Mutations of complement lectin pathway genes MBL2 and MASP2 associated with placental malaria

Malaria Journal

Volumn 11, Issue , 2012, Pages

  Holmberg, Ville ^a,b   Onkamo, Päivi ^b   Lahtela, Elisa ^a   Lahermo, Päivi ^b   Bedu Addo, George ^c   Mockenhaupt, Frank ^d   Meri, Seppo ^a,e  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Ghana)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Complement; Ficolin; Innate immunity; Lectin pathway; Malaria; Mannose binding lectin; MASP2; MBL2; Placenta; Pregnancy

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; COMPLEMENT COMPONENT C3; COMPLEMENT FACTOR PROPERDIN; FICOLIN 1; FICOLIN 2; FICOLIN 3; LECTIN; MANNAN BINDING LECTIN SERINE PEPTIDASE 1; MANNAN BINDING LECTIN SERINE PEPTIDASE 2; MANNOSE BINDING LECTIN 2; THROMBOMODULIN; THROMBOSPONDIN 1; THROMBOSPONDIN 2; THROMBOSPONDIN 3; THROMBOSPONDIN 4; UNCLASSIFIED DRUG; COMPLEMENT; MANNAN BINDING LECTIN ASSOCIATED SERINE PROTEINASE; MANNOSE BINDING LECTIN; MASP2 PROTEIN, HUMAN; MBL2 PROTEIN, HUMAN;

ADULT; ARTICLE; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALARIA; MISSENSE MUTATION; NONSENSE MUTATION; PLACENTAL MALARIA; PRIMIPARA; SINGLE NUCLEOTIDE POLYMORPHISM; COMPLEMENT ACTIVATION; GENETIC PREDISPOSITION; GENETICS; GENOTYPING TECHNIQUE; GHANA; IMMUNOLOGY; INNATE IMMUNITY; MALARIA FALCIPARUM; PARASITOLOGY; PLACENTA; PLASMODIUM FALCIPARUM; PREGNANCY; PREGNANCY COMPLICATION;

ADULT; COMPLEMENT ACTIVATION; COMPLEMENT SYSTEM PROTEINS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPING TECHNIQUES; GHANA; HUMANS; IMMUNITY, INNATE; MALARIA, FALCIPARUM; MANNOSE-BINDING LECTIN; MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES; PLACENTA; PLASMODIUM FALCIPARUM; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY; PREGNANCY COMPLICATIONS, PARASITIC;

EID: 84857663129     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-11-6122380611     Document Type: Article

References (44)

