메뉴 건너뛰기




Volumn 13, Issue 2, 2012, Pages 225-235

An insight into the interaction between clopidogrel and proton pump inhibitors

Author keywords

Acute coronary syndrome (ACS); Clopidogrel; Cytochrome P450 (CYP); Drug drug interaction; Genetic polymorphism; Proton pump inhibitors (PPIs)

Indexed keywords

ACETYLSALICYLIC ACID; AMLODIPINE; CLOPIDOGREL; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; ESOMEPRAZOLE; ITRACONAZOLE; LANSOPRAZOLE; NIFEDIPINE; OMEPRAZOLE; PANTOPRAZOLE; PROTON PUMP INHIBITOR;

EID: 84857606031     PISSN: 13892002     EISSN: 18755453     Source Type: Journal    
DOI: 10.2174/138920012798918390     Document Type: Article
Times cited : (21)

References (79)
  • 1
    • 34248371253 scopus 로고    scopus 로고
    • Clinical aspects of platelet inhibitors and thrombus formation
    • DOI 10.1161/01.RES.0000264509.36234.51, PII 0000301220070511000004
    • Meadows, T. A.; Bhatt, D. L., Clinical aspects of platelet inhibitors and thrombus formation. Circ. Res., 2007, 100(9), 1261-1275. (Pubitemid 46742917)
    • (2007) Circulation Research , vol.100 , Issue.9 , pp. 1261-1275
    • Meadows, T.A.1    Bhatt, D.L.2
  • 2
    • 0035899289 scopus 로고    scopus 로고
    • Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation
    • DOI 10.1056/NEJMoa010746
    • Yusuf, S.; Zhao, F.; Mehta, S. R.; Chrolavicius, S.; Tognoni, G.; Fox, K. K., Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N. Engl. J. Med., 2001, 345(7), 494-502. (Pubitemid 32758501)
    • (2001) New England Journal of Medicine , vol.345 , Issue.7 , pp. 494-502
    • Yusuf, S.1    Zhao, F.2    Mehta, S.R.3    Chrolavicius, S.4    Tognoni, G.5    Fox, K.K.6
  • 4
    • 0038291914 scopus 로고    scopus 로고
    • Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement
    • Muller, I.; Besta, F.; Schulz, C.; Massberg, S.; Schonig, A.; Gawaz, M., Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement. Thromb. Haemost., 2003, 89(5), 783-787. (Pubitemid 36603418)
    • (2003) Thrombosis and Haemostasis , vol.89 , Issue.5 , pp. 783-787
    • Muller, I.1    Besta, F.2    Schulz, C.3    Massberg, S.4    Schonig, A.5    Gawaz, M.6
  • 5
    • 0038649988 scopus 로고    scopus 로고
    • Clopidogrel for coronary stenting: Response variability, drug resistance, and the effect of pretreatment platelet reactivity
    • DOI 10.1161/01.CIR.0000072771.11429.83
    • Gurbel, P. A.; Bliden, K. P.; Hiatt, B. L.; O'Connor, C. M., Clopidogrel for coronary stenting: Response variability, drug resistance, and the effect of pretreatment platelet reactivity. Circulation, 2003, 107(23), 2908-2913. (Pubitemid 36736631)
    • (2003) Circulation , vol.107 , Issue.23 , pp. 2908-2913
    • Gurbel, P.A.1    Bliden, K.P.2    Hiatt, B.L.3    O'Connor, C.M.4
  • 6
    • 1642453779 scopus 로고    scopus 로고
    • Contribution of Hepatic Cytochrome P450 3A4 Metabolic Activity to the Phenomenon of Clopidogrel Resistance
    • DOI 10.1161/01.CIR.0000112378.09325.F9
    • Lau, W. C.; Gurbel, P. A.; Watkins, P. B.; Neer, C. J.; Hopp, A. S.; Carville, D. G.; Guyer, K. E.; Tait, A. R.; Bates, E. R., Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance. Circulation, 2004, 109(2), 166-171. (Pubitemid 38114134)
    • (2004) Circulation , vol.109 , Issue.2 , pp. 166-171
    • Lau, W.C.1    Gurbel, P.A.2    Watkins, P.B.3    Neer, C.J.4    Hopp, A.S.5    Carville, D.G.M.6    Guyer, K.E.7    Tait, A.R.8    Bates, E.R.9
  • 7
    • 10444235983 scopus 로고    scopus 로고
    • Clopidogrel resistance: A new chapter in a fast-moving story
    • Wiviott, S. D.; Antman, E. M., Clopidogrel resistance: A new chapter in a fast-moving story. Circulation, 2004, 109(25), 3064-3067.
