Adverse drug reactions in children-A systematic review

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Smyth, Rebecca Mary Diane ^a   Gargon, Elizabeth ^b   Kirkham, Jamie ^b   Cresswell, Lynne ^b   Golder, Su ^c   Smyth, Rosalind ^b   Williamson, Paula ^b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c UNIVERSITY OF YORK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; ANTICONVULSIVE AGENT; ANTIHISTAMINIC AGENT; ANTIINFECTIVE AGENT; BRONCHODILATING AGENT; CORTICOSTEROID; CYTOTOXIC AGENT; DIURETIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; STEROID; VACCINE;

ABDOMINAL PAIN; ADRENAL SUPPRESSION; ADVERSE DRUG REACTION; AGGRESSIVENESS; ALOPECIA; ANAPHYLAXIS; ANEMIA; ANGIONEUROTIC EDEMA; ANOREXIA; APHASIA; APLASTIC ANEMIA; APNEA; ARTHROPATHY; ATAXIA; BACKACHE; BRAIN DISEASE; CATARACT; CENTRAL NERVOUS SYSTEM DISEASE; CEREBELLUM DISEASE; CHEILITIS; CHILD; CHILD HOSPITALIZATION; CLINICAL FEATURE; COLITIS; COMA; CONSTIPATION; CONVULSION; CUSHING SYNDROME; CUSHINGOID SYNDROME; DIABETES MELLITUS; DIARRHEA; DIURESIS; DIZZINESS; DROWSINESS; DRUG CLASSIFICATION; DRUG ERUPTION; DRUG EXPOSURE; DRUG FATALITY; DRUG FEVER; DRUG HYPERSENSITIVITY; DRUG INDUCED HEADACHE; DRUG SAFETY; EOSINOPHILIA; ERYTHEMA; ERYTHEMA MULTIFORME; FEBRILE CONVULSION; FEVER; GASTRITIS; GASTROINTESTINAL DISEASE; GASTROINTESTINAL SYMPTOM; HEAD LAG; HEALING IMPAIRMENT; HEMATEMESIS; HEMATURIA; HOSPITAL ADMISSION; HOSPITALIZED CHILD; HOT FLUSH; HUMAN; HYPERACTIVITY; HYPERGLYCEMIA; HYPERHIDROSIS; HYPERTENSION; HYPERTRANSAMINASEMIA; HYPOTONIC HYPORESPONSIVE EPISODE; ILEUS; IMMUNE DEFICIENCY; INCIDENCE; INCREASED APPETITE; INJECTION SITE ABSCESS; INJECTION SITE INFLAMMATION; INJECTION SITE PAIN; INTRACRANIAL HYPERTENSION; IRRITABILITY; JAUNDICE; KIDNEY FUNCTION; LETHARGY; LEUKOENCEPHALOPATHY; LEUKOPENIA; LIMB SWELLING; LIVER FAILURE; LIVER FUNCTION TEST; LUNG FUNCTION TEST; MACULOPAPULAR RASH; MELENA; MOTOR DYSFUNCTION; MOTOR REGRESSION; MOUTH ULCER; MUCOCUTANEOUS LYMPH NODE SYNDROME; MUCOSA INFLAMMATION; NAUSEA; NERVOUSNESS; NEURITIS; NEUROLOGIC DISEASE; NEUTROPENIA; OFF LABEL DRUG USE; OUTPATIENT; PALLOR; PAPULAR RASH; PARADOXICAL DRUG REACTION; PERIORBITAL EDEMA; POLYPHARMACY; POSTOPERATIVE HEMORRHAGE; PSYCHOSIS; RASH; RECTUM HEMORRHAGE; RESPIRATION DEPRESSION; RESPIRATORY DISTRESS; REVIEW; REYE SYNDROME; RISK ASSESSMENT; RISK FACTOR; SECONDARY INFECTION; SEDATION; SEIZURE; SEX DIFFERENCE; SIDE EFFECT; SKIN ALLERGY; SKIN MANIFESTATION; SLEEP DISORDER; STEVENS JOHNSON SYNDROME; STOMACH IRRITATION; SYSTEMATIC REVIEW; TACHYCARDIA; THROMBOCYTOPENIA; THROMBOPHLEBITIS; THRUSH; TREMOR; UPPER GASTROINTESTINAL BLEEDING; URTICARIA; VOMITING; XEROSTOMIA; DRUG TOXICITY; HOSPITALIZATION; STATISTICS;

CHILD; DRUG TOXICITY; HOSPITALIZATION; HUMANS; OUTPATIENTS;

EID: 84857772838     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024061     Document Type: Review

References (113)

1. Wester K, Jonsson AK, Spigset O, Druid H, Hagg S, (2008) Incidence of fatal adverse drug reactions: a population based study. Br J Clin Pharmacol 65: 573-579.
