Cancer prevention in populations high at-risk for the development of oral cancer: Clinical trials with black raspberries

Berries and Cancer Prevention

Volumn , Issue , 2011, Pages 259-280

  Knobloch, Thomas J ^a   Casto, Bruce C ^a   Agrawal, Amit ^b   Clinton, Steven K ^b   Weghorst, Christopher M ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Bioactive food components; Biomarkers; Black raspberries; Cancer risk reduction; Chemoprevention; Clinical trial; Dietary intervention; Nutraceutical; Oral cancer; Phytochemical; Whole food intervention

Indexed keywords

EID: 84857660617     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4419-7554-6_14     Document Type: Chapter

References (78)

1. Adelstein DJ, Ridge JA, Gillison ML, Chaturvedi AK, D'Souza G, Gravitt PE, Westra W, Psyrri A, Kast WM, Koutsky LA, Giuliano A, Krosnick S, Trotti A, Schuller DE, Forastiere A, Ullmann CD (2009). Head and neck squamous cell cancer and the human papillomavirus: summary of a National Cancer Institute State of the Science Meeting, November 9-10, 2008, Washington, DC. Head Neck 31:1391-1422
2. American Cancer Society. Cancer Facts & Figures 2009. Atlanta: American Cancer Society; 2009
3. Appalachian Regional Commission (2010) http://www.arc.gov/
4. Berridge MV, Tan AS, McCoy KD, Wang R (1996) The Biochemical and cellular basis of cell proliferation assays that use tetrazolium salts. Biochemica 4:14-19
5. Braakhuis BJM, Tabor MP, Kummer JA, Leemans CR, Brakenhoff RH (2003) A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implication. Cancer Res 63:1727-1730
6. Califano J, van der Riet P, Westra W, Nawroz H, Clayman G, Piantadosi S, Corio R, Lee D, Greenberg B, Koch W, Sidransky D (1996) Genetic progression model for head and neck cancer: implications for field cancerization. Cancer Res 56:2488-2492
7. Casto BC, Kresty LA, Kraly CL, Pearl DK, Knobloch TJ, Schut HA, Stoner GD, Mallery SR, Weghorst CM (2002) Chemoprevention of oral cancer by black raspberries. Anticancer Res 22:4005-4015
8. Casto BC, Sharma S, Fisher JL, Knobloch TJ, Agrawal A, Weghorst CM (2009) Oral cancer in Appalachia. J Health Care Poor Underserved 20:274-285
9. Choi S, Myers JN (2008) Molecular pathogenesis of oral squamous cell carcinoma: implications for therapy. J Dent Res 87:14-32 Review
10. Cooper JS, Pajak TF, Rubin P, Tupchong L, Brady L, Leibel SA, Laramore GE, Marcial VA, Cox JD (1989) Second malignancies in patients who have head and neck cancer: incidence, effect on survival and implications based on the ROTG experience. Int J Radiat Oncol Biol Phys 17:449-456
11. Decker J, Goldstein JC (1982) Risk factors in head and neck cancer. N Engl J Med 306:1151-1155
12. Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, Lempicki RA (2003) DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 4:P3
13. D'Ambrosio SM, Gibson-D'Ambrosio RE, Milo GE, Casto BC, Kelloff GJ, Steele VE (2000) Differential response of normal premalignant and malignant human oral epithelial cells to growth inhibition by chemopreventive agents. Anticancer Res 20:2273-2280
14. D'Ambrosio SM, Gibson-D'Ambrosio RE, Wani G, Casto BC, Milo GE, Kelloff GJ, Steele VE (2001) Modulation of Ki67, p53, RARβ expression in normal, premalignant, and malignant human oral epithelial cells by chemopreventive agents. Anticancer Res 21:3229-3235
15. Forastiere A, Koch W, Trotti A, Sidransky D (2001) Head and neck cancer. N Engl J Med 345:1890-1900
16. Garzino-Demo P, Dell'Acqua A, Dalmasso P, Fasolis M, La Terra Maggiore GM, Ramieri G, Berrone S, Rampino M, Schena M (2006) Clinico-pathological parameters and outcome of 245 patients operated for oral squamous cell carcinoma. J Craniomaxillofac Surg 34:344-350
