Surface loops of extracellular phospholipase A 1 determine both substrate specificity and preference for lysophospholipids

Journal of Lipid Research

Volumn 53, Issue 3, 2012, Pages 513-521

  Arima, Naoaki ^a   Inoue, Asuka ^a   Makide, Kumiko ^a,c   Nonaka, Takamasa ^b   Aoki, Junken ^a,c  

^a TOHOKU UNIVERSITY   (Japan)

^b IWATE MEDICAL UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Lid; Lipase; Lysophospholipase; Lysophospholipid; Phospholipases; Phospholipids; Phospholipids phosphatidic acid; Phospholipids phosphatidylserine; Surface loop

Indexed keywords

LYSOPHOSPHATIDYLSERINE; LYSOPHOSPHOLIPID; MUTANT PROTEIN; PHOSPHOLIPASE A1;

ARTICLE; BETA CHAIN; CHIMERA; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME SPECIFICITY; ENZYME STRUCTURE; HUMAN; HUMAN CELL; LIPID ANALYSIS; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN DETERMINATION; SURFACE PROPERTY;

BLOTTING, WESTERN; CELL LINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; LYSOPHOSPHOLIPIDS; PHOSPHATIDIC ACIDS; PHOSPHATIDYLSERINES; PHOSPHOLIPASES A1; PROTEIN STRUCTURE, SECONDARY; SUBSTRATE SPECIFICITY;

EID: 84857748283     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M022400     Document Type: Article

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