Adverse drug reactions causing admission to a paediatric hospital: A pilot study

Journal of Clinical Pharmacy and Therapeutics

Volumn 36, Issue 2, 2011, Pages 194-199

  Gallagher, R M ^a   Bird, K A ^b   Mason, J R ^b   Peak, M ^b   Williamson, P R ^a   Nunn, A J ^b   Turner, M A ^a   Pirmohamed, M ^a   Smyth, R L ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b ALDER HEY CHILDREN S HOSPITAL   (United Kingdom)

Author keywords

admission to hospital; adverse drug reactions; children

Indexed keywords

AMOXICILLIN; ANALGESIC AGENT; ANTIBIOTIC AGENT; ANTINEOPLASTIC AGENT; ASPARAGINASE MACROGOL; CARBOPLATIN; CEFACLOR; CYCLOPHOSPHAMIDE; CYCLOSPORIN; CYTARABINE; DAUNORUBICIN; DICLOFENAC; DIPHTHERIA PERTUSSIS TETANUS HAEMOPHILUS INFLUENZAE TYPE B VACCINE; DOXORUBICIN; ETOPOSIDE; HYDROCORTISONE; IMMUNOSUPPRESSIVE AGENT; MEASLES MUMPS RUBELLA VACCINE; MEFLOQUINE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; ONDANSETRON; PARACETAMOL; PNEUMOCOCCUS VACCINE; PREDNISOLONE; SCOPOLAMINE BUTYL BROMIDE; TACROLIMUS; TRAMADOL; VINCRISTINE;

ADVERSE OUTCOME; ANAPHYLAXIS; ANEMIA; ARTICLE; CELLULITIS; CLINICAL ARTICLE; CONSCIOUSNESS LEVEL; CONSTIPATION; DIARRHEA; DRUG SURVEILLANCE PROGRAM; FEVER; HEMATEMESIS; HOSPITAL ADMISSION; HUMAN; IMMUNE DEFICIENCY; INCIDENCE; IRRITABILITY; KIDNEY FUNCTION; METHODOLOGY; NEUTROPENIA; OBSERVATIONAL STUDY; PEDIATRIC HOSPITAL; PILOT STUDY; PROSPECTIVE STUDY; RASH; SIDE EFFECT; THROMBOCYTOPENIA; UNITED KINGDOM; VOMITING; WARD;

ADVERSE DRUG REACTION REPORTING SYSTEMS; CHILD; DATABASES, FACTUAL; DRUG TOXICITY; GREAT BRITAIN; HOSPITAL DEPARTMENTS; HOSPITALIZATION; HOSPITALS, PEDIATRIC; HUMANS; INCIDENCE; PHARMACEUTICAL PREPARATIONS; PILOT PROJECTS; PROSPECTIVE STUDIES;

EID: 79952269085     PISSN: 02694727     EISSN: 13652710     Source Type: Journal    
DOI: 10.1111/j.1365-2710.2010.01194.x     Document Type: Article

References (20)

1. Impicciatore P, Choonara I, Clarkson A, Provasi D, Pandolfini C, Bonati M, (2001) Incidence of adverse drug reactions in paediatric in/out-patients: a systematic review and meta-analysis of prospective studies. British Journal of Clinical Pharmacology, 52, 77-83. (Pubitemid 32862772)
2. McKenzie MW, Marchall GL, Netzloff ML, Cluff LE, (1976) Adverse drug reactions leading to hospitalization in children. The Journal of Pediatrics, 89, 487-490.
3. Easton KL, Chapman CB, Brien JE, (2004) Frequency and characteristics of hospital admissions associated with drug-related problems in paediatrics. British Journal of Clinical Pharmacology, 57, 611-615. (Pubitemid 38582181)
4. Martínez-Mir I, García-Lõpez M, Palop V, Ferrer JM, Rubio E, Morales-Olivas FJ, (1996) A prospective study of adverse drug reactions as a cause of admission to a paediatric hospital. British Journal of Clinical Pharmacology, 42, 319-324. (Pubitemid 26284420)
5. Mitchell A, Lacouture P, Sheehan J, Kauffman R, Shapiro S, (1988) Adverse drug reactions in children leading to hospital admission. Pediatrics, 82, 24-29.
6. Jonville-Béra AP, Giraudeau B, Blanc P, Beau-Salinas F, Autret-Leca E, (2002) Frequency of adverse drug reactions in children: a prospective study. British Journal of Clinical Pharmacology, 53, 207-210. (Pubitemid 34264278)
7. Le J, Nguyen T, Law AV, Hodding J, (2006) Adverse drug reactions among children over a 10-year period. Pediatrics, 118, 555-562. (Pubitemid 46085410)
8. Moore TJ, Weiss SR, Kaplan S, Blaisdell CJ, (2002) Reported adverse drug events in infants and children under 2 years of age. Pediatrics, 110, e53.
9. Whyte J, Greenan E, (1977) Drug usage and adverse drug reactions in paediatric patients. Acta Paediatrica Scandinavica, 66, 767-775. (Pubitemid 8219204)
10. Adverse Drug Reactions In Children, University of Liverpool, 2009. Available at: (accessed 1 March 2010).
11. Medicines and Healthcare products Regulatory Agency, updated 19th April 2010, Reporting suspected adverse drug reactions. Available at: (accessed 28 June 2010).
12. Hazell L, Shakir S, (2006) Under-reporting of adverse drug reactions: a systematic review. Drug Safety, 29, 385-396.
13. Pirmohamed M, James S, Meakin S, et al. (2004) Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients. BMJ (Clinical Research Ed), 329, 15-19. (Pubitemid 38869995)
14. Edwards IR, Aronson JK, (2000) Adverse drug reactions: definitions, diagnosis, and management. Lancet, 356, 1255-1259.
15. Electronic Medicines Compendium, Datapharm Communications Ltd, 1999. Available at: (accessed 1 March 2010).
16. British National Formulary (2008) Published by BMJ publishing group, London.
17. Naranjo CA, Busto U, Sellers EM, et al. (1981) A method for estimating the probability of adverse drug reactions. Clinical Pharmacology and Therapeutics, 30, 239-245. (Pubitemid 12149145)
18. Rawlins MD, Thompson JW, (1977) Pathogenesis of adverse drug reactions. In:, Davies DM, ed. Textbook of adverse drug reactions. Oxford: Oxford University Press, 10-31.
19. Hartwig S, Siegel J, Schneider P, (1992) Preventability and severity assessment in reporting adverse drug reactions. American Journal of Health-System Pharmacy, 49, 2229-2232.
20. Hallas J, Harvald B, Gram LF, Grodum E, BrÃsen K, Haghfelt T, Damsbo N, (1990) Drug related hospital admissions: the role of definitions and intensity of data collection, and the possibility of prevention. Journal of Internal Medicine, 228, 83-90. (Pubitemid 20257272)