2. (WHO) WHO (2002) Safety of Medicines- a guide to detecting and reporting adverse drug reactions.
3. Impicciatore P, Choonara I, Clarkson A, Provasi D, Pandolfini C, et al. (2001) Incidence of adverse drug reactions in paediatric in/out-patients: A systematic review and meta-analysis of prospective studies. British Journal of Clinical Pharmacology 52: 77-83.
4. Clavenna A, Bonati M, (2009) Adverse drug reactions in childhood: a review of prospective studies and safety alerts. Arch Dis Child 94: 724-728.
5. Aagaard L, Christensen A, Hansen EH, (2010) Information about adverse drug reactions reported in children: a qualitative review of empirical studies. Br J Clin Pharmacol 70: 481-491.
6. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, et al. (1981) A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 30: 239-245.
7. Schumock GT, Thornton JP, (1992) Focusing on the preventability of adverse drug reactions. Hospital Pharmacy 27: 538.
8. WHO, (1972) International drug monitoring: the role of national centres. Tech Rep Ser 498.
9. Duczmal E, Breborowicz A, (2006) Adverse drug reactions as a cause of hospital admission. Przeglad Pediatryczny 36: 14-18.
10. Easton KL, Chapman CB, Brien JE, (2004) Frequency and characteristics of hospital admissions associated with drug-related problems in paediatrics. British Journal of Clinical Pharmacology 57: 611-615.
11. Hewitt J, (1995) Drug-related unplanned readmissions to hospital. Australian Journal of Hospital Pharmacy 25: 400-403.
12. Ives TJ, Bentz EJ, Gwyther RE, (1987) Drug-related admissions to a family medicine inpatient service. Archives of Internal Medicine 147: 1117-1120.
13. McDonnell PJ, Jacobs MR, (2002) Hospital admissions resulting from preventable adverse drug reactions.[see comment]. Annals of Pharmacotherapy 36: 1331-1336.
14. McKenzie MW, Marchall GL, Netzloff ML, Cluff LE, (1976) Adverse drug reactions leading to hospitalization in children. Jornal De Pediatria 89: 487-490.
15. Mitchell AA, Lacouture PG, Sheehan JE, Kauffman RE, Shapiro S, (1988) Adverse drug reactions in children leading to hospital admission. Pediatrics 82: 24-29.
16. Santos RP, Benjamin G, Paje-Villar E, (2000) Drug-related hospitalization among pediatric patients in a tertiary hospital Santo Tomas. Journal of Medicine 49: 141-152.
17. van der Hooft CS, Sturkenboom MCJM, van Grootheest K, Kingma HJ, Stricker BHC, (2006) Adverse drug reaction-related hospitalisations: a nationwide study in The Netherlands. Drug Safety 29: 161-168.
18. Yosselson-Superstine S, Weiss T, (1982) Drug-related hospitalization in pediatric patients. J Clin Hosp Pharm 7: 195-203.