    • (2004) Circulation , vol.109 , Issue.25 , pp. 3064-3067
    • Wiviott, S.D.1    Antman, E.M.2
  • 8
    • 0142186281 scopus 로고    scopus 로고
    • Platelet activation after stenting with heparin-coated versus noncoated stents
    • Gurbel, P. A.; Bliden, K. P., Platelet activation after stenting with heparin-coated versus noncoated stents. Am. Heart J., 2003, 146(4), E10.
    • (2003) Am. Heart J. , vol.146 , Issue.4
    • Gurbel, P.A.1    Bliden, K.P.2
  • 9
    • 34249990913 scopus 로고    scopus 로고
    • Clopidogrel resistance?
    • DOI 10.1016/j.thromres.2006.08.012, PII S0049384806003847
    • Gurbel, P. A.; Tantry, U. S., Clopidogrel resistance? Thromb. Res., 2007, 120(3), 311-321. (Pubitemid 46881255)
    • (2007) Thrombosis Research , vol.120 , Issue.3 , pp. 311-321
    • Gurbel, P.A.1    Tantry, U.S.2
  • 10
    • 33845474736 scopus 로고    scopus 로고
    • Monitoring platelet inhibition after clopidogrel with the VerifyNow-P2Y12 rapid analyzer: The VERIfy Thrombosis risk ASsessment (VERITAS) study
    • DOI 10.1016/j.thromres.2006.01.019, PII S0049384806000491
    • Malinin, A.; Pokov, A.; Spergling, M.; Defranco, A.; Schwartz, K.; Schwartz, D.; Mahmud, E.; Atar, D.; Serebruany, V., Monitoring platelet inhibition after clopidogrel with the VerifyNow-P2Y12(R) rapid analyzer: The VERIfy Thrombosis risk ASsessment (VERITAS) study. Thromb. Res., 2007, 119(3), 277-284. (Pubitemid 44918092)
    • (2007) Thrombosis Research , vol.119 , Issue.3 , pp. 277-284
    • Malinin, A.1    Pokov, A.2    Spergling, M.3    Defranco, A.4    Schwartz, K.5    Schwartz, D.6    Mahmud, E.7    Atar, D.8    Serebruany, V.9
  • 17
  • 18
    • 84857542239 scopus 로고    scopus 로고
    • Product package insert for clopidogrel (PLAVIX ®) available online, accessed January 03
    • Product package insert for clopidogrel (PLAVIX ®) available online. http://products.sanofi-Aventis.us/PLAVIX/PLAVIX.html (accessed January 03, 2011).
    • (2011)
  • 21
    • 40749094082 scopus 로고    scopus 로고
    • Effects of the proton pump inhibitor lansoprazole on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel
    • DOI 10.1177/0091270008315310
    • Small, D. S.; Farid, N. A.; Payne, C. D.; Weerakkody, G. J.; Li, Y. G.; Brandt, J. T.; Salazar, D. E.; Winters, K. J., Effects of the Proton Pump Inhibitor Lansoprazole on the Pharmacokinetics and Pharmacodynamics of Prasugrel and Clopidogrel. The Journal of Clinical Pharmacology, 2008, 48(4), 475-484. (Pubitemid 351389118)
    • (2008) Journal of Clinical Pharmacology , vol.48 , Issue.4 , pp. 475-484
    • Small, D.S.1    Farid, N.A.2    Payne, C.D.3    Weerakkody, G.J.4    Li, Y.G.5    Brandt, J.T.6    Salazar, D.E.7    Winters, K.J.8
  • 22
    • 42649083329 scopus 로고    scopus 로고
    • High-dose atorvastatin does not negatively influence clinical outcomes among clopidogrel treated acute coronary syndrome patients-A Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) analysis
    • Lotfi, A.; Schweiger, M. J.; Giugliano, G. R.; Murphy, S. A.; Cannon, C. P., High-dose atorvastatin does not negatively influence clinical outcomes among clopidogrel treated acute coronary syndrome patients-A Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) analysis. Am. Heart. J., 2008, 155(5), 954-958.
