Knocking-in the R142C mutation in transglutaminase 1 disrupts the stratum corneum barrier and postnatal survival of mice

Journal of Dermatological Science

Volumn 65, Issue 3, 2012, Pages 196-206

  Nakagawa, Noboru ^a   Yamamoto, Masaaki ^a   Imai, Yasutomo ^a   Sakaguchi, Yoshiko ^a   Takizawa, Takami ^b   Ohta, Noboru ^c   Yagi, Naoto ^c   Hatta, Ichiro ^c   Hitomi, Kiyotaka ^d   Takizawa, Toshihiro ^b   Takeda, Junji ^e   Tsuda, Tatsuya ^a   Matsuki, Masato ^a   Yamanishi, Kiyofumi ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

^c JAPAN SYNCHROTRON RADIATION RESEARCH INSTITUTE   (Japan)

^d NAGOYA UNIVERSITY   (Japan)

^e OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cre loxP system; Knock in mice; Point mutation; Skin barrier; Stratum corneum; Transglutaminase 1

Indexed keywords

LIPID; LORICRIN; MUTANT PROTEIN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; TOLONIUM CHLORIDE; TRANSGLUTAMINASE 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LOSS; CONTROLLED STUDY; ENZYME STABILITY; FEMALE; GENE EXPRESSION; GENE TARGETING; KERATINOCYTE; LETHALITY; MALE; MOUSE; MOUSE STRAIN; MUTANT; NONHUMAN; PERINATAL PERIOD; PERMEABILITY BARRIER; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; SKIN DEFECT; SKIN FUNCTION; SKIN PERMEABILITY; SKIN STRUCTURE; SKIN WATER LOSS; STRATUM CORNEUM; SURVIVAL; X RAY DIFFRACTION;

ANIMALS; ANIMALS, NEWBORN; DISEASE MODELS, ANIMAL; EPIDERMIS; GENE KNOCK-IN TECHNIQUES; ICHTHYOSIS; MICE; MICE, TRANSGENIC; PHENOTYPE; POINT MUTATION; SURVIVAL RATE; TRANSGLUTAMINASES; X-RAY DIFFRACTION;

EID: 84857646583     PISSN: 09231811     EISSN: 1873569X     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2011.12.011     Document Type: Article

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