19. Bordet R, Gautier S, Le Louet H, Dupuis B, Caron J, (2001) Analysis of the direct cost of adverse drug reactions in hospitalised patients. European Journal of Clinical Pharmacology 56: 935-941.
20. Impicciatore P, Mohn A, Chiarelli F, Pandolfini C, Bonati M, (2002) Adverse drug reactions to off-label drugs on a paediatric ward: An Italian prospective pilot study. Paediatric and Perinatal Drug Therapy 5: 19-24.
21. Kunac DL, Kennedy J, Austin N, Reith D, (2009) Incidence, preventability, and impact of Adverse Drug Events (ADEs) and potential ADEs in hospitalized children in New Zealand: a prospective observational cohort study. Paediatric Drugs 11: 153-160.
22. Le J, Nguyen T, Law AV, Hodding J, (2005) Retrospective analysis of adverse drug reactions in pediatrics over a 10-year period. Pharmacotherapy 25: 1432.
23. Oshikoya KA, Njokanma OF, Chukwura HA, Ojo IO, (2007) Adverse drug reactions in Nigerian children. Paediatric and Perinatal Drug Therapy 8: 81-88.
24. Whyte J, Greenan E, (1977) Drug usage and adverse drug reactions in paediatric patients. Acta Paediatrica Scandinavica 66: 767-775.
25. Al-Tajir GK, Kelly WN, (2005) Epidemiology, comparative methods of detection, and preventability of adverse drug events. Annals of Pharmacotherapy 39: 1169-1174.
26. Buajordet I, Wesenberg F, Brors O, Langslet A, (2002) Adverse drug events in children during hospitalization and after discharge in a Norwegian University Hospital. Acta Paediatrica, International Journal of Paediatrics 91: 88-94.
27. Gallagher, (2011) Adverse drug reactions causing admission to a paediatric hospital: a pilot study. J Clin Pharm Ther 36: 194-199.
28. Speranza N, Lucas L, Telechea H, Santurio A, Giachetto G, et al. (2008) Adverse Drugs Reactions in Hospitalized Children A Public Health Problem. Drug Safety 31 (10): 885-960 doi:10.2165/0002018-200831100-00007.
29. Gallagher, (2011) (2011) Adverse Drug Reactions Causing Admission to a Paediatric Hospital Unpublished.
30. Easton KL, Parsons BJ, Starr M, Brien JE, (1998) The incidence of drug-related problems as a cause of hospital admissions in children. Medical Journal of Australia 169: 356-359.
31. Lamabadusuriya SP, Sathiadas G, (2003) Adverse drug reactions in children requiring hospital admission. Ceylon Medical Journal 48: 86-87.
32. Major S, Badr S, Bahlawan L, Hassan G, Khogaoghlanian T, et al. (1998) Drug-related hospitalization at a tertiary teaching center in Lebanon: Incidence, associations, and relation to self-medicating behavior. Clinical Pharmacology & Therapeutics 64: 450-461.
33. Pouyanne P, Haramburu F, Imbs JL, Begaud B, (2000) Admissions to hospital caused by adverse drug reactions: cross sectional incidence study. French Pharmacovigilance Centres. BMJ 320: 1036.
34. McKenzie MW, Stewart RB, Weiss CF, Cluff LE, (1973) Pharmacist-based study of the epidemiology of adverse drug reactions in pediatric medicine patients. American Journal of Hospital Pharmacy 30: 898-903.
35. Al-Olah YH, Al Thiab KM, (2008) Admissions through the emergency department due to drug-related problems. Annals of Saudi Medicine 28: 426-429.
36. Schneeweiss S, Hasford J, Gottler M, Hoffmann A, Riethling A-K, et al. (2002) Admissions caused by adverse drug events to internal medicine and emergency departments in hospitals: a longitudinal population-based study. European Journal of Clinical Pharmacology 58: 285-291.
37. Jonville-Bera AP, Giraudeau B, Blanc P, Beau-Salinas F, Autret-Leca E, (2002) Frequency of adverse drug reactions in children: A prospective study. British Journal of Clinical Pharmacology 53: 207-210.
