The pikfyve inhibitor YM201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Dukes, Joseph D ^a   Whitley, Paul ^a   Chalmers, Andrew D ^a  

^a University of Bath   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CLAUDIN 1; CLAUDIN 2; ENZYME INHIBITOR; OCCLUDIN; PROTEIN KINASE; PROTEIN KINASE PIKFYVE; PROTEIN KINASE PIKFYVE INHIBITOR; PROTEIN ZO1; UNCLASSIFIED DRUG; UVOMORULIN; YM 201636; 6 AMINO N (3 (4 (4 MORPHOLINYL)PYRIDO(3',2' 4,5)FURO(3,2 D)PYRIMIDIN 2 YL)PHENYL) 3 PYRIDINECARBOXAMIDE; 6-AMINO-N-(3-(4-(4-MORPHOLINYL)PYRIDO(3',2'-4,5)FURO(3,2-D)PYRIMIDIN-2-YL)PHENYL)-3-PYRIDINECARBOXAMIDE; AMINOPYRIDINE DERIVATIVE; CALCIUM; CLAUDIN; CYCLOHEXIMIDE; ESCRT PROTEIN; FUSED HETEROCYCLIC RINGS; MEMBRANE PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE INHIBITOR; PROTEIN SYNTHESIS INHIBITOR;

ARTICLE; CELL CYCLE ARREST; CELL MIGRATION; CELL STRAIN; CELL TRANSPORT; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG INHIBITION; DRUG UPTAKE; ENDOCYTOSIS; EPITHELIUM CELL; PERMEABILITY BARRIER; PROTEIN LOCALIZATION; ANIMAL; DOG; DRUG ANTAGONISM; DRUG EFFECT; EPITHELIUM; FLUORESCENCE MICROSCOPY; METABOLISM; METHODOLOGY; PERMEABILITY; PROTEIN TRANSPORT; TIGHT JUNCTION;

AMINOPYRIDINES; ANIMALS; CALCIUM; CLAUDINS; CYCLOHEXIMIDE; DOGS; ENDOCYTOSIS; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; EPITHELIUM; HETEROCYCLIC COMPOUNDS, 3-RING; MEMBRANE PROTEINS; MICROSCOPY, FLUORESCENCE; PERMEABILITY; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN KINASE INHIBITORS; PROTEIN SYNTHESIS INHIBITORS; PROTEIN TRANSPORT; TIGHT JUNCTIONS;

EID: 84857700653     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028659     Document Type: Article

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