Crystal structures of the Chromobacterium violaceumω-transaminase reveal major structural rearrangements upon binding of coenzyme PLP

FEBS Journal

Volumn 279, Issue 5, 2012, Pages 779-792

  Humble, Maria S ^a,e   Cassimjee, Karim E ^a   Hãkansson, Maria ^b   Kimbung, Yengo R ^b   Walse, Björn ^b   Abedi, Vahak ^c   Federsel, Hans Jürgen ^c   Berglund, Per ^a   Logan, Derek T ^b,d  

^a ALBANOVA UNIVERSITY CENTER   (Sweden)

^b SARomics Biostructures AB   (Sweden)

^c ASTRAZENECA R AND D   (Sweden)

^d LUND UNIVERSITY   (Sweden)

^e STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

3D structure; class I transaminase; cofactor binding; phosphate cup; pyridoxal 5' phosphate (PLP)

Indexed keywords

AMINOTRANSFERASE; OMEGA TRANSAMINASE; PYRIDOXAL 5 PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; BINDING ASSAY; BINDING SITE; CHROMOBACTERIUM VIOLACEUM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; LIGHT SCATTERING; MOLECULAR WEIGHT; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; CHROMOBACTERIUM; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; PROTEIN CONFORMATION; PYRIDOXAL PHOSPHATE; SUBSTRATE SPECIFICITY; TRANSAMINASES;

BACTERIA (MICROORGANISMS); CHROMOBACTERIUM; CHROMOBACTERIUM VIOLACEUM;

EID: 84857650697     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2012.08468.x     Document Type: Article

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