38. van der Hooft CS, Dieleman JP, Siemes C, Aarnoudse ALHJ, Verhamme KMC, et al. (2008) Adverse drug reaction-related hospitalisations: A population-based cohort study. Pharmacoepidemiology and Drug Safety 17: 365-371.
39. Gill AM, Leach HJ, Hughes J, Barker C, Nunn AJ, et al. (1995) Adverse drug reactions in a paediatric intensive care unit. Acta Paediatrica, International Journal of Paediatrics 84: 438-441.
40. Haffner S, von Laue N, Wirth S, Thurmann PA, (2005) Detecting adverse drug reactions on paediatric wards- Intensified surveillance versus computerised screening of laboratory values. Drug Safety 28: 453-464.
41. Baniasadi S, Fahimi F, Shalviri G, (2008) Developing an adverse drug reaction reporting system at a teaching hospital. Basic & Clinical Pharmacology & Toxicology 102: 408-411.
42. Classen DC, Pestotnik SL, Evans RS, Burke JP, (1991) Computerized surveillance of adverse drug events in hospital patients. Journal of the American Medical Association 266: 2847-2851.
43. Fincham JE, (1989) Pilot Study of Adr Reporting by Physicians-Phase Ii. ASHP Annual Meeting 46: PI-6.
44. Ramesh M, Pandit J, Parthasarathi G, (2003) Adverse drug reactions in a South Indian hospital- Their severity and cost involved. Pharmacoepidemiology and Drug Safety 12: 687-692.
45. Seidl LG, Thornton GF, Smith JW, Cluff LE, (1966) Studies on the epidemiology of adverse drug reactions III. Reactions in patients on a general medical service The Johns Hopkins Hospital bulletin 119: 299-315.
46. Smidt NA, McQueen EG, (1972) Adverse reactions to drugs: a comprehensive hospital inpatient survey. New Zealand Medical Journal 76: 397-401.
47. Jose J, Rao PGM, (2006) Pattern of adverse drug reactions notified by spontaneous reporting in an Indian tertiary care teaching hospital. Pharmacological Research 54: 226-233.
48. Ganeva M, Gancheva T, Lazarova R, Tzvetanova Y, Hristakieva E, (2007) A prospective study of adverse drug reactions in a dermatology department. Methods & Findings in Experimental & Clinical Pharmacology 29: 107-112.
49. Fattahi F, Pourpak Z, Moin M, Kazemnejad A, Khotoei GT, et al. (2005) Adverse drug reactions in hospitalized children in a department of infectious diseases. Journal of Clinical Pharmacology 45: 1313-1318.
50. Martinez-Mir I, Garcia LM, Palop V, Ferrer JM, Estan L, et al. (1996) A prospective study of adverse drug reactions as a cause of admission to a paediatric hospital. British Journal of Clinical Pharmacology 42: 319-324.
51. Barstow L, Vorce-West T, Butcher B, (1988) Comparative Study of Three Voluntary Adr Reporting Systems. Ashp Midyear Clinical Meeting 23: P-290.
52. Choonara IA, Harris F, (1984) Adverse drug reactions in medical inpatients. Archives of Disease in Childhood 59: 578-580.
53. Dharnidharka VR, Kandoth PN, Anand RK, (1993) Adverse drug reactions in pediatrics with a study of in-hospital intensive surveillance. Indian Pediatrics 30: 745-751.
54. dos Santos DB, Coelho HLL, (2006) Adverse drug reactions in hospitalized children in Fortaleza, Brazil. Pharmacoepidemiology & Drug Safety 15: 635-640.
55. Easton-Carter KL, Chapman CB, Brien JE, (2003) Emergency department attendances associated with drug-related problems in paediatrics. Journal of Paediatrics and Child Health 39: 124-129.