17. Gillison ML, Koch WM, Capone RB, Spafford M, Westra WH, Wu L, Zahurak ML, Daniel RW, Viglione M, Symer DE, Shah KV, Sidransky D (2000) Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst 92:709-720
18. Gillison ML, Shah KV (2001) Human papillomavirus-associated head and neck squamous cell carcinoma: mounting evidence for an etiologic role for human papillomavirus in a subset of head and neck cancers. Curr Opin Oncol 13:183-188
19. Glade MJ (1999) Food, nutrition, and the prevention of cancer: a global perspective. American Institute for Cancer Research/World Cancer Research Fund, American Institute for Cancer Research, 1997. Nutrition 15:523-526
20. Han C, Ding H, Casto B, Stoner GD, D'Ambrosio SM (2005) Inhibition of the growth of prema-lignant and malignant human oral cell lines by extracts and components of black raspberries. Nutr Cancer 51:207-217
21. He J, Wallace TC, Keatley KE, Failla ML, Giusti MM (2009) Stability of black raspberry antho-cyanins in the digestive tract lumen and transport efficiency into gastric and small intestinal tissues in the rat. J Agric Food Chem 57:3141-3148
22. Hong WK, Spitz MR, Lippman SM (2000) Cancer chemoprevention in the 21st century: genetics, risk modeling, and molecular targets. J Clin Oncol 18(21 Suppl):9S-18S
23. Huang DW, Sherman BT, Lempicki RA (2009) Systematic and integrative analysis of large gene lists using DAVID Bioinformatics Resources. Nature Protoc 4:44-57
24. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2004) IARC monographs on the evaluation of carcinogenic risks to humans, tobacco smoke and involuntary smoking, vol 83. IARC Press, Lyon, France
25. IARC working group on the evaluation of carcinogenic risks to humans (2007) IARC Monographs on the evaluation of carcinogenic risks to humans, human papillomaviruses, vol 90. IARC Press, Lyon
26. Jemal A, Tiwari RC, Murray T, Ghafoor A, Samuels A, Ward E, Feuer EJ, Thun MJ (2004) Cancer statistics, 2004. CA Cancer J Clin 54:8-29
27. Kanehisa M, Goto S, Furumichi M, Tanabe M, Hirakawa M (2010) KEGG for representation and analysis of molecular networks involving diseases and drugs. Nucleic Acids Res 38(Database issue):D355-D360
28. Kelloff GJ, Sigman CC, Greenwald P (1999) Cancer chemoprevention: progress and promise. Eur. J. Cancer 35:2031-2038
29. Knobloch TJ, Casto BC, Stoner GD, Weghorst CM (2003). Black raspberry extract-responsive genes in oral cancer cells (in vitro), unpublished
30. Knobloch TJ, Pearl DK, Huang K, Weghorst CM (2008). Analysis of lyophilized black raspberry extract-responsive genes in oral cancer, unpublished
31. Knobloch TJ, Pearl DK, Uhrig LK, Sardo CL, Warner BM, Ferguson JM, Agrawal A, Shuller DE, Clinton SK, Weghorst CM (2010). Interim analysis of black raspberry-responsive genes in oral cancer patients following short-term clinical exposures, unpublished
32. Kreimer AR, Clifford GM, Boyle P, Franceschi S (2005) Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol Biomarkers Prev 14:467-475
33. Kresty LA, Frankel WL, Hammond CD, Baird ME, Mele JM, Stoner GD, Fromkes JJ (2006) Transitioning from preclinical to clinical chemopreventive assessments of lyophilized black raspberries: interim results show berries modulate markers of oxidative stress in Barrett's esophagus patients. Nutr Cancer 54:148-156
34. Kresty LA, Morse MA, Morgan C, Carlton PS, Lu J, Gupta A, Blackwood M, Stoner GD (2001) Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries. Cancer Res 61:6112-6119
