Dysregulation of gene expression in a lysosomal storage disease varies between brain regions implicating unexpected mechanisms of neuropathology

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Parente, Michael K ^a   Rozen, Ramona ^a,c   Cearley, Cassia N ^a,d   Wolfe, John H ^a,b  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c Global Lab Diagnostic Services   (Israel)

^d LEK Consulting   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTOME; ION CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DEVELOPMENTAL GENE; DOWN REGULATION; FEMALE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE MUTATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC DISORDER; HISTOPATHOLOGY; IMMUNE SYSTEM; LYSOSOME STORAGE DISEASE; MALE; MOUSE; MUCOPOLYSACCHARIDOSIS TYPE 7; NEUROANATOMY; NEUROPATHOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; OLIGODENDROGLIA; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; BRAIN; CELL ADHESION; CELL CYCLE; CELL NUCLEUS; CIRCADIAN RHYTHM; CYTOLOGY; EXTRACELLULAR MATRIX; GENETICS; GLIOSIS; IMMUNOLOGY; METABOLISM; MICROGLIA; MYELIN SHEATH; NERVE CELL; OLFACTORY BULB; PATHOLOGY; PHYSIOLOGY;

MUS;

ANIMALS; BRAIN; CELL ADHESION; CELL CYCLE; CELL NUCLEUS; CIRCADIAN RHYTHM; EXTRACELLULAR MATRIX; FEMALE; GLIOSIS; ION CHANNELS; MALE; MICE; MICROGLIA; MUCOPOLYSACCHARIDOSIS VII; MYELIN SHEATH; NEURONS; OLFACTORY BULB; SIGNAL TRANSDUCTION; TRANSCRIPTOME;

EID: 84857729023     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032419     Document Type: Article

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