    • (2008) Am. Heart.J. , vol.155 , Issue.5 , pp. 954-958
    • Lotfi, A.1    Schweiger, M.J.2    Giugliano, G.R.3    Murphy, S.A.4    Cannon, C.P.5
  • 23
    • 73149119363 scopus 로고    scopus 로고
    • Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite
    • Kazui, M.; Nishiya, Y.; Ishizuka, T.; Hagihara, K.; Farid, N. A.; Okazaki, O.; Ikeda, T.; Kurihara, A., Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite. Drug Metab. Dispos., 2010, 38(1), 92-99.
    • (2010) Drug Metab. Dispos. , vol.38 , Issue.1 , pp. 92-99
    • Kazui, M.1    Nishiya, Y.2    Ishizuka, T.3    Hagihara, K.4    Farid, N.A.5    Okazaki, O.6    Ikeda, T.7    Kurihara, A.8
  • 24
    • 33744968214 scopus 로고    scopus 로고
    • Increased risk of atherothrombotic events associated with cytochrome P450 3A5 polymorphism in patients taking clopidogrel
    • Suh, J. W.; Koo, B. K.; Zhang, S. Y.; Park, K. W.; Cho, J. Y.; Jang, I. J.; Lee, D. S.; Sohn, D. W.; Lee, M. M.; Kim, H. S., Increased risk of atherothrombotic events associated with cytochrome P450 3A5 polymorphism in patients taking clopidogrel. CMAJ, 2006, 174(12), 1715-1722.
    • (2006) CMAJ , vol.174 , Issue.12 , pp. 1715-1722
    • Suh, J.W.1    Koo, B.K.2    Zhang, S.Y.3    Park, K.W.4    Cho, J.Y.5    Jang, I.J.6    Lee, D.S.7    Sohn, D.W.8    Lee, M.M.9    Kim, H.S.10
  • 26
    • 54349121974 scopus 로고    scopus 로고
    • Calciumchannel blockers reduce the antiplatelet effect of clopidogrel
    • Siller-Matula, J. M.; Lang, I.; Christ, G.; Jilma, B., Calciumchannel blockers reduce the antiplatelet effect of clopidogrel. J. Am. Coll. Cardiol., 2008, 52(19), 1557-1563.
    • (2008) J. Am. Coll. Cardiol. , vol.52 , Issue.19 , pp. 1557-1563
    • Siller-Matula, J.M.1    Lang, I.2    Christ, G.3    Jilma, B.4
  • 28
    • 0037422534 scopus 로고    scopus 로고
    • Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: A new drug-drug interaction
    • DOI 10.1161/01.CIR.0000047060.60595.CC
    • Lau, W. C.; Waskell, L. A.; Watkins, P. B.; Neer, C. J.; Horowitz, K.; Hopp, A. S.; Tait, A. R.; Carville, D. G.; Guyer, K. E.; Bates, E. R., Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: A new drug-drug interaction. Circulation, 2003, 107(1), 32-37. (Pubitemid 36070929)
    • (2003) Circulation , vol.107 , Issue.1 , pp. 32-37
    • Lau, W.C.1    Waskell, L.A.2    Watkins, P.B.3    Neer, C.J.4    Horowitz, K.5    Hopp, A.S.6    Tait, A.R.7    Carville, D.G.M.8    Guyer, K.E.9    Bates, E.R.10
  • 29
    • 0042780283 scopus 로고    scopus 로고
    • Lack of adverse clopidogrel-atorvastatin clinical interaction from secondary analysis of a randomized, placebo-controlled clopidogrel trial
    • DOI 10.1161/01.CIR.0000088780.57432.43
    • Saw, J.; Steinhubl, S. R.; Berger, P. B.; Kereiakes, D. J.; Serebruany, V. L.; Brennan, D.; Topol, E. J., Lack of adverse clopidogrel-Atorvastatin clinical interaction from secondary analysis of a randomized, placebo-controlled clopidogrel trial. Circulation, 2003, 108(8), 921-924. (Pubitemid 37048218)
    • (2003) Circulation , vol.108 , Issue.8 , pp. 921-924
    • Saw, J.1    Steinhubl, S.R.2    Berger, P.B.3    Kereiakes, D.J.4    Serebruany, V.L.5    Brennan, D.6    Topol, E.J.7
  • 31
    • 60949111715 scopus 로고    scopus 로고
    • Multiple mechanisms affect the clopidogrel response
    • Siasos, G.; Tousoulis, D.; Stefanadis, C., Multiple Mechanisms Affect the Clopidogrel Response. J. Am. Coll. Cardiol., 2009, 53(10), 900-A-901.
