Transcription of genes in the biosynthetic pathway for fumonisin mycotoxins is epigenetically and differentially regulated in the fungal maize pathogen fusarium verticillioides

Eukaryotic Cell

Volumn 11, Issue 3, 2012, Pages 252-259

  Visentin, I ^a   Montis, V ^a   Doll K ^b   Alabouvette, C ^c   Tamietti, G ^a   Karlovsky, P ^b   Cardinale, F ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c UNIVERSITÉ DE BOURGOGNE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FUMONISIN; HISTONE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; MYCOTOXIN;

ACETYLATION; ARTICLE; BIOSYNTHESIS; CHROMATIN; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMATIN IMMUNOPRECIPITATION; DRUG EFFECT; FUNGAL GENE; FUSARIUM; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETIC TRANSCRIPTION; GENETICS; MAIZE; METABOLISM; MICROBIOLOGY; MULTIGENE FAMILY; PHYSIOLOGY; PROMOTER REGION;

ACETYLATION; CHROMATIN; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMATIN IMMUNOPRECIPITATION; EPIGENESIS, GENETIC; FUMONISINS; FUSARIUM; GENE EXPRESSION REGULATION, FUNGAL; GENES, FUNGAL; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HISTONES; MULTIGENE FAMILY; MYCOTOXINS; PROMOTER REGIONS, GENETIC; TRANSCRIPTION, GENETIC; ZEA MAYS;

ANIMALIA; FUNGI; GIBBERELLA; GIBBERELLA FUJIKUROI; GIBBERELLA MONILIFORMIS; MONILIFORMIS; ZEA MAYS;

EID: 84857776423     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.05159-11     Document Type: Article

References (37)

