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle. Mol. Cell Biol. 30, 3519-3530 (2010).
9. Du, Q. & Macara, I. G. Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins. Cell 119, 503-516 (2004). (Pubitemid 39482350)
10. Sumara, I. et al. Roles of polo-like kinase 1 in the assembly of functional mitotic spindles. Curr. Biol. 14, 1712-1722 (2004). (Pubitemid 39301160)
11. Bayliss, R., Sardon, T., Vernos, I. & Conti, E. Structural basis of Aurora-A activation by TPX2 at the mitotic spindle. Mol. Cell 12, 851-862 (2003). (Pubitemid 37352779)
12. Lampson, M. A. & Cheeseman, I. M. Sensing centromere tension: Aurora B and the regulation of kinetochore function. Trends Cell Biol. 21, 133-140 (2011).
13. Kalab, P., Weis, K. & Heald, R. Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extracts. Science 295, 2452-2456 (2002). (Pubitemid 34270259)
14. Kalab, P. & Heald, R. The RanGTP gradient-a GPS for the mitotic spindle. J. Cell Sci. 121, 1577-1586 (2008). (Pubitemid 351911814)
15. Kornbluth, S., Dasso, M. & Newport, J. Evidence for a dual role for TC4 protein in regulating nuclear structure and cell cycle progression. J. Cell Biol. 125, 705-719 (1994). (Pubitemid 24151168)
16. Nishitani, H. et al. Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis. EMBO J. 10, 1555-1564 (1991). (Pubitemid 21905620)
17. Wiese, C. et al. Role of importin-β in coupling Ran to downstream targets in microtubule assembly. Science 291, 653-656 (2001). (Pubitemid 32150424)
18. Nachury, M. V. et al. Importin β is a mitotic target of the small GTPase Ran in spindle assembly. Cell 104, 95-106 (2001). (Pubitemid 32144975)
19. Wee, B., Johnston, C. A., Prehoda, K. E. & Doe, C. Q. Canoe binds RanGTP to promote PinsTPR/Mud-mediated spindle orientation. J. Cell Biol. 195, 369-376 (2011).
20. Fink, J. et al. External forces control mitotic spindle positioning. Nat. Cell Biol. 13, 771-778 (2011).
21. Knoblich, J. A. Asymmetric cell division: recent developments and their implications for tumour biology. Nat. Rev. Mol. Cell Biol. 11, 849-860 (2010).
22. Kline, S. L., Cheeseman, I. M., Hori, T., Fukagawa, T. & Desai, A. The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation. J. Cell Biol. 173, 9-17 (2006).
23. Cheeseman, I. M. et al. A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. Genes Dev. 18, 2255-2268 (2004). (Pubitemid 39209574)
24. Schmidt, J. C. et al. Aurora B kinase controls the targeting of the Astrin-SKAP complex to bioriented kinetochores. J. Cell Biol. 191, 269-280 (2010).
25. Hutchins, J. R. et al. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science 328, 593-599 (2010).
26. Cheeseman, I. M. & Desai, A. A combined approach for the localization and tandem affinity purification of protein complexes from metazoans. Sci. STKE 2005, p11 (2005).
27. Washburn, M. P., Wolters, D. & Yates, J. R. 3rd Large-scale analysis of the yeast proteome by multidimensional protein identification technology. Nat. Biotechnol. 19, 242-247 (2001). (Pubitemid 32220565)
28. Weis, K., Dingwall, C. & Lamond, A. I. Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities. EMBO J. 15, 7120-7128 (1996). (Pubitemid 27023282)