The proinflammatory environment in potential heart and lung donors: Prevalence and impact of donor management and hormonal therapy

Transplantation

Volumn 88, Issue 4, 2009, Pages 582-588

  Venkateswaran, Rajamiyer V ^a   Dronavalli, Vamsidhar ^a   Lambert, Peter A ^b   Steeds, Richard P ^a   Wilson, Ian C ^a   Thompson, Richard D ^a   Mascaro, Jorge G ^a   Bonser, Robert S ^a  

^a UNIVERSITY HOSPITALS BIRMINGHAM NHS FOUNDATION TRUST   (United Kingdom)

^b ASTON UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; INTERLEUKIN 1; INTERLEUKIN 6; LIOTHYRONINE; METHYLPREDNISOLONE; PLACEBO; PROCALCITONIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HEART FUNCTION; HEART INDEX; HEART LEFT VENTRICLE EJECTION FRACTION; HEART TRANSPLANTATION; HORMONAL THERAPY; HUMAN; LUNG FUNCTION; LUNG TRANSPLANTATION; MALE; ORGAN DONOR; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADULT; ANTI-INFLAMMATORY AGENTS; BIOLOGICAL MARKERS; BRAIN DEATH; BRAIN STEM; C-REACTIVE PROTEIN; CALCITONIN; DOUBLE-BLIND METHOD; FEMALE; HEART TRANSPLANTATION; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-1; INTERLEUKIN-6; LUNG TRANSPLANTATION; MALE; METHYLPREDNISOLONE; MIDDLE AGED; PROSPECTIVE STUDIES; PROTEIN PRECURSORS; TISSUE DONORS; TRIIODOTHYRONINE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 70349158086     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181b11e5d     Document Type: Article

References (27)

1. Wood KE, Becker BN, McCartney JG, et al. Care of the potential organ donor. N Engl J Med 2004; 351: 2730.
2. Wilhelm MJ, Pratschke J, Beato F, et al. Activation of proinflammatory mediators in heart transplants from brain-dead donors: Evidence from a model of chronic rat cardiac allograft rejection. Transplant Proc 2002; 34: 2359.
3. Segel LD, vonHaag DW, Zhang J, et al. Selective overexpression of inflammatory molecules in hearts from brain-dead rats. J Heart Lung Transplant 2002; 21: 804.
4. Birks EJ, Yacoub MH, Burton PS, et al. Activation of apoptotic and inflammatory pathways in dysfunctional donor hearts. Transplantation 2000; 70: 1498.
5. Birks EJ, Burton PB, Owen VJ, et al. Molecular and cellular mechanisms of donor heart dysfunction. Transplant Proc 2001; 33: 2749.
6. Birks EJ, Burton PB, Owen V, et al. Elevated tumor necrosis factor-alpha and interleukin-6 in myocardium and serum of malfunctioning donor hearts. Circulation 2000; 102: 352.
7. Birks EJ, Owen VJ, Burton PB, et al. Tumor necrosis factor-alpha is expressed in donor heart and predicts right ventricular failure after human heart transplantation. Circulation 2000; 102: 326.
8. Plenz G, Eschert H, Erren M, et al. The interleukin-6/interleukin-6- receptor system is activated in donor hearts. J Am Coll Cardiol 2002; 39: 1508.
9. Deng MC, Plenz G, Labarrere C, et al. The role of IL6 cytokines in acute cardiac allograft rejection. Transpl Immunol 2002; 9: 115.
10. Wilhelm MJ, Pratschke J, Laskowski IA, et al. Brain death and its impact on the donor heart-Lessons from animal models. J Heart Lung Transplant 2000; 19: 414.
11. Wagner FD, Jonitz B, Potapov EV, et al. Procalcitonin, a donor-specific predictor of early graft failure-related mortality after heart transplantation. Circulation 2001; 104: I192.
12. Potapov EV, Wagner FD, Loebe M, et al. Elevated donor cardiac tro-ponin T and procalcitonin indicate two independent mechanisms of early graft failure after heart transplantation. Int J Cardiol 2003; 92: 163.
13. Wan S, DeSmet JM, Antoine M, et al. Steroid administration in heart and heart-lung transplantation: Is the timing adequate? Ann Thorac Surg 1996; 61: 674.
14. McLean KM, Duffy JY, Pandalai PK, et al. Glucocorticoids alter the balance between pro- and anti-inflammatory mediators in the myocar-dium in a porcine model of brain death. J Heart Lung Transplant 2007; 26: 78.
15. Lyons JM, Pearl JM, McLean KM, et al. Glucocorticoid administration reduces cardiac dysfunction after brain death in pigs. J Heart Lung Transplant 2005; 24: 2249.
16. Venkateswaran RV, Patchell VB, Wilson IC, et al. Early donor management increases the retrieval rate of lungs for transplantation. Ann Tho-rac Surg 2008; 85: 278.
17. Folkesson HG, Norlin A, Wang Y, et al. Dexamethasone and thyroid hormone pretreatment upregulate alveolar epithelial fluid clearance in adult rats. J Appl Physiol 2000; 88: 416.
18. Venkateswaran RV, Steeds RP, Quinn DW, et al. The haemodynamic effects of adjunctive hormone therapy in potential heart donors: A prospective randomized double blind factorially designed controlled trial. Eur Heart J 2009; Epub ahead of print.
19. Klemperer JD, Klein I, Gomez M, et al. Thyroid hormone treatment after coronary-artery bypass surgery. N Engl J Med 1995; 333: 1522.
20. Ranasinghe AM, Quinn DW, Pagano D, et al. Glucose-insulin-potassium and tri-iodothyronine individually improve hemodynamic performance and are associated with reduced troponin I release after on-pump coronary artery bypass grafting. Circulation 2006; 114: I245.
21. Potter CD, Wheeldon DR, Wallwork J. Functional assessment and management of heart donors: A rationale for characterization and a guide to therapy. J Heart Lung Transplant 1995; 14: 59.
22. Torre-Amione G, Kapadia S, Lee J, et al. Tumor necrosis factor-alpha and tumor necrosis factor receptors in the failing human heart. Circulation 1996; 93: 704.
23. Deswal A, Petersen NJ, Feldman AM, et al. Cytokines and cytokine receptors in advanced heart failure: An analysis of the cytokine database from the Vesnarinone trial (VEST). Circulation 2001; 103: 2055.
24. Pratschke J, Wilhelm MJ, Kusaka M, et al. Activation of proinflamma-tory genes in somatic organs as a consequence of brain death. Transplant Proc 1999; 31: 1003.
25. Wilhelm MJ, Pratschke J, Beato F, et al. Activation of the heart by donor brain death accelerates acute rejection after transplantation. Circulation 2000; 102: 2426.
26. Wagner FD, Jonitz B, Potapov E, et al. Procalcitonin: A donor-specific predictor of early graft failure and early graft failure mortality after heart transplantation. J Heart Lung Transplant 2001; 20: 206.
27. Follette DM, Rudich SM, Babcock WD. Improved oxygenation and increased lung donor recovery with high-dose steroid administration after brain death. J Heart Lung Transplant 1998; 17: 423.