1. Bojja RS, Cerny RL, Proctor RH, Du L. 2004. Determining the biosynthetic sequence in the early steps of the fumonisin pathway by use of three gene-disruption mutants of Fusarium verticillioides. J. Agric. Food Chem. 52:2855-2860.
2. Bok JW, et al. 2006. Genomic mining for Aspergillus natural products. Chem. Biol. 13:31-37.
3. Bok JW, Keller NP. 2004. LaeA, a regulator of secondary metabolism in Aspergillus spp. Eukaryot. Cell 3:527-535.
4. Bok JW, Noordermeer D, Kale SP, Keller NP. 2006. Secondary metabolic gene cluster silencing in Aspergillus nidulans. Mol. Microbiol. 61: 1636-1645.
5. Brown DW, Butchko RA, Busman M, Proctor RH. 2007. The Fusarium verticillioides FUM gene cluster encodes a Zn(II)2Cys6 protein that affects FUM gene expression and fumonisin production. Eukaryot. Cell 6:1210-1218.
6. Brown RL, Cleveland TE, Woloshuk CP, Payne GA, Bhatnagar D. 2001. Growth inhibition of a Fusarium verticillioides GUS strain in corn kernels of aflatoxin-resistant genotypes. Appl. Microbiol. Biotechnol. 57:708-711.
7. Field B, et al. 2011. Formation of plant metabolic gene clusters within dynamic chromosomal regions. Proc. Natl. Acad. Sci. U. S. A. 108:16116-16121.
8. Flaherty JE, Pirttila AM, Bluhm BH, Woloshuk CP. 2003. PAC1, a pH-regulatory gene from Fusarium verticillioides. Appl. Environ. Microbiol. 69:5222-5227.
9. Guether M, et al. 2009. Genome-wide reprogramming of regulatory networks, transport, cell wall and membrane biogenesis during arbuscular mycorrhizal symbiosis in Lotus japonicus. New Phytol. 182:200-212.
10. Keller NP, Turner G, Bennet JW. 2005. Fungal secondary metabolism- from biochemistry to genomics. Nat. Rev. Microbiol. 3:937-947.
11. Keller NP, Hohn TM. 1997. Metabolic pathway gene clusters in filamentous fungi. Fungal Genet. Biol. 21:17-29.
12. Li Y, et al. 2011. The HDF1 histone deacetylase gene is important for conidiation, sexual reproduction, and pathogenesis in Fusarium graminearum. Mol. Plant Microbe Interact. 24:487-496.
13. Mueller JE, Canze M, Bryk M. 2006. The requirements for COMPASS and Paf1 in transcriptional silencing and methylation of histone H3 in Saccharomyces cerevisiae. Genetics 173:557-567.
14. Myung K, et al. 2009. FvVE1 regulates biosynthesis of the mycotoxins fumonisins and fusarins in Fusarium verticillioides. J. Agric. Food Chem. 57:5089-5094.
15. Ng HH, Bird A. 2000. Histone deacetylases: silencers for hire. Trends Biochem. Sci. 25:121-126.
16. Palmer JM, Keller NP. 2010. Secondary metabolism in fungi: does chromosomal location matter? Curr. Opin. Microbiol. 13:431-436.
17. Picot A, et al. 2010. Factors of the Fusarium verticillioides-maize environment modulating fumonisin production. Crit. Rev. Microbiol. 36:221-231.
18. Proctor RH, Brown DW, Plattner RD, Desjardins AE. 2003. Coexpression of 15 contiguous genes delineates a fumonisin biosynthetic gene cluster in Gibberella moniliformis. Fungal Genet. Biol. 38:237-249.
19. Proctor RH, Desjardins AE, Plattner RD, Hohn TM. 1999. A polyketide synthase gene required for biosynthesis of fumonisin mycotoxins in Gibberella fujikuroi mating population A. Fungal Genet. Biol. 27:100-112.
20. Proctor RH, Hohn TM, McCormick SP. 1995. Reduced virulence of Gibberella zeae caused by disruption of a trichothecene toxin biosynthetic gene. Mol. Biol. Evol. 8:593-601.
21. Qi X, et al. 2004. A gene cluster for secondary metabolism in oat: implications for the evolution of metabolic diversity in plants. Proc. Natl. Acad. Sci. U. S. A. 101:8233-8238.
22. Reyes-Dominguez Y, et al. 2010. Heterochromatic marks are associated with the repression of secondary metabolism clusters in Aspergillus nidulans. Mol. Microbiol. 76:1376-1386.
23. Rheeder JP, Marasas WF, Vismer HF. 2002. Production of fumonisin analogs by Fusarium species. Appl. Environ. Microbiol. 68:2101-2105.
24. Roth SY, Denu JM, Allis CD. 2001. Histone acetyltransferases. Annu. Rev. Biochem. 70:81-120.
25. Roze LV, Arthur AE, Hong SY, Chanda A, Linz JE. 2007. The initiation and pattern of spread of histone H4 acetylation parallel the order of transcriptional activation of genes in the aflatoxin cluster. Mol. Microbiol. 66:713-726.
26. Seo JA, Proctor RH, Plattner RD. 2001. Characterization of four clustered and coregulated genes associated with fumonisin biosynthesis in Fusarium verticillioides. Fungal Genet. Biol. 34:155-165.
27. Shim WB, Woloshuk CP. 2001. Regulation of fumonisin B(1) biosynthesis and conidiation in Fusarium verticillioides by a cyclin-like (C-type) gene, FCC1. Appl. Environ. Microbiol. 67:1607-1612.
28. Shwab EK, et al. 2007. Histone deacetylase activity regulates chemical diversity in Aspergillus. Eukaryot. Cell 6:1656-1664.
29. Shwab EK, Keller NP. 2008. Regulation of secondary metabolite production in filamentous ascomycetes. Mycol. Res. 112:225-230.
30. Strauss J, Reyes-Dominguez Y. 2011. Regulation of secondary metabolism by chromatin structure and epigenetic codes. Fungal Genet. Biol. 48:62-69.
31. Takken FL, et al. 2004. A one-step method to convert vectors into binary vectors suited for Agrobacterium-mediated transformation. Curr. Genet. 45:242-248.
32. Trojer P, et al. 2003. Histone deacetylases in fungi: novel members, new facts. Nucleic Acids Res. 31:3971-3981.
33. van Driel R, Fransz PF, Verschure PJ. 2003. The eukaryotic genome: a system regulated at different hierarchical levels. J. Cell Sci. 116:4067-4075.
34. Visentin I, et al. 2009. The ITS region as a taxonomic discriminator between Fusarium verticillioides and Fusarium proliferatum. Mycol. Res. 113:1137-1145.
35. Williams LD, et al. 2007. Fumonisin disruption of ceramide biosynthesis in maize roots and the effects on plant development and Fusarium verticillioides-induced seedling disease. J. Agric. Food Chem. 55:2937-2946.
36. Williams RB, Henrikson JC, Hoover AR, Lee AE, Cichewicz RH. 2008. Epigenetic remodeling of the fungal secondary metabolome. Org. Biomol. Chem. 6:1895-1897.
37. Zhang Y, Choi YE, Zou X, Xu JR. 2011. The FvMK1 mitogen-activated protein kinase gene regulates conidiation, pathogenesis, and fumonisin production in Fusarium verticillioides. Fungal Genet. Biol. 48:71-79.