    • (2009) J. Am. Coll. Cardiol. , vol.53 , Issue.10 , pp. 900-901
    • Siasos, G.1    Tousoulis, D.2    Stefanadis, C.3
  • 32
    • 79952355781 scopus 로고    scopus 로고
    • Impact of genetic polymorphisms and drug-drug interactions on clopidogrel and prasugrel response variability
    • Fontana
    • Ancrenaz, V.; Daali, Y.; Fontana, P.; Besson, M.; Samer, C.; Dayer, P.; Desmeules, J., Impact of genetic polymorphisms and drug-drug interactions on clopidogrel and prasugrel response variability. Curr. Drug Metab., 2010, 11(8), 667-677.
    • (2010) Curr. Drug Metab. , vol.11 , Issue.8 , pp. 667-677
    • Ancrenaz, V.1    Daali, Y.P.2    Besson, M.3    Samer, C.4    Dayer, P.5    Desmeules, J.6
  • 33
    • 77958608904 scopus 로고    scopus 로고
    • Potentiation of clopidogrel active metabolite formation by rifampicin leads to greater P2Y12 receptor blockade and inhibition of platelet aggregation after clopidogrel
    • Judge, H. M.; Patil, S. B.; Buckland, R. J.; Jakubowski, J. A.; Storey, R. F., Potentiation of clopidogrel active metabolite formation by rifampicin leads to greater P2Y12 receptor blockade and inhibition of platelet aggregation after clopidogrel. J. Thromb. Haemost., 2010, 8(8), 1820-1827.
    • (2010) J. Thromb. Haemost. , vol.8 , Issue.8 , pp. 1820-1827
    • Judge, H.M.1    Patil, S.B.2    Buckland, R.J.3    Jakubowski, J.A.4    Storey, R.F.5
  • 35
    • 33750079553 scopus 로고    scopus 로고
    • Influence of omeprazol on the antiplatelet action of clopidogrel associated to aspirin [8]
    • DOI 10.1111/j.1538-7836.2006.02162.x
    • Gilard, M.; Arnaud, B.; Le Gal, G.; Abgrall, J. F.; Boschat, J., Influence of omeprazol on the antiplatelet action of clopidogrel associated to aspirin. J. Thromb. Haemost., 2006, 4(11), 2508-2509. (Pubitemid 44575451)
    • (2006) Journal of Thrombosis and Haemostasis , vol.4 , Issue.11 , pp. 2508-2509
    • Gilard, M.1    Arnaud, B.2    Le Gal, G.3    Abgrall, J.F.4    Boschat, J.5
  • 36
    • 38349065084 scopus 로고    scopus 로고
    • Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: The randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study
    • Gilard, M.; Arnaud, B.; Cornily, J. C.; Le Gal, G.; Lacut, K.; Le Calvez, G.; Mansourati, J.; Mottier, D.; Abgrall, J. F.; Boschat, J., Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: The randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study. J. Am. Coll. Cardiol., 2008, 51(3), 256-260.
    • (2008) J. Am. Coll. Cardiol. , vol.51 , Issue.3 , pp. 256-260
    • Gilard, M.1    Arnaud, B.2    Cornily, J.C.3    Le Gal, G.4    Lacut, K.5    Le Calvez, G.6    Mansourati, J.7    Mottier, D.8    Abgrall, J.F.9    Boschat, J.10
  • 37
    • 3242676832 scopus 로고    scopus 로고
    • Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities
    • DOI 10.1124/dmd.32.8.821
    • Li, X. Q.; Andersson, T. B.; Ahlstrom, M.; Weidolf, L., Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab. Dispos., 2004, 32(8), 821-827. (Pubitemid 38955611)
    • (2004) Drug Metabolism and Disposition , vol.32 , Issue.8 , pp. 821-827
    • Li, X.-Q.1    Andersson, T.B.2    Ahlstrom, M.3    Weidolf, L.4
  • 39
    • 57149104093 scopus 로고    scopus 로고
    • Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrel
    • Siller-Matula, J. M.; Spiel, A. O.; Lang, I. M.; Kreiner, G.; Christ, G.; Jilma, B., Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrel. Am. Heart. J., 2009, 157(1), 148 e141-145.
    • (2009) Am. Heart.J. , vol.157 , Issue.1
    • Siller-Matula, J.M.1    Spiel, A.O.2    Lang, I.M.3    Kreiner, G.4    Christ, G.5    Jilma, B.6
  • 42
    • 51049115517 scopus 로고    scopus 로고
    • Initial assessment of clinical impact of a drug interaction between clopidogrel and proton pump inhibitors
    • author reply 1039
    • Pezalla, E.; Day, D.; Pulliadath, I., Initial assessment of clinical impact of a drug interaction between clopidogrel and proton pump inhibitors. J. Am. Coll. Cardiol., 2008, 52(12), 1038-1039; author reply 1039.
