Generation and characterization of pilocarpine-sensitive C57BL/6 mice as a model of temporal lobe epilepsy

Behavioural Brain Research

Volumn 230, Issue 1, 2012, Pages 182-191

  Bankstahl, Marion ^a,b   Müller, Christine J ^a,b   Wilk, Esther ^a   Schughart, Klaus ^a   Löscher, Wolfgang ^a,b  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^b CENTER FOR SYSTEMS NEUROSCIENCE   (Germany)

Author keywords

Genetics; Seizure; Status epilepticus; Strain difference; Synuclein

Indexed keywords

PILOCARPINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; C57BL 6 MOUSE; CONTROLLED STUDY; CROSS BREEDING; DISEASE PREDISPOSITION; DISEASE SEVERITY; EPILEPTIC STATE; EPILEPTOGENESIS; FEMALE; GENE IDENTIFICATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HIPPOCAMPUS; HYBRID; MALE; MATING; MOLECULAR GENETICS; MOUSE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SIBLING; TEMPORAL LOBE EPILEPSY;

ALPHA-SYNUCLEIN; ANIMALS; DISEASE MODELS, ANIMAL; DISEASE SUSCEPTIBILITY; DOSE-RESPONSE RELATIONSHIP, DRUG; EPILEPSY, TEMPORAL LOBE; FEMALE; GENOTYPE; HIPPOCAMPUS; MALE; MICE; MICE, INBRED C57BL; MUSCARINIC AGONISTS; MUTATION; PILOCARPINE; SEX FACTORS; STATISTICS, NONPARAMETRIC; TIME FACTORS;

EID: 84857666081     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2012.02.004     Document Type: Article

References (42)