1. Epidemiology and burden of malaria in pregnancy. Desai M ter Kuile FO Nosten F McGready R, Asamoa K Brabin B, Newman RD,, Lancet Infect Dis 2007 7 93 104 10.1016/S1473-3099(07)70021-X 17251080 (Pubitemid 46123132)
2. Plasmodium in the placenta: parasites, parity, protection, prevention and possibly preeclampsia. Duffy PE, Parasitology 2007 134 1877 1881 17958923 (Pubitemid 350014550)
3. Quantifying the number of pregnancies at risk of malaria in 2007: a demographic study. Dellicour S Tatem AJ Guerra CA Snow RW, Ter Kuile FO,, PLoS Med 2010 7 1000221 10.1371/journal.pmed.1000221 20126256
4. Malaria elicits type 1 cytokines in the human placenta: IFN-gamma and TNF-alpha associated with pregnancy outcomes. Fried M Muga RO, Misore AO Duffy PE, J Immunol 1998 160 2523 2530 9498798 (Pubitemid 28119939)
5. Malaria and pregnancy: placental cytokine expression and its relationship to intrauterine growth retardation. Moormann AM Sullivan AD Rochford RA Chensue SW, Bock PJ Nyirenda T, Meshnick SR,, J Infect Dis 1999 180 1987 1993 10.1086/315135 10558956
6. Maternal antibodies block malaria. Fried M Nosten F Brockman A Brabin BJ, Duffy PE,, Nature 1998 395 851 852 10.1038/27570 9804416
7. Antibodies that inhibit Plasmodium falciparum adhesion to chondroitin sulfate A are associated with increased birth weight and the gestational age of newborns. Duffy PE Fried M, Infect Immun 2003 71 6620 6623 10.1128/IAI.71.11. 6620-6623.2003 14573685 (Pubitemid 37337723)
8. The sick placenta-the role of malaria. Brabin BJ Romagosa C, Abdelgalil S Menendez C, Verhoeff FH McGready R, Fletcher KA Owens S, D'Alessandro U Nosten F, Fischer PR Ordi J, Placenta 2004 25 359 378 10.1016/j.placenta.2003.10.019 15081631
9. How might infant and paediatric immune responses influence malaria vaccine efficacy? Moormann AM, Parasite Immunol 2009 31 547 559 10.1111/j.1365-3024.2009.01137.x 19691558
10. TLR-mediated cell signaling by malaria GPIs. Gowda DC, Trends Parasitol 2007 23 596 604 10.1016/j.pt.2007.09.003 17980663 (Pubitemid 350161430)
11. Common polymorphisms of toll-like receptors 4 and 9 are associated with the clinical manifestation of malaria during pregnancy. Mockenhaupt FP Hamann L von Gaertner C Bedu-Addo G, von Kleinsorgen C Schumann RR, Bienzle U,, J Infect Dis 2006 194 184 188 10.1086/505152 16779724 (Pubitemid 44087189)
12. The toll-like receptor 1 variant S248N influences placental malaria. Hamann L Bedu-Addo G Eggelte TA Schumann RR, Mockenhaupt FP,, Infect Genet Evol 2010 10 785 789 10.1016/j.meegid.2010.05.005 20478407
13. A variant in the gene FUT9 is associated with susceptibility to placental malaria infection. Sikora M Ferrer-Admetlla A Laayouni H Menendez C, Mayor A Bardaji A, Sigauque B Mandomando I, Alonso PL Bertranpetit J, Casals F,, Hum Mol Genet 2009 18 3136 3144 10.1093/hmg/ddp240 19460885
14. Molecular interactions between MASP-2, C4, and C2 and their activation fragments leading to complement activation via the lectin pathway. Wallis R Dodds AW, Mitchell DA Sim RB, Reid KB Schwaeble WJ, J Biol Chem 2007 282 7844 7851 10.1074/jbc.M606326200 17204478
15. Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins. Thiel S, Mol Immunol 2007 44 3875 3888 10.1016/j.molimm.2007.06.005 17768106 (Pubitemid 47337117)
16. Essential role of mannose-binding lectin-associated serine protease-1 in activation of the complement factor D. Takahashi M Ishida Y, Iwaki D Kanno K, Suzuki T Endo Y, Homma Y Fujita T, J Exp Med 2010 207 29 37 10.1084/jem.20090633 20038603