56. Gonzalez-Martin G, Caroca CM, Paris E, (1998) Adverse drug reactions (ADRs) in hospitalized pediatric patients. A prospective study. International Journal of Clinical Pharmacology and Therapeutics 36: 530-533.
57. Jha N, Bajracharya O, Namgyal T, (2007) Prevalence of adverse drug reactions with commonly prescribed drugs in different hospitals of Kathmandu valley.[see comment]. Kathmandu University Medical Journal 5: 504-510.
58. Kaushal R, Bates DW, Landrigan C, McKenna KJ, Clapp MD, et al. (2001) Medication errors and adverse drug events in pediatric inpatients. Journal of the American Medical Association 285: 2114-2120.
59. Takata GS, Mason W, Taketomo C, Logsdon T, Sharek PJ, (2008) Development, testing, and findings of a pediatric-focused trigger tool to identify medication-related harm in US children's hospitals. Pediatrics 121: E927-E935.
60. Takata GS, Taketomo CK, Waite S, (2008) Characteristics of medication errors and adverse drug events in hospitals participating in the California Pediatric Patient Safety Initiative. American Journal of Health-System Pharmacy 65: 2036-2044.
61. Uppal R, Jhaj R, Malhotra S, (2000) Adverse drug reactions among inpatients in a north Indian referral hospital. National Medical Journal of India 13: 16-18.
62. Vazquez de la Villa A, Luna del Castillo JD, Galdo Munoz G, Puche Canas E, (1989) [Adverse reactions caused by drugs in pediatrics]. Anales Espanoles de Pediatria 31: 49-53.
63. Dos Santos L, Martinbiancho JK, Silva MM, da Silva RG, (2009) Adverse Drug Reactions in General Pediatrics Units of a University Hospital. Latin American Journal of Pharmacy 28: 695-699.
64. Wang JK, Herzog NS, Kaushal R, Park C, Mochizuki C, et al. (2007) Prevention of pediatric medication errors by hospital pharmacists and the potential benefit of computerized physician order entry. Pediatrics 119: e77-85.
65. Buckley MS, Erstad BL, Kopp BJ, Theodorou AA, Priestley G, (2007) Direct observation approach for detecting medication errors and adverse drug events in a pediatric intensive care unit.[see comment]. Pediatric Critical Care Medicine 8: 145-152.
66. Shockrollah F, (2009) Adverse drug and medical instrument reactions in a pediatric intensive care unit. Allergy (Oxford) 64: 401.
67. Telechea MS, Lucas N, Giachetto L, Nanni G, Menchaca A, (2010) Importance of drug-induced pathology in an intensive care unit of children. Unpublished data.
68. Benkirane RR, Abouqal R, Haimeur CC, S Ech Cherif El Kettani SS, Azzouzi AA, et al. (2009) Incidence of adverse drug events and medication errors in intensive care units: a prospective multicenter study.[Erratum appears in J Patient Saf. 2010 Mar;6(1):57 Note: R-Abouqal, Redouane [corrected to Abouqal, Redounane]]. Journal of patient safety 5: 16-22.
69. Agarwal S, Classen D, Larsen G, Tofil NM, Hayes LW, et al. (2010) Prevalence of adverse events in pediatric intensive care units in the United States. Pediatr Crit Care Med 11: 568-578.
70. Leach HJ, (1998) Adverse Drug Reactions in Children. Thesis.
71. Neubert A, Dormann H, Weiss J, Egger T, Criegee-Rieck M, et al. (2004) The impact of unlicensed and off-label drug use on adverse drug reactions in paediatric patients. Drug Safety 27: 1059-1067.
72. Neubert A, Dormann H, Weiss J, Criegee-Rieck M, Ackermann A, et al. (2006) Are computerised monitoring systems of value to improve pharmacovigilance in paediatric patients? European Journal of Clinical Pharmacology 62: 959-965.
