Multiple Mechanisms Affect the Clopidogrel Response

Journal of the American College of Cardiology

Volumn 53, Issue 10, 2009, Pages 900-901

  Siasos, Gerasimos ^a   Tousoulis, Dimitris ^a   Stefanadis, Christodoulos ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; CLOPIDOGREL; CYTOCHROME P450 2C19; CYTOCHROME P450 3A1; CYTOCHROME P450 3A5; FIBRINOGEN; FIBRINOGEN RECEPTOR; GLYCOPROTEIN IIIA; PURINERGIC P2Y12 RECEPTOR; VERY LATE ACTIVATION ANTIGEN 2;

ACUTE CORONARY SYNDROME; BODY MASS; CARDIOVASCULAR DISEASE; DIABETES MELLITUS; DRUG MECHANISM; DRUG RESPONSE; FIBRINOGEN BLOOD LEVEL; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HEREDITY; HUMAN; LETTER; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; THROMBOCYTE;

BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; CYTOCHROME P-450 ENZYME SYSTEM; DIABETES COMPLICATIONS; FIBRINOGEN; HUMANS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; POLYMORPHISM, GENETIC; TICLOPIDINE;

EID: 60949111715     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2008.09.062     Document Type: Letter

References (4)

1. Ang L., Palakodeti V., Khalid A., et al. Elevated plasma fibrinogen and diabetes mellitus are associated with lower inhibition of platelet reactivity with clopidogrel. J Am Coll Cardiol 52 (2008) 1052-1059
2. Angiolillo D.J., Fernandez-Ortiz A., Bernardo E., et al. Contribution of gene sequence variations of the hepatic cytochrome P450 3A4 enzyme to variability in individual responsiveness to clopidogrel. Arterioscler Thromb Vasc Biol 26 (2006) 1895-1900
3. Frere C., Cuisset T., Moragne P.E., et al. Effect of cytochrome P450 polymorphisms on platelet reactivity after treatment with clopidogrel in acute coronary syndrome. Am J Cardiol 101 (2008) 1088-1093
4. Lev E.I., Patel R.T., Guthikonda S., et al. Genetic polymorphisms of the platelet receptors P2Y(12), P2Y(1) and GP IIIa and response to aspirin and clopidogrel. Thromb Res 119 (2007) 355-360