    • (2008) J. Am. Coll. Cardiol. , vol.52 , Issue.12 , pp. 1038-1039
    • Pezalla, E.1    Day, D.2    Pulliadath, I.3
  • 43
    • 62649164844 scopus 로고    scopus 로고
    • A population-based study of the drug interaction between proton pump inhibitors and clopidogrel
    • Juurlink, D. N.; Gomes, T.; Ko, D. T.; Szmitko, P. E.; Austin, P. C.; Tu, J. V.; Henry, D. A.; Kopp, A.; Mamdani, M. M., A population-based study of the drug interaction between proton pump inhibitors and clopidogrel. CMAJ, 2009, 180(7), 713-718.
    • (2009) CMAJ , vol.180 , Issue.7 , pp. 713-718
    • Juurlink, D.N.1    Gomes, T.2    Ko, D.T.3    Szmitko, P.E.4    Austin, P.C.5    Tu, J.V.6    Henry, D.A.7    Kopp, A.8    Mamdani, M.M.9
  • 47
    • 77649187092 scopus 로고    scopus 로고
    • A national study of the effect of individual proton pump inhibitors on cardiovascular outcomes in patients treated with clopidogrel following coronary stenting: The Clopidogrel Medco Outcomes study
    • Abstract
    • Stanek, E. J.; Aubert, R. E.; Rolf, P.; Kreutz, R. P.; Yao, J.; Breall, J. A., A national study of the effect of individual proton pump inhibitors on cardiovascular outcomes in patients treated with clopidogrel following coronary stenting: The Clopidogrel Medco Outcomes study. In 32nd Annual SCAI Scientific Sessions, Las Vegas, Nevada, 2009 (Abstract).
    • (2009) 32nd Annual SCAI Scientific Sessions, Las Vegas, Nevada
    • Stanek, E.J.1    Aubert, R.E.2    Rolf, P.3    Kreutz, R.P.4    Yao, J.5    Breall, J.A.6
  • 49
    • 73449122247 scopus 로고    scopus 로고
    • Cardiovascular outcomes and mortality in patients using clopidogrel with proton pump inhibitors after percutaneous coronary intervention or acute coronary syndrome
    • Rassen, J. A.; Choudhry, N. K.; Avorn, J.; Schneeweiss, S., Cardiovascular outcomes and mortality in patients using clopidogrel with proton pump inhibitors after percutaneous coronary intervention or acute coronary syndrome. Circulation, 2009, 120(23), 2322-2329.
    • (2009) Circulation , vol.120 , Issue.23 , pp. 2322-2329
    • Rassen, J.A.1    Choudhry, N.K.2    Avorn, J.3    Schneeweiss, S.4
  • 53
    • 64849116567 scopus 로고    scopus 로고
    • Baseline proton pump inhibitors use is associated with increased cardiovascular events with and without the use of clopidogrel in the CREDO trial
    • Abstract
    • Dunn, S. P.; Macaulay, T. E.; Brennan, D. M.; Campbell, C. L.; Charnigo, R. J.; Smyth, S. S.; Berger, B. B.; Steinhubl, S. R.; Topol, E. J., Baseline proton pump inhibitors use is associated with increased cardiovascular events with and without the use of clopidogrel in the CREDO trial. Circulation, 2008, 118, S-815 (Abstract).
    • (2008) Circulation , vol.118
    • Dunn, S.P.1    Macaulay, T.E.2    Brennan, D.M.3    Campbell, C.L.4    Charnigo, R.J.5    Smyth, S.S.6    Berger, B.B.7    Steinhubl, S.R.8    Topol, E.J.9
  • 56
    • 85027923473 scopus 로고    scopus 로고
    • Intronic polymorphisms of cytochromes P450
    • Ingelman-Sundberg, M.; Sim, S. C., Intronic polymorphisms of cytochromes P450. Hum. Genomics, 2010, 4(6), 402-405.
    • (2010) Hum. Genomics , vol.4 , Issue.6 , pp. 402-405
    • Ingelman-Sundberg, M.1    Sim, S.C.2
  • 57
    • 75749102996 scopus 로고    scopus 로고
    • Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogrel, and prasugrel in humans
    • Farid, N. A.; Kurihara, A.; Wrighton, S. A., Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogrel, and prasugrel in humans. J Clin. Pharmacol., 2010, 50 (2), 126-142.