17. Recognition of Plasmodium falciparum proteins by mannan-binding lectin, a component of the human innate immune system. Klabunde J Uhlemann AC Tebo AE Kimmel J, Schwarz RT Kremsner PG, Kun JF,, Parasitol Res 2002 88 113 117 11936498
18. Mannose binding protein deficiency is not associated with malaria, hepatitis B carriage nor tuberculosis in Africans. Bellamy R Ruwende C McAdam KP Thursz M, Sumiya M Summerfield J, Gilbert SC Corrah T, Kwiatkowski D Whittle HC, Hill AV,, QJM 1998 91 13 18 10.1093/qjmed/91.1.13 9519208 (Pubitemid 28041002)
19. Mannose-binding lectin plasma levels and gene polymorphisms in Plasmodium falciparum malaria. Luty AJ Kun JF Kremsner PG,, J Infect Dis 1998 178 1221 1224 10.1086/515690 9806066 (Pubitemid 28452230)
20. Human genetic polymorphisms and asymptomatic Plasmodium falciparum malaria in Gabonese schoolchildren. Mombo LE Ntoumi F Bisseye C Ossari S, Lu CY Nagel RL, Krishnamoorthy R,, AmJTrop Med Hyg 2003 68 186 190 (Pubitemid 38240544)
21. Association of a new mannose-binding lectin variant with severe malaria in Gabonese children. Boldt AB Luty A, Grobusch MP Dietz K, Dzeing A Kombila M, Kremsner PG Kun JF, Genes Immun 2006 7 393 400 10.1038/sj.gene.6364312 16738667 (Pubitemid 44111644)
22. Mannose-binding lectin variant associated with severe malaria in young African children. Holmberg V Schuster F Dietz E Sagarriga Visconti JC, Anemana SD Bienzle U, Mockenhaupt FP,, Microbes Infect 2008 10 342 348 10.1016/j.micinf.2007.12.008 18396436
23. Genetic polymorphisms of mannose-binding lectin do not influence placental malaria but are associated with preterm deliveries. Thevenon AD Leke RG Suguitan AL Jr Zhou JA, Taylor DW,, Infect Immun 2009 77 1483 1491 10.1128/IAI.01069-08 19139195
24. Detection and clinical manifestation of placental malaria in southern Ghana. Mockenhaupt FP Bedu-Addo G von Gaertner C Boye R, Fricke K Hannibal I, Karakaya F Schaller M, Ulmen U Acquah PA, Dietz E Eggelte TA, Bienzle U,, Malar J 2006 5 119 10.1186/1475-2875-5-119 17166266
25. High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction. Snounou G Viriyakosol S, Zhu XP Jarra W, Pinheiro L do Rosario VE, Thaithong S Brown KN, Mol Biochem Parasitol 1993 61 315 320 10.1016/0166-6851(93)90077-B 8264734
26. Studies on maturity in newborn infants. IX. Further observations on the use of external characteristics in estimating gestational age. Finnstrom O, Acta Paediatr Scand 1977 66 601 604 10.1111/j.1651-2227.1977.tb07954.x 899778 (Pubitemid 8195135)
27. Complement driven innate immune response to malaria: fuelling severe malarial diseases. Silver KL Higgins SJ, McDonald CR Kain KC, Cell Microbiol 2010 12 1036 1045 10.1111/j.1462-5822.2010.01492.x 20545944
28. PLINK: a tool set for whole-genome association and population-based linkage analyses. Purcell S Neale B Todd-Brown K Thomas L, Ferreira MA Bender D, Maller J Sklar P, de Bakker PI Daly MJ, Sham PC,, Am J Hum Genet 2007 81 559 575 10.1086/519795 17701901 (Pubitemid 47330214)
29. Medepi.com, R Package for Epidemiological Data and Graphics. http://medepi.com/epitools/
30. Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity. Thiel S Kolev M Degn S Steffensen R, Hansen AG Ruseva M, Jensenius JC,, J Immunol 2009 182 2939 2947 10.4049/jimmunol.0802053 19234189
31. Genome-wide linkage analysis of malaria infection intensity and mild disease. Timmann C Evans JA Konig IR Kleensang A, Ruschendorf F Lenzen J, Sievertsen J Becker C, Enuameh Y Kwakye KO, Opoku E Browne EN, Ziegler A Nurnberg P, Horstmann RD,, PLoS Genet 2007 3 48 10.1371/journal.pgen.0030048 17381244