1. Cavalheiro E.A., Naffah-Mazacoratti M.G., Mello L.E., Leite J.P. The pilocarpine model of seizures. Models of seizures and epilepsy 2006, 433-448. Elsevier, Amsterdam. A. Pitkänen, P.A. Schwartzkroin, S.L. Moshé (Eds.).
2. Curia G., Longo D., Biagini G., Jones R.S., Avoli M. The pilocarpine model of temporal lobe epilepsy. J Neurosci Methods 2008, 172(2):143-157.
3. Andre V., Dube C., Francois J., Leroy C., Rigoulot M.A., Roch C., et al. Pathogenesis and pharmacology of epilepsy in the lithium-pilocarpine model. Epilepsia 2007, 48(Suppl. 5):41-47.
4. Sharma A.K., Reams R.Y., Jordan W.H., Miller M.A., Thacker H.L., Snyder P.W. Mesial temporal lobe epilepsy: pathogenesis, induced rodent models and lesions. Toxicol Pathol 2007, 35(7):984-999.
5. Scorza F.A., Arida R.M., Naffah-Mazzacoratti M.G., Scerni D.A., Calderazzo L., Cavalheiro E.A. The pilocarpine model of epilepsy: what have we learned?. An Acad Bras Cienc 2009, 81(3):345-365.
6. Löscher W., Brandt C. Prevention or modification of epileptogenesis after brain insults: experimental approaches and translational research. Pharmacol Rev 2010, 62:668-700.
7. Turski W.A., Cavalheiro E.A., Schwarz M., Czuczwar S.J., Kleinrok Z., Turski L. Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study. Behav Brain Res 1983, 9:315-335.
8. Shibley H., Smith B.N. Pilocarpine-induced status epilepticus results in mossy fiber sprouting and spontaneous seizures in C57BL/6 and CD-1 mice. Epilepsy Res 2002, 49(2):109-120.
9. Borges K., Gearing M., McDermott D.L., Smith A.B., Almonte A.G., Wainer B.H., et al. Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model. Exp Neurol 2003, 182(1):21-34.
10. Müller C.J., Gröticke I., Bankstahl M., Löscher W. Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice. Exp Neurol 2009, 219:284-297.
11. Crawley J.N. Behavioral phenotyping of rodents. Comp Med 2003, 53(2):140-146.
12. Engstrom F.L., Woodbury D.M. Seizure susceptibility in DBA and C57 mice: the effects of various convulsants. Epilepsia 1988, 29(4):389-395.
13. Kosobud A.E., Crabbe J.C. Genetic correlations among inbred strain sensitivities to convulsions induced by 9 convulsant drugs. Brain Res 1990, 526(1):8-16.
14. Schauwecker P.E., Steward O. Genetic determinants of susceptibility to excitotoxic cell death: implications for gene targeting approaches. Proc Natl Acad Sci USA 1997, 94(8):4103-4108.
15. Ferraro T.N., Golden G.T., Snyder R., Laibinis M., Smith G.G., Buono R.J., et al. Genetic influences on electrical seizure threshold. Brain Res 1998, 813(1):207-210.
16. Ferraro T.N., Golden G.T., Smith G.G., DeMuth D., Buono R.J., Berrettini W.H. Mouse strain variation in maximal electroshock seizure threshold. Brain Res 2002, 936(1-2):82-86.
17. McLin J.P., Steward O. Comparison of seizure phenotype and neurodegeneration induced by systemic kainic acid in inbred, outbred, and hybrid mouse strains. Eur J Neurosci 2006, 24(8):2191-2202.
18. Bryant C.D., Zhang N.N., Sokoloff G., Fanselow M.S., Ennes H.S., Palmer A.A., et al. Behavioral differences among C57BL/6 substrains: implications for transgenic and knockout studies. J Neurogenet 2008, 22(4):315-331.
19. Zurita E., Chagoyen M., Cantero M., Alonso R., Gonzalez-Neira A., Lopez-Jimenez A., et al. Genetic polymorphisms among C57BL/6 mouse inbred strains. Transgenic Res 2011, 20(3):481-489.
20. Morse H.C. Origins of inbred mice 1978, Academic Press, New York.
21. Mekada K., Abe K., Murakami A., Nakamura S., Nakata H., Moriwaki K., et al. Genetic differences among C57BL/6 substrains. Exp Anim 2009, 58(2):141-149.
22. Müller C.J., Gröticke I., Hoffmann K., Schughart K., Löscher W. Differences in sensitivity to the convulsant pilocarpine in substrains and sublines of C57BL/6 mice. Genes Brain Behav 2009, 8:481-492.
23. Festing M.F.W. Origins and characteristics of inbred strains of mice 1996, Oxford University Press, Oxford, UK.
24. Gröticke I., Hoffmann K., Löscher W. Behavioral alterations in the pilocarpine model of temporal lobe epilepsy in mice. Exp Neurol 2007, 207(2):329-349.
25. Racine R.J. Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalogr Clin Neurophysiol 1972, 32:281-294.
26. Paxinos G., Franklin K.B.J. The mouse brain in stereotaxic coordinates 2001, Academic Press, New York.
27. Müller C.J., Bankstahl M., Gröticke I., Löscher W. Pilocarpine vs. lithium-pilocarpine for induction of status epilepticus in mice: development of spontaneous seizures, behavioral alterations and neuronal damage. Eur J Pharmacol 2009, 619(1-3):15-24.
28. Specht C.G., Schoepfer R. Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice. BMC Neurosci 2001, 2:11.
29. Yang Y., Beyer B.J., Otto J.F., O'Brien T.P., Letts V.A., White H.S., et al. Spontaneous deletion of epilepsy gene orthologs in a mutant mouse with a low electroconvulsive threshold. Hum Mol Genet 2003, 12(9):975-984.
30. Beyer B., Deleuze C., Letts V.A., Mahaffey C.L., Boumil R.M., Lew T.A., et al. Absence seizures in C3H/HeJ and knockout mice caused by mutation of the AMPA receptor subunit Gria4. Hum Mol Genet 2008, 17(12):1738-1749.
31. Lowenstein D.H. The management of refractory status epilepticus: an update. Epilepsia 2006, 47(Suppl. 1):35-40.
32. Löscher W. Molecular mechanisms of drug resistance in status epilepticus. Epilepsia 2009, 50(Suppl. 12):19-21.
33. Jones D.M., Esmaeil N., Maren S., Macdonald R.L. Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus. Epilepsy Res 2002, 50(3):301-312.
34. Chen J.W., Wasterlain C.G. Status epilepticus: pathophysiology and management in adults. Lancet Neurol 2006, 5(3):246-256.
35. Wasterlain C.G., Chen J.W. Mechanistic and pharmacologic aspects of status epilepticus and its treatment with new antiepileptic drugs. Epilepsia 2008, 49(Suppl 9):63-73.
36. Löscher W. Mechanisms of drug resistance in status epilepticus. Epilepsia 2007, 48(Suppl. 8):74-77.
37. Oaks A.W., Sidhu A. Synuclein modulation of monoamine transporters. FEBS Lett 2011, 585(7):1001-1006.
38. Duda J.E., Lee V.M., Trojanowski J.Q. Neuropathology of synuclein aggregates. J Neurosci Res 2000, 61(2):121-127.
39. Surguchov A. Molecular and cellular biology of synucleins. Int Rev Cell Mol Biol 2008, 270:225-317.
40. Li A., Choi Y.S., Dziema H., Cao R., Cho H.Y., Jung Y.J., et al. Proteomic profiling of the epileptic dentate gyrus. Brain Pathol 2010, 20(6):1077-1089.
41. Mohajeri M.H., Madani R., Saini K., Lipp H.P., Nitsch R.M., Wolfer D.P. The impact of genetic background on neurodegeneration and behavior in seizured mice. Genes Brain Behav 2004, 3(4):228-239.
42. Sloviter R.S. Hippocampal pathology and pathophysiology in temporal lobe epilepsy. Neurologia 1996, 11(Suppl. 4):29-32.