Secretion and n-linked glycosylation are required for prostatic acid phosphatase catalytic and antinociceptive activity

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Hurt, Julie K ^a   Fitzpatrick, Brendan J ^a   Norris Drouin, Jacqueline ^b   Zylka, Mark J ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID PHOSPHATASE PROSTATE ISOENZYME; RECOMBINANT ACID PHOSPHATASE PROSTATE ISOENZYME; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; ANALGESIC AGENT; PROTEIN TYROSINE PHOSPHATASE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALYSIS; CELL LYSATE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME GLYCOSYLATION; ENZYME MODIFICATION; ENZYME PURIFICATION; ENZYME RELEASE; ENZYME STABILITY; ENZYME SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATORY PAIN; MALE; MOUSE; NEUROPATHIC PAIN; NONHUMAN; NUCLEOTIDE SEQUENCE; PAIN; PICHIA PASTORIS; POINT MUTATION; PROTEIN EXPRESSION; WESTERN BLOTTING; WILD TYPE; ANIMAL; CHEMISTRY; GENETICS; GLYCOSYLATION; HUMAN; METABOLISM; PHYSIOLOGY; PICHIA; PROTEIN PROCESSING; SITE DIRECTED MUTAGENESIS;

ANIMALIA; MUS; PICHIA; PICHIA PASTORIS;

ANALGESICS; ANIMALS; GLYCOSYLATION; HUMANS; MALE; MICE; MUTAGENESIS, SITE-DIRECTED; PAIN; PICHIA; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TYROSINE PHOSPHATASES;

EID: 84857621778     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032741     Document Type: Article

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