    • (2010) J Clin. Pharmacol. , vol.50 , Issue.2 , pp. 126-142
    • Farid, N.A.1    Kurihara, A.2    Wrighton, S.A.3
  • 58
  • 59
    • 45249088224 scopus 로고    scopus 로고
    • The effect of CYP2C19 polymorphism on the pharmacokinetics and pharmacodynamics of clopidogrel: A possible mechanism for clopidogrel resistance
    • Kim, K. A.; Park, P. W.; Hong, S. J.; Park, J. Y., The effect of CYP2C19 polymorphism on the pharmacokinetics and pharmacodynamics of clopidogrel: A possible mechanism for clopidogrel resistance. Clin. Pharmacol. Ther., 2008, 84(2), 236-242.
    • (2008) Clin. Pharmacol. Ther. , vol.84 , Issue.2 , pp. 236-242
    • Kim, K.A.1    Park, P.W.2    Hong, S.J.3    Park, J.Y.4
  • 60
    • 84857547093 scopus 로고    scopus 로고
    • available online, accessed July 18
    • CYP2C19 allele nomenclature, available online. http://www.cypalleles.ki. se/cyp2c19.htm (accessed July 18, 2011).
    • (2011) CYP2C19 Allele Nomenclature
  • 63
    • 37849002889 scopus 로고    scopus 로고
    • Prasugrel achieves greater and faster P2Y12receptor-mediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirin-treated patients with coronary artery disease
    • Wallentin, L.; Varenhorst, C.; James, S.; Erlinge, D.; Braun, O. O.; Jakubowski, J. A.; Sugidachi, A.; Winters, K. J.; Siegbahn, A., Prasugrel achieves greater and faster P2Y12receptor-mediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirin-treated patients with coronary artery disease. Eur. Heart. J., 2008, 29(1), 21-30.
    • (2008) Eur. Heart.J. , vol.29 , Issue.1 , pp. 21-30
    • Wallentin, L.1    Varenhorst, C.2    James, S.3    Erlinge, D.4    Braun, O.O.5    Jakubowski, J.A.6    Sugidachi, A.7    Winters, K.J.8    Siegbahn, A.9
  • 64
    • 43049179414 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 681G>A Polymorphism and High On-Clopidogrel Platelet Reactivity Associated With Adverse 1-Year Clinical Outcome of Elective Percutaneous Coronary Intervention With Drug-Eluting or Bare-Metal Stents
    • DOI 10.1016/j.jacc.2007.12.056, PII S0735109708008656
    • Trenk, D.; Hochholzer, W.; Fromm, M. F.; Chialda, L. E.; Pahl, A.; Valina, C. M.; Stratz, C.; Schmiebusch, P.; Bestehorn, H. P.; Buttner, H. J.; Neumann, F. J., Cytochrome P450 2C19 681G>A polymorphism and high on-clopidogrel platelet reactivity associated with adverse 1-year clinical outcome of elective percutaneous coronary intervention with drug-eluting or bare-metal stents. J. Am. Coll. Cardiol., 2008, 51(20), 1925-1934. (Pubitemid 351636443)
    • (2008) Journal of the American College of Cardiology , vol.51 , Issue.20 , pp. 1925-1934
    • Trenk, D.1    Hochholzer, W.2    Fromm, M.F.3    Chialda, L.-E.4    Pahl, A.5    Valina, C.M.6    Stratz, C.7    Schmiebusch, P.8    Bestehorn, H.-P.9    Buttner, H.J.10    Neumann, F.-J.11
  • 65
    • 34548545280 scopus 로고    scopus 로고
    • ACC/AHA 2007 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
    • (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non STElevation Myocardial Infarction): Developed in collaboration with the American College of Emergency Physicians, The Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons: Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine
    • Anderson, J. L.; Adams, C. D.; Antman, E. M.; Bridges, C. R.; Califf, R. M.; Casey, D. E., Jr.; Chavey, W. E., 2nd; Fesmire, F. M.; Hochman, J. S.; Levin, T. N.; Lincoff, A. M.; Peterson, E. D.; Theroux, P.; Wenger, N. K.; Wright, R. S.; Smith, S. C., Jr.; Jacobs, A. K.; Halperin, J. L.; Hunt, S. A.; Krumholz, H. M.; Kushner, F. G.; Lytle, B. W.; Nishimura, R.; Ornato, J. P.; Page, R. L.; Riegel, B., ACC/AHA 2007 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non STElevation Myocardial Infarction): Developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons: Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. Circulation, 2007, 116(7), e148-304.