73. Weiss J, Krebs S, Hoffmann C, Werner U, Neubert A, et al. (2002) Survey of adverse drug reactions on a pediatric ward: A strategy for early and detailed detection. Pediatrics 110: 254-257.
74. Farrokhi S, Nahvi H, Pourpak Z, Moin M, Majdinasab P, et al. (2006) Adverse drug reactions in a department of pediatric surgery. Journal of Tropical Pediatrics 52: 72-73.
75. Imbs JL, Pouyanne P, Haramburu F, Welsch M, Decker N, et al. (1999) [Iatrogenic medication: estimation of its prevalence in French public hospitals. Regional Centers of Pharmacovigilance]. Therapie 54: 21-27.
76. Mitchell AA, Goldman P, Shapiro S, Slone D, (1979) Drug utilization and reported adverse reactions in hospitalized children. American Journal of Epidemiology 110: 196-204.
77. Turner S, Nunn AJ, Fielding K, Choonara I, (1999) Adverse drug reactions to unlicensed and off-label drugs on paediatric wards: a prospective study. Acta Paediatrica 88: 965-968.
78. Doomra R, Gupta SK, (2001) Intensive adverse drug reaction monitoring in various speciality clinics of a teriary care hospital in North India. International Journal of Medical Toxicology and Legal Medicine 4: 1-4.
79. Maistrello I, Di Pietro P, Renna S, Boscarini M, Nobili A, (1999) A surveillance-oriented medical record as a source of data for both drug and quality of care surveillance. Pharmacoepidemiology and Drug Safety 8: 131-139.
80. Calderon-Ospina C, Orozco-Diaz J, (2008) [Adverse drug reactions as the reason for visiting an emergency department]. Revista de Salud Publica 10: 315-321.
81. Cirko-Begovic A, Vrhovac B, Bakran I, (1989) Intensive monitoring of adverse drug reactions in infants and preschool children. European Journal of Clinical Pharmacology 36: 63-65.
82. Dennehy CE, Kishi DT, Louie C, (1996) Drug-related illness in emergency department patients. Am J Health Syst Pharm 53: 1422-1426.
83. Doval DN, Gulati C, Bhargava A, (1981) A survey of adverse effects of drugs in an outpatient population. Indian Journal of Public Health 25: 133-138.
84. Phan H, Leder M, Fishley M, Moeller M, Nahata M, (2010) Off-label and unlicensed medication use and associated adverse drug events in a pediatric emergency department. Pediatric Emergency Care 26: 424-430.
85. Easton-Carter KL, Chapman CB, Brien JAE, (2003) Adverse drug reactions in paediatrics: Are we getting the full picture? Journal of Pharmacy Practice and Research 33: 106-110.
86. Juntti-Patinen L, Kuitunen T, Pere P, Neuvonen PJ, (2006) Drug-related visits to a district hospital emergency room. Basic and Clinical Pharmacology and Toxicology 98: 212-217.
87. Planchamp F, Nguyen KA, Vial T, Nasri S, Javouhey E, et al. (2009) Active drug monitoring of adverse drug reactions in pediatric emergency department. Archives de Pediatrie 16: 106-111.
88. Prince BS, Goetz CM, Rihn TL, Olsky M, (1992) Drug-related emergency department visits and hospital admissions. Am J Hosp Pharm 49: 1696-1700.
89. Rebelo Gomes E, Fonseca J, Araujo L, Demoly P, (2008) Drug allergy claims in children: From self-reporting to confirmed diagnosis. Clinical and Experimental Allergy 38: 191-198.
90. Sharma H, Aqil M, Imam F, Alam MS, Kapur P, et al. (2007) A pharmacovigilance study in the Department of Medicine of a University Teaching Hospital. Pharmacy Practice 5: 46-49.
91. Stoukides CA, D'Agostino PR, Kaufman MB, (1993) Adverse drug reaction surveillance in an emergency room. Am J Hosp Pharm 50: 712-714.
