Expression of bcl-2 in classical Hodgkin's lymphoma: An independent predictor of poor outcome

Journal of Clinical Oncology

Volumn 23, Issue 16, 2005, Pages 3773-3779

  Sup, Stephen J ^a   Alemañy, Carlos A ^a   Pohlman, Brad ^a   Elson, Paul ^a   Malhi, Serena ^a   Thakkar, Snehal ^a   Steinle, Roxanne ^a   Hsi, Eric D ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; CDKN1A PROTEIN, HUMAN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; TUMOR MARKER;

ADULT; ARTICLE; CANCER STAGING; CANCER SURVIVAL; CONSENSUS; CONTROLLED STUDY; FEMALE; FOLLOW UP; HODGKIN DISEASE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SCORING SYSTEM; TREATMENT OUTCOME; ENZYME IMMUNOASSAY; GENE EXPRESSION REGULATION; METABOLISM; MICROARRAY ANALYSIS; MIDDLE AGED; PATHOLOGY; PREDICTION AND FORECASTING; SURVIVAL RATE;

CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HODGKIN DISEASE; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MICROARRAY ANALYSIS; MIDDLE AGED; NEOPLASM STAGING; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-BCL-2; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 20544445939     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2005.04.358     Document Type: Article

References (25)

1. Franklin J, Paulus U, Lieberz D, et al: Is the International Prognostic Score for advanced stage Hodgkin's disease applicable to early stage patients? German Hodgkin Lymphoma Study Group. Ann Oncol 11:617-623, 2000
2. Hasenclever D, Diehl V: A prognostic score for advanced Hodgkin's disease: International Prognostic Factors Project on Advanced Hodgkin's Disease. N Engl J Med 339:1506-1514, 1998
3. Naresh KN, O'Conor GT, Soman CS, et al: A study of p53 protein, proliferating cell nuclear antigen, and p21 in Hodgkin's disease at presentation and relapse. Hum Pathol 28:549-555, 1997
4. Wang J, Taylor CR: Apoptosis and cell cycle-related genes and proteins in classical Hodgkin lymphoma: Application of tissue microarray technique. Appl Immunohistochem Mol Morphol 11:206-213, 2003
5. Rassidakis GZ, Medeiros LJ, Vassilakopoulos TP, et al: BCL-2 expression in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease predicts a poorer prognosis in patients treated with ABVD or equivalent regimens. Blood 100:3935-3941, 2002
6. Smolewski P, Niewiadomska H, Blonski JZ, et al: Expression of proliferating cell nuclear antigen (PCNA) and p53, bcl-2 or C-erb B-2 proteins on Reed-Sternberg cells: Prognostic significance in Hodgkin's disease. Neoplasma 45: 140-147, 1998
7. Xerri L, Bouabdallah R, Camerlo J, et al: Expression of the p53 gene in Hodgkin's disease: Dissociation between immunohistochemistry and clinicopathological data. Hum Pathol 25:449-454, 1994
8. Dukers DF, Meijer CJ, ten Berge RL, et al: High numbers of active caspase 3-positive Reed-Sternberg cells in pretreatment biopsy specimens of patients with Hodgkin disease predict favorable clinical outcome. Blood 100:36-42, 2002
9. Brink AA, Oudejans JJ, van den Brule AJ, et al: Low p53 and high bcl-2 expression in Reed-Sternberg cells predicts poor clinical outcome for Hodgkin's disease: Involvement of apoptosis resistance? Mod Pathol 11:376-383, 1998
10. Smolewski P, Robak T, Krykowski E, et al: Prognostic factors in Hodgkin's disease: Multivariate analysis of 327 patients from a single institution. Clin Cancer Res 6:1150-1160, 2000
11. Vassallo J, Metze K, Traina F, et al: The prognostic relevance of apoptosis-related proteins in classical Hodgkin's lymphomas. Leuk Lymphoma 44:483-488, 2003
12. Carbone PP, Kaplan HS, Musshoff K, et al: Report of the Committee on Hodgkin's Disease Staging Classification. Cancer Res 31:1860-1861, 1971
13. Chilosi M, Doglioni C, Magalini A, et al: p21/WAF1 cyclin-kinase inhibitor expression in non-Hodgkin's lymphomas: A potential marker of p53 tumor-suppressor gene function. Blood 88: 4012-4020, 1996
14. Marafioti T, Hummel M, Foss HD, et al: Hodgkin and Reed-Sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription. Blood 95:1443-1450, 2000
15. Garcia JF, Camacho FI, Morente M, et al: Hodgkin and Reed-Sternberg cells harbor alterations in the major tumor suppressor pathways and cell-cycle checkpoints: Analyses using tissue microarrays. Blood 101:681-689, 2003
16. Kuppers R: Molecular biology of Hodgkin's lymphoma. Adv Cancer Res 84:277-312, 2002
17. Rajewsky K: Clonal selection and learning in the antibody system. Nature 381:751-758, 1996
18. Rassidakis GZ, Medeiros LJ, McDonnell TJ, et al: BAX expression in Hodgkin and Reed-Sternberg cells of Hodgkin's disease: Correlation with clinical outcome. Clin Cancer Res 8:488-493, 2002
19. Hinz M, Loser P, Mathas S, et al: Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells. Blood 97:2798-2807, 2001
20. Montalban C, Garcia JF, Abraira V, et al: Influence of biologic markers on the outcome of Hodgkin's lymphoma: A study by the Spanish Hodgkin's Lymphoma Study Group. J Clin Oncol 22:1664-1673, 2004
21. Morente MM, Piris MA, Abraira V, et al: Adverse clinical outcome in Hodgkin's disease is associated with loss of retinoblastoma protein expression, high Ki67 proliferation index, and absence of Epstein-Barr virus-latent membrane protein 1 expression. Blood 90:2429-2436, 1997
22. Lauritzen AF, Hou-Jensen K, Ralfkiaer E: P53 protein expression in Hodgkin's disease. APMIS 101:689-694, 1993
23. Elenitoba-Johnson KS, Medeiros LJ, Khorsand J, et al: P53 expression in Reed-Sternberg cells does not correlate with gene mutations in Hodgkin's disease. Am J Clin Pathol 106:728-738, 1996
24. Chen WG, Chen YY, Kamel OW, et al: p53 mutations in Hodgkin's disease. Lab Invest 75: 519-527, 1996
25. Trumper LH, Brady G, Bagg A, et al: Single-cell analysis of Hodgkin and Reed-Sternberg cells: Molecular heterogeneity of gene expression and p53 mutations. Blood 81:3097-3115, 1993