32. Genome-wide and fine-resolution association analysis of malaria in West Africa. Jallow M Teo YY Small KS Rockett KA, Deloukas P Clark TG, Kivinen K Bojang KA, Conway DJ Pinder M, Sirugo G Sisay-Joof F, Usen S Auburn S, Bumpstead SJ Campino S, Coffey A Dunham A, Fry AE Green A, Gwilliam R Hunt SE, Inouye M Jeffreys AE, Mendy A Palotie A, Potter S Ragoussis J, Rogers J Rowlands K, Somaskantharajah E Whittaker P, Widden C Donnelly P, Howie B Marchini J, Morris A Sanjoaquin M, Achidi EA Agbenyega T, Allen A Amodu O, Corran P Djimde A, Dolo A Doumbo OK, Drakeley C Dunstan S, Evans J Farrar J, Fernando D Hien TT, Horstmann RD Ibrahim M, Karunaweera N Kokwaro G, Koram KA Lemnge M, Makani J Marsh K, Michon P Modiano D, Molyneux ME Mueller I, Parker M Peshu N, Plowe CV Puijalon O, Reeder J Reyburn H, Riley EM Sakuntabhai A, Singhasivanon P Sirima S, Tall A Taylor TE, Thera M Troye-Blomberg M, Williams TN Wilson M, Kwiatkowski DP,, Nat Genet 2009 41 657 665 10.1038/ng.388 19465909
33. Complement in human diseases: lessons from complement deficiencies. Botto M Kirschfink M, Macor P Pickering MC, Wurzner R Tedesco F, Mol Immunol 2009 46 2774 2783 10.1016/j.molimm.2009.04.029 19481265
34. Disease-associated mutations in human mannose-binding lectin compromise oligomerization and activity of the final protein. Larsen F Madsen HO Sim RB Koch C, Garred P,, J Biol Chem 2004 279 21302 21311 10.1074/jbc.M400520200 14764589
35. Association of mannose-binding lectin polymorphisms with sepsis and fatal outcome, in patients with systemic inflammatory response syndrome. Garred P JS J Quist L Taaning E, Madsen HO,, J Infect Dis 2003 188 1394 1403 10.1086/379044 14593599 (Pubitemid 37433712)
36. National Center for Biotechnology Information, SNP rs12085877. http://www.ncbi.nlm.nih.gov/snp/?term=rs12085877
37. Anti-microbial activities of mannose-binding lectin. Jack DL Turner MW, Biochem Soc Trans 2003 31 753 757 12887297 (Pubitemid 36981119)
38. Simultaneous activation of complement and coagulation by MBL-associated serine protease 2. Krarup A Wallis R Presanis JS Gal P, Sim RB,, PLoS One 2007 2 623 10.1371/journal.pone.0000623 17637839
39. C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: potential implications for placental malaria. Conroy A Serghides L Finney C Owino SO, Kumar S Gowda DC, Liles WC Moore JM, Kain KC,, PLoS One 2009 4 4953 10.1371/journal.pone.0004953 19308263
40. Complement activation: a critical mediator of adverse fetal outcomes in placental malaria? Conroy AL McDonald CR Silver KL Liles WC, Kain KC,, Trends Parasitol 2011 27 294 299 10.1016/j.pt.2011.02.005 21493146
41. The dark side of C5a in sepsis. Ward PA, Nat Rev Immunol 2004 4 133 142 10.1038/nri1269 15040586 (Pubitemid 38209207)
42. A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria. Cockburn IA Mackinnon MJ O'Donnell A Allen SJ, Moulds JM Baisor M, Bockarie M Reeder JC, Rowe JA,, Proc Natl Acad Sci USA 2004 101 272 277 10.1073/pnas.0305306101 14694201 (Pubitemid 38084240)
43. The down-stream effects of mannan-induced lectin complement pathway activation depend quantitatively on alternative pathway amplification. Harboe M Garred P, Karlstrom E Lindstad JK, Stahl GL Mollnes TE, Mol Immunol 2009 47 373 380 10.1016/j.molimm.2009.09.005 19800125
44. Selective inhibition of the lectin pathway of complement with phage display selected peptides against mannose-binding lectin-associated serine protease (MASP)-1 and -2: significant contribution of MASP-1 to lectin pathway activation. Kocsis A Kekesi KA, Szasz R Vegh BM, Balczer J Dobo J, Zavodszky P Gal P, Pal G, J Immunol 2010 185 4169 4178 10.4049/jimmunol.1001819 20817870