92. Valladares J, Ferrer JM, Palop V, Rubio E, Morales Olivas FJ, (1992) [Adverse reactions to medications in patients in ambulatory otorhinolaryngology]. Acta Otorrinolaringologica Espanola 43: 213-217.
93. Munoz MJ, Ayani I, Rodriguez-Sasiain JM, Gutierrez G, Aguirre C, (1998) Adverse drug reaction surveillance in pediatric and adult patients in an emergency room. Medicina Clinica 111: 92-98.
94. Otero Lopez MJ, Bajo Bajo A, Mederuelo Fernandez JA, Dominguez-Gil Hurle A, (1999) Preventable adverse drug events in a hospital Emergency Department. Revista Clinica Espanola 199: 796-805.
95. Smith KM, McAdams JW, Frenia ML, Todd MW, (1997) Drug related problems in emergency department patients. American Journal of Health-System Pharmacy 54: 295-298.
96. Kushwaha KP, Verma RB, Singh YD, Rathi AK, (1994) Surveillance of drug induced diseases in children. Indian Journal of Pediatrics 61: 357-365.
97. Zahraoui M, (2010) Study for developing intensive pharmacovigilance system at pediatri cemergency department. Fundamental and Clinical Pharmacology 24.
98. Horen B, Montastruc J-L, Lapeyre-Mestre M, (2002) Adverse drug reactions and off-label drug use in paediatric outpatients. British Journal of Clinical Pharmacology 54: 665-670.
99. Kaushal R, Goldmann DA, Keohane CA, Christino M, Honour M, et al. (2007) Adverse drug events in pediatric outpatients. Ambulatory Pediatrics 7: 383-389.
100. Kramer MS, Hutchinson TA, Flegel KM, Naimark L, Contardi R, et al. (1985) Adverse drug reactions in general pediatric outpatients. Journal of Pediatrics 106: 305-310.
101. Martys CR, (1979) Adverse reactions to drugs in general practice. British Medical Journal 2: 1194-1197.
102. Menniti-Ippolito F, Raschetti R, Da Cas R, Giaquinto C, Cantarutti L, et al. (2000) Active monitoring of adverse drug reactions in children. Lancet 355: 1613-1614.
103. Lemer C, Bates DW, Yoon C, Keohane C, Fitzmaurice G, et al. (2009) The role of advice in medication administration errors in the pediatric ambulatory setting. Journal of patient safety 5: 168-175.
104. Miller GC, Britt HC, Valenti L, (2006) Adverse drug events in general practice patients in Australia. Medical Journal of Australia 184: 321-324.
105. Mulroy R, (1973) Iatrogenic disease in general practice: its incidence and effects. British Medical Journal 2: 407-410.
106. Sanz E, Boada J, (1987) Adverse drug reactions in pediatric outpatients. Int J Clin Pharmacol Res 7: 169-172.
107. Woods CG, Rylance ME, Cullen RE, Rylance GW, (1987) Adverse reactions to drugs in children. Br Med J 294: 869-870.
108. Lewinski D, Wind S, Belgardt C, Plate V, Behles C, et al. (2010) Prevalence and safety-relevance of drug-related problems in German community pharmacies. Pharmacoepidemiology & Drug Safety 19: 141-149.
109. Knopf H, Du Y, (2010) Perceived adverse drug reactions among non-institutionalized children and adolescents in Germany. British Journal of Clinical Pharmacology 70: 409-417.
110. Campbell WH, Johnson RE, Sentft RA, (1978) Adverse drug reactions in a disadvantaged population. J Community Health 3: 205-215.
111. Schumock GT, Thornton JP, (1992) Focusing on the preventability of adverse drug reactions. Hosp Pharm 27: 538.
112. Lazarou J, Pomeranz BH, Corey PN, (1998) Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. JAMA 279: 1200-1205.
113. Hartwig SC, Siegel J, Schneider PJ, (1992) Preventability and severity assessment in reporting adverse drug reactions. Am J Hosp Pharm 49: 2229-2232.