    • (2007) Circulation , vol.116 , Issue.7
    • Anderson, J.L.1    Adams, C.D.2    Antman, E.M.3    Bridges, C.R.4    Califf, R.M.5    Casey Jr., D.E.6    Chavey II, W.E.7    Fesmire, F.M.8    Hochman, J.S.9    Levin, T.N.10    Lincoff, A.M.11    Peterson, E.D.12    Theroux, P.13    Wenger, N.K.14    Wright, R.S.15    Smith Jr., S.C.16    Jacobs, A.K.17    Halperin, J.L.18    Hunt, S.A.19    Krumholz, H.M.20    more..
  • 66
    • 30344457586 scopus 로고    scopus 로고
    • A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants
    • DOI 10.1016/j.clpt.2005.10.002, PII S0009923605004613
    • Sim, S. C.; Risinger, C.; Dahl, M. L.; Aklillu, E.; Christensen, M.; Bertilsson, L.; Ingelman-Sundberg, M., A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants. Clin. Pharmacol. Ther., 2006, 79(1), 103-113. (Pubitemid 43069582)
    • (2006) Clinical Pharmacology and Therapeutics , vol.79 , Issue.1 , pp. 103-113
    • Sim, S.C.1    Risinger, C.2    Dahl, M.-L.3    Aklillu, E.4    Christensen, M.5    Bertilsson, L.6    Ingelman-Sundberg, M.7
  • 67
    • 49549107264 scopus 로고    scopus 로고
    • Pharmacogenetics of oral anticoagulants: A basis for dose individualization
    • Stehle, S.; Kirchheiner, J.; Lazar, A.; Fuhr, U., Pharmacogenetics of oral anticoagulants: A basis for dose individualization. Clin. Pharmacokinet., 2008, 47(9), 565-594.
    • (2008) Clin. Pharmacokinet. , vol.47 , Issue.9 , pp. 565-594
    • Stehle, S.1    Kirchheiner, J.2    Lazar, A.3    Fuhr, U.4
  • 69
    • 76649115043 scopus 로고    scopus 로고
    • Pharmacogenetics of CYP2C19: Functional and clinical implications of a new variant CYP2C19 17
    • Li-Wan-Po, A.; Girard, T.; Farndon, P.; Cooley, C.; Lithgow, J., Pharmacogenetics of CYP2C19: Functional and clinical implications of a new variant CYP2C19 17. Br. J. Clin. Pharmacol., 2010, 69(3), 222-230.
    • (2010) Br. J. Clin. Pharmacol. , vol.69 , Issue.3 , pp. 222-230
    • Li-Wan-Po, A.1    Girard, T.2    Farndon, P.3    Cooley, C.4    Lithgow, J.5
  • 71
    • 79651472053 scopus 로고    scopus 로고
    • Individual variability in the disposition of and response to clopidogrel: Pharmacogenomics and beyond
    • Xie, H.-G.; Zou, J.-J.; Hu, Z.-Y.; Zhang, J.-J.; Ye, F.; Chen, S.-L., Individual variability in the disposition of and response to clopidogrel: Pharmacogenomics and beyond. Pharmacology & Therapeutics, 2011, 129(3), 267-289.
    • (2011) Pharmacology & Therapeutics , vol.129 , Issue.3 , pp. 267-289
    • Xie, H.-G.1    Zou, J.-J.2    Hu, Z.-Y.3    Zhang, J.-J.4    Ye, F.5    Chen, S.-L.6
  • 72
    • 76349098199 scopus 로고    scopus 로고
    • Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement
    • Sibbing, D.; Koch, W.; Gebhard, D.; Schuster, T.; Braun, S.; Stegherr, J.; Morath, T.; Schomig, A.; von Beckerath, N.; Kastrati, A., Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement. Circulation, 2010, 121(4), 512-518.