35. Lang JC, Tobin EJ, Knobloch TJ, Schuller DE, Bartynski KJ, Mountain RE, Nicholson R, DeYoung BR, Weghorst CM (1998) Frequent mutation of p16 in squamous cell carcinoma of the head and neck. Laryngoscope 108:923-928
36. Lee H, Li D, Prior T, Casto B, Weghorst CM, Shuler CF, Milo GE (1997) Ineffectiveness of the presence of H-ras/p53 combination mutations in squamous cell carcinoma cells to induce the conversion of a nontumorigenic to a tumorigenic tumor type. Cell Biol Toxicol 13:419-434
37. Leon X, Quer M, Diez S, Orus C, Lopez-Pousa A, Burgues J (1999) Second neoplasm in patients with head and neck cancer. Head Neck 21:204-210
38. Li C, Wong WH (2001) Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc Natl Acad Sci USA 98:31-36
39. Liang C, McClean MD, Marsit C, Christensen B, Peters E, Nelson HH, Kelsey KT (2009) A population-based case-control study of marijuana use and head and neck squamous cell carcinoma. Cancer Prev Res 2:759-768
40. Lippman SM, Sudbø J, Hong WK (2005) Oral cancer prevention and the evolution of molecular-targeted drug development. J Clin Oncol 23:346-356
41. Mao L, Hong WK, Papadimitrakopoulou VA (2004) Focus on head and neck cancer. Cancer Cell 5:311-316
42. Mashberg A, Boffetta P, Winkelman R, Garfinkel L (1993) Tobacco smoking, alcohol drinking and cancer of the oral cavity and oropharynx among US veterans. Cancer 72:1369-1375
43. Moyer RA, Hummer KE, Finn CE, Frei B, Wrolstad RE (2002) Anthocyanins, phenolics, and antioxidant capacity in diverse small fruits: vaccinium, rubus, and ribes. J Agric Food Chem 50:519-525
44. Orr IM (1933) Oral cancer in betel nut chewers in Travancore, its aetiology, pathology, and treatment. Lancet II:575-580
45. Papadimitrakopoulou V, Izzo J, Lippman SM, Lee JS, Fan YH, Clayman G, Ro JY, Hittelman WN, Lotan R, Hong WK, Mao L (1997) Frequent inactivation of p16INK4a in oral premalignant lesions. Oncogene 14:1799-1803
46. Parkin DM et al (eds) (2002) Cancer incidence in five continents, vol 8. IARC Scientific Publications No. 155, IARC, Lyon
47. Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin 55:74-108
48. Parmigiani G et al (eds) (2003) DNA-Chip Analyzer (dChip). In: The analysis of gene expression data: methods and software. Springer, New York, NY, pp 120-141
49. Pavia M, Pileggi C, Nobile CG, Angelillo IF (2006) Association between fruit and vegetable consumption and oral cancer: a meta-analysis of observational studies. Am J Clin Nutr 83:1126-1134
50. Reed AL, Califano J, Cairns P, Westra WH, Jones RM, Koch W, Ahrendt S, Eby Y, Sewell D, Nawroz H, Bartek J, Sidransky D (1996) High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma. Cancer Res 56:3630-3633
51. Reibel J (2003) Update on the evidence, with recommendations. Med Princ Pract 1(suppl 12): 22-32
52. Sasaki T, Moles DR, Imai Y, Speight PM (2005) Clinico-pathological features of squamous cell carcinoma of the oral cavity in patients <40 years of age. J Oral Pathol Med 34:129-133
53. Schwartz LH, Ozsahin M, Zhang GN, Touboul E, De Vataire F, Andolenko P, Lacau-Saint-Guily J, Laugier A, Schlienger M (1994) Synchronous and metachronous head and neck carcinomas. Cancer 74:1933-1938
54. Slaughter DP (1944) Multiplicity of origin of malignant tumors; collective review. Internat Abstr Surg 79:89-98
55. Slaughter DP (1946) Multicentric origin of intraoral carcinoma. Surgery 20:133-146
56. Slaughter DP, Southwick HW, Smejkal W (1953) "Field cancerization" in oral stratified squamous epithelium: clinical implications of multicentric origin. Cancer 6:963-968
57. Sobin LH, Gospodarowicz MK, Wittekind C (eds) (2009) TNM classification of malignant tumours, 7th edn. Wiley, Hoboken, NJ
