The impact of early hormonal therapy in catastrophic brain-injured patients and its effect on organ procurement

American Surgeon

Volumn 78, Issue 3, 2012, Pages 318-324

  Lam, Lydia ^a   Inaba, Kenji ^a   Branco, Bernardino Castelo ^a   Putty, Bradley ^b   Salim, Ali ^c   Green, Donald J ^a   Talving, Peep ^a   Demetriades, Demetrios ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b LANDSTUHL REGIONAL MEDICAL CENTER   (Germany)

^c CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; DOPAMINE; LEVOTHYROXINE; METHYLPREDNISOLONE; NORADRENALIN; PHENYLEPHRINE; PIG INSULIN; VASOPRESSIN;

ADULT; ARTICLE; BRAIN DEATH; BRAIN INJURY; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMOGRAPHY; DRUG DOSE TITRATION; FEMALE; HORMONAL THERAPY; HOSPITAL ADMISSION; HUMAN; HYPOTENSION; MAJOR CLINICAL STUDY; MALE; ORGAN DONOR; ORGAN TRANSPLANTATION; TRAUMATIC BRAIN INJURY; TREATMENT RESPONSE; UNITED STATES;

ADULT; BRAIN DEATH; BRAIN INJURIES; COMORBIDITY; FEMALE; HORMONES; HUMANS; HYPOTENSION; LOS ANGELES; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SECONDARY PREVENTION; TISSUE AND ORGAN HARVESTING; TISSUE AND ORGAN PROCUREMENT; VASOCONSTRICTOR AGENTS;

EID: 84857604373     PISSN: 00031348     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. United Network for Organ Sharing. Available at: www.unos. org. Accessed October 6, 2010.
2. Salim A, Martin M, Brown C, et al. Using thyroid hormone in brain-dead donors to maximize the number of organs available for transplantation. Clin Transplant 2007;21:405-9. (Pubitemid 46711405)
3. Abdelnour T, Rieke S. Relationship of hormonal resuscitation therapy and central venous pressure on increasing organs for transplant. J Heart Lung Transplant 2009;28:480-5.
4. Venkateswaran RV, Steeds RP, Quinn DW, et al. The haemodynamic effects of adjunctive hormone therapy in potential heart donors: a prospective randomized double-blind factorially designed controlled trial. Eur Heart J 2009;30: 1771-80.
5. Venkateswaran RV, Patchell VB, Wilson IC, et al. Early donor management increases the retrieval rate of lungs for transplantation. Ann Thorac Surg 2008;85:278-86; discussion 286.
6. Rosendale JD, Kauffman HM, McBride MA, et al. Aggressive pharmacologic donor management results in more transplanted organs. Transplantation 2003;75:482-7. (Pubitemid 36241143)
7. Rosendale JD, Chabalewski FL, McBride MA, et al. Increased transplanted organs from the use of a standardized donor management protocol. Am J Transplant 2002;2:761-8. (Pubitemid 36342619)
8. Salim A, Martin M, Brown C, et al. The effect of a protocol of aggressive donor management: implications for the national organ donor shortage. J Trauma 2006;61:429-33; discussion 433-5.
9. Van Bakel AB, Pitzer S, Drake P, et al. Early hormonal therapy stabilizes hemodynamics during donor procurement. Transplant Proc 2004;36:2573-8. (Pubitemid 40036782)
10. Venkateswaran RV, Dronavalli V, Lambert PA, et al. The proinflammatory environment in potential heart and lung donors: prevalence and impact of donor management and hormonal therapy. Transplantation 2009;88:582-8.
11. Rosendale JD, Kauffman HM, McBride MA, et al. Hormonal resuscitation yields more transplanted hearts, with improved early function. Transplantation 2003;75:1336-41. (Pubitemid 36513044)
12. Novitzky D, Cooper DK, Reichart B. Hemodynamic and metabolic responses to hormonal therapy in brain-dead potential organ donors. Transplantation 1987;43:852-4. (Pubitemid 17084263)
13. Novitzky D, Cooper DK, Reichart B. Value of triiodothyronine (T3) therapy to brain-dead potential organ donors. J Heart Transplant 1986;5:486-7.
14. Wheeldon DR, Potter CD, Oduro A, et al. Transforming the 'unacceptable' donor: outcomes from the adoption of a standardized donor management technique. J Heart Lung Transplant 1995; 14:734-42.
15. Wood KE, Becker BN, McCartney JG, et al. Care of the potential organ donor. N Engl J Med 2004;351:2730-9. (Pubitemid 39665326)
16. Jeevanandam V, Todd B, Hellman S, et al. Use of triiodothyronine replacement therapy to reverse donor myocardial dysfunction: creating a larger donor pool. Transplant Proc 1993;25: 3305-6. (Pubitemid 24007330)
17. Salim A, Velmahos GC, Brown C, et al. Aggressive organ donor management significantly increases the number of organs available for transplantation. J Trauma 2005;58:991-4. (Pubitemid 40776905)
18. Salim A, Vassiliu P, Velmahos GC, et al. The role of thyroid hormone administration in potential organ donors. Arch Surg 2001; 136:1377-80. (Pubitemid 33117043)
19. Roth BJ, Sher L, Murray JA, et al. Cadaveric organ donor recruitment at Los Angeles County Hospital: improvement after formation of a structured clinical, educational and administrative service. Clin Transplant 2003;17(suppl 9):52-7. (Pubitemid 36958186)
20. Salim A, Brown C, Inaba K, et al. Improving consent rates for organ donation: the effect of an inhouse coordinator program. J Trauma 2007;62:1411-4; discussion 1414-5.
21. Chen JM, Cullinane S, Spanier TB, et al. Vasopressin deficiency and pressor hypersensitivity in hemodynamically unstable organ donors. Circulation 1999;100(suppl):II244-6. (Pubitemid 29523542)
22. Pennefather SH, Bullock RE, Mantle D, Dark JH. Use of low dose arginine vasopressin to support brain-dead organ donors. Transplantation 1995;59:58-62.
23. Follette DM, Rudich SM, Babcock WD. Improved oxygenation and increased lung donor recovery with high-dose steroid administration after brain death. J Heart Lung Transplant 1998;17: 423-9. (Pubitemid 28196962)
24. McElhinney DB, Khan JH, Babcock WD, Hall TS. Thoracic organ donor characteristics associated with successful lung procurement. Clin Transplant 2001;15:68-71. (Pubitemid 32094338)