    • (2010) Circulation , vol.121 , Issue.4 , pp. 512-518
    • Sibbing, D.1    Koch, W.2    Gebhard, D.3    Schuster, T.4    Braun, S.5    Stegherr, J.6    Morath, T.7    Schomig, A.8    Von Beckerath, N.9    Kastrati, A.10
  • 73
    • 34547760330 scopus 로고    scopus 로고
    • A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease
    • DOI 10.1093/eurheartj/ehm226
    • Lordkipanidze, M.; Pharand, C.; Schampaert, E.; Turgeon, J.; Palisaitis, D. A.; Diodati, J. G., A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease. Eur. Heart J., 2007, 28(14), 1702-1708. (Pubitemid 47227104)
    • (2007) European Heart Journal , vol.28 , Issue.14 , pp. 1702-1708
    • Lordkipanidze, M.1    Pharand, C.2    Schampaert, E.3    Turgeon, J.4    Palisaitis, D.A.5    Diodati, J.G.6
  • 74
    • 56049105925 scopus 로고    scopus 로고
    • Aspirin and clopidogrel response variability: Review of the published literature
    • Ferguson, A. D.; Dokainish, H.; Lakkis, N., Aspirin and clopidogrel response variability: Review of the published literature. Tex. Heart Inst. J., 2008, 35(3), 313-320.
    • (2008) Tex. Heart Inst.J. , vol.35 , Issue.3 , pp. 313-320
    • Ferguson, A.D.1    Dokainish, H.2    Lakkis, N.3
  • 75
    • 77950796980 scopus 로고    scopus 로고
    • Aspirin and clopidogrel resistance: Methodological challenges and opportunities
    • Gasparyan, A. Y., Aspirin and clopidogrel resistance: Methodological challenges and opportunities. Vasc. Health Risk Manag., 2010, 6, 109-112.
    • (2010) Vasc. Health Risk Manag. , vol.6 , pp. 109-112
    • Gasparyan, A.Y.1
  • 76
    • 78649696637 scopus 로고    scopus 로고
    • ACCF/ACG/AHA 2010 expert consensus document on the concomitant use of proton pump inhibitors and thienopyridines: A focused update of the ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use. A Report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents
    • Abraham, N. S.; Hlatky, M. A.; Antman, E. M.; Bhatt, D. L.; Bjorkman, D. J.; Clark, C. B.; Furberg, C. D.; Johnson, D. A.; Kahi, C. J.; Laine, L.; Mahaffey, K. W.; Quigley, E. M.; Scheiman, J.; Sperling, L. S.; Tomaselli, G. F., ACCF/ACG/AHA 2010 expert consensus document on the concomitant use of proton pump inhibitors and thienopyridines: A focused update of the ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use. A Report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents. J. Am. Coll. Cardiol., 2010, 56(24), 2051-2066.
    • (2010) J. Am. Coll. Cardiol. , vol.56 , Issue.24 , pp. 2051-2066
    • Abraham, N.S.1    Hlatky, M.A.2    Antman, E.M.3    Bhatt, D.L.4    Bjorkman, D.J.5    Clark, C.B.6    Furberg, C.D.7    Johnson, D.A.8    Kahi, C.J.9    Laine, L.10    Mahaffey, K.W.11    Quigley, E.M.12    Scheiman, J.13    Sperling, L.S.14    Tomaselli, G.F.15
  • 77
    • 79955118104 scopus 로고    scopus 로고
    • Clopidogrel and proton pump inhibitors: Influence of pharmacological interactions on clinical outcomes and mechanistic explanations
    • Tantry, U. S.; Kereiakes, D. J.; Gurbel, P. A., Clopidogrel and proton pump inhibitors: Influence of pharmacological interactions on clinical outcomes and mechanistic explanations. JACC Cardiovasc. Interv., 2011, 4(4), 365-380.
    • (2011) JACC Cardiovasc. Interv. , vol.4 , Issue.4 , pp. 365-380
    • Tantry, U.S.1    Kereiakes, D.J.2    Gurbel, P.A.3
  • 78
    • 84857518462 scopus 로고    scopus 로고
    • US Food and Drug Administration Information on Clopidogrel Bisulfate (marketed as Plavix), accessed July
    • US Food and Drug Administration. Information on Clopidogrel Bisulfate (marketed as Plavix). http://www.fda.gov/Drugs/Drug-Safety/ PostmarketDrugSafetyInformationforPatientsandProviders/ucm190836.htm (accessed July 2011).
    • (2011)
  • 79
    • 84857513942 scopus 로고    scopus 로고
    • European Medicines Agency. Public Statement on Interaction between clopidogrel and proton-pump inhibitors. Available online at, accessed July 24
    • European Medicines Agency. Public Statement on Interaction between clopidogrel and proton-pump inhibitors. Available online at. http://www.ema.europa.eu/docs/en-GB/document-library/Public-statement/2010/03/ WC500076346.pdf (accessed July 24, 2011).
    • (2011)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.