58. Sporn MB (1976) Approaches to prevention of epithelial cancer during the preneoplastic period. Cancer Res 36:2699-2702
59. Sporn MB, Dunlop NM, Newton DL, Smith JM (1976) Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids). Fed Proc 35:1332-1338
60. Stocks P (1933). Cancer incidence in North Wales and Liverpool region in relation to habits and environment. British Empire Cancer Campaign 35th Annual Report (Suppl. to Part 2):1-127
61. Stoner GD (2009) Foodstuffs for preventing cancer: the preclinical and clinical development of berries. Cancer Prev Res 2:187-194
62. Stoner GD, Morse MA, Kelloff GJ (1997) Perspectives in cancer chemoprevention. Environ Health Perspect 105(Suppl 4):945-954
63. Stoner GD, Sardo C, Apseloff G, Mullet D, Wargo W, Pound V, Singh A, Sanders J, Aziz R, Casto B, Sun X (2005) Pharmacokinetics of anthocyanins and ellagic acid in healthy volunteers fed freeze-dried black raspberries daily for 7 days. J Clin Pharmacol 45:1153-1164
64. Tian Q, Giusti MM, Stoner GD, Schwartz SJ (2006) Urinary excretion of black raspberry (Rubus occidentalis) anthocyanins and their metabolites. J Agric Food Chem 54:1467-1472
65. U.S. Department of Health and Human Services (Nov 2000) Healthy people 2010: understanding and improving health, 2nd edn. US Government Printing Office, Washington, DC
66. U.S. Department of Health and Human Services. Common Terminology Criteria for Adverse Events (CTCAE): Version 4.02. [http://evs.nci.nih.gov/ftp1/CTCAE/ CTCAE-4.02-2009-09-15-QuickReferenc e-8.5x11.pdf]
67. Vokes EE, Weichselbaum RR, Lippman SM, Hong WK (1993) Head and neck cancer. N Engl J Med 328:184-194
68. Wang SY, Lin HS (2000) Antioxidant activity in fruits and leaves of blackberry, raspberry, and strawberry varies with cultivar and developmental stage. J Agric Food Chem 48:140-146
69. Weghorst CM, Clinton SK, Agrawal A (2004). Chemopreventive agent-responsive genes in oral cancer, The Ohio State University, Internal Review Board Protocol OSU0497
70. Weghorst CM, Clinton SK, Agrawal A (2006). Chemoprevention of oral cancer in Appalachia, The Ohio State University, Internal Review Board Protocol OSU06132
71. Weghorst CM, Clinton SK, Agrawal A (2008). Food-based modulation of biomarkers in human tissues at high-risk for oral cancer, The Ohio State University, Internal Review Board Protocol OSU07085
72. Whitmore GA, Lee MLT, Knobloch TJ, Weghorst CM (2008). Interim analysis of oral cancer patients following short-term exposure to lyophilized black raspberries: affymetrix genechip expression profiling, unpublished
73. Wilson WR (1908) The natural history of cancer, with special reference to its causation and prevention. William Wood and Company, New York, NY
74. Wiseman M (2008) The second World Cancer Research Fund/American Institute for Cancer Research expert report. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Proc Nutr Soc 67:253-256
75. Wynder EL, Stellman SD (1977) Comparative epidemiology of tobacco-related cancers. Cancer Res 37:4608-4622
76. Xue H, Aziz RM, Sun N, Cassady JM, Kamendulis LM, Xu Y, Stoner GD, Klaunig JE (2001) Inhibition of cellular transformation by berry extracts. Carcinogenesis 22:351-356
77. Yeudall WA, Crawford RY, Ensley JF, Robbins KC (1994) MTS1/CDK4I is altered in cell lines derived from primary and metastatic oral squamous cell carcinoma. Carcinogenesis 15: 2683-2686
78. Zhang ZF, Morgenstern H, Spitz MR, Tashkin DP, Yu GP, Marshall JR, Hsu TC, Schantz SP (1999) Marijuana use and increased risk of squamous cell carcinoma of the head and neck. Cancer Epidemiol Biomarkers Prev 8:1071-1078