Sustained miRNA-mediated knockdown of mutant AAT with simultaneous augmentation of wild-type AAT has minimal effect on global liver miRNA profiles

Molecular Therapy

Volumn 20, Issue 3, 2012, Pages 590-600

  Mueller, Christian ^a   Tang, Qiushi ^a,b   Gruntman, Alisha ^a   Blomenkamp, Keith ^c   Teckman, Jeffery ^c   Song, Lina ^a   Zamore, Phillip D ^a   Flotte, Terence R ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b Population Life Science and Technology Research Institute of Jilin Province   (China)

^c SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; MICRORNA; PARVOVIRUS VECTOR; SHORT HAIRPIN RNA;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE SILENCING; GENE TARGETING; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRON; LIVER; LIVER CELL; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TRANSCRIPTION INITIATION SITE; VIRAL GENE DELIVERY SYSTEM;

ADENO-ASSOCIATED VIRUS; ANIMALIA; MUS MUSCULUS;

EID: 84857787568     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2011.292     Document Type: Article

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